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1. 发明申请

US20050256532A1 Cardiovascular defect patch device and method 审中-公开
标题翻译：心血管缺损补片装置及方法
公开(公告)号：US20050256532A1
公开(公告)日：2005-11-17
申请号：US10845439
申请日：2004-05-12
申请人： Asha Nayak , Sean Saint , Terry Guinan , Ronan Thornton , Patrick Hanley , Hilda Mulvihill
发明人： Asha Nayak , Sean Saint , Terry Guinan , Ronan Thornton , Patrick Hanley , Hilda Mulvihill
IPC分类号： A61B17/00 , A61F2/06 , A61F2/82 , A61F2/04
CPC分类号： A61B17/0057 , A61B2017/00575 , A61B2017/00579 , A61B2017/0061
摘要： The present invention provides a defect patch device and method that patches a defect in the heart or other cardiovascular tissue. One aspect provides a PFO closure device and method that patches a PFO in the right atrium without the device extending through the PFO into the left atrium. The patch device includes a patch and a heart tissue engaging member for attaching the device over the defect. A deployment device and method includes a device positioner to advance the device out of a catheter and to position the device over the defect to attach the device to the tissue around the defect. The positioner may include a device expander or opener that opens the device for deployment.
摘要翻译：本发明提供一种补片在心脏或其他心血管组织中的缺陷的缺陷补丁装置和方法。一个方面提供了一种PFO闭合装置和方法，其在右心房中修补PFO，而不将装置延伸穿过PFO进入左心房。补片装置包括补片和心脏组织接合构件，用于将装置附接在缺陷上。部署装置和方法包括：装置定位器，用于将装置推出导管并将装置定位在缺陷上以将装置附接到缺陷周围的组织。定位器可以包括打开用于部署的设备的设备扩展器或开启器。

2. 发明申请

US20050209559A1 Apparatus and methods for the treatment of chronic total occlusions 审中-公开
标题翻译：用于治疗慢性全部闭塞的装置和方法
公开(公告)号：US20050209559A1
公开(公告)日：2005-09-22
申请号：US11084842
申请日：2005-03-18
申请人： Ronan Thornton , Anthony Semedo
发明人： Ronan Thornton , Anthony Semedo
IPC分类号： A61B17/00 , A61B17/22 , A61F2/958 , A61M25/00 , A61M25/01 , A61M29/00
CPC分类号： A61M25/0054 , A61B17/3207 , A61B2017/003 , A61B2017/22038 , A61B2017/22044 , A61B2017/22068 , A61B2017/22069 , A61M25/0068 , A61M25/008 , A61M25/0082 , A61M25/0147 , A61M25/10 , A61M2025/015
摘要： According to a first aspect of the invention there is provided a catheter assembly. A lumen extends through the catheter assembly and terminates with an exit port. The lumen being configured to receive a guide wire therein. The catheter assembly comprises a flexible distal segment having a predetermined length and a first predetermined outer diameter, a proximal segment having a second outer diameter greater than that of the first outer diameter, and an intermediate tapered section between the first proximal segment and the distal segment.
摘要翻译：根据本发明的第一方面，提供了一种导管组件。管腔延伸穿过导管组件并终止于出口。管腔构造成在其中容纳导丝。导管组件包括具有预定长度和第一预定外径的柔性远端段，具有大于第一外径的第二外径的近端段，以及在第一近端段和远段之间的中间锥形区段。

3. 发明授权

US09468746B2 Systems and methods for local bioactive material delivery 有权
标题翻译：用于局部生物活性物质输送的系统和方法
公开(公告)号：US09468746B2
公开(公告)日：2016-10-18
申请号：US11466322
申请日：2006-08-22
申请人： Ronan Thornton , Sean Whelan
发明人： Ronan Thornton , Sean Whelan
IPC分类号： A61F2/06 , A61M29/02 , A61F2/07 , A61B17/00 , A61M25/04 , A61M25/10 , A61F2/89
CPC分类号： A61M29/02 , A61B2017/00243 , A61B2017/00889 , A61B2017/00893 , A61F2/07 , A61F2/89 , A61F2250/0067 , A61M25/04 , A61M2025/105 , A61M2025/1054
摘要： Disclosed herein are removable devices adapted to allow localized and contained delivery of bioactive materials to a treatment site within a lumen such as a blood vessel such that the flow of fluid through the lumen is not blocked during bioactive material delivery.
摘要翻译：本文公开了适于允许生物活性材料局部和包含输送到管腔诸如血管内的处理部位的可移除装置，使得在生物活性物质输送期间通过内腔的流体流不被阻塞。

4. 发明申请

US20050085899A1 Stent with increased longitudinal flexibility and scaffolding 有权
标题翻译：支架具有增加的纵向弹性和脚手架
公开(公告)号：US20050085899A1
公开(公告)日：2005-04-21
申请号：US10685328
申请日：2003-10-15
申请人： Ronan Thornton
发明人： Ronan Thornton
IPC分类号： A61F2/06 , A61F2/90
CPC分类号： A61F2/91 , A61F2/915 , A61F2002/91516 , A61F2002/91525 , A61F2002/91533 , A61F2002/91583
摘要： The present invention relates to a stent manufactured from a thin-walled tube of surgical implant quality. The stent comprises a plurality of main circumferential rings, a plurality of longitudinal links and a plurality of intermediate circumferential rings. The main circumferential rings are longitudinally spaced apart along a longitudinal axis. Circumferential gaps are formed between adjacent main circumferential rings. The longitudinal links span the gaps and are attached to adjacent main circumferential rings. The intermediate circumferential rings fill in the circumferential gaps and are attached to the longitudinal links. The present invention thereby provides a stent with adequate radial strength to properly deploy, adequate scaffolding affect to properly support vessel walls and increased longitudinal flexibility to easily maneuver through tortuous vessels.
摘要翻译：本发明涉及由外科植入物质量的薄壁管制造的支架。支架包括多个主圆周环，多个纵向连杆和多个中间圆周环。主圆周环沿着纵向轴线纵向间隔开。在相邻的主圆周环之间形成圆周间隙。纵向连杆跨越间隙并连接到相邻的主圆周环上。中间圆周环填充在周向间隙中并且附接到纵向连杆。因此，本发明提供了具有足够径向强度的支架以适当地部署，足够的脚手架影响以适当地支撑血管壁并增加纵向灵活性以容易地通过曲折血管操纵。

5. 发明申请

US20050070997A1 Laminated drug-polymer coated stent with dipped and cured layers 有权
标题翻译：具有浸渍和固化层的层压药物聚合物涂层支架
公开(公告)号：US20050070997A1
公开(公告)日：2005-03-31
申请号：US10674296
申请日：2003-09-29
申请人： Ronan Thornton , Finbar Dolan
发明人： Ronan Thornton , Finbar Dolan
IPC分类号： A61L31/10 , A61L31/16 , B32B7/00 , A61F2/06
CPC分类号： A61L31/16 , A61L31/10 , A61L2300/608 , A61L2420/02 , A61L2420/08 , Y10T428/31663 , C08L83/04 , C08L39/06 , C08L33/02
摘要： The present invention provides a method of applying a drug-polymer coating on a stent. A stent framework is dipped into a first polymeric solution including a first polymer, a first therapeutic agent, and a first solvent. The polymeric solution is dried and the first polymer is cured to form a thin drug-polymer layer on the stent framework. The steps of dipping the stent framework into the first polymeric solution, drying the first polymeric solution, and curing the first polymer are repeated until a target drug-polymer coating thickness is disposed on the stent framework. A drug-polymer coated stent including a stent framework and a laminated drug-polymer coated stent, a system for treating a vascular condition, and a method of treating a vascular condition are also disclosed.
摘要翻译：本发明提供了在支架上涂敷药物 - 聚合物涂层的方法。将支架框架浸入包括第一聚合物，第一治疗剂和第一溶剂的第一聚合溶液中。将聚合物溶液干燥，并将第一聚合物固化以在支架框架上形成薄的药物 - 聚合物层。重复将支架框架浸入第一聚合物溶液，干燥第一聚合物溶液和固化第一聚合物的步骤，直到目标药物 - 聚合物涂层厚度设置在支架框架上。还公开了一种药物聚合物涂覆的支架，其包括支架框架和层叠药物聚合物涂覆的支架，用于治疗血管病症的系统和治疗血管病症的方法。

6. 发明授权

US07727268B2 Methods and devices for placing a fistula device in fluid communication with a target vessel 有权
标题翻译：用于放置与目标血管流体连通的瘘装置的方法和装置
公开(公告)号：US07727268B2
公开(公告)日：2010-06-01
申请号：US10887541
申请日：2004-07-07
申请人： Brendan Cunniffe , Niall Duffy , Noel Coyle , Richard William Alan Francis , Ronan Thornton
发明人： Brendan Cunniffe , Niall Duffy , Noel Coyle , Richard William Alan Francis , Ronan Thornton
IPC分类号： A61F2/06
CPC分类号： A61F2/2493 , A61B2017/00247 , A61B2018/00392 , A61F2/064 , A61F2/95
摘要： According to an aspect of the invention there is provided an apparatus for deploying a fistula device. The apparatus comprises an elongate cover member having a proximal end and a distal end, and an elongate support member within the cover member for supporting the fistula device and configured for relative movement with respect to the cover member so as to release the fistula device at a desired location.
摘要翻译：根据本发明的一个方面，提供了一种用于部署瘘装置的装置。该装置包括具有近端和远端的细长盖构件和在盖构件内的细长支撑构件，用于支撑瘘装置并构造成用于相对于盖构件的相对运动，以便将瘘装置以理想位置。

7. 发明申请

US20100130852A1 NAVIGATION ENABLED LEAD DELIVERY CATHETER 审中-公开
标题翻译：导航启用导线导管
公开(公告)号：US20100130852A1
公开(公告)日：2010-05-27
申请号：US12275405
申请日：2008-11-21
申请人： Michael R. Neidert , Niall Duffy , Neil L. Purcell , Ronan Thornton
发明人： Michael R. Neidert , Niall Duffy , Neil L. Purcell , Ronan Thornton
IPC分类号： A61M25/092 , A61B5/055
CPC分类号： A61M25/0043 , A61M25/0045 , A61M25/005 , A61M2025/0024 , A61M2025/0025 , A61M2025/0681 , A61N1/056
摘要： A catheter system for positioning of a medical instrument that includes a first elongate member having a first lumen. The catheter system also includes a second elongate member that includes a second lumen that receives the medical instrument. The second elongate member is coupled directly to the first elongate member, and the second elongate member is operable to be at least partially segmented generally along a second longitudinal axis thereof to allow movement of the medical instrument outside the second lumen. The second elongate member is selectively collapsible and expandable to change a size of the second lumen.
摘要翻译：一种用于定位医疗器械的导管系统，其包括具有第一腔的第一细长构件。导管系统还包括第二细长构件，其包括接收医疗器械的第二腔。第二细长构件直接连接到第一细长构件，并且第二细长构件可操作以沿其第二纵向轴线至少部分地分段，以允许医疗器械在第二内腔外移动。第二细长构件选择性地可折叠和可膨胀以改变第二内腔的尺寸。

8. 发明授权

US07060090B2 Stent with increased longitudinal flexibility and scaffolding 有权
标题翻译：支架具有增加的纵向弹性和脚手架
公开(公告)号：US07060090B2
公开(公告)日：2006-06-13
申请号：US10685328
申请日：2003-10-15
申请人： Ronan Thornton
发明人： Ronan Thornton
IPC分类号： A61F2/06
CPC分类号： A61F2/91 , A61F2/915 , A61F2002/91516 , A61F2002/91525 , A61F2002/91533 , A61F2002/91583
摘要： The present invention relates to a stent manufactured from a thin-walled tube of surgical implant quality. The stent comprises a plurality of main circumferential rings, a plurality of longitudinal links and a plurality of intermediate circumferential rings. The main circumferential rings are longitudinally spaced apart along a longitudinal axis. Circumferential gaps are formed between adjacent main circumferential rings. The longitudinal links span the gaps and are attached to adjacent main circumferential rings. The intermediate circumferential rings fill in the circumferential gaps and are attached to the longitudinal links. The present invention thereby provides a stent with adequate radial strength to properly deploy, adequate scaffolding affect to properly support vessel walls and increased longitudinal flexibility to easily maneuver through tortuous vessels.
摘要翻译：本发明涉及由外科植入物质量的薄壁管制造的支架。支架包括多个主圆周环，多个纵向连杆和多个中间圆周环。主圆周环沿着纵向轴线纵向间隔开。在相邻的主圆周环之间形成圆周间隙。纵向连杆跨越间隙并连接到相邻的主圆周环上。中间圆周环填充在周向间隙中并且附接到纵向连杆。因此，本发明提供了具有足够径向强度的支架以适当地部署，足够的脚手架影响以适当地支撑血管壁并增加纵向灵活性以容易地通过曲折血管操纵。

9. 发明申请

US20050033401A1 Methods and devices for placing a fistula device in fluid communication with a target vessel 有权
标题翻译：用于放置与目标血管流体连通的瘘装置的方法和装置
公开(公告)号：US20050033401A1
公开(公告)日：2005-02-10
申请号：US10887541
申请日：2004-07-07
申请人： Brendan Cunniffe , Niall Duffy , Noel Coyle , Richard Francis , Ronan Thornton
发明人： Brendan Cunniffe , Niall Duffy , Noel Coyle , Richard Francis , Ronan Thornton
IPC分类号： A61B17/00 , A61F2/02 , A61F2/06 , A61F2/95
CPC分类号： A61F2/2493 , A61B2017/00247 , A61B2018/00392 , A61F2/064 , A61F2/95
摘要： According to an aspect of the invention there is provided an apparatus for deploying a fistula device. The apparatus comprises an elongate cover member having a proximal end and a distal end, and an elongate support member within the cover member for supporting the fistula device and configured for relative movement with respect to the cover member so as to release the fistula device at a desired location.
摘要翻译：根据本发明的一个方面，提供了一种用于部署瘘装置的装置。该装置包括具有近端和远端的细长盖构件和在盖构件内的细长支撑构件，用于支撑瘘装置并构造成用于相对于盖构件的相对运动，以便将瘘装置以理想位置。

10. 发明申请

US20100228342A1 Laminated Drug-Polymer Coated Stent with Dipped and Cured Layers 有权
标题翻译：具有浸渍和固化层的层压药物聚合物涂层支架
公开(公告)号：US20100228342A1
公开(公告)日：2010-09-09
申请号：US12782286
申请日：2010-05-18
申请人： Ronan Thornton , Finbar Dolan
发明人： Ronan Thornton , Finbar Dolan
IPC分类号： A61F2/82 , A61M25/00 , B05D1/18
CPC分类号： A61L31/16 , A61L31/10 , A61L2300/608 , A61L2420/02 , A61L2420/08 , Y10T428/31663 , C08L83/04 , C08L39/06 , C08L33/02
摘要： The present invention provides a method of applying a drug-polymer coating on a stent. A stent framework is dipped into a first polymeric solution including a first polymer, a first therapeutic agent, and a first solvent. The polymeric solution is dried and the first polymer is cured to form a thin drug-polymer layer on the stent framework. The steps of dipping the stent framework into the first polymeric solution, drying the first polymeric solution, and curing the first polymer are repeated until a target drug-polymer coating thickness is disposed on the stent framework. A drug-polymer coated stent including a stent framework and a laminated drug-polymer coated stent, a system for treating a vascular condition, and a method of treating a vascular condition are also disclosed.
摘要翻译：本发明提供了在支架上涂敷药物 - 聚合物涂层的方法。将支架框架浸入包括第一聚合物，第一治疗剂和第一溶剂的第一聚合溶液中。将聚合物溶液干燥，并将第一聚合物固化以在支架框架上形成薄的药物 - 聚合物层。重复将支架框架浸入第一聚合物溶液，干燥第一聚合物溶液和固化第一聚合物的步骤，直到目标药物 - 聚合物涂层厚度设置在支架框架上。还公开了一种药物聚合物涂覆的支架，其包括支架框架和层叠药物聚合物涂覆的支架，用于治疗血管病症的系统和治疗血管病症的方法。

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