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1. 发明申请

US20090163596A1 Bimatoprost crystalline form I 有权
标题翻译：比马前列素结晶I
公开(公告)号：US20090163596A1
公开(公告)日：2009-06-25
申请号：US11896002
申请日：2007-08-29
申请人： Arie Gutman , Igor Rukhman , Boris Tishin , Lev Yudovich , Alexander Vilensky , Boris Pertsikov , Gennady Nisnevich
发明人： Arie Gutman , Igor Rukhman , Boris Tishin , Lev Yudovich , Alexander Vilensky , Boris Pertsikov , Gennady Nisnevich
IPC分类号： A61K31/165 , C07C235/34 , C07C231/24 , A61P27/02 , C07F7/18
CPC分类号： C07C405/00 , A61K9/0048 , C07C2601/08 , C07F7/1804
摘要： The invention provides a novel polymorphic form I of crystalline bimatoprost, method for preparation thereof and new crystalline intermediates in the preparation. This form I of crystalline bimatoprost is used in purification of crude bimatoprost and in storage of bimatoprost as active pharmaceutical intermediate. Use of the physical form of bimatoprost in the manufacture of a medicament is also disclosed.
摘要翻译：本发明提供了结晶比马前列素的新型多晶型I，其制备方法和制备中的新型结晶中间体。结晶比马前列素的形式I用于纯化比马前列素和作为活性药物中间体的比马前列素的储存。还公开了在生产药物中使用比马前列素的物理形式。

2. 发明申请

US20110288179A1 BIMATOPROST CRYSTALLINE FORM I 审中-公开
公开(公告)号：US20110288179A1
公开(公告)日：2011-11-24
申请号：US13113136
申请日：2011-05-23
申请人： Arie GUTMAN , Igor Rukhman , Boris Tishin , Lev Yudovich , Alexander Vilensky , Boris Pertsikov , Gennady Nisnevich
发明人： Arie GUTMAN , Igor Rukhman , Boris Tishin , Lev Yudovich , Alexander Vilensky , Boris Pertsikov , Gennady Nisnevich
IPC分类号： A61K31/166 , C07C233/11
CPC分类号： C07C405/00 , A61K9/0048 , C07C2601/08 , C07F7/1804
摘要： The invention provides a novel polymorphic form I of crystalline bimatoprost, method for preparation thereof and new crystalline intermediates in the preparation. This form I of crystalline bimatoprost is used in purification of crude bimatoprost and in storage of bimatoprost as active pharmaceutical intermediate. Use of the physical form of bimatoprost in the manufacture of a medicament is also disclosed.
摘要翻译：本发明提供了结晶比马前列素的新型多晶型I，其制备方法和制备中的新型结晶中间体。结晶比马前列素的形式I用于纯化比马前列素和作为活性药物中间体的比马前列素的储存。还公开了在生产药物中使用比马前列素的物理形式。

3. 发明授权

US07947740B2 Bimatoprost crystalline form I 有权
标题翻译：比马前列素结晶I
公开(公告)号：US07947740B2
公开(公告)日：2011-05-24
申请号：US11896002
申请日：2007-08-29
申请人： Arie Gutman , Igor Rukhman , Boris Tishin , Lev Yudovich , Alexander Vilensky , Boris Pertsikov , Gennady Nisnevich
发明人： Arie Gutman , Igor Rukhman , Boris Tishin , Lev Yudovich , Alexander Vilensky , Boris Pertsikov , Gennady Nisnevich
IPC分类号： A61K31/165 , C07C235/34 , C07C231/24 , A61P27/02 , C07F7/18
CPC分类号： C07C405/00 , A61K9/0048 , C07C2601/08 , C07F7/1804
摘要： The invention provides a novel polymorphic form I of crystalline bimatoprost, method for preparation thereof and new crystalline intermediates in the preparation. This form I of crystalline bimatoprost is used in purification of crude bimatoprost and in storage of bimatoprost as active pharmaceutical intermediate. Use of the physical form of bimatoprost in the manufacture of a medicament is also disclosed.
摘要翻译：本发明提供了结晶比马前列素的新型多晶型I，其制备方法和制备中的新型结晶中间体。结晶比马前列素的形式I用于纯化比马前列素和作为活性药物中间体的比马前列素的储存。还公开了在生产药物中使用比马前列素的物理形式。

4. 发明申请

US20050239837A1 Process for production of highly pure donepezil hydrochloride 审中-公开
标题翻译：生产高纯度盐酸多奈哌齐的方法
公开(公告)号：US20050239837A1
公开(公告)日：2005-10-27
申请号：US11112002
申请日：2005-04-22
申请人： Arie Gutman , Marina Etinger , Boris Tishin , Boris Pertsikov , Boris Fedotev , Alexander Vilensky , Pavel Potyabin , Gennady Nisnevich
发明人： Arie Gutman , Marina Etinger , Boris Tishin , Boris Pertsikov , Boris Fedotev , Alexander Vilensky , Pavel Potyabin , Gennady Nisnevich
IPC分类号： C07D211/32 , A61K31/445 , C07D211/06
CPC分类号： C07D211/32
摘要： Disclosed is a process for production of highly pure donepezil hydrochloride in the form of polymorph I that does not involve the isolation of donepezil base. The disclosed process involves intramolecular cyclization of N-benzyl-2-(3,4-dimethoxybenzyl)-3-(4-piperidine)propionic acid followed by treatment with HCl.
摘要翻译：公开了以不含多奈哌齐碱分离的多晶型I形式的高纯度多奈哌齐盐酸盐的制造方法。所公开的方法包括N-苄基-2-（3,4-二甲氧基苄基）-3-（4-哌啶）丙酸的分子内环化，然后用HCl处理。

5. 发明授权

US06830207B2 Screen cleaning and comminuting system 有权
标题翻译：屏幕清洗和粉碎系统
公开(公告)号：US06830207B2
公开(公告)日：2004-12-14
申请号：US10266890
申请日：2002-10-08
申请人： William B. Galanty , Alexander Vilensky
发明人： William B. Galanty , Alexander Vilensky
IPC分类号： B02C108
CPC分类号： B02C18/0092 , B01D29/035 , B01D29/6476 , B01D29/76 , B02C18/24 , B07B1/20
摘要： A comminuting apparatus including a filtering screen member for collecting solids carried by an effluent stream. The filtering screen member has an upstream side and a downstream side. The comminutor apparatus further includes a twin shaft grinder for grinding solids contained in the effluent stream and for cleaning the filtering screen member of solids collected thereon. The comminutor apparatus also includes a mounting member in the form of frame-like structure for mounting the twin shaft grinder at a spaced apart distance from the upstream side of the filtering screen member. Additionally, the comminutor apparatus includes a moving device in the form of a drive motor for moving the twin shaft grinder past the upstream side of the filtering screen member such that the twin shaft grinder is continuously spaced from the filtering screen member during the movement of the twin shaft grinder.
摘要翻译：一种粉碎设备，包括用于收集由流出物流携带的固体的过滤筛构件。过滤筛构件具有上游侧和下游侧。粉碎设备还包括用于研磨包含在流出物流中的固体并用于清洁其上收集的固体的过滤网构件的双轴研磨机。该粉碎设备还包括一种用于将双轴研磨机与过滤丝网部件的上游侧间隔开的距离安装成框状结构形式的安装部件。此外，该粉碎设备包括一个驱动马达形式的移动装置，用于使双轴研磨机通过过滤丝网部件的上游侧，使得双轴磨床在过滤丝网部件运动期间与过滤丝网部件连续间隔开双轴磨床。

6. 发明授权

US06311905B1 Screen cleaning and comminuting system 失效
标题翻译：屏幕清洗和粉碎系统
公开(公告)号：US06311905B1
公开(公告)日：2001-11-06
申请号：US09498855
申请日：2000-02-07
申请人： William B. Galanty , Alexander Vilensky
发明人： William B. Galanty , Alexander Vilensky
IPC分类号： B02C1840
CPC分类号： B02C18/0092 , B01D29/035 , B01D29/6476 , B01D29/76 , B02C18/24 , B07B1/20
摘要： A sewage cleaning and comminuting system is provided with a transverse semi-circular concave filtering screen that extends across an influent channel which intercepts all solids too large to pass therethrough. A combined screen cleaning and comminuting grinder unit is mounted in front of the screen in close relationship. It has a concave surface for reciprocating motion therebetween along the full extent of the screen, so as to clean and remove large solids intercepted by the screen surface, and to subsequently comminute such larger solids. As they are recirculated back into incoming flow of sewage, larger solids are ground into smaller solids by the grinder so that they can pass through the screen. A semi-circular screen in combination with a grinder is a preferred embodiment of the system. The system includes a single or multiple drive means whereby the comminuting grinder is actuated and provided with the reciprocating motion along the surface of the screen.
摘要翻译：污水清洁和粉碎系统设有横向半圆形凹形过滤网，横过横流通道拦截所有固体太大而不能通过。组合的屏幕清洁和粉碎研磨机组件紧密地安装在屏幕前面。它具有用于沿着筛网的整个范围往复运动的凹面，以便清洁和去除由筛面拦截的大的固体，并随后粉碎这样大的固体。当它们再循环回到进入污水的流入中时，较大的固体被研磨机研磨成更小的固体，使得它们可以通过筛网。与研磨机组合的半圆形筛是系统的优选实施例。该系统包括单个或多个驱动装置，由此粉碎研磨机被致动并沿屏幕表面提供往复运动。

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