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    • 1. 发明授权
    • Compositions and methods for improving overall tooth health and appearance
    • 用于改善整体牙齿健康和外观的组合和方法
    • US09139731B2
    • 2015-09-22
    • US12140501
    • 2008-06-17
    • Arif Ali BaigRobert Vincent FallerGeorge Endel Deckner
    • Arif Ali BaigRobert Vincent FallerGeorge Endel Deckner
    • A61K6/00C08L71/02A61K8/19A61K8/21A61K8/24A61K8/55A61K8/81A61Q11/00C08G65/335
    • A61K8/55A61K6/0067A61K8/19A61K8/21A61K8/24A61K8/416A61K8/4926A61K8/556A61K8/81A61K8/8147A61Q11/00C08G65/3355C08L71/02A61K6/0017C08L33/08C08L33/10
    • Disclosed are oral care compositions comprising selected surface-active organophosphate compounds and methods of use to provide protection of teeth from erosion caused by the action of chemicals, such as harsh abrasives and acids. The surface-active organophosphate compounds are substantive to teeth, the phosphate groups binding the calcium in teeth and thus preventing loss of calcium from dissolution when contacted with acids. The organophosphate compound may also deposit a protective surface coating that prevents contact of teeth with erosive challenges. Selected organophosphate compounds contain one or more phosphate groups and are combined in the oral care composition with one or more of a fluoride ion agent, an antimicrobial agent preferably selected from quaternary ammonium compounds and polyvalent metal salts, an anticalculus agent and additional surfactant, to provide benefits including superior anti-erosion, anticaries, antiplaque and anti-staining as demonstrated by enhanced fluoride uptake, remineralization, resistance to acid demineralization and antimicrobial activities, resulting in improved overall tooth health, structural integrity and appearance.
    • 公开了包含选择的表面活性有机磷酸酯化合物的口腔护理组合物和用于保护牙齿免受化学物质(例如刺激性磨料和酸)的作用所引起的侵蚀的方法。 表面活性有机磷酸酯化合物对牙齿是实质的,磷酸基团结合牙齿中的钙,从而防止当与酸接触时钙的溶解丧失。 有机磷酸盐化合物还可以沉积防止牙齿与侵蚀性挑战接触的保护性表面涂层。 所选的有机磷酸酯化合物含有一个或多个磷酸酯基,并且在口腔护理组合物中与一种或多种氟离子剂,优选选自季铵化合物和多价金属盐的抗微生物剂,抗结石剂和另外的表面活性剂组合,以提供 通过增强氟化物吸收,再矿化,抗酸脱矿质和抗微生物活性所证明的优点,包括优异的抗侵蚀,防褪色,抗菌斑和抗染色,从而改善整体牙齿健康状况,结构完整性和外观。
    • 2. 发明申请
    • Compositions and Methods for Improving Overall Tooth Health and Appearance
    • 提高整体牙齿健康和外观的组成和方法
    • US20080247973A1
    • 2008-10-09
    • US12140501
    • 2008-06-17
    • Arif Ali BaigRobert Vincent FallerGeorge Endel Deckner
    • Arif Ali BaigRobert Vincent FallerGeorge Endel Deckner
    • A61K8/55A61Q11/00
    • A61K8/55A61K6/0067A61K8/19A61K8/21A61K8/24A61K8/416A61K8/4926A61K8/556A61K8/81A61K8/8147A61Q11/00C08G65/3355C08L71/02A61K6/0017C08L33/08C08L33/10
    • Disclosed are oral care compositions comprising selected surface-active organophosphate compounds and methods of use to provide protection of teeth from erosion caused by the action of chemicals, such as harsh abrasives and acids. The surface-active organophosphate compounds are substantive to teeth, the phosphate groups binding the calcium in teeth and thus preventing loss of calcium from dissolution when contacted with acids. The organophosphate compound may also deposit a protective surface coating that prevents contact of teeth with erosive challenges. Selected organophosphate compounds contain one or more phosphate groups and are combined in the oral care composition with one or more of a fluoride ion agent, an antimicrobial agent preferably selected from quaternary ammonium compounds and polyvalent metal salts, an anticalculus agent and additional surfactant, to provide benefits including superior anti-erosion, anticaries, antiplaque and anti-staining as demonstrated by enhanced fluoride uptake, remineralization, resistance to acid demineralization and antimicrobial activities, resulting in improved overall tooth health, structural integrity and appearance.
    • 公开了包含选择的表面活性有机磷酸酯化合物的口腔护理组合物和用于保护牙齿免受化学物质(例如刺激性磨料和酸)的作用所引起的侵蚀的方法。 表面活性有机磷酸酯化合物对牙齿是实质的,磷酸基团结合牙齿中的钙,从而防止当与酸接触时钙的溶解丧失。 有机磷酸盐化合物还可以沉积防止牙齿与侵蚀性挑战接触的保护性表面涂层。 所选的有机磷酸酯化合物含有一个或多个磷酸酯基,并且在口腔护理组合物中与一种或多种氟离子剂,优选选自季铵化合物和多价金属盐的抗微生物剂,抗结石剂和另外的表面活性剂组合,以提供 通过增强氟化物吸收,再矿化,抗酸脱矿质和抗微生物活性所证明的优点,包括优异的抗侵蚀,防褪色,抗菌斑和抗染色,从而改善整体牙齿健康状况,结构完整性和外观。