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1. 发明申请

US20110046893A1 METHOD FOR NORMALIZING THE RESULTS OF AN IN-VITRO ANALYTICAL METHOD 审中-公开
标题翻译：用于正常化体内分析方法的结果的方法
公开(公告)号：US20110046893A1
公开(公告)日：2011-02-24
申请号：US12859429
申请日：2010-08-19
申请人： Arne HENGERER , Marcus Pfister , Sebastian Schmidt
发明人： Arne HENGERER , Marcus Pfister , Sebastian Schmidt
IPC分类号： G06F19/00 , G01N33/48
CPC分类号： A61B6/00 , G06T1/00
摘要： A method is disclosed for normalizing the results of an in-vitro analytical method for one or more diagnostically and/or prognostically relevant substances in an organism (biomarker) or one or more substances supplied to an organism from the outside. In at least one embodiment of the method a) one or more concentration values of the substance(s) in an organism, said concentration value(s) being obtained in an in-vitro analytical method is (are) provided, b) data obtained from an imaging study of the same organism are provided, c) from the data according to b), one or more quantitative values are determined as imaging value(s), d) from the values according to a) and c), one or more diagnostic parameters are determined by relating the values according to a) and c) to one another, and also to the use of this method for the type-correct dosage finding of drugs and for the in-vitro diagnosis, prognosis and monitoring the course of a disease. In addition, at least one embodiment of the invention relates to a program for a data processing system which, when carried out in a suitable computer system, carries out the above method, and also to an electronically readable data carrier having electronically readable control information stored thereon, which control information is configured in such a manner that they carry out the above method when a suitable data carrier is used in a suitable computer system.
摘要翻译：公开了一种用于使生物体（生物标志物）中的一种或多种诊断和/或预后相关物质或从外部提供给生物体的一种或多种物质的体外分析方法的结果归一化的方法。在方法的至少一个实施方案中a）提供生物体内物质的一个或多个浓度值，所述浓度值在体外分析方法中获得，b）得到的数据提供来自相同生物体的成像研究，c）根据b）的数据，一个或多个定量值被确定为成像值，d）根据a）和c）的值，一个或多个通过将根据a）和c）的值相互关联来确定更多的诊断参数，并且还使用该方法用于药物的类型正确剂量发现和用于体外诊断，预后和监测过程的疾病此外，本发明的至少一个实施例涉及一种用于数据处理系统的程序，当在合适的计算机系统中执行时，执行上述方法，并且还涉及具有存储的电子可读控制信息的电子可读数据载体在其上配置有这样的控制信息，即当在合适的计算机系统中使用合适的数据载体时，它们执行上述方法。

2. 发明申请

US20100240970A1 METHOD FOR AN IN VIVO MEASUREMENT USING A DEVICE IMPLANTED IN A PATIENT, AND CORRESPONDING DEVICE 审中-公开
标题翻译：用于使用植入在患者中的装置进行体内测量的方法以及相关装置
公开(公告)号：US20100240970A1
公开(公告)日：2010-09-23
申请号：US12723940
申请日：2010-03-15
申请人： Arne HENGERER , Andreas Kappel , Luis Lasalvia , Andrea Lichte , Thomas Mertelmeier , Sven Meyburg , Christoph Petry , Marcus Pfister , Martin Requardt
发明人： Arne HENGERER , Andreas Kappel , Luis Lasalvia , Andrea Lichte , Thomas Mertelmeier , Sven Meyburg , Christoph Petry , Marcus Pfister , Martin Requardt
IPC分类号： A61B5/145 , A61M31/00
CPC分类号： A61B5/0002 , A61B5/14503 , A61B5/4839 , A61B10/0045
摘要： An embodiment of the present invention relates to a device, which can be implanted into a patient, for an in vivo measurement. In an embodiment, the device includes a catheter for guiding a sample of the patient town analysis unit in the device. A measurement result is determined in the analysis unit by analyzing the sample with the aid of a reagent. In an embodiment, the device furthermore includes an interchange chamber, with the aid of which the reagent can be removed from the device or can be inserted into the device. The interchange chamber has a connector allowing removal or insertion of the reagent while the device is implanted.
摘要翻译：本发明的一个实施例涉及可以植入患者体内的用于体内测量的装置。在一个实施例中，该装置包括用于引导装置中的患者镇分析单元的样本的导管。借助于试剂分析样品，在分析单元中测定结果。在一个实施方案中，该装置还包括一个互换室，借助于此可以将该试剂从该装置中移除或者可插入该装置中。交换室具有连接器，其允许在植入装置时移除或插入试剂。

3. 发明申请

US20110046455A1 METHODS AND DEVICES FOR EXAMINING A PARTICULAR TISSUE VOLUME IN A BODY, AND A METHOD AND A DEVICE FOR SEGMENTING THE PARTICULAR TISSUE VOLUME 审中-公开
标题翻译：用于检查身体中特定组织体积的方法和装置，以及用于分离特定组织体积的方法和装置
公开(公告)号：US20110046455A1
公开(公告)日：2011-02-24
申请号：US12857919
申请日：2010-08-17
申请人： Arne HENGERER , Andreas Kappel , Luis Lasalvia , Andrea Lichte , Thomas Mertelmeier , Sven Meyburg , Christoph Petry , Marcus Pfister , Martin Requardt
发明人： Arne HENGERER , Andreas Kappel , Luis Lasalvia , Andrea Lichte , Thomas Mertelmeier , Sven Meyburg , Christoph Petry , Marcus Pfister , Martin Requardt
IPC分类号： A61B5/107 , A61M25/00 , A61B5/055 , A61B5/145 , A61B6/00 , A61B5/053 , A61B6/03
CPC分类号： A61B10/02 , A61B5/055 , A61B5/6852 , A61B10/0045 , A61B10/0283
摘要： A tip of an elongate device is navigated into a particular tissue volume in order to examine the particular tissue volume in a body and part of the tissue volume is analyzed in real-time by way of a biosensor. In at least one embodiment, in the process, either the biosensor can be arranged on the tip of the device or the device includes a catheter, by which a substance to be analyzed is transported out of the tissue volume from the tip to the biosensor arranged at the proximal end of the catheter.
摘要翻译：细长装置的尖端被导航到特定组织体积中以便检查身体中的特定组织体积，并且通过生物传感器实时分析部分组织体积。在至少一个实施例中，在该过程中，生物传感器可以布置在装置的尖端上，或者该装置包括导管，通过该导管将要分析的物质从组织体积从尖端传送到布置的生物传感器在导管的近端。

4. 发明申请

US20100247438A1 IN VITRO METHOD FOR DIAGNOSING TUMOR DISEASES 审中-公开
标题翻译：用于诊断肿瘤疾病的体外方法
公开(公告)号：US20100247438A1
公开(公告)日：2010-09-30
申请号：US12731499
申请日：2010-03-25
申请人： Arne Hengerer , Andreas Kappel , Luis Lasalvia , Andrea Lichte , Thomas Mertelmeier , Sven Meyburg , Christoph Petry , Marcus Pfister , Martin Requardt
发明人： Arne Hengerer , Andreas Kappel , Luis Lasalvia , Andrea Lichte , Thomas Mertelmeier , Sven Meyburg , Christoph Petry , Marcus Pfister , Martin Requardt
IPC分类号： A61K49/00 , G01N33/53 , G01N33/573 , G01N33/48 , A61B1/00
CPC分类号： G01N33/57488 , G01N33/57407 , G01N33/57419 , G01N33/57473 , G01N2333/585 , G01N2333/70503 , G01N2333/96486
摘要： An in vitro method is for diagnosing a tumor disease in a patient. In at least one embodiment, the method includes: (i) determining an IVD marker or an IVD marker panel in at least one biological sample of a patient, wherein the IVD marker has a high sensitivity to the tumor disease, (ii) determining the proportion of patients tested positive due to an adapted reference range of the IVD marker/IVD marker panel, wherein the reference range was adapted such that the number of individuals with false negative tests, the number of individuals with false positive tests and the number of individuals ultimately needing to be subjected to imaging diagnostics to clarify false negative and false positive results are balanced in respect of one another such that tumor screening can be carried out, possibly: (iii) deciding to carry out an imaging method specific to the respective tumor disease for clarifying possible false negative and/or false positive IVD results, or (iv) repeating stages (i) and (ii) after a defined time interval, or (v) carrying out an imaging method for imaging the tumor.
摘要翻译：体外方法是用于诊断患者的肿瘤疾病。在至少一个实施方案中，该方法包括：（i）确定患者的至少一个生物样品中的IVD标记或IVD标记物组，其中IVD标记对肿瘤疾病具有高度敏感性，（ii）确定由于IVD标记/ IVD标记物组的适应参考范围，患者的比例为阳性，其中参考范围被改编为使得具有假阴性测试的个体数量，具有假阳性测试的个体数量和个体数量最终需要进行成像诊断以澄清假阴性和假阳性结果在彼此之间相互平衡，使得可以进行肿瘤筛选，可能：（iii）决定执行特定于各自肿瘤疾病的成像方法用于澄清可能的假阴性和/或假阳性IVD结果，或（iv）在限定的时间间隔后重复阶段（i）和（ii），或（v）进行成像肿瘤成像方法。

5. 发明授权

US08165660B2 System and method for selecting a guidance mode for performing a percutaneous procedure 有权
标题翻译：用于选择执行经皮程序的引导模式的系统和方法
公开(公告)号：US08165660B2
公开(公告)日：2012-04-24
申请号：US12431518
申请日：2009-04-28
申请人： Marcus Pfister , Norbert Strobel
发明人： Marcus Pfister , Norbert Strobel
IPC分类号： A61B6/00 , A61B19/00 , G03B42/02
CPC分类号： A61B6/12 , A61B6/4441 , A61B6/5229 , A61B90/11 , A61B90/13 , A61B2034/107 , A61B2090/364 , A61B2090/376 , A61N2005/1061 , G06F19/00
摘要： A system for planning a percutaneous procedure provides a patient 3-dimensional image data set within which an instrument trajectory is defined, for example, by selecting a skin entry point and a target point. A line, or “planned path,” is generated between the points. The system determines whether the path can be targeted so an optical axis of a movable arm coincides with the path so that a laser can be used for instrument guidance or whether a planned path can be targeted so that a C-arm can be made to coincide with the path so that the extension of the path is projected onto a radiation detector, using x-ray radiation. If neither laser guidance or x-ray guidance can be used, the path is replanned.
摘要翻译：用于规划经皮程序的系统提供例如通过选择皮肤入口点和目标点来定义仪器轨迹的患者3维图像数据集。点之间产生一行或“计划路径”。该系统确定路径是否可以被定向，使得可移动臂的光轴与路径重合，使得激光可以用于仪器引导，或者是否可以定向计划路径，使得C臂可以重合具有路径，使得路径的延伸被投射到使用x射线辐射的辐射检测器上。如果不能使用激光引导或X射线引导，则路径被重新设置。

6. 发明申请

US20120022366A1 REGISTRATION OF AORTA TO PATIENT VIA TWO 2D IMAGES FOR PLACEMENT OF A STENT 审中-公开
标题翻译：通过用于放置一个STENT的两个2D图像将AORTA注册给患者
公开(公告)号：US20120022366A1
公开(公告)日：2012-01-26
申请号：US12840649
申请日：2010-07-21
申请人： Marcus Pfister
发明人： Marcus Pfister
IPC分类号： A61B5/05
CPC分类号： A61B6/032 , A61B6/12 , A61B6/481 , A61B6/504 , A61B6/5235 , G06T7/33 , G06T2207/10081 , G06T2207/10116 , G06T2207/20221 , G06T2207/30101
摘要： In a method for visualizing placement of a stent in an aorta of a patient with reduced use of contrast agent, a 3D volume image of the aorta of the patient is provided from a CT scan before placing the stent. An angiography system with a C-arm is provided to take 2D images of the patient. A computer is provided having registration software for registering the 3D volume image and 2D images taken by the angiography system. A first segmentation is performed on the 3D volume image to segment the aorta from remaining parts of the 3D image. A second segmentation is performed using the first segmentation on the 3D volume image to segment a bony structure of the patient from remaining parts of the 3D volume image. A first 2D image of the aorta is obtained from a first direction with use of a contrast agent. A second 2D image is obtained from a second direction but without use of contrast agent. The segmented aorta in the 3D volume image is registered to the C-arm to create a registered 3D volume image by registering the first 2D image to the segmented aorta and registering the second 2D image to the segmented bony structure. The stent is placed in the aorta while observing on the angiography system a third continuous 2D image taken by the angiography system superimposed on the registered 3D volume image.
摘要翻译：在使用造影剂的患者的主动脉中放置支架的可视化方法中，在放置支架之前，从CT扫描提供患者主动脉的3D体积图像。提供具有C臂的血管造影系统以获取患者的2D图像。提供具有注册软件的计算机，用于注册3D体积图像和由血管造影系统拍摄的2D图像。在3D体积图像上执行第一分割，以从3D图像的其余部分分割主动脉。使用3D体积图像上的第一分割来执行第二分割，以从3D体积图像的剩余部分分割患者的骨骼结构。使用造影剂从第一方向获得主动脉的第一2D图像。从第二方向获得第二2D图像，但不使用造影剂。 3D体积图像中的分割主动脉通过将第一2D图像注册到分割的主动脉并将第二2D图像注册到分段骨结构来登记到C臂以创建注册的3D体积图像。将支架放置在主动脉中，同时在血管造影系统上观察血管造影系统拍摄的第三连续2D图像，该图像叠加在注册的3D体积图像上。

7. 发明授权

US08036453B2 Analytical method for a number of two-dimensional projection images of a three-dimensional examination object 有权
标题翻译：用于三维检查对象的多个二维投影图像的分析方法
公开(公告)号：US08036453B2
公开(公告)日：2011-10-11
申请号：US11986857
申请日：2007-11-27
申请人： Wolfgang Härer , Marcus Pfister
发明人： Wolfgang Härer , Marcus Pfister
IPC分类号： G06K9/00
CPC分类号： G06T11/006
摘要： A number of two-dimensional projection images of a three-dimensional examination object are assigned image times and imaging parameters. The projection images are combined into reconstruction groups including projection images with image times specifically assigned or within a time interval specific to the reconstruction groups. The reconstruction groups are determined in such a way that three-dimensional reconstructions of the examination object with direction-dependent local resolution can be determined based on the projection images of the reconstruction groups; it is not possible to determine three-dimensional reconstructions of the examination object with direction-independent local resolution. Three-dimensional reconstructions of the examination are determined based on the projection images of the reconstruction groups. Reconstruction times are determined based on the image times assigned to the projection images of the reconstruction groups and assigned to the three-dimensional reconstructions. Further analyses are performed as a function of the temporal sequence of the three-dimensional reconstructions.
摘要翻译：将三维检查对象的多个二维投影图像分配给图像时间和成像参数。将投影图像组合成重建组，包括具有特定分配的图像时间的投影图像或者在重建组特有的时间间隔内。确定重建组，使得可以基于重建组的投影图像来确定具有方向依赖性局部分辨率的检查对象的三维重建; 不可能用方向独立的局部分辨率来确定检查对象的三维重建。根据重建组的投影图像确定检查的三维重建。基于分配给重建组的投影图像的图像时间并分配给三维重建来确定重建时间。作为三维重建的时间序列的函数进行进一步的分析。

8. 发明申请

US20110048433A1 Method for forming an interventional aid with the aid of self-organizing nanorobots consisting of catoms and associated system unit 审中-公开
标题翻译：借助于由组织和相关系统单元组成的自组织纳米机构形成介入助剂的方法
公开(公告)号：US20110048433A1
公开(公告)日：2011-03-03
申请号：US12872015
申请日：2010-08-31
申请人： Marcus Pfister
发明人： Marcus Pfister
IPC分类号： A61B19/00
CPC分类号： B82Y15/00 , A61B17/12022 , A61B17/12109 , A61B17/1214 , A61B17/12181 , A61B2017/00256 , A61B2017/00345 , A61B2017/22038 , A61F2/07 , A61F2240/002 , B82Y5/00 , B82Y10/00 , B82Y30/00
摘要： A method for forming at least a part of a preferably endovascular interventional aid with the aid of self-organizing nanorobots consisting of catoms and an associated system are provided. A form of the required interventional aid is determined from at least one 3D image data record of a target region. The determined form is converted to a readable and executable program code for the respective catoms of the nanorobots and is transferred to a storage unit. The program code is executed which prompts self-organization of the previously unstructured catoms to form the required interventional aid according to the previously determined form.
摘要翻译：提供了一种用于通过自组织纳米机构来构成至少一部分优选血管内介入助剂的方法。从目标区域的至少一个3D图像数据记录确定所需介入辅助的形式。所确定的形式被转换成用于纳米机器的各自的可读和可执行的程序代码，并将其转移到存储单元。执行程序代码，其根据先前确定的形式提示先前未结构化的catoms的自组织形成所需的介入辅助。

9. 发明申请

US20110007071A1 Method for Supporting Puncture Planning in a Puncture of an Examination Object 审中-公开
标题翻译：支持穿刺针刺检查对象的方法
公开(公告)号：US20110007071A1
公开(公告)日：2011-01-13
申请号：US12845403
申请日：2010-07-28
申请人： Marcus Pfister
发明人： Marcus Pfister
IPC分类号： G06T17/00 , G06K9/34
CPC分类号： G06T19/00 , A61B34/10 , A61B2034/107 , G06F19/321 , G06K9/00201 , G06T7/0012 , G06T2207/10081 , G06T2219/028
摘要： In order to enable improved and faster performance of punctures, a method is provided for technically supporting guidance to a target during a puncture of an examination object. A 3D data set of a body volume of the examination object that is to be treated is segmented. A puncture target is marked in the segmented 3D data set. The available puncture sites are assessed in terms of their suitability as insertion points on the basis of the information obtained through the segmentation.
摘要翻译：为了能够提高和快速地进行穿刺的性能，提供了在检查对象的穿刺期间技术上支持对目标的指导的方法。要对待处理的检查对象的身体体积的3D数据集进行分割。在分割的3D数据集中标记穿刺目标。根据通过分割获得的信息，将可用的穿刺部位作为插入点进行评估。

10. 发明授权

US07860281B2 Method for the automatic recognition of an object in an image 有权
标题翻译：用于自动识别图像中的对象的方法
公开(公告)号：US07860281B2
公开(公告)日：2010-12-28
申请号：US11515285
申请日：2006-08-31
申请人： Marcus Pfister , Bernhard Sandkamp
发明人： Marcus Pfister , Bernhard Sandkamp
IPC分类号： G06K9/00
CPC分类号： G06T7/0012 , G06T7/74 , G06T2207/10121 , G06T2207/20132 , G06T2207/30021
摘要： To enable a rapid and safe automatic recognition of the position of the catheter, particularly for an electrophysiological examination with an automatic control system of an electrode catheter, a two-stage image evaluation of an x-ray fluoroscopy image is provided. In the first analysis step, frequency polygons are herewith developed as potential locations of the catheter with the aid of structures contained in the image. In the second analysis step, only the previously identified potential catheter positions are investigated with the aid of a template method and the actual catheter position is identified.
摘要翻译：为了能够快速，安全地自动识别导管的位置，特别是对于使用电极导管的自动控制系统的电生理检查，提供了X射线透视图像的两阶段图像评估。在第一分析步骤中，借助于包含在图像中的结构，频率多边形在这里被发展为导管的潜在位置。在第二分析步骤中，借助于模板方法仅研究先前识别的潜在的导管位置，并且识别实际的导管位置。

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