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1. 发明授权

US07079955B2 System and method for integrated analysis of data for characterizing carbohydrate polymers 失效
标题翻译：用于综合分析碳水化合物聚合物数据的系统和方法
公开(公告)号：US07079955B2
公开(公告)日：2006-07-18
申请号：US10415955
申请日：2001-11-05
申请人： Assaf Peretz Oron , Einat Or , Ofer Markman , Leonid Shvartser , Nava Zaarur
发明人： Assaf Peretz Oron , Einat Or , Ofer Markman , Leonid Shvartser , Nava Zaarur
IPC分类号： G06F19/00
CPC分类号： G01N33/5308
摘要： A system and method for characterizing carbohydrate polymers according to maps obtained from experimental data. Preferably, the data is obtained from a plurality of different types of experimental assays for characterizing the carbohydrate polymer. More preferably, at least one such assay involves binding a saccharide-binding agent to the carbohydrate polymer. One or more features of the carbohydrate polymer are then preferably characterized. These features are preferably derived from maps of the data obtained from assays involving the sample carbohydrate polymer. These maps are more preferably analyzed at a plurality of levels, with each level providing more abstract biological information. Most preferably, new types of experimental data are introduced to the process of analysis at each level, in order to support more complex analyses of the data. Optionally and most preferably, maps are eliminated at each level as being inconsistent with the experimental data. New maps are most preferably added at a higher level only if they are derived from the new experimental data which has been introduced at that level, in order to prevent a combinatorial explosion at successive levels of data analysis.
摘要翻译：根据从实验数据获得的图谱来表征碳水化合物聚合物的系统和方法。优选地，数据是从用于表征碳水化合物聚合物的多种不同类型的实验测定中获得的。更优选地，至少一种这样的测定包括将糖结合剂结合到碳水化合物聚合物上。然后优选表征碳水化合物聚合物的一个或多个特征。这些特征优选地衍生自从涉及样品碳水化合物聚合物的测定获得的数据的图。这些图更优选地在多个级别分析，每个级别提供更抽象的生物信息。最优选地，将新类型的实验数据引入到每个级别的分析过程，以便支持更复杂的数据分析。可选地，最优选地，在每个级别消除与实验数据不一致的映射。只有当新地图来自于在该级别引入的新实验数据时，才能更高级地添加新地图，以防止连续数据分析级别的组合爆炸。

2. 发明申请

US20080182282A1 Methods for comparitive analysis of carbohydrate polymers and carbohydrate polymers identified using same 审中-公开
标题翻译：碳水化合物聚合物和碳水化合物聚合物的比较分析方法
公开(公告)号：US20080182282A1
公开(公告)日：2008-07-31
申请号：US11982399
申请日：2007-10-31
申请人： Ofer Markman , Chana Rothemann-Scherz , Yehudit Amor , Assaf Peretz Oron , Einat Or
发明人： Ofer Markman , Chana Rothemann-Scherz , Yehudit Amor , Assaf Peretz Oron , Einat Or
IPC分类号： C12Q1/34 , G01N33/00 , C12Q1/00 , C12Q1/48 , G01N33/536 , C40B30/04
CPC分类号： G01N33/66 , G01N33/6893 , G01N2500/00 , Y10T436/142222 , Y10T436/143333
摘要： Disclosed is a method for characterizing a carbohydrate polymer by identifying at least two binding agents that bind to the carbohydrate polymer. Binding is preferably determined by contacting the carbohydrate polymer with substrate that contains a plurality of first saccharide-binding agents affixed at predetermined locations on the substrate. The carbohydrate polymer is allowed to contact the substrate under conditions that allow for formation of a first complex between the first saccharide-binding agent and the carbohydrate polymer. A second saccharide-binding agent, which preferably includes a label, is also contacted with the carbohydrate polymer under conditions that allow for formation of a second complex between the second binding agent and the first complex. Identification of the first and second binding agent allows for characterization of the polysaccharide.
摘要翻译：公开了通过鉴定结合至碳水化合物聚合物的至少两种结合剂来表征碳水化合物聚合物的方法。优选通过使碳水化合物聚合物与含有固定在基材上预定位置的多个第一糖结合剂的底物接触来确定结合。允许碳水化合物聚合物在允许在第一糖结合剂和碳水化合物聚合物之间形成第一配合物的条件下接触底物。优选包括标签的第二糖结合剂在允许在第二结合剂和第一配合物之间形成第二配合物的条件下也与碳水化合物聚合物接触。鉴定第一和第二结合剂允许表征多糖。

3. 发明申请

US20080293075A1 Method and Composition for Analyzing A Carbohydrate Polymer 审中-公开
标题翻译：分析碳水化合物聚合物的方法和组成
公开(公告)号：US20080293075A1
公开(公告)日：2008-11-27
申请号：US12176959
申请日：2008-07-21
申请人： Ofer Markman , Assaf Peretz Oron , Chana Rothemann-Schertz
发明人： Ofer Markman , Assaf Peretz Oron , Chana Rothemann-Schertz
IPC分类号： G01N33/53
CPC分类号： G01N33/5308 , G01N2400/00
摘要： Disclosed is a method for characterizing carbohydrate polymer by identifying at least two binding agents that bind to the carbohydrate polymer. Binding is preferably determined by contacting the carbohydrate polymer with substrate that contains a plurality of first saccharide-binding agents affixed at predetermined locations on the substrate. The carbohydrate polymer is allowed to contact the substrate under conditions that allow for formation of a first complex between the first saccharide-binding agent and the carbohydrate polymer. A second saccharide-binding agent, which preferably includes a label, is also contacted with the carbohydrate polymer under conditions that allow for formation of a second complex between the second binding agent and the first complex. Identification of the first and second binding agent allows for characterization of the polysaccharide.
摘要翻译：公开了通过鉴定结合碳水化合物聚合物的至少两种结合剂来表征碳水化合物聚合物的方法。优选通过使碳水化合物聚合物与含有固定在基材上预定位置的多个第一糖结合剂的底物接触来确定结合。允许碳水化合物聚合物在允许在第一糖结合剂和碳水化合物聚合物之间形成第一配合物的条件下接触底物。优选包括标签的第二糖结合剂在允许在第二结合剂和第一配合物之间形成第二配合物的条件下也与碳水化合物聚合物接触。鉴定第一和第二结合剂允许表征多糖。

4. 发明申请

US20050158146A1 Method of preparing purified biologically active oligosaccharide libraries 审中-公开
标题翻译：制备纯化的生物活性寡糖文库的方法
公开(公告)号：US20050158146A1
公开(公告)日：2005-07-21
申请号：US10493050
申请日：2002-10-16
申请人： Amor Yehudit , Ofer Markman , Mirit Gulko , Albena Samokovlisky , Idil Kelson , Ana Grosz-Moraga , Leonid Shvartser
发明人： Amor Yehudit , Ofer Markman , Mirit Gulko , Albena Samokovlisky , Idil Kelson , Ana Grosz-Moraga , Leonid Shvartser
IPC分类号： C12P19/04 , C12P19/14 , F16B21/00
CPC分类号： C12P19/04 , C12P19/14
摘要： Disclosed are methods of making oligosaccharide libraries whose members have defined structural and/or functional properties, as well as methods of making and using the oligosaccharide libraries.
摘要翻译：公开了制备其成员具有定义结构和/或功能性质的寡糖文库的方法，以及制备和使用寡糖文库的方法。

5. 发明申请

US20120277116A1 Disease diagnosis according to saccharide binding 审中-公开
标题翻译：疾病诊断根据糖结合
公开(公告)号：US20120277116A1
公开(公告)日：2012-11-01
申请号：US13545118
申请日：2012-07-10
申请人： Ofer Markman , Assaf (Assaph) Peretz Oron , Chana Rothmann-Schertz
发明人： Ofer Markman , Assaf (Assaph) Peretz Oron , Chana Rothmann-Schertz
IPC分类号： C40B30/04 , C12Q1/70 , G01N33/574 , G01N33/569 , G01N33/566 , G01N33/53
CPC分类号： G01N33/5308 , G01N2400/00
摘要： Disclosed is a method for characterizing carbohydrate polymer by identifying at least two binding agents that bind to the carbohydrate polymer. Binding is preferably determined by contacting the carbohydrate polymer with substrate that contains a plurality of first saccharide-binding agents affixed at predetermined locations on the substrate. The carbohydrate polymer is allowed to contact the substrate under conditions that allow for formation of a first complex between the first saccharide-binding agent and the carbohydrate polymer. In one aspect, the method is used in the diagnosis of a disease, including a viral disease, an autoimmune disease, a bacterial infection, or cancer.
摘要翻译：公开了通过鉴定结合碳水化合物聚合物的至少两种结合剂来表征碳水化合物聚合物的方法。优选通过使碳水化合物聚合物与含有固定在基材上预定位置的多个第一糖结合剂的底物接触来确定结合。允许碳水化合物聚合物在允许在第一糖结合剂和碳水化合物聚合物之间形成第一配合物的条件下接触底物。一方面，该方法用于诊断疾病，包括病毒性疾病，自身免疫疾病，细菌感染或癌症。

6. 发明授权

US08119357B2 Method for analyzing a glycomolecule 失效
标题翻译：分析糖分子的方法
公开(公告)号：US08119357B2
公开(公告)日：2012-02-21
申请号：US12895064
申请日：2010-09-30
申请人： Yehudit Amor , Ofer Markman , Mirit Kolog Gulko , Albena Samokovlisky , Fredi Kleinman , Tal Alergand , Rakefet Rosenfeld , Ruth Maya , Sabina Rebe , Idil Kelson Kasuto , Haim Bangio
发明人： Yehudit Amor , Ofer Markman , Mirit Kolog Gulko , Albena Samokovlisky , Fredi Kleinman , Tal Alergand , Rakefet Rosenfeld , Ruth Maya , Sabina Rebe , Idil Kelson Kasuto , Haim Bangio
IPC分类号： G01N33/53
CPC分类号： G01N33/5308 , G01N2333/42 , G01N2333/924 , G01N2400/02
摘要： The invention relates generally the structural analysis of glycomolecule-containing macromolecules, such as those that occur either attached to proteins (proteoglycans, glycoproteins), lipids, or as free saccharides.
摘要翻译：本发明一般涉及含糖分子的大分子的结构分析，例如与蛋白质（蛋白聚糖，糖蛋白），脂质或游离糖连接的那些。

7. 发明授权

US07455979B2 Polysaccharide structure and sequence determination 失效
标题翻译：多糖结构和序列测定
公开(公告)号：US07455979B2
公开(公告)日：2008-11-25
申请号：US11403507
申请日：2006-04-12
申请人： Ofer Markman
发明人： Ofer Markman
IPC分类号： G01N33/53
CPC分类号： G01N33/66 , C12Q1/34 , G01N33/5308 , G01N2333/42 , G01N2333/924 , G01N2400/00 , G01N2400/02 , G01N2400/10 , Y10T436/143333
摘要： The invention provides a method for the structural analysis of a saccharide, comprising: a) providing on a surface a plurality of essentially sequence- and/or site-specific binding agents; b) contacting said surface with a saccharide to be analyzed, or with a mixture comprising a plurality of fragments of said saccharide; c) washing or otherwise removing unbound saccharide or saccharide fragments; d) adding to the surface obtained in step c) an essentially sequence- and/or site-specific marker, or a mixture of essentially sequence- and/or site-specific markers; e) acquiring one or more images of the markers that are bound to said surface; and f) deriving information related to the identity of the saccharide being analyzed from said image.
摘要翻译：本发明提供了一种用于糖的结构分析的方法，包括：a）在表面上提供多个基本上序列和/或位点特异性结合剂; b）使所述表面与待分析的糖接触，或与包含所述糖的多个片段的混合物接触; c）洗涤或以其他方式去除未结合的糖或糖片段; d）加入步骤c）中获得的表面基本上是序列和/或位点特异性标记，或基本上序列和/或位点特异性标记的混合物; e）获取结合到所述表面的标记的一个或多个图像; 以及f）从所述图像导出与正在分析的糖的身份有关的信息。

8. 发明授权

US07741061B2 Polysaccharide structure and sequence determination 失效
标题翻译：多糖结构和序列测定
公开(公告)号：US07741061B2
公开(公告)日：2010-06-22
申请号：US12269273
申请日：2008-11-12
申请人： Ofer Markman
发明人： Ofer Markman
IPC分类号： G01N33/53
CPC分类号： G01N33/66 , C12Q1/34 , G01N33/5308 , G01N2333/42 , G01N2333/924 , G01N2400/00 , G01N2400/02 , G01N2400/10 , Y10T436/143333
摘要： The invention provides a method for the structural analysis of a saccharide, comprising: a) providing on a surface a plurality of essentially sequence- and/or site-specific binding agents; b) contacting said surface with a saccharide to be analyzed, or with a mixture comprising a plurality of fragments of said saccharide; c) washing or otherwise removing unbound saccharide or saccharide fragments; d) adding to the surface obtained in step c) an essentially sequence- and/or site-specific marker, or a mixture of essentially sequence- and/or site-specific markers; e) acquiring one or more images of the markers that are bound to said surface; and f) deriving information related to the identity of the saccharide being analyzed from said image.
摘要翻译：本发明提供了一种用于糖的结构分析的方法，包括：a）在表面上提供多个基本上序列和/或位点特异性结合剂; b）使所述表面与待分析的糖接触，或与包含所述糖的多个片段的混合物接触; c）洗涤或以其他方式去除未结合的糖或糖片段; d）加入步骤c）中获得的表面基本上是序列和/或位点特异性标记，或基本上序列和/或位点特异性标记的混合物; e）获取结合到所述表面的标记的一个或多个图像; 以及f）从所述图像导出与正在分析的糖的身份有关的信息。

9. 发明授权

US07407773B2 Method for characterizing a carbohydrate polymer 失效
标题翻译：表征碳水化合物聚合物的方法
公开(公告)号：US07407773B2
公开(公告)日：2008-08-05
申请号：US11402646
申请日：2006-04-11
申请人： Ofer Markman , Assaf (Assaph) Peretz Oron , Chana Rothmann-Schertz
发明人： Ofer Markman , Assaf (Assaph) Peretz Oron , Chana Rothmann-Schertz
IPC分类号： C12Q1/34
CPC分类号： G01N33/5308 , G01N2400/00
摘要： Disclosed is a method for characterizing carbohydrate polymer by identifying at least two binding agents that bind to the carbohydrate polymer. Binding is preferably determined by contacting the carbohydrate polymer with substrate that contains a plurality of first saccharide-binding agents affixed at predetermined locations on the substrate. The carbohydrate polymer is allowed to contact the substrate under conditions that allow for formation of a first complex between the first saccharide-binding agent and the carbohydrate polymer. A second saccharide-binding agent, which preferably includes a label, is also contacted with the carbohydrate polymer under conditions that allow for formation of a second complex between the second binding agent and the first complex. Identification of the first and second binding agent allows for characterization of the polysaccharide.
摘要翻译：公开了通过鉴定结合碳水化合物聚合物的至少两种结合剂来表征碳水化合物聚合物的方法。优选通过使碳水化合物聚合物与含有固定在基材上预定位置的多个第一糖结合剂的底物接触来确定结合。允许碳水化合物聚合物在允许在第一糖结合剂和碳水化合物聚合物之间形成第一配合物的条件下接触底物。优选包括标签的第二糖结合剂在允许在第二结合剂和第一配合物之间形成第二配合物的条件下也与碳水化合物聚合物接触。鉴定第一和第二结合剂允许表征多糖。

10. 发明授权

US07056678B1 Polysaccharide structure and sequence determination 失效
公开(公告)号：US07056678B1
公开(公告)日：2006-06-06
申请号：US09979610
申请日：2000-05-04
申请人： Ofer Markman
发明人： Ofer Markman
IPC分类号： G01N33/53
CPC分类号： G01N33/6803 , G01N33/5308
摘要： The invention provides a method for the structural analysis of a saccharide, comprising: a) providing on a surface a plurality of essentially sequence- and/or site-specific binding agents; b) contacting said surface with a saccharide to be analyzed, or with a mixture comprising a plurality of fragments of said saccharide; c) washing or otherwise removing unbound saccharide or saccharide fragments; d) adding to the surface obtained in step c) an essentially sequence- and/or site-specific marker, or a mixture of essentially sequence- and/or site-specific markers; e) acquiring one or more images of the markers that are bound to said surface; and f) deriving information related to the identity of the saccharide being analyzed from said image.

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