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1. 发明授权

US4400384A 5-o-Cyanobenzyl-4,5,6,7-tetrahydrothieno [3,2-c] pyridine methanesulfonate and other novel salts thereof 失效
标题翻译： 5'-氰基苄基-4,5,6,7-四氢噻吩并[3,2-c]吡啶甲磺酸盐及其它新的盐
公开(公告)号：US4400384A
公开(公告)日：1983-08-23
申请号：US193906
申请日：1980-10-06
申请人： Armand Amselem , Fernand Eloy , Jean-Pierre Maffrand
发明人： Armand Amselem , Fernand Eloy , Jean-Pierre Maffrand
IPC分类号： C07D495/04 , C07D513/04 , A61K31/44
CPC分类号： C07D495/04 , Y10S514/821
摘要： The invention concerns novel 5-o-cyanobenzyl-4, 5, 6, 7-tetrahydrothieno-[3,2-c] pyridine acid addition salts having inhibitory action against blood platelet aggregation without anti-inflammatory activity, and the compositions and methods of use therefor.
摘要翻译：本发明涉及对没有抗炎活性的血小板聚集具有抑制作用的新的5-邻氰基苄基-4,5,6,7-四氢噻吩并[3,2-c]吡啶酸加成盐，以及其组合物和方法用于此。

2. 发明授权

US4321266A 5-o-Cyanobenzyl-4,5,6,7-tetrahydrothieno [3,2-C] pyridine 失效
标题翻译： 5'-氰基苄基-4,5,6,7-四氢噻吩并[3,2-C]吡啶
公开(公告)号：US4321266A
公开(公告)日：1982-03-23
申请号：US193907
申请日：1980-10-06
申请人： Armand Amselem , Fernand Eloy , Jean-Pierre Maffrand
发明人： Armand Amselem , Fernand Eloy , Jean-Pierre Maffrand
IPC分类号： C07D495/04 , A61K31/395
CPC分类号： C07D495/04 , Y10S514/822
摘要： The free base, 5-o-cyanobenzyl-4,5,6,7-tetrahydrothieno [3,2-c] pyridine, a method for the preparation thereof, therapeutic compositions having blood-platelet aggregation inhibiting activity, therapeutic dosage units of the compositions, and a method for the treatment of warm-blooded animals to inhibit blood platelet aggregation, are described.
摘要翻译：游离碱5-邻氨基苄基-4,5,6,7-四氢噻吩并[3,2-c]吡啶，其制备方法，具有血小板聚集抑制活性的治疗组合物，治疗剂量单位为描述了用于治疗温血动物以抑制血小板聚集的组合物和方法。

3. 发明授权

US3957995A Pharmaceutical composition comprising vincamine and theophylline 失效
标题翻译：药物组合物包含长春胺和茶碱
公开(公告)号：US3957995A
公开(公告)日：1976-05-18
申请号：US536942
申请日：1974-12-23
申请人： Armand Amselem
发明人： Armand Amselem
IPC分类号： A61K31/52 , A61K31/475 , A61K31/515
CPC分类号： A61K31/52 , Y10S514/929
摘要： The herein disclosed invention is directed to pharmaceutical compositions of vincamine and theophylline having cerebral vasodilator activity.
摘要翻译：本文公开的本发明涉及具有脑血管扩张剂活性的长春胺和茶碱的药物组合物。

4. 发明授权

US4018786A 2-Aminothiazolines and a process for preparation thereof 失效
标题翻译： 2-氨基噻唑啉及其制备方法
公开(公告)号：US4018786A
公开(公告)日：1977-04-19
申请号：US495214
申请日：1974-08-06
申请人： Armand Amselem
发明人： Armand Amselem
IPC分类号： C07D277/18 , C07D277/38 , C07D277/42
CPC分类号： C07D277/42 , C07D277/18
摘要： Amino-2 thiazoles of the formulae ##STR1## and ##STR2## wherein R.sub.1 and R.sub.2 are each selected from hydrogen, lower alkenyl radicals, lower alkyl radicals, lower cycloalkyl radicals, phenyl radical, lower cycloalkylphenyl radicals, lower phenylalkyl radicals, lower halogenoalkenyl radicals, lower halogenoalkyl radicals, lower halogenocycloalkyl radicals, halogenophenyl radicals, lower halogenoalkyl radicals, and the same radicals substituted by at least a hydroxy, R.sub.3 and R.sub.4 are each selected from hydrogen, lower alkyl and lower cycloalkyl, one at least of R.sub.1 and R.sub.2 being cyclic, and their salts, have valuable hypocholesterolemic activity.
摘要翻译：其中R 1和R 2各自选自氢，低级烯基，低级烷基，低级环烷基，苯基，低级环烷基苯基，低级苯基烷基，低级卤代烯基，低级卤代烷基，低级卤代环烷基，卤代苯基，低级卤代烷基，以及至少被羟基取代的相同的基团，R3和R4各自选自氢，低级烷基和低级环烷基，至少R1和R2为环状及其盐具有有价值的低胆固醇血症活性。

5. 发明授权

US4097482A 5-O-Cyanobenzyl-4,5,6,7-tetrahydro-thieno�3,2-c!pyridine maleate 失效
标题翻译： 5-O-氰基苄基-4,5,6,7-四氢 - 噻吩并{8,2-c {9吡啶马来酸盐
公开(公告)号：US4097482A
公开(公告)日：1978-06-27
申请号：US703837
申请日：1976-07-09
申请人： Armand Amselem
发明人： Armand Amselem
IPC分类号： A61K31/435 , A61P7/02 , A61P9/08 , A61P29/00 , C07D495/04 , C07D513/04
CPC分类号： C07D495/04 , Y10S514/822 , Y10S514/929
摘要： The present invention relates to pyridine derivatives having the formula: ##STR1## in which: R is a radical selected from a phenyl radical mono- and polysubstituted with a group selected from the aryl, carboxy, alkoxycarbonyl, cyano, hydroxymethyl and ethylenedioxy groups; a styryl, thienyl and benzhydryl radical optionally mono- and polysubstituted with a group selected from halogen, lower alkyl, lower alkoxy, aryl, nitro, amino, sulfonylamino, carboxy, alkoxycarbonyl, cyano, hydroxymethyl and methylenedioxy; R.sub.1 and R.sub.2 represent each a group selected from hydrogen, halogen, hydroxy, lower alkyl, lower alkoxy, nitro and amino; R.sub.3 represents a group selected from hydrogen, halogen, hydroxy, lower alkyl, lower alkoxy, nitro and amino; and n is an integer from 1 to 15, And in which the symbols R.sub.3 may have different meanings in each radical CHR.sub.3 when n is greater than 1, And their inorganic and organic acid addition salts and quaternary ammonium derivatives, particularly 5-o-cyanobenzyl-4,5,6,7-tetrahydro-thieno�3,2-c!pyridine maleate. Said derivatives are therapeutically valuable in view of their anti-inflammatory and vasodilator activities and their inhibitor action on blood-platelet aggregation.
摘要翻译：本发明涉及具有下式的吡啶衍生物：其中：

6. 发明授权

US3995050A Amino-2 imidazoles 失效
标题翻译：氨基-2-咪唑
公开(公告)号：US3995050A
公开(公告)日：1976-11-30
申请号：US568362
申请日：1975-04-15
申请人： Armand Amselem
发明人： Armand Amselem
IPC分类号： C07D233/58 , A61K31/4192 , C07D233/60 , C07D233/88 , C07D401/04 , C07D403/04
CPC分类号： C07D233/88
摘要： Aminoimidazoles of the formula ##SPC1##Wherein R.sub.1 is optionally substituted phenyl, R.sub.4 is hydrogen or alkyl, R.sub. 5 is hydrogen or methyl and R.sub.2 and R.sub.3 form, together with the nitrogen atom to which they are bonded, a saturated heterocycle having 4 to 8 ring members, have valuable psychostimulant properties.
摘要翻译：式+ q，10的氨基咪唑其中R 1为任选取代的苯基，R 4为氢或烷基，R 5为氢或甲基，R 2和R 3与它们所键合的氮原子一起形成具有4至 8个戒指成员，具有宝贵的精神兴奋剂特性。

7. 发明授权

US4080447A Therapeutic composition having an inhibiting activity on blood plate aggregation 失效
标题翻译：对血板聚集具有抑制活性的治疗组合物
公开(公告)号：US4080447A
公开(公告)日：1978-03-21
申请号：US671496
申请日：1976-03-29
申请人： Armand Amselem
发明人： Armand Amselem
IPC分类号： A61K20060101 , A61K31/38 , A61K31/395 , A61K31/435 , A61K31/445 , A61K31/60 , A61K31/625 , C07D495/04
CPC分类号： A61K31/60
摘要： This invention relates to a therapeutic composition comprising, as active ingredient, a combination of 5-(2-chloro-benzyl)-4,5,6,7-tetrahydro-thieno[3,2-c]-pyridine and acetylsalicylic acid, the components of the combination being both present in the free state or as a pharmacologically acceptable salt. Said composition is useful both preventively and curatively for the treatment of thrombo-embolic diseases.
摘要翻译：本发明涉及治疗组合物，其包含作为活性成分的5-（2-氯 - 苄基）-4,5,6,7-四氢 - 噻吩并[3,2-c] - 吡啶和乙酰水杨酸的组合，组合的组分都以游离状态存在或作为药理学上可接受的盐。所述组合物既用于治疗血栓栓塞性疾病又有预防和治疗的作用。

8. 发明授权

US3957981A Pharmaceutical composition comprising vincamine and acetylsalicyclic acid 失效
标题翻译：包含长春胺和乙酰水杨酸的药物组合物
公开(公告)号：US3957981A
公开(公告)日：1976-05-18
申请号：US536941
申请日：1974-12-23
申请人： Armand Amselem
发明人： Armand Amselem
IPC分类号： A61K31/60 , A61K31/475 , A61K31/625
CPC分类号： A61K31/60
摘要： The herein disclosed invention is directed to pharmaceutical compositions of vincamine and acetylsalicylic acid having cerebral vasodilator activity.
摘要翻译：本文公开的本发明涉及具有脑血管扩张剂活性的长春胺和乙酰水杨酸的药物组合物。

9. 发明授权

US3983125A Thieno-pyridine derivatives, process for their preparation and their applications 失效
标题翻译：噻吩衍生物，其制备方法及其应用
公开(公告)号：US3983125A
公开(公告)日：1976-09-28
申请号：US593051
申请日：1975-07-03
申请人： Armand Amselem
发明人： Armand Amselem
IPC分类号： C07D471/04 , A61K31/4365 , C07D333/20 , C07D333/22 , C07D495/04 , C07D213/28
CPC分类号： C07D495/04 , C07D333/20 , C07D333/22 , Y10S514/822
摘要： This invention relates to thieno-pyridine derivatives which may be represented by either one of the following formulae: ##SPC1##In which R is hydrogen or an alkyl radical having 1-6 carbon atoms, and their acid addition salts with inorganic or organic acids.Said derivatives have anti-inflammatory, antalgic and blood-platelet aggregation-inhibiting activity in mice and rats. In addition, they may also be used as intermediates in the synthesis of a large number of derivatives used both in the chemical and pharmaceutical industries.
摘要翻译：本发明涉及噻吩并吡啶衍生物，其可以由下式之一表示：

10. 发明授权

US3969358A Process for the preparation of thieno [3,2-c] pyridine and thieno [2,3-c] p y 失效
标题翻译：制备噻吩并[8,3-c {9 {0吡啶和噻吩并[8,2,3- C {9 {0吡啶
公开(公告)号：US3969358A
公开(公告)日：1976-07-13
申请号：US590132
申请日：1975-06-25
申请人： Armand Amselem
发明人： Armand Amselem
IPC分类号： C07D513/04 , B23D53/12 , C07D333/20 , C07D333/22 , C07D495/04 , C07D213/28
CPC分类号： C07D495/04 , B23D53/12 , C07D333/20 , C07D333/22
摘要： The present invention relates to a process for the preparation of thieno[3,2-c]pyridine or thieno[2,3-c]pyridine, comprising cyclizing a N-(3-thienyl)-methyl-N-[ 2,2-(OR).sub.2 ]ethyl-para-toluene sulfonamide or a N-(2-thienyl)-methyl-N-[2,2-(OR).sub.2 ]ethyl-para-toluene sulfonamide, respectively, in which R is lower alkyl or both R groups form together a 2- or 3-membered alkylene radical, by treatment with an acid in the presence of an inert organic solvent.
摘要翻译：本发明涉及制备噻吩并[3,2-c]吡啶或噻吩并[2,3-c]吡啶的方法，包括使N-（3-噻吩基） - 甲基-N- [2,2 - （OR）2]乙基对甲苯磺酰胺或N-（2-噻吩基） - 甲基-N- [2,2-（OR）2]乙基 - 对 - 甲苯磺酰胺，其中R较低烷基或两个R基团通过在惰性有机溶剂的存在下用酸处理而形成2-或3-元亚烷基。

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