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1. 发明申请

US20080081834A1 Methods and compositions employing bicifadine for treating disability or functional impairment associated with acute pain, chronic pain, or neuropathic disorders 审中-公开
标题翻译：使用双倍他啶治疗与急性疼痛，慢性疼痛或神经性疾病相关的残疾或功能障碍的方法和组合物
公开(公告)号：US20080081834A1
公开(公告)日：2008-04-03
申请号：US11708951
申请日：2007-02-20
申请人： Arnold Lippa , Warren Stern , Janet Codd , Brian Boland , Johnson Lim
发明人： Arnold Lippa , Warren Stern , Janet Codd , Brian Boland , Johnson Lim
IPC分类号： A61K31/403 , A61P25/00 , A61P43/00
CPC分类号： A61K31/403 , A61K9/2054
摘要： Methods and compositions are provided for formulating and administering bicifadine and related compounds to treat or prevent functional impairment and disabilities associated with acute pain, chronic pain, and neuropathic disorders.
摘要翻译：提供方法和组合物用于配制和施用二化蓖苷和相关化合物以治疗或预防与急性疼痛，慢性疼痛和神经性疾病相关的功能障碍和残疾。

2. 发明申请

US20080027119A1 Methods and compositions employing bicifadine for the treatment of acute pain, chronic pain, and symptoms of neuropathic disorders 审中-公开
标题翻译：采用二西他准治疗急性疼痛，慢性疼痛和神经性疾病症状的方法和组合
公开(公告)号：US20080027119A1
公开(公告)日：2008-01-31
申请号：US11260887
申请日：2005-10-26
申请人： Arnold Lippa , Warren Stern , Janet Codd , Brian Boland , Lim Johnson
发明人： Arnold Lippa , Warren Stern , Janet Codd , Brian Boland , Lim Johnson
IPC分类号： A61K31/403 , A61P25/00
CPC分类号： A61K9/2009 , A61K9/2027 , A61K9/2054 , A61K31/403 , A61K31/439
摘要： Methods and compositions are provided for formulating and administering bicifadine and related compounds to treat acute pain, chronic pain, and symptoms associated with neuropathic disorders.
摘要翻译：提供方法和组合物用于配制和施用二西他准及相关化合物以治疗急性疼痛，慢性疼痛和与神经性疾病相关的症状。

3. 发明申请

US20070225351A1 Methods and compositions for controlling body weight and appetite 审中-公开
标题翻译：用于控制体重和食欲的方法和组合物
公开(公告)号：US20070225351A1
公开(公告)日：2007-09-27
申请号：US11603974
申请日：2006-11-21
申请人： Arnold Lippa , Joseph Epstein , Anthony Basile , Joseph Tizzano
发明人： Arnold Lippa , Joseph Epstein , Anthony Basile , Joseph Tizzano
IPC分类号： A61K31/403 , C07D209/52
CPC分类号： C07D209/52 , A61K31/403
摘要： The present invention provides novel compositions and methods for the controlling appetite and weight and/or treating obesity using a (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane or related compound. The invention also provides novel compositions and methods for treating or preventing disorders related to or complicated by excessive body weight or obesity, including coronary heart disease, osteoarthritis, osteoporosis, dislipidemias, gout, atherosclerosis, joint pain, sexual and fertility problems, respiratory problems, gall bladder disease, skin conditions, hypertension, diabetes, stroke, pulmonary embolism, sleep apnea, idiopathic intracranial hypertension, lower extremity venous stasis disease, gastro-esophageal reflux, urinary stress incontinence, metabolic syndrome, insulin resistance and cancer. The methods and compositions of the invention may employ a (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane or related compound alone, or in combination with a second anti-appetite or anti-obesity agent.
摘要翻译：本发明提供了使用（+）-1-（3,4-二氯苯基）-3-氮杂双环[3.1.0]己烷或相关化合物来控制食欲和体重和/或治疗肥胖症的新型组合物和方法。本发明还提供了用于治疗或预防与体重过重或肥胖相关或复杂的疾病的新型组合物和方法，包括冠心病，骨关节炎，骨质疏松症，血脂异常，痛风，动脉粥样硬化，关节疼痛，性和生殖问题，呼吸问题，胆囊疾病，皮肤病，高血压，糖尿病，中风，肺栓塞，睡眠呼吸暂停，特发性颅内高压，下肢静脉淤滞疾病，胃食管反流，尿失禁，代谢综合征，胰岛素抵抗和癌症。本发明的方法和组合物可以单独使用（+）-1-（3,4-二氯苯基）-3-氮杂双环[3.1.0]己烷或相关化合物，或与第二抗食欲或抗 - 肥胖剂。

4. 发明申请

US20060173064A1 (-)-1-(3,4-Dichlorophenyl)-3-azabi cyclo[3.1.0]hexane, compositions thereof, and uses for treating alcohol-related disorders 审中-公开
标题翻译：（ - ） - 1-（3,4-二氯苯基）-3-氮杂环[3.1.0]己烷及其组合物，以及用于治疗酒精相关疾病
公开(公告)号：US20060173064A1
公开(公告)日：2006-08-03
申请号：US11254242
申请日：2005-10-18
申请人： Arnold Lippa , Anthony Basile , Joseph Epstein
发明人： Arnold Lippa , Anthony Basile , Joseph Epstein
IPC分类号： C07D209/52 , A61K31/403
CPC分类号： C07D209/52 , A61K31/403
摘要： The present invention relates to (−)-1-(3,4-dichlorophenyl )-3-azabicyclo[3.1.0]hexane and pharmaceutically acceptable salts thereof, compositions comprising (−)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane or a pharmaceutically acceptable salt thereof, and methods for treating or preventing a disorder alleviated by inhibiting dopamine reuptake. In certain embodiments the methods and compositions of the invention are effective for treating attention-deficit disorder, depression, obesity, Parkinson's disease, a tic disorder, and/or an addictive disorder. In more detailed embodiments, methods and compositions of the invention are provided for treating an alcohol-related addictive disorder, for example alcohol abuse, alcohol dependence, excess alcohol consumption, and/or alcohol withdrawal. The (−)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane or pharmaceutically acceptable salt thereof may be employed within the methods and compositions of the invention in a form or composition that is substantially free of its corresponding (+)-enantiomer.
摘要翻译：本发明涉及（ - ） - 1-（3,4-二氯苯基）-3-氮杂双环[3.1.0]己烷及其药学上可接受的盐，其包含（ - ） - 1-（3,4-二氯苯基） 3-氮杂双环[3.1.0]己烷或其药学上可接受的盐，以及用于治疗或预防通过抑制多巴胺再摄取而减轻的病症的方法。在某些实施方案中，本发明的方法和组合物对于治疗注意力缺陷障碍，抑郁症，肥胖，帕金森病，抽动障碍和/或成瘾性障碍是有效的。在更详细的实施方案中，提供本发明的方法和组合物用于治疗醇相关的成瘾症，例如酒精滥用，酒精依赖，过量饮酒和/或戒酒。（ - ） - 1-（3,4-二氯苯基）-3-氮杂双环[3.1.0]己烷或其药学上可接受的盐可以在本发明的方法和组合物中以基本上不含其对应的（+） - 对映异构体。

5. 发明申请

US20070082939A1 Methods and compositions for the treatment of neuropathies and related disorders 审中-公开
标题翻译：用于治疗神经病和相关疾病的方法和组合物
公开(公告)号：US20070082939A1
公开(公告)日：2007-04-12
申请号：US11492608
申请日：2006-07-24
申请人： Arnold Lippa , Phil Skolnick , Anthony Basile , Zhengming Chen , Joseph Epstein
发明人： Arnold Lippa , Phil Skolnick , Anthony Basile , Zhengming Chen , Joseph Epstein
IPC分类号： A61K31/403
CPC分类号： A61K31/403
摘要： The present invention provides novel compositions and methods for treating symptoms associated with neuropathic disorders such as hyperalgesia, allodynia, and parasthesias, using a 1-aryl-3-azabicyclo[3.1.0] hexane. The invention further relates to the use of 1-aryl-3-azabicyclo[3.1.0] hexanes in pharmaceutical compositions and methods for treating neuropathic disorders and related symptoms in mammals. Patients amenable to treatment according to the invention include those suffering from diabetic neuropathies, post-herpetic neuralgia, trigeminal neuralgia, chronic lower back pain, sciatica, idiopathic and post-traumatic neuropathies, HIV-associated neuropathic pain, among many other neuropathic disorders and related symptoms.
摘要翻译：本发明提供了使用1-芳基-3-氮杂双环[3.1.0]己烷治疗与神经性疾病相关的症状的新颖的组合物和方法，所述神经性疾病例如痛觉过敏，异常性疼痛和副症状。本发明还涉及1-芳基-3-氮杂双环[3.1.0]己烷在用于治疗哺乳动物神经病症和相关症状的药物组合物和方法中的用途。根据本发明治疗的患者包括患有糖尿病性神经病，疱疹后神经痛，三叉神经痛，慢性下背痛，坐骨神经痛，特发性和创伤后神经病变，HIV相关神经性疼痛等许多其他神经病变和相关的患者症状

6. 发明申请

US20080081781A1 Methods and compositions for the treatment of metabolic syndrome 审中-公开
标题翻译：用于治疗代谢综合征的方法和组合物
公开(公告)号：US20080081781A1
公开(公告)日：2008-04-03
申请号：US11784294
申请日：2007-04-06
申请人： Arnold Lippa , Jian-Dong Jiang , Jing Wei , Wei-Jia Kong , Li-Xun Zhao , Dan-Qing Song
发明人： Arnold Lippa , Jian-Dong Jiang , Jing Wei , Wei-Jia Kong , Li-Xun Zhao , Dan-Qing Song
IPC分类号： A61K31/4355 , A61K31/555 , A61K38/28 , A61P3/00
CPC分类号： A61K31/4375
摘要： Methods and compositions containing a berberine compound or berberine related or proto-berberine or derivative compound are provided for the prevention and treatment of metabolic and cardiovascular disorders including metabolic syndrome, hyperlipidemia, obesity, diabetes, insulin resistance, hyperglycemia, hypertension and elevated cholesterol in mammalian subjects. The methods and compositions of the invention are effective for prevention and treatment of metabolic syndrome, hyperlipidemia, obesity, diabetes, insulin resistance, hyperglycemia, hypertension and elevated cholesterol. Additional compositions and methods are provided which employ a berberine compound or berberine related or derivative compound in combination with a second anti-therapeutic agent to yield more effective treatment tools against metabolic disorders, and/or dual activity therapeutic methods and formulations useful to prevent or reduce hyperlipidemia and/or hyperglycemia and one or more causal or related symptoms or conditions associated with hyperlipidemia and/or hyperglycemia in mammalian subjects.
摘要翻译：提供含有小檗碱化合物或小檗碱相关或原小檗碱或衍生化合物的方法和组合物用于预防和治疗哺乳动物代谢和心血管疾病，包括代谢综合征，高脂血症，肥胖，糖尿病，胰岛素抵抗，高血糖，高血压和升高的胆固醇科目。本发明的方法和组合物可有效预防和治疗代谢综合征，高脂血症，肥胖症，糖尿病，胰岛素抵抗，高血糖症，高血压和升高的胆固醇。提供了额外的组合物和方法，其使用小檗碱化合物或小檗碱相关或衍生化合物与第二抗治疗剂组合以产生针对代谢紊乱的更有效的治疗工具，和/或可用于预防或减少的双重活性治疗方法和制剂高脂血症和/或高血糖症和哺乳动物受试者中与高脂血症和/或高血糖相关的一个或多个因果或相关症状或病症。

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