专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明专利

JP2014001142A Cycloalkane compound 审中-公开
标题翻译：环己酮化合物
公开(公告)号：JP2014001142A
公开(公告)日：2014-01-09
申请号：JP2010226100
申请日：2010-10-05
申请人： Astellas Pharma Inc , アステラス製薬株式会社
发明人： YAMAZAKI SHINGO , HONJO ERIKO , MITSUMIZU KIYOTOMO , KURODA AKIO , YONEZAWA KOICHI , HAYASHIBE SATOSHI , SUZUKI TAKAYUKI , HOSHII HIROAKI , MITANI YASUYUKI , AKASHIBA HIROAKI
IPC分类号： C07C229/46 , A61K31/196 , A61K31/27 , A61K31/275 , A61K31/35 , A61K31/41 , A61K31/44 , A61K31/4406 , A61K31/47 , A61P25/28 , A61P43/00 , C07C255/58 , C07C271/24 , C07C317/48 , C07C381/00 , C07D213/38 , C07D215/12 , C07D257/04 , C07D309/04
CPC分类号： C07D211/70 , C07C229/46 , C07C233/54 , C07C233/63 , C07C237/18 , C07C237/30 , C07C255/58 , C07C271/24 , C07C271/28 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2603/74 , C07D211/72 , C07D213/38 , C07D213/46 , C07D215/12 , C07D215/14 , C07D251/04 , C07D257/04 , C07D295/14 , C07D295/16 , C07D309/04 , C07D311/80 , C07D317/72
摘要： PROBLEM TO BE SOLVED: To provide a novel cycloalkane compound or a pharmaceutically acceptable salt thereof that powerfully suppresses production of Aβ42 and has a regulatory effect on the function of γ-secretase and that is useful particularly as a prophylactic and therapeutic agent for alzheimer disease.SOLUTION: In a compound (I), a carboxy group or a tetrazole group is bound to a cycloalkane part through a linker. An amine is bound to the cycloalkane part directly or through a linker.
摘要翻译：要解决的问题：提供一种强效抑制Aβ42产生的新型环烷烃化合物或其药学上可接受的盐，并且对γ-分泌酶的功能具有调节作用，并且其特别用作阿尔茨海默病的预防和治疗剂疾病。解决方案：在化合物（I）中，羧基或四唑基团通过接头与环烷烃部分结合。胺直接或通过连接体与环烷烃部分结合。

2. 发明专利

RS57532B1 BICIKLIČNO JEDINJENJE KOJE SADRŽI SUMPOR 未知
公开(公告)号：RS57532B1
公开(公告)日：2018-10-31
申请号：RSP20180865
申请日：2014-10-17
申请人： ASTELLAS PHARMA INC
发明人： SHIRAISHI NOBUYUKI , HOSHII HIROAKI , HAMAGUCHI WATARU , HONJO ERIKO , TAKUWA TOMOFUMI , KONDO YUJI , GOTO TAKAYUKI
IPC分类号： C07D495/04 , A61K31/519 , A61K31/5377 , A61K31/541 , A61K31/554 , A61P25/00 , A61P25/18 , A61P25/22 , A61P43/00 , C07D519/00

3. 发明专利

MY177271A SULFUR-CONTAINING BICYCLIC COMPOUND 未知
公开(公告)号：MY177271A
公开(公告)日：2020-09-10
申请号：MYPI2016701379
申请日：2014-10-17
申请人： ASTELLAS PHARMA INC
发明人： SHIRAISHI NOBUYUKI , HOSHII HIROAKI , HAMAGUCHI WATARU , HONJO ERIKO , TAKUWA TOMOFUMI , KONDO YUJI , GOTO TAKAYUKI
摘要： [Problem] Provided is a compound which is useful as a pharmaceutical composition for preventing and/or treating schizophrenia, cognitive impairment associated with schizophrenia (CIAS), cognitive impairment, fragile X syndrome, autism spectrum disorder, spasticity, anxiety disorder, substance addiction, pain, fibromyalgia, Charcot Marie- Tooth disease, or the like. [Means for Solution] The present inventors have studied that a pharmaceutical composition for preventing and/or treating schizophrenia, cognitive impairment associated with schizophrenia (CIAS), cognitive impairment, fragile X syndrome, autism spectrum disorder, spasticity, anxiety disorder, substance addiction, pain, fibromyalgia, Charcot Marie- Tooth disease, or the like, which has a positive allosteric modulator (PAM action) of GABAs, and have found that a sulfur-containing bicyclic compound is a PAM of a GABAs receptor, thereby completing the present invention. The sulfur-containing bicyclic compound of the present invention has a PAM action of GABAs, and can be used as an agent for preventing and/or treating schizophrenia, CIAS, cognitive impairment, fragile X syndrome, autism spectrum disorder, spasticity, anxiety disorder, substance addiction, pain, fibromyalgia, or Charcot-Marie-Tooth disease.

4. 发明专利

HUE040208T2 Kéntartalmú biciklikus vegyület 未知
公开(公告)号：HUE040208T2
公开(公告)日：2019-02-28
申请号：HUE14853825
申请日：2014-10-17
申请人： ASTELLAS PHARMA INC
发明人： SHIRAISHI NOBUYUKI , HOSHII HIROAKI , HAMAGUCHI WATARU , HONJO ERIKO , TAKUWA TOMOFUMI , KONDO YUJI , GOTO TAKAYUKI
IPC分类号： A61P25/00 , A61P25/18 , A61P25/22 , A61P43/00

5. 发明专利

SI3059239T1 ŽVEPLO VSEBUJOČA BICIKLIČNA SPOJINA 未知
公开(公告)号：SI3059239T1
公开(公告)日：2018-08-31
申请号：SI201430780
申请日：2014-10-17
申请人： ASTELLAS PHARMA INC
发明人： SHIRAISHI NOBUYUKI , HOSHII HIROAKI , HAMAGUCHI WATARU , HONJO ERIKO , TAKUWA TOMOFUMI , KONDO YUJI , GOTO TAKAYUKI
IPC分类号： C07D495/00 , A61K31/00 , A61P25/00 , A61P43/00 , C07D519/00

6. 发明专利

MX2016004944A COMPUESTO BICICLICO QUE CONTIENE AZUFRE. 未知
公开(公告)号：MX2016004944A
公开(公告)日：2016-07-11
申请号：MX2016004944
申请日：2014-10-17
申请人： ASTELLAS PHARMA INC
发明人： SHIRAISHI NOBUYUKI , HAMAGUCHI WATARU , HOSHII HIROAKI , HONJO ERIKO , TAKUWA TOMOFUMI , KONDO YUJI , GOTO TAKAYUKI
IPC分类号： C07D495/04 , A61K31/519 , A61K31/5377 , A61K31/541 , A61K31/554 , A61P25/00 , A61P25/18 , A61P25/22 , A61P43/00 , C07D519/00
摘要： Se provee un compuesto que es útil como una composición farmacéutica para la prevención y/o el tratamiento de esquizofrenia, daño cognitivo asociado con esquizofrenia (CIAS), deterioro cognitivo, síndrome de X frágil, trastorno de espectro autista, espasticidad, trastorno de ansiedad, adicción a sustancias, dolor, fibromialgia, síndrome de Charcot-Marie-Tooth, o similares afecciones. Los presentes inventores han estudiado que una composición farmacéutica para la prevención y/o el tratamiento de esquizofrenia, daño cognitivo asociado con esquizofrenia (CIAS), deterioro cognitivo, síndrome de X frágil, trastorno de espectro autista, espasticidad, trastorno de ansiedad, adicción a sustancias, dolor, fibromialgia, síndrome de Charcot-Marie-Tooth, o similares, que tiene un modulador alostérico positivo (acción PAM) de GABAB, y han hallado que un compuesto bicíclico que contiene azufre es un PAM de un receptor GABAB, de modo de completar así la presente invención. El compuesto bicíclico que contiene azufre de la presente invención tiene una acción PAM de GABAB, y puede usarse como un agente para la prevención y/o el tratamiento de esquizofrenia, CIAS, deterioro cognitivo, síndrome de X frágil, trastorno de espectro autista, espasticidad, trastorno de ansiedad, adicción a sustancias, dolor, fibromialgia, o síndrome de Charcot-Marie-Tooth.

7. 发明专利

CA2927518C SULFUR-CONTAINING BICYCLIC COMPOUND 未知
公开(公告)号：CA2927518C
公开(公告)日：2022-04-12
申请号：CA2927518
申请日：2014-10-17
申请人： ASTELLAS PHARMA INC
发明人： SHIRAISHI NOBUYUKI , HOSHII HIROAKI , HAMAGUCHI WATARU , HONJO ERIKO , TAKUWA TOMOFUMI , KONDO YUJI , GOTO TAKAYUKI
IPC分类号： C07D495/04 , A61K31/519 , A61K31/5377 , A61K31/541 , A61K31/554 , A61P25/00 , A61P25/18 , A61P25/22 , A61P43/00 , C07D519/00
摘要： Provided is a compound of formula (I) and pharmaceutical compositions thereof for preventing and/or treating schizophrenia, cognitive impairment associated with schizophrenia (CIAS), cognitive impairment, fragile X syndrome, autism spectrum disorder, spasticity, anxiety disorder, substance addiction, pain, fibromyalgia or Charcot-Marie-Tooth disease. The sulfur-containing bicyclic compound of formula (I) has a PAM action of GABA8 , and can be used as an agent for preventing and/or treating schizophrenia, CIAS, cognitive impairment, fragile X syndrome, autism spectrum disorder, spasticity, anxiety disorder, substance addiction, pain, fibromyalgia, or Charcot-Marie-Tooth disease. (see formula I)

8. 发明专利

CY1120880T1 ΔΙΚΥΚΛΙΚΗ ΕΝΩΣΗ ΠΟΥ ΠΕΡΙΕΧΕΙ ΘΕΙΟ 未知
公开(公告)号：CY1120880T1
公开(公告)日：2020-05-29
申请号：CY181100858
申请日：2018-08-14
申请人： ASTELLAS PHARMA INC
发明人： SHIRAISHI NOBUYUKI , HOSHII HIROAKI , HAMAGUCHI WATARU , HONJO ERIKO , TAKUWA TOMOFUMI , KONDO YUJI , GOTO TAKAYUKI
IPC分类号： C07D495/04 , A61K31/519 , A61K31/5377 , A61K31/541 , A61K31/554 , A61P25/00 , A61P25/18 , A61P25/22 , A61P43/00 , C07D519/00
摘要： [Πρόβλημα] Παροχήένωσηςπουείναιχρήσιμηωςφαρμακευτικήσύνθεσηγιαπρόληψηή/καιθεραπείαασθενειώνόπωςσχιζοφρένειας. [Επίλυση] Οιεφευρέτεςανέπτυξαντηνπαρούσαεφεύρεσηκατάτηδιερεύνησηφαρμακευτικήςσύνθεσηςπουέχειαποτελέσματαωςθετικόςαλλοστερικόςρυθμιστής GABAB (αποτελέσματαωςΡΑΜ) γιαπρόληψηθεραπείαςασθενειώνόπωςσχιζοφρένειαςκαιεπιβεβαίωσηότιδικυκλικήένωσηπουπεριέχειθείοέχειαποτελέσματαως GABAB ΡΑΜ. Αυτήη δικυκλικήένωσηπουπεριέχειθείοέχειαποτελέσματαως GABAB ΡΑΜκαιμπορείναχρησιμοποιηθείωςπροληπτικόςή/καιθεραπευτικόςπαράγωνγιαασθένειεςόπωςσχιζοφρένεια. (Στοντύπο, Χαντιπροσωπεύει CH, R1 αντιπροσωπεύεικατώτερηαλκύλ, R2 αντιπροσωπεύεικατώτερηαλκύλ, R3 αντιπροσωπεύει -Η, R4 αντιπροσωπεύει -Η, δακτύλιοςΑ είναιδακτύλιοςκυκλοεξανίου, RY αντιπροσωπεύειομάδαπουαντιπροσωπεύεταιαπότοντύπο (III), ΥαντιπροσωπεύειΝΗ, κ.λπ., και RL αντιπροσωπεύεικατώτερηαλκύλ.

9. 发明专利

PL3059239T3 ZWIĄZEK BICYKLICZNY ZAWIERAJĄCY SIARKĘ 未知
公开(公告)号：PL3059239T3
公开(公告)日：2018-10-31
申请号：PL14853825
申请日：2014-10-17
申请人： ASTELLAS PHARMA INC
发明人： SHIRAISHI NOBUYUKI , HOSHII HIROAKI , HAMAGUCHI WATARU , HONJO ERIKO , TAKUWA TOMOFUMI , KONDO YUJI , GOTO TAKAYUKI
IPC分类号： C07D495/04 , A61K31/519 , A61K31/5377 , A61K31/541 , A61K31/554 , A61P25/00 , A61P25/18 , A61P25/22 , A61P43/00 , C07D519/00

10. 发明专利

SG11201602926UA SULFUR-CONTAINING BICYCLIC COMPOUND 未知
公开(公告)号：SG11201602926UA
公开(公告)日：2016-05-30
申请号：SG11201602926U
申请日：2014-10-17
申请人： ASTELLAS PHARMA INC
发明人： SHIRAISHI NOBUYUKI , HOSHII HIROAKI , HAMAGUCHI WATARU , HONJO ERIKO , TAKUWA TOMOFUMI , KONDO YUJI , GOTO TAKAYUKI
IPC分类号： C07D495/04 , A61K31/519 , A61K31/5377 , A61K31/541 , A61K31/554 , A61P25/00 , A61P25/18 , A61P25/22 , A61P43/00 , C07D519/00
摘要： [Problem] Provided is a compound which is useful as a pharmaceutical composition for preventing and/or treating schizophrenia, cognitive impairment associated with schizophrenia (CIAS), cognitive impairment, fragile X syndrome, autism spectrum disorder, spasticity, anxiety disorder, substance addiction, pain, fibromyalgia, Charcot-Marie-Tooth disease, or the like. [Means for Solution] The present inventors have studied that a pharmaceutical composition for preventing and/or treating schizophrenia, cognitive impairment associated with schizophrenia (CIAS), cognitive impairment, fragile X syndrome, autism spectrum disorder, spasticity, anxiety disorder, substance addiction, pain, fibromyalgia, Charcot-Marie-Tooth disease, or the like, which has a positive allosteric modulator (PAM action) of GABA B , and have found that a sulfur-containing bicyclic compound is a PAM of a GABA B receptor, thereby completing the present invention. The sulfur-containing bicyclic compound of the present invention has a PAM action of GABA B , and can be used as an agent for preventing and/or treating schizophrenia, CIAS, cognitive impairment, fragile X syndrome, autism spectrum disorder, spasticity, anxiety disorder, substance addiction, pain, fibromyalgia, or Charcot-Marie-Tooth disease.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式