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1. 发明授权

US08545858B2 Porous calcium phosphate bone material 有权
标题翻译：多孔磷酸钙骨料
公开(公告)号：US08545858B2
公开(公告)日：2013-10-01
申请号：US13438207
申请日：2012-04-03
申请人： Aron D. Rosenberg , Laurent D. Gillès de Pélichy , Shrikar Bondre , Michael Strunk
发明人： Aron D. Rosenberg , Laurent D. Gillès de Pélichy , Shrikar Bondre , Michael Strunk
IPC分类号： A61K9/12 , A61K9/00 , A61K48/00 , A61K9/46 , A61K33/42 , A61K33/24 , A61K38/18
CPC分类号： A61L27/54 , A61K9/0024 , A61K38/1875 , A61L27/12 , A61L27/56 , A61L2300/252 , A61L2300/256 , A61L2300/406 , A61L2300/414 , A61L2300/416 , A61L2300/434 , A61L2300/60 , A61L2430/02 , A61K2300/00
摘要： Porous calcium phosphate implant compositions that approximate the chemical composition of natural bone mineral are provided. In addition to calcium phosphate, the compositions include an effervescent agent to promote the formation of interconnected pores and a cohesiveness agent to maintain the shape and hardness of the hardened composition. When introduced at an implant site, the calcium phosphate compositions are remodeled into bone. Methods for using the calcium phosphate compositions, e.g., to repair or replace bone, are also provided.
摘要翻译：提供近似天然骨矿物化学成分的多孔磷酸钙植入物组合物。除了磷酸钙之外，组合物还包括促进互连孔形成的泡腾剂和粘结剂以保持硬化组合物的形状和硬度。当在植入部位引入时，磷酸钙组合物被重塑成骨。还提供了使用磷酸钙组合物例如修复或替代骨的方法。

2. 发明申请

US20120282301A1 POROUS CALCIUM PHOSPHATE BONE MATERIAL 有权
标题翻译：多孔磷酸钙骨料
公开(公告)号：US20120282301A1
公开(公告)日：2012-11-08
申请号：US13438207
申请日：2012-04-03
申请人： Aron D. Rosenberg , Laurent D. Gillès de Pélichy , Shrikar Bondre , Michael Strunk
发明人： Aron D. Rosenberg , Laurent D. Gillès de Pélichy , Shrikar Bondre , Michael Strunk
IPC分类号： A61K9/12 , A61P19/00 , A61K9/00
CPC分类号： A61L27/54 , A61K9/0024 , A61K38/1875 , A61L27/12 , A61L27/56 , A61L2300/252 , A61L2300/256 , A61L2300/406 , A61L2300/414 , A61L2300/416 , A61L2300/434 , A61L2300/60 , A61L2430/02 , A61K2300/00
摘要： Porous calcium phosphate implant compositions that approximate the chemical composition of natural bone mineral are provided. In addition to calcium phosphate, the compositions include an effervescent agent to promote the formation of interconnected pores and a cohesiveness agent to maintain the shape and hardness of the hardened composition. When introduced at an implant site, the calcium phosphate compositions are remodeled into bone. Methods for using the calcium phosphate compositions, e.g., to repair or replace bone, are also provided.
摘要翻译：提供近似天然骨矿物化学成分的多孔磷酸钙植入物组合物。除了磷酸钙之外，组合物还包括促进互连孔形成的泡腾剂和粘结剂以保持硬化组合物的形状和硬度。当在植入部位引入时，磷酸钙组合物被重塑成骨。还提供了使用磷酸钙组合物例如修复或替代骨的方法。

3. 发明授权

US08147860B2 Porous calcium phosphate bone material 有权
标题翻译：多孔磷酸钙骨料
公开(公告)号：US08147860B2
公开(公告)日：2012-04-03
申请号：US11294819
申请日：2005-12-06
申请人： Aron D. Rosenberg , Laurent D. Gillès de Pélichy , Shrikar Bondre , Michael Strunk
发明人： Aron D. Rosenberg , Laurent D. Gillès de Pélichy , Shrikar Bondre , Michael Strunk
IPC分类号： A61K48/00 , A61K38/18 , A61K9/46 , A61K33/42 , A61K33/24
CPC分类号： A61L27/54 , A61K9/0024 , A61K38/1875 , A61L27/12 , A61L27/56 , A61L2300/252 , A61L2300/256 , A61L2300/406 , A61L2300/414 , A61L2300/416 , A61L2300/434 , A61L2300/60 , A61L2430/02 , A61K2300/00
摘要： Porous calcium phosphate implant compositions that approximate the chemical composition of natural bone mineral are provided. In addition to calcium phosphate, the compositions include an effervescent agent to promote the formation of interconnected pores and a cohesiveness agent to maintain the shape and hardness of the hardened composition. When introduced at an implant site, the calcium phosphate compositions are remodeled into bone. Methods for using the calcium phosphate compositions, e.g., to repair or replace bone, are also provided.
摘要翻译：提供近似天然骨矿物化学成分的多孔磷酸钙植入物组合物。除了磷酸钙之外，组合物还包括促进互连孔形成的泡腾剂和粘结剂以保持硬化组合物的形状和硬度。当在植入部位引入时，磷酸钙组合物被重塑成骨。还提供了使用磷酸钙组合物例如修复或替代骨的方法。

4. 发明授权

US09314545B2 Minimally invasive treatment of vertebra (MITV) using a calcium phosphate combination bone cement 有权
标题翻译：使用磷酸钙组合骨水泥微创治疗椎骨（MITV）
公开(公告)号：US09314545B2
公开(公告)日：2016-04-19
申请号：US12937944
申请日：2009-04-15
申请人： Aliassghar N. Tofighi , Aron D. Rosenberg , Tak Lung Chang , Michael Strunk
发明人： Aliassghar N. Tofighi , Aron D. Rosenberg , Tak Lung Chang , Michael Strunk
IPC分类号： A61B17/88 , A61L24/02 , A61L24/00 , A61L27/12 , A61L27/46 , A61L27/50
CPC分类号： A61L24/02 , A61B17/8811 , A61L24/0005 , A61L24/0015 , A61L24/0036 , A61L24/0042 , A61L24/0063 , A61L24/0084 , A61L24/06 , A61L27/12 , A61L27/46 , A61L27/50 , A61L2300/44 , A61L2400/06 , A61L2400/12 , A61L2430/02 , A61L2430/38
摘要： Featured are a biocompatible, injectable, self-setting, cohesive, bone-bonding and remodeling calcium phosphate composite material and its use in methods of repairing defective bone, e.g., in vertebroplasty augmentation and kyphoplasty.
摘要翻译：特征是生物相容性，可注射，自定型，凝聚力，骨粘合和重塑磷酸钙复合材料，并且其用于修复有缺陷的骨的方法，例如在椎体成形术增大和椎体后凸成形术中。

5. 发明申请

US20110224675A1 MINIMALLY INVASIVE TREATMENT OF VERTEBRA (MITV) USING A CALCIUM PHOSPHATE COMBINATION BONE CEMENT 有权
标题翻译：使用磷酸钙组合骨水泥进行VERTEBRA（MITV）的微量免疫治疗
公开(公告)号：US20110224675A1
公开(公告)日：2011-09-15
申请号：US12937944
申请日：2009-04-15
申请人： Aliassghar N. Tofighi , Aron D. Rosenberg , Tak Lung Chang , Michael Strunk
发明人： Aliassghar N. Tofighi , Aron D. Rosenberg , Tak Lung Chang , Michael Strunk
IPC分类号： A61L24/04 , A61B17/56 , A61L24/02 , A61L24/06 , A61L24/10 , A61L24/08 , A61P29/00 , A61P31/00 , A61P21/02 , A61P1/06 , A61P25/24 , C04B12/02 , B82Y5/00
CPC分类号： A61L24/02 , A61B17/8811 , A61L24/0005 , A61L24/0015 , A61L24/0036 , A61L24/0042 , A61L24/0063 , A61L24/0084 , A61L24/06 , A61L27/12 , A61L27/46 , A61L27/50 , A61L2300/44 , A61L2400/06 , A61L2400/12 , A61L2430/02 , A61L2430/38
摘要： Featured are a biocompatible, injectable, self-setting, cohesive, bone-bonding and remodeling calcium phosphate composite material and its use in methods of repairing defective bone, e.g., in vertebroplasty augmentation and kyphoplasty.
摘要翻译：特征是生物相容性，可注射，自定型，凝聚力，骨粘合和重塑磷酸钙复合材料，并且其用于修复有缺陷的骨的方法，例如在椎体成形术增大和椎体后凸成形术中。

6. 发明申请

US20110112543A1 BONE CEMENT MIXING AND DELIVERY SYSTEM AND METHODS OF USE THEREOF 有权
标题翻译：骨水泥混合和输送系统及其使用方法
公开(公告)号：US20110112543A1
公开(公告)日：2011-05-12
申请号：US12675455
申请日：2008-08-28
申请人： Robert Palazzolo , Manish Sutaria , Aliassghar N. Tofighi , Tak L. Chang , Aron D. Rosenberg
发明人： Robert Palazzolo , Manish Sutaria , Aliassghar N. Tofighi , Tak L. Chang , Aron D. Rosenberg
IPC分类号： A61B17/58
CPC分类号： B01F15/0201 , A61B17/8827 , B01F5/0685 , B01F5/0688 , B01F11/0071 , B01F15/0225
摘要： Bone cement mixing and delivery device and methods are disclosed. The device includes a first tube/barrel (e.g., a syringe barrel) containing a bone cement powder and a second tube/barrel that can be filled with or that contains a liquid; the first and second tubes/barrels can be fluidly connected end-to-end such that there is fluid communication between the tubes/barrels. Also disclosed are methods of preparing the device for use, methods for forming a bone cement using the device, and methods and device design to extend the shelf life of the device.
摘要翻译：公开了骨水泥混合输送装置和方法。该装置包括含有骨水泥粉末的第一管/桶（例如，注射器筒）和可填充或含有液体的第二管/桶; 第一和第二管/桶可以端对端流体连接，使得管/桶之间存在流体连通。还公开了制备使用装置的方法，使用该装置形成骨水泥的方法以及延长装置的保质期的方法和装置设计。

7. 发明申请

US20080188946A1 Osteoinductive bone material 有权
标题翻译：骨诱导骨材料
公开(公告)号：US20080188946A1
公开(公告)日：2008-08-07
申请号：US12009888
申请日：2008-01-23
申请人： Aron D. Rosenberg , Laurent D. Gilles de Pelichy , Daniel Egan , Aliassghar N. Tofighi , Dosuk D. Lee , Youngmi M. Lee
发明人： Aron D. Rosenberg , Laurent D. Gilles de Pelichy , Daniel Egan , Aliassghar N. Tofighi , Dosuk D. Lee , Youngmi M. Lee
IPC分类号： A61F2/28
CPC分类号： A61L27/3608 , A61F2/28 , A61F2002/2817 , A61F2310/00293 , A61F2310/00359 , A61L27/227 , A61L27/26 , A61L27/34 , A61L27/365 , A61L27/46 , A61L27/48 , A61L2430/02 , C08L89/00
摘要： Osteogenic bone implant compositions that approximate the chemical composition of natural bone are provided. The organic component of these implant compositions is osteoinductive despite the presence of the inorganic component and, further, is present in an amount sufficient to maximize the regenerative capabilities of the implant without compromising its formability and mechanical strength. The composition may be an osteoinductive powder, including demineralized bone matrix (DBM) particles, a calcium phosphate powder, and, optionally, a biocompatible cohesiveness agent. The powder may be combined with a physiologically-acceptable fluid to produce a formable, osteoinductive paste that self-hardens to form a poorly crystalline apatitic (PCA) calcium phosphate having significant compressive strength. The bone implant materials retain their cohesiveness when introduced at an implant site and are remodeled into bone in vivo. Methods for using these implant materials to repair damaged bone and a method of assaying the content of DBM particles, by weight, in a bone implant material are also provided.
摘要翻译：提供了近似天然骨骼化学成分的成骨骨植入组合物。这些植入物组合物的有机组分是骨诱导的，尽管存在无机组分，并且还存在足以使植入物的再生能力最大化的量，而不损害其成形性和机械强度。组合物可以是骨诱导性粉末，包括软化骨基质（DBM）颗粒，磷酸钙粉末和任选的生物相容性粘合剂。粉末可以与生理上可接受的流体组合以产生可成形的骨诱导性浆料，其自硬化以形成具有显着抗压强度的不良结晶磷灰石（PCA）磷酸钙。骨植入材料在植入部位引入时保持其内聚性，并在体内重塑成骨。还提供了使用这些植入材料修复受损骨的方法以及测定骨植入材料中重量的DBM颗粒含量的方法。

8. 发明授权

US08454988B2 Osteoinductive bone material 有权
标题翻译：骨诱导骨材料
公开(公告)号：US08454988B2
公开(公告)日：2013-06-04
申请号：US12009888
申请日：2008-01-23
申请人： Aron D. Rosenberg , Laurent D. Gilles de Pelichy , Daniel Egan , Aliassghar N. Tofighi , Youngmi M. Lee
发明人： Aron D. Rosenberg , Laurent D. Gilles de Pelichy , Daniel Egan , Aliassghar N. Tofighi , Dosuk D. Lee
IPC分类号： A61F2/28
CPC分类号： A61L27/3608 , A61F2/28 , A61F2002/2817 , A61F2310/00293 , A61F2310/00359 , A61L27/227 , A61L27/26 , A61L27/34 , A61L27/365 , A61L27/46 , A61L27/48 , A61L2430/02 , C08L89/00
摘要： Osteogenic bone implant compositions that approximate the chemical composition of natural bone are provided. The organic component of these implant compositions is osteoinductive despite the presence of the inorganic component and, further, is present in an amount sufficient to maximize the regenerative capabilities of the implant without compromising its formability and mechanical strength. The composition may be an osteoinductive powder, including demineralized bone matrix (DBM) particles, a calcium phosphate powder, and, optionally, a biocompatible cohesiveness agent. The powder may be combined with a physiologically-acceptable fluid to produce a formable, osteoinductive paste that self-hardens to form a poorly crystalline apatitic (PCA) calcium phosphate having significant compressive strength. The bone implant materials retain their cohesiveness when introduced at an implant site and are remodeled into bone in vivo. Methods for using these implant materials to repair damaged bone and a method of assaying the content of DBM particles, by weight, in a bone implant material are also provided.
摘要翻译：提供了近似天然骨骼化学成分的成骨骨植入组合物。这些植入物组合物的有机组分是骨诱导的，尽管存在无机组分，并且还存在足以使植入物再生能力最大化的量，而不损害其成形性和机械强度。组合物可以是骨诱导性粉末，包括软化骨基质（DBM）颗粒，磷酸钙粉末和任选的生物相容性粘合剂。粉末可以与生理上可接受的流体组合以产生可成形的骨诱导性浆料，其自硬化以形成具有显着抗压强度的不良结晶磷灰石（PCA）磷酸钙。骨植入材料在植入部位引入时保持其内聚性，并在体内重塑成骨。还提供了使用这些植入材料修复受损骨的方法以及测定骨植入材料中重量的DBM颗粒含量的方法。

9. 发明授权

US08221781B2 Osteoinductive bone material 有权
标题翻译：骨诱导骨材料
公开(公告)号：US08221781B2
公开(公告)日：2012-07-17
申请号：US10822540
申请日：2004-04-12
申请人： Aron D. Rosenberg , Laurent D. Gilles de Pelichy , Daniel Egan , Aliassghar N. Tofighi , Dosuk D. Lee
发明人： Aron D. Rosenberg , Laurent D. Gilles de Pelichy , Daniel Egan , Aliassghar N. Tofighi , Dosuk D. Lee
IPC分类号： A61F2/28 , A61F2/26
CPC分类号： A61L27/3608 , A61F2/28 , A61F2002/2817 , A61F2310/00293 , A61F2310/00359 , A61L27/227 , A61L27/26 , A61L27/34 , A61L27/365 , A61L27/46 , A61L27/48 , A61L2430/02 , C08L89/00
摘要： Osteogenic bone implant compositions that approximate the chemical composition of natural bone are provided. The organic component of these implant compositions is osteoinductive despite the presence of the inorganic component and, further, is present in an amount sufficient to maximize the regenerative capabilities of the implant without compromising its formability and mechanical strength. The composition may be an osteoinductive powder, including demineralized bone matrix (DBM) particles, a calcium phosphate powder, and, optionally, a biocompatible cohesiveness agent. The powder may be combined with a physiologically-acceptable fluid to produce a formable, osteoinductive paste that self-hardens to form a poorly crystalline apatitic (PCA) calcium phosphate having significant compressive strength. The bone implant materials retain their cohesiveness when introduced at an implant site and are remodeled into bone in vivo. Methods for using these implant materials to repair damaged bone and a method of assaying the content of DBM particles, by weight, in a bone implant material are also provided.
摘要翻译：提供了近似天然骨骼化学成分的成骨骨植入组合物。这些植入物组合物的有机组分是骨诱导的，尽管存在无机组分，并且还存在足以使植入物的再生能力最大化的量，而不损害其成形性和机械强度。组合物可以是骨诱导性粉末，包括软化骨基质（DBM）颗粒，磷酸钙粉末和任选的生物相容性粘合剂。粉末可以与生理上可接受的流体组合以产生可成形的骨诱导性浆料，其自硬化以形成具有显着抗压强度的不良结晶磷灰石（PCA）磷酸钙。骨植入材料在植入部位引入时保持其内聚性，并在体内重塑成骨。还提供了使用这些植入材料修复受损骨的方法以及测定骨植入材料中重量的DBM颗粒含量的方法。

10. 发明授权

US07582309B2 Cohesive demineralized bone compositions 有权
标题翻译：粘性脱矿质骨组合物
公开(公告)号：US07582309B2
公开(公告)日：2009-09-01
申请号：US10298112
申请日：2002-11-15
申请人： Aron D. Rosenberg , Laurent Gilles de Pelichy
发明人： Aron D. Rosenberg , Laurent Gilles de Pelichy
IPC分类号： A61F2/28
CPC分类号： A61F2/4644 , A61F2002/4645 , A61L27/3608 , A61L27/3616 , A61L27/50
摘要： Demineralized bone matrix fibers and a demineralized bone matrix composition are provided. The demineralized bone matrix fibers have an average fiber length in the range from about 250 μm to about 2 mm and an aspect ratio of greater than about 4. The demineralized bone matrix composition includes demineralized bone matrix fibers and a biocompatible liquid in an amount to produce a coherent, formable mass. The formable mass retains its cohesiveness when immersed in a liquid. Methods for making the demineralized bone matrix fibers and composition are also provided.
摘要翻译：提供脱矿质骨基质纤维和脱矿质骨基质组合物。脱矿质骨基质纤维的平均纤维长度范围为约250μm至约2mm，纵横比大于约4.软化骨基质组合物包括脱矿质骨基质纤维和生产相容性液体一个连贯，可形成的群众。当可浸入液体中时，可成型物质保持其内聚力。还提供了制备脱钙骨基质纤维和组合物的方法。

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