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1. 发明申请

US20140031339A1 INHIBITORS OF LEUKOTRIENE PRODUCTION 有权
标题翻译：白藜芦素生产抑制剂
公开(公告)号：US20140031339A1
公开(公告)日：2014-01-30
申请号：US13942988
申请日：2013-07-16
申请人： Asitha ABEYWARDANE , Steven Richard BRUNETTE , Michael Jason BURKE , Thomas Martin KIRRANE, JR. , Chuk Chui MAN , Daniel Richard MARSHALL , Anil Kumar PADYANA , Hossein RAZAVI , Robert SIBLEY , Lana Louise SMITH KEENAN , Roger John SNOW , Ronald John SORCEK , Hidenori TAKAHASHI , Steven John TAYLOR , Michael Robert TURNER , Erick Richard Roush YOUNG , Qiang ZHANG , Yunlong ZHANG , Renee M. ZINDELL
发明人： Asitha ABEYWARDANE , Steven Richard BRUNETTE , Michael Jason BURKE , Thomas Martin KIRRANE, JR. , Chuk Chui MAN , Daniel Richard MARSHALL , Anil Kumar PADYANA , Hossein RAZAVI , Robert SIBLEY , Lana Louise SMITH KEENAN , Roger John SNOW , Ronald John SORCEK , Hidenori TAKAHASHI , Steven John TAYLOR , Michael Robert TURNER , Erick Richard Roush YOUNG , Qiang ZHANG , Yunlong ZHANG , Renee M. ZINDELL
IPC分类号： C07D401/14 , C07D413/14 , C07D487/04 , C07D498/04 , C07D497/08 , A61K31/5377 , A61K31/55 , A61K31/549 , A61K31/496 , A61K31/4545 , A61K31/454 , C07D405/12 , A61K31/551
CPC分类号： C07D487/04 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/5377 , A61K31/549 , A61K31/55 , A61K31/551 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/20 , C07D491/20 , C07D497/08 , C07D498/04
摘要： The present invention relates to compounds of formula (I): or a pharmaceutically acceptable salt thereof, wherein A1, A2, L1 and B are as defined herein. The compounds of formula (I) are useful as inhibitors of leukotriene A4 hydrolase (LTA4H) and treating LTA4H related disorders. The present invention also relates to pharmaceutical compositions comprising the compounds of formula (I), methods of using these compounds in the treatment of various diseases and disorders, and processes for preparing these compounds.
摘要翻译：本发明涉及式（I）化合物或其药学上可接受的盐，其中A1，A2，L1和B如本文所定义。式（I）化合物可用作白三烯A4水解酶（LTA4H）的抑制剂和治疗LTA4H相关疾病。本发明还涉及包含式（I）化合物的药物组合物，使用这些化合物治疗各种疾病和病症的方法，以及制备这些化合物的方法。

2. 发明申请

US20130244996A1 BENZODIOXANE INHIBITORS OF LEUKOTRIENE PRODUCTION 有权
标题翻译：雷诺酮生产的苯并咪唑抑制剂
公开(公告)号：US20130244996A1
公开(公告)日：2013-09-19
申请号：US13785034
申请日：2013-03-05
申请人： Asitha ABEYWARDANE , Steven Richard BRUNETTE , Michael J. BURKE , Suresh R. KAPADIA , Thomas Martin KIRRANE , Matthew Russell NETHERTON , Hossein RAZAVI , Sonia RODRIGUEZ , Anjan SAHA , Robert SIBLEY , Lana Louise SMITH-KEENAN , Hidenori TAKAHASHI , Michael Robert TURNER , Jiang-Ping WU , Erick Richard Roush YOUNG , Qiang ZHANG , Qing ZHANG , Renee M. ZINDELL
发明人： Asitha ABEYWARDANE , Steven Richard BRUNETTE , Michael J. BURKE , Suresh R. KAPADIA , Thomas Martin KIRRANE , Matthew Russell NETHERTON , Hossein RAZAVI , Sonia RODRIGUEZ , Anjan SAHA , Robert SIBLEY , Lana Louise SMITH-KEENAN , Hidenori TAKAHASHI , Michael Robert TURNER , Jiang-Ping WU , Erick Richard Roush YOUNG , Qiang ZHANG , Qing ZHANG , Renee M. ZINDELL
IPC分类号： C07D491/052 , C07D513/04 , C07D295/155 , C07D405/10 , C07D295/096
CPC分类号： C07D491/052 , A61K31/357 , C07D295/096 , C07D295/155 , C07D319/20 , C07D405/10 , C07D405/12 , C07D405/14 , C07D413/10 , C07D417/10 , C07D417/14 , C07D471/10 , C07D487/04 , C07D487/08 , C07D487/10 , C07D491/04 , C07D513/04 , C07D519/00
摘要： The present invention relates to compounds of formula (I): wherein R1 to R3, A, X and n are as defined herein. The compounds of formula (I) are useful as inhibitors of leukotriene A4 hydrolase (LTA4H) and treating LTA4H related disorder. The present invention also relates to pharmaceutical compositions comprising the compounds of formula (I), methods of using these compounds in the treatment of various diseases and disorders, and processes for preparing these compounds.
摘要翻译：本发明涉及式（I）的化合物：其中R1至R3，A，X和n如本文所定义。式（I）化合物可用作白三烯A4水解酶（LTA4H）的抑制剂和治疗LTA4H相关病症。本发明还涉及包含式（I）化合物的药物组合物，使用这些化合物治疗各种疾病和病症的方法，以及制备这些化合物的方法。

3. 发明申请

US20130345195A1 BENZODIOXANE INHIBITORS OF LEUKOTRIENE PRODUCTION 审中-公开
公开(公告)号：US20130345195A1
公开(公告)日：2013-12-26
申请号：US13974879
申请日：2013-08-23
申请人： Asitha ABEYWARDANE , Michael J. BURKE , Thomas Martin KIRRANE , Matthew Russell NETHERTON , Anil Kumar PADYANA , Lana Louise SMITH KEENAN , Hidenori TAKAHASHI , Michael Robert TURNER , QIANG ZHANG , Qing ZHANG
发明人： Asitha ABEYWARDANE , Michael J. BURKE , Thomas Martin KIRRANE , Matthew Russell NETHERTON , Anil Kumar PADYANA , Lana Louise SMITH KEENAN , Hidenori TAKAHASHI , Michael Robert TURNER , QIANG ZHANG , Qing ZHANG
IPC分类号： C07D487/08 , C07D295/096 , C07D471/10 , C07D405/14 , C07D405/12 , C07D487/04 , C07D319/20 , C07D405/10 , C07D295/16
CPC分类号： C07D295/16 , A61K31/397 , A61K31/5377 , C07D295/096 , C07D319/20 , C07D405/10 , C07D405/12 , C07D405/14 , C07D417/10 , C07D417/14 , C07D471/10 , C07D487/04 , C07D487/08 , C07D487/10 , C07D491/056
摘要： The present invention relates to compounds of formula (I): wherein R1 to R3, A, X and n are as defined herein. The compounds of formula (I) are useful as inhibitors of leukotriene A4 hydrolase (LTA4H) and treating LTA4H related disorder. The present invention also relates to pharmaceutical compositions comprising the compounds of formula (I), methods of using these compounds in the treatment of various diseases and disorders, and processes for preparing these compounds.

4. 发明申请

US20120322795A1 BIARYLAMIDE INHIBITORS OF LEUKOTRIENE PRODUCTION 有权
标题翻译：白藜芦素生产的氨基酰胺抑制剂
公开(公告)号：US20120322795A1
公开(公告)日：2012-12-20
申请号：US13325564
申请日：2011-12-14
申请人： Angela BERRY , Zhidong CHEN , Stephane DE LOMBAERT , Michel Jose EMMANUEL , Pui Leng LOKE , Chuk Chui MAN , Tina Marie MORWICK , Hidenori TAKAHASHI
发明人： Angela BERRY , Zhidong CHEN , Stephane DE LOMBAERT , Michel Jose EMMANUEL , Pui Leng LOKE , Chuk Chui MAN , Tina Marie MORWICK , Hidenori TAKAHASHI
IPC分类号： A61K31/506 , C07D405/14 , C07D417/14 , C07D413/14 , A61K31/5377 , C07D471/04 , A61K31/519 , C07D239/42 , A61K31/505 , C07D413/12 , C07D417/12 , A61K31/4439 , C07D401/12 , A61K31/501 , A61K31/4709 , A61K31/427 , A61K31/541 , A61K31/444 , C07D403/12 , C07D513/04 , A61P9/00 , A61P9/10 , A61P29/00 , A61P37/08 , A61P11/00 , A61P13/12 , A61P35/00 , C07D405/10
CPC分类号： C07D405/10 , C07D239/42 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要： The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein A, B, C, R1a, R1b, R2, R3, R4a and R4b are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
摘要翻译：本发明涉及式（I）化合物及其药学上可接受的盐，其中A，B，C，R 1a，R 1b，R 2，R 3，R 4a和R 4b如本文所定义。本发明还涉及包含这些化合物的药物组合物，使用这些化合物治疗各种疾病和病症的方法，制备这些化合物的方法和可用于这些方法的中间体。

5. 发明申请

US20110301161A1 BENZIMIDAZOLE INHIBITORS OF LEUKOTRIENE PRODUCTION 有权
标题翻译：紫杉醇生产的苯并咪唑抑制剂
公开(公告)号：US20110301161A1
公开(公告)日：2011-12-08
申请号：US12957766
申请日：2010-12-01
申请人： Zhidong CHEN , Ming-Hong HAO , Weimin LIU , Ho-Yin LO , Pui Leng LOKE , Chuk Chui MAN , Tina Marie MORWICK , Peter Allen NEMOTO , Hidenori TAKAHASHI , Heather TYE , Lifen WU
发明人： Zhidong CHEN , Ming-Hong HAO , Weimin LIU , Ho-Yin LO , Pui Leng LOKE , Chuk Chui MAN , Tina Marie MORWICK , Peter Allen NEMOTO , Hidenori TAKAHASHI , Heather TYE , Lifen WU
IPC分类号： A61K31/506 , C07D471/04 , C07D401/14 , C07D413/14 , A61K31/437 , A61P35/00 , A61K31/5377 , A61K31/497 , A61P9/00 , A61P29/00 , A61P37/08 , A61P13/12 , C07D403/14 , A61K31/4439
CPC分类号： C07D471/04 , C07D401/12 , C07D403/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： The present invention relates to compounds of formula (I): and pharmaceutically acceptable salt thereof, wherein R1-R7 are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
摘要翻译：本发明涉及式（I）化合物及其药学上可接受的盐，其中R 1 -R 7如本文所定义。本发明还涉及包含这些化合物的药物组合物，使用这些化合物治疗各种疾病和病症的方法，制备这些化合物的方法和可用于这些方法的中间体。

6. 发明申请

US20150018333A1 INHIBITORS OF LEUKOTRIENE PRODUCTION 有权
标题翻译：白藜芦素生产抑制剂
公开(公告)号：US20150018333A1
公开(公告)日：2015-01-15
申请号：US14330297
申请日：2014-07-14
申请人： Asitha ABEYWARDANE , John BROADWATER , Hidenori TAKAHASHI
发明人： Asitha ABEYWARDANE , John BROADWATER , Hidenori TAKAHASHI
IPC分类号： C07D401/14 , A61K31/4709 , A61K31/496
CPC分类号： C07D401/14 , A61K31/4709 , A61K31/496
摘要： The present invention relates to compounds of formula (I): or a pharmaceutically acceptable salt thereof, wherein R1 is defined herein. The compounds of formula (I) are useful as inhibitors of leukotriene A4 hydrolase (LTA4H) and treating LTA4H related disorders. The present invention also relates to pharmaceutical compositions comprising the compounds of formula (I), methods of using these compounds in the treatment of various diseases and disorders, and processes for preparing these compounds.
摘要翻译：本发明涉及式（I）化合物或其药学上可接受的盐，其中R 1在本文中定义。式（I）化合物可用作白三烯A4水解酶（LTA4H）的抑制剂和治疗LTA4H相关疾病。本发明还涉及包含式（I）化合物的药物组合物，使用这些化合物治疗各种疾病和病症的方法，以及制备这些化合物的方法。

7. 发明申请

US20120231393A1 ACTINIC-RAY- OR RADIATION-SENSITIVE RESIN COMPOSITION AND METHOD OF FORMING A PATTERN USING THE SAME 有权
标题翻译：抗紫外线或辐射敏感性树脂组合物及其形成图案的方法
公开(公告)号：US20120231393A1
公开(公告)日：2012-09-13
申请号：US13421684
申请日：2012-03-15
申请人： Kana FUJII , Tomotaka TSUCHIMURA , Toru FUJIMORI , Hidenori TAKAHASHI , Takayuki ITO
发明人： Kana FUJII , Tomotaka TSUCHIMURA , Toru FUJIMORI , Hidenori TAKAHASHI , Takayuki ITO
IPC分类号： G03F7/027 , G03F7/016 , G03F7/20 , G03F7/004
CPC分类号： G03F7/0392 , G03F7/0045 , G03F7/0397 , G03F7/2041 , G03F7/30 , Y10S430/106 , Y10S430/111 , Y10S430/12
摘要： According to one embodiment, an actinic-ray- or radiation-sensitive resin composition includes a resin that is decomposed when acted on by an acid to thereby increase its solubility in an alkali developer, a compound that generates an acid when exposed to actinic rays or radiation, and any of basic compounds of general formula (1) below.
摘要翻译：根据一个实施方案，光化射线或辐射敏感性树脂组合物包括当被酸作用时分解的树脂，从而增加其在碱性显影剂中的溶解度，当暴露于光化射线时产生酸的化合物或辐射和下述通式（1）的任何碱性化合物。

8. 发明申请

US20120219758A1 RESIST COMPOSITION, RESIST FILM THEREFROM AND METHOD OF FORMING NEGATIVE PATTERN USING THE COMPOSITION 审中-公开
标题翻译：耐蚀组合物，其抗静电膜和使用组合物形成负面图案的方法
公开(公告)号：US20120219758A1
公开(公告)日：2012-08-30
申请号：US13406213
申请日：2012-02-27
申请人： Tadahiro ODANI , Hidenori TAKAHASHI , Kana FUJII
发明人： Tadahiro ODANI , Hidenori TAKAHASHI , Kana FUJII
IPC分类号： B32B3/30 , G03F7/20 , G03F7/027
CPC分类号： G03F7/0046 , G03F7/0045 , G03F7/0397 , G03F7/2041 , G03F7/325 , Y10T428/24479
摘要： Provided is a resist composition including a resin (A) containing any of repeating units (a) of general formulae (RI-a) and (RI-b) below, any of repeating units (b) of general formula (R2) below, any of repeating units (c) of general formula (R3) below and a repeating unit (d) being different from the repeating units (c) and containing a group that when acted on by an acid, is decomposed, a compound (B) that when exposed to actinic rays or radiation, is decomposed to thereby generate an acid, and any of compounds (C) of general formula (PDA-1) below.
摘要翻译：本发明提供一种抗蚀剂组合物，其含有下述通式（RI-a）和（RI-b）的重复单元（a），下述通式（R2）的重复单元（b）下列通式（R 3）的重复单元（c）和重复单元（d）与重复单元（c）不同且含有被酸作用的基团分解的化合物（B）当暴露于光化射线或辐射时，其被分解，从而产生酸，以及下述通式（PDA-1）的任何化合物（C）。

9. 发明申请

US20110222858A1 OPTICAL COMMUNICATION APPARATUS AND OPTICAL COMMUNICATION METHOD 审中-公开
标题翻译：光通信装置和光通信方法
公开(公告)号：US20110222858A1
公开(公告)日：2011-09-15
申请号：US13011400
申请日：2011-01-21
申请人： Hidenori TAKAHASHI , Itsuro MORITA
发明人： Hidenori TAKAHASHI , Itsuro MORITA
IPC分类号： H04J14/00 , H04J14/02
CPC分类号： H04B10/548
摘要： A present invention provides an optical communication apparatus and method which can use a data modulator and an OFDM modulator more narrow band than a transmission band.The optical communication apparatus comprise an intensity modulation means for modulating intensity of continuous light with a sine wave, a means for separating optical signal outputted by said intensity modulation means into a bottom sideband and an upper sideband and outputting, a first modulation means for modulating said upper sideband with a first electrical signal, a second modulation means for modulating said bottom sideband with a second electrical signal, and a multiplex means for multiplexing an output signal from said first modulation means and an output signal from said second modulation means and outputting.
摘要翻译：本发明提供一种可以使用比传输频带更窄的数据调制器和OFDM调制器的光通信装置和方法。光通信装置包括用于以正弦波调制连续光的强度的强度调制装置，用于将由所述强度调制装置输出的光信号分离为底边带和上边带的装置，并输出第一调制装置，用于调制所述具有第一电信号的上边带，用于用第二电信号调制所述底边带的第二调制装置，以及用于对来自所述第一调制装置的输出信号和来自所述第二调制装置的输出信号进行多路复用的多路复用装置，并输出。

10. 发明申请

US20120171618A1 ACTINIC-RAY- OR RADIATION-SENSITIVE RESIN COMPOSITION AND METHOD OF FORMING A PATTERN USING THE SAME 审中-公开
标题翻译：抗紫外线或辐射敏感性树脂组合物及其形成图案的方法
公开(公告)号：US20120171618A1
公开(公告)日：2012-07-05
申请号：US13421680
申请日：2012-03-15
申请人： Yusuke IIZUKA , Hidenori TAKAHASHI , Michihiro SHIRAKAWA , Masahiro YOSHIDOME , Shuji HIRANO
发明人： Yusuke IIZUKA , Hidenori TAKAHASHI , Michihiro SHIRAKAWA , Masahiro YOSHIDOME , Shuji HIRANO
IPC分类号： G03F7/20 , G03F7/004
CPC分类号： C08F220/26 , G03F7/0397 , G03F7/2041
摘要： According to one embodiment, an actinic-ray- or radiation-sensitive resin composition includes a resin containing a repeating unit (A) containing both a structural moiety (S1) that is decomposed by an action of an acid to thereby generate an alkali-soluble group and a structural moiety (S2) that is decomposed by an action of an alkali developer to thereby increase its rate of dissolution into the alkali developer, and a compound that generates an acid when exposed to actinic rays or radiation.
摘要翻译：根据一个实施方案，光化射线或辐射敏感性树脂组合物包含含有重复单元（A）的树脂，所述重复单元（A）含有通过酸的作用而分解的结构部分（S1），从而产生碱溶性基团和通过碱性显影剂的作用分解的结构部分（S2），从而增加其对碱性显影剂的溶解速率，以及当暴露于光化射线或辐射时产生酸的化合物。

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