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1. 发明授权

US06949557B2 Hydroanthracene based compounds as anticancer agents 失效
标题翻译：基于氢化蒽的化合物作为抗癌剂
公开(公告)号：US06949557B2
公开(公告)日：2005-09-27
申请号：US10426026
申请日：2003-04-29
申请人： Asish Kumar Banerjee , Venkatachalam Sesha Giri , Rama Mukherjee , Kamal K. Kapoor , Gautam Desiraju , Manu Jaggi , Anu T. Singh , Sankar Kumar Dutta , Kalapatapu V. V. M. Sairam
发明人： Asish Kumar Banerjee , Venkatachalam Sesha Giri , Rama Mukherjee , Kamal K. Kapoor , Gautam Desiraju , Manu Jaggi , Anu T. Singh , Sankar Kumar Dutta , Kalapatapu V. V. M. Sairam
IPC分类号： A61P35/00 , C07C43/23 , C07C49/753 , C07C49/755 , C07C50/34 , C07C50/38 , C07C69/00 , C07C69/013 , C07C69/145 , C07C69/157 , C07C229/34 , C07C271/22 , C07D239/30 , C07D263/06 , C07C50/16 , A61K31/12 , C07C263/06 , C07C239/28
CPC分类号： C07D239/30 , C07C43/23 , C07C49/753 , C07C49/755 , C07C50/34 , C07C50/38 , C07C69/013 , C07C69/14 , C07C229/34 , C07C271/22 , C07C2603/24 , C07D263/06
摘要： The invention relates to the use of novel anthracene based compounds for the inhibition or prevention of the growth or multiplication of cancer cells, and to therapeutic compositions containing such compounds. The invention relates more specifically to the use of hydroanthracene based compounds for the inhibition and/or prevention of cancer of the colon, pancreas, prostate, lung, larynx, ovary, breast, glioblastoma, oral cavity, endothelial cells and leukemias. The agents of the invention form a distinct class, distinct from the anthracene, anthrone or anthraquinone derivatives.
摘要翻译：本发明涉及新型蒽基化合物在抑制或预防癌细胞生长或增殖中的应用，以及含有这些化合物的治疗组合物的用途。本发明更具体地涉及使用基于氢蒽的化合物用于抑制和/或预防结肠，胰腺，前列腺，肺，喉，卵巢，乳腺，成胶质细胞瘤，口腔，内皮细胞和白血病的癌症。本发明的药剂形成与蒽，蒽酮或蒽醌衍生物不同的不同类别。

2. 发明授权

US06613793B2 Anticancer activity of imino acid conjugates or methylglyoxal 失效
标题翻译：甲基乙二醛的亚氨基酸共轭物的抗癌活性
公开(公告)号：US06613793B2
公开(公告)日：2003-09-02
申请号：US10187420
申请日：2002-07-01
申请人： Anand C. Burman , Rama Mukherjee , Manu Jaggi , Anu T. Singh , Kamal K. Kapoor , Sudhanand Prasad , Manju Ray
发明人： Anand C. Burman , Rama Mukherjee , Manu Jaggi , Anu T. Singh , Kamal K. Kapoor , Sudhanand Prasad , Manju Ray
IPC分类号： A61K3140
CPC分类号： C07D207/28
摘要： The invention relates to the use of imino acid conjugates of methylglyoxal for the inhibition and/or treatment of cancer. The invention relates more specifically to the use imino acid conjugates of methylglyoxal for inhibition and/or treatment of cancer of the Colon, Prostate, Larynx, Kidney, Pancreas, Lung, Breast, Intestine, Oral cavity, Ovary, Glioblastoma, and Leukemia. The invention also relates to compositions and methods of inhibiting cancer using imino acid conjugates of methylglyoxal.
摘要翻译：本发明涉及甲基乙二醛的亚氨基酸偶联物用于抑制和/或治疗癌症的用途。本发明更具体地涉及使用甲基乙二醛的亚氨基酸缀合物用于抑制和/或治疗结肠，前列腺，喉，肾，胰腺，肺，乳腺，肠，口腔，卵巢，成胶质细胞瘤和白血病的癌症。本发明还涉及使用甲基乙二醛的亚氨基酸缀合物抑制癌症的组合物和方法。

3. 发明授权

US08022055B2 Betulinic acid derivatives 失效
标题翻译：桦木酸衍生物
公开(公告)号：US08022055B2
公开(公告)日：2011-09-20
申请号：US11883753
申请日：2005-12-29
申请人： Rama Mukherjee , Sanjay Kumar Srivastava , Mohammad Jamshed Ahmed Siddiqui , Manu Jaggi , Anu T. Singh , Anand Vardhan , Manoj Kumar Singh , Praveen Rajendran , Hemant Kumar Jajoo , Anand C. Burman , Vivek Kumar , Nidhi Rani , Shiv Kumar Agarwal
发明人： Rama Mukherjee , Sanjay Kumar Srivastava , Mohammad Jamshed Ahmed Siddiqui , Manu Jaggi , Anu T. Singh , Anand Vardhan , Manoj Kumar Singh , Praveen Rajendran , Hemant Kumar Jajoo , Anand C. Burman , Vivek Kumar , Nidhi Rani , Shiv Kumar Agarwal
IPC分类号： A61K31/33 , A61K31/40 , A61K31/34
CPC分类号： C07J71/0005 , C07J71/0047
摘要： The invention relates to novel betulinic acid derivatives of formula (I), wherein R is C(═CH2)CH3 or CH(CH3)2; R2 together with the adjacent carbonyl group forms a carboxylic acid, carboxylic acid ester or amide or substituted amide; R3 or R4 are hydrogen or aryl with the proviso that both are not independently hydrogen or alkyl or R3 and R4 are combined together to form an aryl ring optionally substituted with a group X, wherein X is selected from halogen, alkyl, cyano, nitro, alkoxy, amino or substituted amine; Y is N or O; and R1 is zero when Y is O, and R1 is hydrogen, alkyl or aryl alkyl when Y is N, useful for inhibition of tumor cancer cells.
摘要翻译：本发明涉及式（I）的新颖的桦木酸衍生物，其中R是C（= CH 2）CH 3或CH（CH 3）2; R2与相邻的羰基一起形成羧酸，羧酸酯或酰胺或取代的酰胺; R 3或R 4是氢或芳基，条件是两者不是独立地是氢或烷基，或者R 3和R 4结合在一起形成任选地被基团X取代的芳基，其中X选自卤素，烷基，氰基，硝基，烷氧基，氨基或取代的胺; Y是N或O; 当Y为O时，R1为零，当Y为N时，R1为氢，烷基或芳基烷基，可用于抑制肿瘤细胞。

4. 发明授权

US06828304B1 Peptides for treatment of cancer 失效
标题翻译：用于治疗癌症的肽
公开(公告)号：US06828304B1
公开(公告)日：2004-12-07
申请号：US09630345
申请日：2000-07-31
申请人： Anand C. Burman , Sudhanand Prasad , Rama Mukherjee , Manu Jaggi , Anu T. Singh , Rajan Sharma
发明人： Anand C. Burman , Sudhanand Prasad , Rama Mukherjee , Manu Jaggi , Anu T. Singh , Rajan Sharma
IPC分类号： A61K3800
CPC分类号： C07K7/06 , A61K38/00 , C07K14/57563
摘要： This invention relates to novel antiproliferative and anti secrectory peptides that are inhibitory to vasoactive intestinal peptide receptor and are useful in the treatment of cancer. The invention particularly relates to the synthesis of lipid-peptide conjugates containing fatty acids of different sizes, which inhibits the binding of VIP to its receptors. The invention encompasses methods for generation of these peptides, composition containing these peptides and the pharmacological applications of these peptides especially in the treatment and prevention of cancer.
摘要翻译：本发明涉及抑制血管活性肠肽受体并可用于治疗癌症的新型抗增殖和抗分解肽。本发明特别涉及含有不同大小的脂肪酸的脂质 - 肽缀合物的合成，其抑制VIP与其受体的结合。本发明包括用于产生这些肽的方法，含有这些肽的组合物以及这些肽的药理学应用，特别是在治疗和预防癌症中。

5. 发明授权

US06632832B1 Anti-cancer activity of carvedilol and its isomers 失效
标题翻译：卡维地洛及其异构体的抗癌活性
公开(公告)号：US06632832B1
公开(公告)日：2003-10-14
申请号：US10238992
申请日：2002-09-10
申请人： Anand C. Burman , Rama Mukherjee , Manu Jaggi , Anu T. Singh
发明人： Anand C. Burman , Rama Mukherjee , Manu Jaggi , Anu T. Singh
IPC分类号： A61K3140
CPC分类号： A61K31/403 , A61K31/00 , Y10S436/813 , Y10S514/908
摘要： The present invention provides for pharmaceutical compositions comprising carvedilol for treatment of cancer. More particularly the invention relates to the use of carvedilol for treatment of cancers of the colon, ovary, breast, prostate, pancreas, lung, melanoma, glioblastoma, oral cancer and leukemias. Although not bound to any theory, the anticancer activity of carvedilol appears to be attributed to the inhibition of Epidermal Growth Factor and Platelet derived growth factor dependent proliferation of cancer cells. Further, carvedilol exerts anticancer effect by inhibition of the Protein kinase C (PKC) activity and that of the cyclooxygenase 2 enzyme. The invention also relates to the anticancer activity of the optically pure isomers S(−) and R(+) of carvedilol and the use of carvedilol and its isomers in pharmaceutical compositions for the treatment of cancer.
摘要翻译：本发明提供包含用于治疗癌症的卡维地洛的药物组合物。更具体地，本发明涉及卡维地洛用于治疗结肠，卵巢，乳腺，前列腺，胰腺，肺，黑素瘤，成胶质细胞瘤，口腔癌和白血病的癌症的用途。虽然不受任何理论的约束，卡维地洛的抗癌活性似乎归因于表皮生长因子和血小板衍生生长因子依赖性增殖的癌细胞的抑制。此外，卡维地洛通过抑制蛋白激酶C（PKC）活性和环加氧酶2酶的活性而发挥抗癌作用。本发明还涉及卡维地洛的光学纯异构体S（ - ）和R（+）的抗癌活性以及用于治疗癌症的药物组合物中卡维地洛及其异构体的用途。

6. 发明授权

US06316414B1 Somatostatin analogs for the treatment of cancer 失效
标题翻译：生长抑素类似物用于治疗癌症
公开(公告)号：US06316414B1
公开(公告)日：2001-11-13
申请号：US09629371
申请日：2000-07-31
申请人： Anand C. Burman , Sudhanand Prasad , Rama Mukherjee , Manu Jaggi , Anu T. Singh , Archna Mathur
发明人： Anand C. Burman , Sudhanand Prasad , Rama Mukherjee , Manu Jaggi , Anu T. Singh , Archna Mathur
IPC分类号： A61K3800
CPC分类号： C07K14/6555 , A61K38/00
摘要： The present invention encompasses novel peptides that are agonists to somatostatin and the use of the agonists for treatment of cancer. The invention particularly relates to the design and synthesis of novel analogs of somatostatin incorporating &agr;, &agr;-dialkylated amino acids in a site specific manner. The invention encompasses methods for the generation of these peptides, compositions containing the peptides and the pharmacological applications of these peptides especially in the treatment and prevention of cancer.
摘要翻译：本发明包括作为促生长抑素激动剂的新型肽以及激动剂用于治疗癌症的用途。本发明特别涉及以特异性位点结合α，α-二烷基化氨基酸的生长抑素的新型类似物的设计和合成。本发明包括产生这些肽的方法，含有肽的组合物和这些肽的药理学应用，特别是在治疗和预防癌症中。

7. 发明授权

US07781398B2 Drug comprising synthetic peptide analogs for the treatment of cancer 失效
标题翻译：包含用于治疗癌症的合成肽类似物的药物
公开(公告)号：US07781398B2
公开(公告)日：2010-08-24
申请号：US11643342
申请日：2006-12-21
申请人： Rama Mukherjee , Anand C. Burman , Anu T. Singh , Manu Jaggi , Sudhanand Prasad , Sarjana Dutt
发明人： Rama Mukherjee , Anand C. Burman , Anu T. Singh , Manu Jaggi , Sudhanand Prasad , Sarjana Dutt
IPC分类号： A01N37/10 , A61K38/00
CPC分类号： A61K38/08 , A61K2300/00
摘要： The present invention relates to a combination of peptides that may be used for treatment of cancer. The peptide combination competes for the binding of specific neuropeptides at the plasma membrane and thereby alters the levels of key intracellular molecules implicated in cell proliferation, resulting in a broad spectrum of anticancer activity. The invention also relates to pharmaceutical compositions containing a combination of such peptide analogs.
摘要翻译：本发明涉及可用于治疗癌症的肽的组合。肽组合竞争在质膜上特异性神经肽的结合，从而改变涉及细胞增殖的关键细胞内分子的水平，导致广谱的抗癌活性。本发明还涉及含有这些肽类似物的组合的药物组合物。

8. 发明申请

US20080293682A1 Novel Betulinic Acid Derivatives 失效
标题翻译：新型桦木酸衍生物
公开(公告)号：US20080293682A1
公开(公告)日：2008-11-27
申请号：US11883753
申请日：2005-12-29
申请人： Rama Mukherjee , Kumar Srivastava , Mohammad Jamshed Ahmed Siddioui , Manu Jaggi , Anu T. Singh , Anand Vardhan , Manoj Kumar Singh , Praveen Rajendran , Hemant Kumar Jajoo , Anand C. Burman , Vivek Kumar , Nidhi Rani , Shiv Kumar Agarwal
发明人： Rama Mukherjee , Kumar Srivastava , Mohammad Jamshed Ahmed Siddioui , Manu Jaggi , Anu T. Singh , Anand Vardhan , Manoj Kumar Singh , Praveen Rajendran , Hemant Kumar Jajoo , Anand C. Burman , Vivek Kumar , Nidhi Rani , Shiv Kumar Agarwal
IPC分类号： A61K31/58 , A61P35/04
CPC分类号： C07J71/0005 , C07J71/0047
摘要： The invention relates to novel betulinic acid derivatives of formula (I), wherein R is C(═CH2) CH3 or CH(CH3)2; R2 together with the adjacent carbonyl group forms a carboxylic acid, carboxylic acid ester or amide or substituted amide; R3 or R4 are hydrogen or aryl with the proviso that both are not independently hydrogen or alkyl or R3 and R4 are combined together to form an aryl ring optionally substituted with a group X, wherein X is selected from halogen, alkyl, cyano, nitro, alkoxy, amino or substituted amine; Y is N or O; and R1 is zero when Y is O, and R1 is hydrogen, alkyl or aryl alkyl when Y is N, useful for inhibition of tumor cancer cells.
摘要翻译：本发明涉及式（I）的新型桦木酸衍生物，其中R为C（-CH 2）CH 3或CH（CH 3）2; R2与相邻的羰基一起形成羧酸，羧酸酯或酰胺或取代的酰胺; R 3或R 4是氢或芳基，条件是两者不是独立地是氢或烷基，或者R 3和R 4结合在一起形成任选地被基团X取代的芳基，其中X选自卤素，烷基，氰基，硝基，烷氧基，氨基或取代的胺; Y是N或O; 当Y为O时，R1为零，当Y为N时，R1为氢，烷基或芳基烷基，可用于抑制肿瘤细胞。

9. 发明授权

US06596692B1 Substance P analogs for the treatment of cancer 失效
标题翻译：物质P类似物治疗癌症
公开(公告)号：US06596692B1
公开(公告)日：2003-07-22
申请号：US09629642
申请日：2000-07-31
申请人： Anand C. Burman , Sudhanand Prasad , Rama Mukherjee , Manu Jaggi , Anu T. Singh
发明人： Anand C. Burman , Sudhanand Prasad , Rama Mukherjee , Manu Jaggi , Anu T. Singh
IPC分类号： A61K3800
CPC分类号： C07K7/22 , A61K38/00
摘要： The present invention encompasses novel synthetic peptide analogs that are antagonists to Substance P, substance P like peptides and related peptides and are useful for the treatment of cancer. The invention particularly relates to the design and synthesis of the novel substance P antagonist analogs incorporating &agr;,&agr;-dialkylated amino acids in a site specific manner. The invention encompasses methods for the generation of these peptides, compositions containing these peptides and pharmacological applications of these peptides specifically in the treatment and prevention of cancer.
摘要翻译：本发明包括对物质P，物质P如肽和相关肽的拮抗剂的新型合成肽类似物，并且可用于治疗癌症。本发明特别涉及以特定方式结合α，α-二烷基化氨基酸的新物质P拮抗剂类似物的设计和合成。本发明包括用于产生这些肽的方法，含有这些肽的组合物和这些肽的药理学应用特异性地用于治疗和预防癌症。

10. 发明授权

US06492330B1 Antiangiogenic drugs 失效
标题翻译：抗血管生成药物
公开(公告)号：US06492330B1
公开(公告)日：2002-12-10
申请号：US09248381
申请日：1999-02-11
申请人： Rama Mukherjee , Manu Jaggi , Sudhanand Prasad , Anand C. Burman , Praveen Rajendran , Archana Mathur , Anu T. Singh
发明人： Rama Mukherjee , Manu Jaggi , Sudhanand Prasad , Anand C. Burman , Praveen Rajendran , Archana Mathur , Anu T. Singh
IPC分类号： A61K3800
CPC分类号： A61K38/31 , A61K38/08 , A61K38/10 , C07K7/086 , C07K7/22 , C07K14/57563 , C07K14/6555
摘要： The invention relates to the use of peptides individually or in combination, for treating and/or preventing angiogenesis. It also relates to the use of peptide analogs or a combination of peptides referred to as MuJ-7 as anticancer drugs in restricting the tumor growth and spread by inhibiting tumor angiogenesis. MuJ-7, in addition inhibits metastasis through its antiangiogenic activity in all cancers. The invention also relates to a pharmaceutical composition containing either individual peptides or in combination, and methods of treatment of human beings and animals for curing and/or preventing angiogenesis.
摘要翻译：本发明涉及肽单独或组合用于治疗和/或预防血管生成的用途。它还涉及肽类似物或被称为MuJ-7的肽的组合作为抗癌药物在限制肿瘤生长和通过抑制肿瘤血管生成而扩散的用途。 MuJ-7还通过其所有癌症中的抗血管生成活性抑制转移。本发明还涉及含有单个肽或组合的药物组合物，以及用于治疗和/或预防血管生成的人和动物的治疗方法。

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