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1. 发明授权

US07060075B2 Distal targeting of locking screws in intramedullary nails 有权
标题翻译：髓内钉锁定螺钉远端靶向
公开(公告)号：US07060075B2
公开(公告)日：2006-06-13
申请号：US10198514
申请日：2002-07-18
申请人： Assaf Govari , Avinoam Dayan , Dale G. Davison , Thomas G. Ferro
发明人： Assaf Govari , Avinoam Dayan , Dale G. Davison , Thomas G. Ferro
IPC分类号： A61B17/17
CPC分类号： A61B17/1725 , A61B17/1707 , A61B2090/397
摘要： In a distal targeting system a hand-held location pad is integral with a guide section for a drill or similar surgical instrument, and has a plurality of magnetic field generators. A sensor, such as a wireless sensor, having a plurality of field transponders, is disposed in an orthopedic appliance, such as an intramedullary nail. The sensor is capable of detecting and discriminating the strength and direction of the different fields generated by the field generators. Control circuitry, preferably located in the location pad is responsive to a signal of the sensor, and determines the displacement and relative directions of an axis of the guide section, and a bore in the orthopedic appliance. A screen display and optional speaker in the location pad provide an operator-perceptible indication that enables the operator to adjust the position of the guide section so as to align its position and direction with the bore.
摘要翻译：在远侧瞄准系统中，手持位置垫与用于钻或类似手术器械的引导部分成一体，并且具有多个磁场发生器。具有多个场应答器的诸如无线传感器的传感器被布置在诸如髓内钉的矫形器具中。传感器能够检测和区分场发生器产生的不同场强度和方向。优选地位于定位垫中的控制电路响应于传感器的信号，并且确定导向部分的轴线的位移和相对方向以及矫形器具中的孔。位置垫中的屏幕显示器和可选的扬声器提供操作者可感知的指示，其使得操作者能够调整引导部分的位置，以便将其位置和方向与孔对准。

2. 发明申请

US20050080427A1 Distal targeting of locking screws in intramedullary nails 审中-公开
标题翻译：髓内钉锁定螺钉远端靶向
公开(公告)号：US20050080427A1
公开(公告)日：2005-04-14
申请号：US10961690
申请日：2004-10-08
申请人： Assaf Govari , Avinoam Dayan , Dale Davison , Thomas Ferro
发明人： Assaf Govari , Avinoam Dayan , Dale Davison , Thomas Ferro
IPC分类号： A61B17/58 , A61B17/00 , A61B17/17
CPC分类号： A61B17/1725 , A61B17/1707 , A61B2090/397
摘要： In a distal targeting system a hand-held location pad is integral with a guide section for a drill or similar surgical instrument, and has a plurality of magnetic field generators. A sensor, such as a wireless sensor, having a plurality of field transponders, is disposed in an orthopedic appliance, such as an intramedullary nail. The sensor is capable of detecting and discriminating the strength and direction of the different fields generated by the field generators. Control circuitry, preferably located in the location pad is responsive to a signal of the sensor, and determines the displacement and relative directions of an axis of the guide section, and a bore in the orthopedic appliance. A screen display and optional speaker in the location pad provide an operator-perceptible indication that enables the operator to adjust the position of the guide section so as to align its position and direction with the bore.
摘要翻译：在远侧瞄准系统中，手持位置垫与用于钻或类似手术器械的引导部分成一体，并且具有多个磁场发生器。具有多个场应答器的诸如无线传感器的传感器被布置在诸如髓内钉的矫形器具中。传感器能够检测和区分场发生器产生的不同场强度和方向。优选地位于定位垫中的控制电路响应于传感器的信号，并且确定导向部分的轴线的位移和相对方向以及矫形器具中的孔。位置垫中的屏幕显示器和可选的扬声器提供操作者可感知的指示，其使得操作者能够调整引导部分的位置，以便将其位置和方向与孔对准。

3. 发明申请

US20070083245A1 STIMULATION FOR TREATING BRAIN EVENTS AND OTHER CONDITIONS 有权
标题翻译：刺激脑部事件和其他条件
公开(公告)号：US20070083245A1
公开(公告)日：2007-04-12
申请号：US11465381
申请日：2006-08-17
申请人： Itschak Lamensdorf , Avinoam Dayan , Hernan Altman
发明人： Itschak Lamensdorf , Avinoam Dayan , Hernan Altman
IPC分类号： A61N1/18
CPC分类号： A61N1/0551 , A61N1/36017 , A61N1/36082
摘要： Apparatus for treatment is provided, including one or more electrodes, configured to be applied to a site of a subject, and adverse cerebrovascular condition treatment functionality. The functionality comprises a control unit configured to drive the one or more electrodes to apply electrical stimulation to the site during a plurality of stimulation periods which includes at least first and last stimulation periods, set an inter-period interval between initiation of the first stimulation period and initiation of the last stimulation period to be at least 24 hours, and configure the stimulation during the first and last stimulation periods to induce at least one neuroprotective occurrence selected from the group consisting of: an increase in cerebral blood flow (CBF) of the subject, and a release of one or more neuroprotective substances. The site is selected from the group consisting of: a sphenopalatine ganglion (SPG), a greater palatine nerve, a lesser palatine nerve, a sphenopalatine nerve, a communicating branch between a maxillary nerve and an SPG, an otic ganglion, an afferent fiber going into the otic ganglion, an efferent fiber going out of the otic ganglion, an infraorbital nerve, a vidian nerve, a greater superficial petrosal nerve, and a lesser deep petrosal nerve. Additional embodiments are also described.
摘要翻译：提供了用于治疗的装置，包括构造成施加到受试者的部位的一个或多个电极和不良的脑血管病症治疗功能。功能包括控制单元，其被配置为驱动一个或多个电极，以在包括至少第一和最后刺激周期的多个刺激周期期间对该部位施加电刺激，设定第一刺激周期的开始之间的周期间隔并且最后刺激期的开始至少24小时，并且在第一和最后刺激期间配置刺激以诱导至少一种选自以下的神经保护作用：增加脑血流量（CBF）受试者和一种或多种神经保护物质的释放。该部位选自下组：蝶腭神经节（SPG），较大的腭神经，较少的腭神经，蝶腭神经，上颌神经与SPG之间的沟通分支，耳神经节，传入纤维进入耳神经节，输出纤维出于耳神经节，下眶神经，维神经，较浅的腹腔神经和较小深的岩石神经。还描述了另外的实施例。

4. 发明授权

US08055347B2 Stimulation for treating brain events and other conditions 有权
标题翻译：刺激治疗脑部事件和其他病症
公开(公告)号：US08055347B2
公开(公告)日：2011-11-08
申请号：US11465381
申请日：2006-08-17
申请人： Itschak Lamensdorf , Avinoam Dayan , Hernan Altman
发明人： Itschak Lamensdorf , Avinoam Dayan , Hernan Altman
IPC分类号： A61N1/36
CPC分类号： A61N1/0551 , A61N1/36017 , A61N1/36082
摘要： Apparatus for treatment is provided, including one or more electrodes, configured to be applied to a site of a subject, and adverse cerebrovascular condition treatment functionality. The functionality comprises a control unit configured to drive the one or more electrodes to apply electrical stimulation to the site during a plurality of stimulation periods which includes at least first and last stimulation periods, set an inter-period interval between initiation of the first stimulation period and initiation of the last stimulation period to be at least 24 hours, and configure the stimulation during the first and last stimulation periods to induce at least one neuroprotective occurrence selected from the group consisting of: an increase in cerebral blood flow (CBF) of the subject, and a release of one or more neuroprotective substances. The site is selected from the group consisting of: a sphenopalatine ganglion (SPG), a greater palatine nerve, a lesser palatine nerve, a sphenopalatine nerve, a communicating branch between a maxillary nerve and an SPG, an otic ganglion, an afferent fiber going into the otic ganglion, an efferent fiber going out of the otic ganglion, an infraorbital nerve, a vidian nerve, a greater superficial petrosal nerve, and a lesser deep petrosal nerve. Additional embodiments are also described.
摘要翻译：提供了用于治疗的装置，包括构造成施加到受试者的部位的一个或多个电极和不良的脑血管病症治疗功能。功能包括控制单元，其被配置为驱动一个或多个电极，以在包括至少第一和最后刺激周期的多个刺激周期期间对该部位施加电刺激，设定第一刺激周期的开始之间的周期间隔并且最后刺激期的开始至少24小时，并且在第一和最后刺激期间配置刺激以诱导至少一种选自以下的神经保护作用：增加脑血流量（CBF）受试者和一种或多种神经保护物质的释放。该部位选自下组：蝶腭神经节（SPG），较大的腭神经，较少的腭神经，蝶腭神经，上颌神经与SPG之间的沟通分支，耳神经节，传入纤维进入耳神经节，输出纤维出于耳神经节，下眶神经，维神经，较浅的腹腔神经和较小深的岩石神经。还描述了另外的实施例。

5. 发明申请

US20090210026A1 SPG STIMULATION FOR ENHANCING NEUROGENESIS AND BRAIN METABOLISM 审中-公开
标题翻译： SPG刺激增强神经细胞和脑代谢
公开(公告)号：US20090210026A1
公开(公告)日：2009-08-20
申请号：US12197614
申请日：2008-08-25
申请人： Yoram Solberg , Gal Ariav , Hernan Altman , Avinoam Dayan
发明人： Yoram Solberg , Gal Ariav , Hernan Altman , Avinoam Dayan
IPC分类号： A61N1/36
CPC分类号： A61N1/36082 , A61N1/36017 , A61N1/37252 , A61N1/3787
摘要： A method is provided, including identifying an electrical stimulation protocol as being suitable for augmenting genesis of one or more cell populations in at least one brain region of the subject. The cell genesis is augmented by applying the identified stimulation protocol to an SPG, a greater palatine nerve, a branch of the greater palatine nerve, a lesser palatine nerve, a sphenopalatine nerve, a communicating branch between a maxillary nerve and an SPG, an otic ganglion, an afferent fiber going into the otic ganglion, an efferent fiber going out of the otic ganglion, an infraorbital nerve, a vidian nerve, a greater superficial petrosal nerve, a lesser deep petrosal nerve, a maxillary nerve, a branch of the maxillary nerve, a nasopalatine nerve, a peripheral site that provides direct or indirect afferent innervation to the SPG, or a peripheral site that is directly or indirectly efferently innervated by the SPG.
摘要翻译：提供了一种方法，其包括将电刺激方案识别为适合于增加受试者的至少一个脑区域中一个或多个细胞群的发生。通过将识别的刺激方案应用于SPG，较大的腭神经，较大的腭神经的分支，较小的腭神经，蝶腭神经，上颌神经和SPG之间的连通分支，耳部神经节，进入耳神经节的传入纤维，从耳神经节出来的传出纤维，下眶神经，维管神经，较大的浅表岩石神经，较小深的岩石神经，上颌神经，上颌分支神经，鼻窦神经，向SPG提供直接或间接传入神经支配的外周部位，或由SPG直接或间接传播的外周部位。

6. 发明授权

US07561919B2 SPG stimulation via the greater palatine canal 有权
标题翻译： SPG刺激通过更大的腭运河
公开(公告)号：US07561919B2
公开(公告)日：2009-07-14
申请号：US11349020
申请日：2006-02-07
申请人： Alon Shalev , Yossi Gross , Hernan Altman , Avinoam Dayan , Leonid Degtyar , Adi Lorian , Amir Natan
发明人： Alon Shalev , Yossi Gross , Hernan Altman , Avinoam Dayan , Leonid Degtyar , Adi Lorian , Amir Natan
IPC分类号： A61N1/18
CPC分类号： A61N1/36017 , A61B5/026 , A61N1/0546 , A61N1/0548 , A61N1/326 , A61N1/36025 , A61N1/36082 , A61N1/37223
摘要： Apparatus for application to a subject is provided, including an elongated support element having a length of between 1.8 cm and 4 cm, and having proximal and distal ends; and one or more electrodes fixed to the support element in a vicinity of the distal end thereof, and adapted to apply an electrical current to a sphenopalatine ganglion (SPG) of the subject. The apparatus further includes a receiver, fixed to the support element, and electrically coupled to the electrodes; and a wireless transmitter, adapted to be placed in an oral cavity of the subject, and to be wirelessly coupled to the receiver. Other embodiments are also described.
摘要翻译：提供了一种用于受试者的装置，包括长度在1.8厘米至4厘米之间的细长支撑元件，并具有近端和远端; 以及在其远端附近固定到支撑元件的一个或多个电极，并且适于向受试者的蝶腭神经节（SPG）施加电流。该装置还包括固定到支撑元件并且电耦合到电极的接收器; 以及适于被放置在所述对象的口腔中并且被无线地耦合到所述接收器的无线发射器。还描述了其它实施例。

7. 发明申请

US20080167700A1 SPG STIMULATION FOR TREATING COMPLICATIONS OF SUBARACHNOID HEMORRHAGE 有权
标题翻译：用于治疗子宫内膜异位症综合征的SPG刺激
公开(公告)号：US20080167700A1
公开(公告)日：2008-07-10
申请号：US11928024
申请日：2007-10-30
申请人： Alon Shalev , Yossi Gross , Hernan Altman , Avinoam Dayan , Leonid Degtyar , Adi Lorian , Amir Natan
发明人： Alon Shalev , Yossi Gross , Hernan Altman , Avinoam Dayan , Leonid Degtyar , Adi Lorian , Amir Natan
IPC分类号： A61N1/05
CPC分类号： A61N1/0548 , A61N1/0546 , A61N1/205 , A61N1/36017 , A61N1/3606 , A61N1/37229
摘要： A method is provided including identifying that a subject has suffered a subarachnoid hemorrhage (SAH), and treating a complication of the SAH by stimulating at least one site of the subject in conjunction with treating the SAH, the site selected from the group consisting of: a sphenopalatine ganglion (SPG), a greater palatine nerve, a lesser palatine nerve, a sphenopalatine nerve, a communicating branch between a maxillary nerve and an SPG, an otic ganglion, an afferent fiber going into the otic ganglion, an efferent fiber going out of the otic ganglion, an infraorbital nerve, a vidian nerve, a greater superficial petrosal nerve, and a lesser deep petrosal nerve.
摘要翻译：提供了一种方法，其包括鉴定受试者遭受蛛网膜下腔出血（SAH），以及通过与治疗SAH一起刺激受试者的至少一个部位来治疗SAH并发症，所述SAH选自：蝶腭神经节（SPG），更大的腭神经，较少的腭神经，蝶腭神经，上颌神经和SPG之间的沟通分支，耳神经节，进入耳神经节的传入纤维，出射纤维出去耳神经节，眶下神经，维神经，较浅的腹腔神经和较小深的岩石神经。

8. 发明授权

US08406869B2 Post-acute electrical stimulation treatment of adverse cerebrovascular events 有权
标题翻译：急性电刺激治疗不良脑血管事件
公开(公告)号：US08406869B2
公开(公告)日：2013-03-26
申请号：US13223929
申请日：2011-09-01
申请人： Itschak Lamensdorf , Avinoam Dayan , Hernan Altman
发明人： Itschak Lamensdorf , Avinoam Dayan , Hernan Altman
IPC分类号： A61N1/18
CPC分类号： A61N1/0551 , A61N1/36017 , A61N1/36082
摘要： A method for treatment is provided, including identifying that a subject has suffered from an adverse cerebrovascular event, excluding Alzheimer's disease and Parkinson's disease. Responsively to the identifying, beginning at least nine hours after the event, electrical stimulation is applied to a site of the subject selected from the group consisting of: a sphenopalatine ganglion (SPG), a greater palatine nerve, a lesser palatine nerve, a sphenopalatine nerve, a communicating branch between a maxillary nerve and an SPG, an otic ganglion, an afferent fiber going into the otic ganglion, an efferent fiber going out of the otic ganglion, an infraorbital nerve, a vidian nerve, a greater superficial petrosal nerve, and a lesser deep petrosal nerve. The stimulation is configured to excite nervous tissue of the site at a strength sufficient to induce at least an increase in cerebral blood flow (CBF) and/or a release of one or more neuroprotective substances.
摘要翻译：提供了一种治疗方法，包括鉴定受试者患有不良脑血管事件，不包括阿尔茨海默病和帕金森病。响应于识别，从事件发生后至少9小时开始，电刺激被应用于选自以下的对象的部位：蝶腭神经节（SPG），较大的腭神经，较少的腭神经，蝶丙氨酸神经，上颌神经和SPG之间的沟通分支，耳神经节，进入耳神经节的传入纤维，离开耳神经节的输出纤维，眶下神经，维生素神经，更大的表浅的岩石神经，和较深的岩石神经。刺激被配置为以足以诱导至少增加脑血流量（CBF）和/或释放一种或多种神经保护性物质的强度来激发部位的神经组织。

9. 发明申请

US20120016434A1 POST-ACUTE ELECTRICAL STIMULATION TREATMENT OF ADVERSE CEREBROVASCULAR EVENTS 有权
标题翻译：急性电刺激治疗不良性脑血管事件
公开(公告)号：US20120016434A1
公开(公告)日：2012-01-19
申请号：US13223929
申请日：2011-09-01
申请人： Itschak Lamensdorf , Avinoam Dayan , Hernan Altman
发明人： Itschak Lamensdorf , Avinoam Dayan , Hernan Altman
IPC分类号： A61N1/36
CPC分类号： A61N1/0551 , A61N1/36017 , A61N1/36082
摘要： A method for treatment is provided, including identifying that a subject has suffered from an adverse cerebrovascular event, excluding Alzheimer's disease and Parkinson's disease. Responsively to the identifying, beginning at least nine hours after the event, electrical stimulation is applied to a site of the subject selected from the group consisting of: a sphenopalatine ganglion (SPG), a greater palatine nerve, a lesser palatine nerve, a sphenopalatine nerve, a communicating branch between a maxillary nerve and an SPG, an otic ganglion, an afferent fiber going into the otic ganglion, an efferent fiber going out of the otic ganglion, an infraorbital nerve, a vidian nerve, a greater superficial petrosal nerve, and a lesser deep petrosal nerve. The stimulation is configured to excite nervous tissue of the site at a strength sufficient to induce at least one neuroprotective occurrence selected from the group consisting of: an increase in cerebral blood flow (CBF) of the subject, and a release of one or more neuroprotective substances.
摘要翻译：提供了一种治疗方法，包括鉴定受试者患有不良脑血管事件，不包括阿尔茨海默病和帕金森病。响应于识别，从事件发生后至少9小时开始，电刺激被应用于选自以下的对象的部位：蝶腭神经节（SPG），较大的腭神经，较少的腭神经，蝶丙氨酸神经，上颌神经和SPG之间的沟通分支，耳神经节，进入耳神经节的传入纤维，离开耳神经节的输出纤维，眶下神经，维神经，更浅的腹腔神经，和较深的岩石神经。刺激被配置为以足以诱导至少一种神经保护作用的强度激发位点的神经组织，所述神经保护作用选自：受试者的脑血流量（CBF）的增加和一种或多种神经保护的释放物质

10. 发明申请

US20060287677A1 SPG stimulation via the greater palatine canal 有权
公开(公告)号：US20060287677A1
公开(公告)日：2006-12-21
申请号：US11349020
申请日：2006-02-07
申请人： Alon Shalev , Yossi Gross , Hernan Altman , Avinoam Dayan , Leonid Degtyar , Adi Lorian , Amir Natan
发明人： Alon Shalev , Yossi Gross , Hernan Altman , Avinoam Dayan , Leonid Degtyar , Adi Lorian , Amir Natan
IPC分类号： A61N1/36
CPC分类号： A61N1/36017 , A61B5/026 , A61N1/0546 , A61N1/0548 , A61N1/326 , A61N1/36025 , A61N1/36082 , A61N1/37223
摘要： Apparatus for application to a subject is provided, including an elongated support element having a length of between 1.8 cm and 4 cm, and having proximal and distal ends; and one or more electrodes fixed to the support element in a vicinity of the distal end thereof, and adapted to apply an electrical current to a sphenopalatine ganglion (SPG) of the subject. The apparatus further includes a receiver, fixed to the support element, and electrically coupled to the electrodes; and a wireless transmitter, adapted to be placed in an oral cavity of the subject, and to be wirelessly coupled to the receiver. Other embodiments are also described.

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