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    • 3. 发明授权
    • Methods, systems, and computer program products for optimization of probes for spectroscopic measurement in turbid media
    • 用于优化浑浊介质中光谱测量的探针的方法,系统和计算机程序产品
    • US07835786B2
    • 2010-11-16
    • US11493020
    • 2006-07-25
    • Gregory M. PalmerNirmala Ramanujam
    • Gregory M. PalmerNirmala Ramanujam
    • A61B6/00G01J3/30G02B6/06
    • G01N21/4738G01N2021/4742G01N2021/4752G01N2201/1296
    • Methods, systems, and computer program products for optimizing a probe geometry for spectroscopic measurement in a turbid medium are provided. A probe geometry comprising one emitting entity and at least on collecting entity is selected. A simulation is performed to generate optical parameter values measured by the probe geometry. The measured optical parameter values are input to an inversion algorithm to produce corresponding optical properties as output. The produced optical properties are compared with known optical properties known and a degree of matching between the produced optical properties and the known optical properties is determined. The simulation and inversion steps are repeated for a plurality of additional probe geometries, each differing in at least one property. An optimization algorithm is applied at each iteration to select an optimal probe geometry.
    • 提供了用于优化用于浑浊介质中的光谱测量的探针几何的方法,系统和计算机程序产品。 选择包括一个发射实体和至少在收集实体上的探针几何形状。 进行模拟以产生由探针几何测量的光学参数值。 测量的光学参数值被输入到反演算法中以产生相应的光学特性作为输出。 将所产生的光学性质与已知的已知光学性能进行比较,并且确定所产生的光学性质和已知的光学性质之间的匹配程度。 针对多个额外的探针几何重复模拟和反转步骤,每个不同于至少一个属性。 在每次迭代中应用优化算法以选择最佳探针几何。
    • 4. 发明授权
    • Monte Carlo based model of fluorescence in turbid media and methods and systems for using same to determine intrinsic fluorescence of turbid media
    • 基于蒙特卡罗的浑浊介质中的荧光模型以及用于确定混浊介质的固有荧光的方法和系统
    • US07818154B2
    • 2010-10-19
    • US11725141
    • 2007-03-16
    • Gregory M. PalmerNirmala Ramanujam
    • Gregory M. PalmerNirmala Ramanujam
    • G06F1/00
    • G01J3/4406A61B5/0071A61B5/0084G01N21/49G01N21/6486G01N2021/6417
    • The subject matter described herein includes a method for modeling fluorescence in turbid media and methods and systems for using the model to determine intrinsic fluorescence of turbid media. According to one aspect, a method for modeling fluorescence of a turbid medium and for using the model to determine intrinsic fluorescence in the turbid medium is provided. The method includes illuminating a turbid medium of interest with an electromagnetic radiation source using a probe of a particular geometry and detecting measured fluorescence for the turbid medium using the probe. At least one set of Monte Carlo simulations is run to determine an escape energy probability map and an absorbed energy density map for the turbid medium. An indication of the intrinsic fluorescence of the turbid medium is determined using the escape probability density map and the absorbed energy density map in a manner that accounts for the geometry of the probe.
    • 本文描述的主题包括用于对混浊介质中的荧光进行建模的方法以及使用该模型确定混浊介质的固有荧光的方法和系统。 根据一个方面,提供了一种用于对浑浊介质的荧光进行建模和使用该模型来确定混浊介质中的固有荧光的方法。 该方法包括使用特定几何形状的探针用电磁辐射源照射感兴趣的混浊介质,并使用探针检测浊度介质的测量荧光。 运行至少一组蒙特卡罗模拟来确定浑浊介质的逃逸能量概率图和吸收的能量密度图。 使用逃避概率密度图和吸收的能量密度图以考虑探针的几何形状的方式确定混浊介质的固有荧光的指示。