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1. 发明授权

US09186361B2 Compounds and compositions for the treatment of parasitic diseases 有权
标题翻译：用于治疗寄生虫病的化合物和组合物
公开(公告)号：US09186361B2
公开(公告)日：2015-11-17
申请号：US14209655
申请日：2014-03-13
申请人： Arnab Kumar Chatterjee , Fang Liang , Casey Jacob Nelson Mathison , Pranab Kumar Mishra , Valentina Molteni , Advait Suresh Nagle , Frantisek Supek , Liying Jocelyn Tan , Agnes Vidal
发明人： Arnab Kumar Chatterjee , Fang Liang , Casey Jacob Nelson Mathison , Pranab Kumar Mishra , Valentina Molteni , Advait Suresh Nagle , Frantisek Supek , Liying Jocelyn Tan , Agnes Vidal
IPC分类号： A01N43/42 , A61K31/44 , A61K31/5377 , A61K31/437 , A61K45/06 , C07D471/04 , C07D498/04
CPC分类号： A61K31/5377 , A61K31/437 , A61K45/06 , C07D471/04 , C07D498/04 , Y02A50/409 , Y02A50/414 , Y02A50/415
摘要： The present invention provides compounds of Formula I: or a pharmaceutically acceptable salt, tautomer, or stereoisomer, thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds and methods of using such compounds for treating, preventing, inhibiting, ameliorating, or eradicating the pathology and/or symptomology of a disease caused by a parasite, such as Leishmaniasis, Human African Trypanosomiasis and Chagas disease.
摘要翻译：本发明提供式I化合物或其药学上可接受的盐，互变异构体或立体异构体，其中变量如本文所定义。本发明还提供包含这些化合物的药物组合物和使用这些化合物治疗，预防，抑制，改善或消除由寄生虫引起的疾病的病理和/或症状的方法，例如利什曼病，人非洲锥虫病和查加斯疾病。

2. 发明授权

US09233961B2 Compounds and compositions for the treatment of parasitic diseases 有权
公开(公告)号：US09233961B2
公开(公告)日：2016-01-12
申请号：US14209536
申请日：2014-03-13
申请人： Arnab Kumar Chatterjee , Fang Liang , Casey Jacob Nelson Mathison , Pranab Kumar Mishra , Valentina Molteni , Advait Suresh Nagle , Frantisek Supek , Liying Jocelyn Tan , Agnes Vidal , Michael Herman Gelb , Frederick Simmons Buckner , Hari Babu Tatipaka , Neil Richard Norcross , John Robert Gillespie
发明人： Arnab Kumar Chatterjee , Fang Liang , Casey Jacob Nelson Mathison , Pranab Kumar Mishra , Valentina Molteni , Advait Suresh Nagle , Frantisek Supek , Liying Jocelyn Tan , Agnes Vidal , Michael Herman Gelb , Frederick Simmons Buckner , Hari Babu Tatipaka , Neil Richard Norcross , John Robert Gillespie
IPC分类号： C07D471/02 , A61K31/50 , A61K31/415 , C07D473/00 , C07D471/04 , C07D487/04 , C07D498/04
CPC分类号： C07D473/00 , C07D471/04 , C07D487/04 , C07D498/04
摘要： The present invention provides compounds of formula I: or a pharmaceutically acceptable salt, tautomer, or stereoisomer, thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds and methods of using such compounds for treating, preventing, inhibiting, ameliorating, or eradicating the pathology and/or symptomology of a disease caused by a parasite, such as Leishmaniasis, Human African Trypanosomiasis and Chagas disease.

3. 发明授权

US09296754B2 Compounds and compositions for the treatment of parasitic diseases 有权
标题翻译：用于治疗寄生虫病的化合物和组合物
公开(公告)号：US09296754B2
公开(公告)日：2016-03-29
申请号：US14209850
申请日：2014-03-13
申请人： Fang Liang , Pranab Kumar Mishra , Valentina Molteni , Advait Suresh Nagle , Frantisek Supek , Liying Jocelyn Tan , Agnes Vidal
发明人： Fang Liang , Pranab Kumar Mishra , Valentina Molteni , Advait Suresh Nagle , Frantisek Supek , Liying Jocelyn Tan , Agnes Vidal
IPC分类号： A61K31/519 , C07D487/04 , A61K45/06
CPC分类号： C07D487/04 , A61K31/519 , A61K45/06 , Y02A50/409 , Y02A50/414 , Y02A50/415 , A61K2300/00
摘要： The present invention provides compounds of formula I: or a pharmaceutically acceptable salt, tautomer, or stereoisomer, thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds and methods of using such compounds for treating, preventing, inhibiting, ameliorating, or eradicating the pathology and/or symptomology of a disease caused by a parasite, such as Leishmaniasis, Human African Trypanosomiasis and Chagas disease.
摘要翻译：本发明提供式I化合物或其药学上可接受的盐，互变异构体或立体异构体，其中变量如本文所定义。本发明还提供包含这些化合物的药物组合物和使用这些化合物治疗，预防，抑制，改善或消除由寄生虫引起的疾病的病理和/或症状的方法，例如利什曼病，人非洲锥虫病和查加斯疾病。

4. 发明授权

US09700559B2 Compounds and compositions for the treatment of parasitic diseases 有权
公开(公告)号：US09700559B2
公开(公告)日：2017-07-11
申请号：US15051446
申请日：2016-02-23
申请人： Agnes Biggart , Fang Liang , Casey Jacob Nelson Mathison , Valentina Molteni , Advait Suresh Nagle , Frantisek Supek , Vince Yeh
发明人： Agnes Biggart , Fang Liang , Casey Jacob Nelson Mathison , Valentina Molteni , Advait Suresh Nagle , Frantisek Supek , Vince Yeh
IPC分类号： C07D487/04 , A61K31/519 , C07D519/00 , C07F5/02 , C07F7/08 , A61K31/5377 , A61K31/695
CPC分类号： A61K31/519 , A61K31/5377 , A61K31/695 , A61K45/06 , C07D487/04 , C07D519/00 , C07F5/027 , C07F7/0814
摘要： The present invention provides compounds of Formula A: or a pharmaceutically acceptable salt, tautomer, or stereoisomer, thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds and methods of using such compounds for treating, preventing, inhibiting, ameliorating, or eradicating the pathology and/or symptomology of a disease caused by a parasite, such as leishmaniasis, human African trypanosomiasis and Chagas disease.

5. 发明授权

US09303034B2 Compounds and compositions for the treatment of parasitic diseases 有权
标题翻译：用于治疗寄生虫病的化合物和组合物
公开(公告)号：US09303034B2
公开(公告)日：2016-04-05
申请号：US14574775
申请日：2014-12-18
申请人： Agnes Biggart , Fang Liang , Casey Jacob Nelson Mathison , Valentina Molteni , Advait Suresh Nagle , Frantisek Supek , Vince Yeh
发明人： Agnes Biggart , Fang Liang , Casey Jacob Nelson Mathison , Valentina Molteni , Advait Suresh Nagle , Frantisek Supek , Vince Yeh
IPC分类号： A61K31/519 , C07D487/04 , C07D519/00 , C07F5/02 , C07F7/08
CPC分类号： A61K31/519 , A61K31/5377 , A61K31/695 , A61K45/06 , C07D487/04 , C07D519/00 , C07F5/027 , C07F7/0814
摘要： The present invention provides compounds of Formula A: or a pharmaceutically acceptable salt, tautomer, or stereoisomer, thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds and methods of using such compounds for treating, preventing, inhibiting, ameliorating, or eradicating the pathology and/or symptomology of a disease caused by a parasite, such as leishmaniasis, human African trypanosomiasis and Chagas disease.
摘要翻译：本发明提供式A化合物或其药学上可接受的盐，互变异构体或立体异构体，其中变量如本文所定义。本发明还提供了包含这些化合物的药物组合物和使用这些化合物治疗，预防，抑制，改善或消除由寄生虫引起的疾病的病理和/或症状的方法，例如利什曼病，人非洲锥虫病和查加斯疾病。

6. 发明申请

US20050009052A1 Differential tag length analysis of cell proliferation 审中-公开
标题翻译：差异标签长度分析细胞增殖
公开(公告)号：US20050009052A1
公开(公告)日：2005-01-13
申请号：US10830708
申请日：2004-04-22
申请人： Frantisek Supek , Nicholas Gekakis
发明人： Frantisek Supek , Nicholas Gekakis
IPC分类号： C12P19/34 , C12Q20060101 , C12Q1/68 , G01N33/50
CPC分类号： G01N33/5011
摘要： The present invention is based on a novel cell tagging approach called “Differential Tag Length” method (DTLA) that allows the quantitative analysis of a mixture of multiple cell types (e.g., strains) grown in very small cultivation volumes. DTLA can also be fully automated and adapted for a high-throughput format. The invention provides methods for detecting proliferation of a mixture of cell types in a culture, for screening a library of compounds to identify those compounds that modulate proliferation of a cell, and for detecting the presence or absence of targets in a sample. The invention also provides kits comprising at least first polynucleotide tag and a second polynucleotide tag.
摘要翻译：本发明基于称为“差异标签长度”（DTLA）的新型细胞标记方法，其允许定量分析以非常小的培养体积生长的多种细胞类型（例如菌株）的混合物。 DTLA也可以完全自动化并适应高吞吐量格式。本发明提供了用于检测培养物中细胞类型混合物的增殖的方法，用于筛选化合物文库以鉴定调节细胞增殖的那些化合物，以及用于检测样品中靶标的存在或不存在。本发明还提供了包含至少第一个多核苷酸标签和第二个多核苷酸标签的试剂盒。

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