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1. 发明授权

US5807992A HIV-2 transmembrane glycoprotein homodimer (gp 80) 失效
标题翻译： HIV-2跨膜糖蛋白同源二聚体（gp 80）
公开(公告)号：US5807992A
公开(公告)日：1998-09-15
申请号：US466273
申请日：1995-06-06
申请人： Ara G. Hovanessian , Marie-Anne Rey , Anne G. Laurent , Bernard Krust , Luc Montagnier
发明人： Ara G. Hovanessian , Marie-Anne Rey , Anne G. Laurent , Bernard Krust , Luc Montagnier
IPC分类号： A61K39/00 , A61P31/18 , A61P37/04 , C07K14/155 , C07K14/16 , C07K16/10
CPC分类号： C07K14/005 , C07K16/1063 , A61K39/00 , C12N2740/15022 , C12N2740/16122 , C12N2740/16222 , Y10S435/974 , Y10S435/975 , Y10S530/826
摘要： Characterization of the envelope transmembrane protein of human immunodeficiency virus type 2 (HIV-2) was carried out using murine polyclonal and monoclonal antibodies or patient sera specific for HIV-2 proteins. A 80-Mr glycoprotein (gp80) was produced in HIV-2 infected cells along with three other glycoproteins that were recently reported: the extracellular glycoprotein (gp125), the envelope glycoprotein precursor (gp140), and the transient dimeric form of gp140 (gp300). The gp125 and gp80 were detectable after the synthesis of gp140 and the formation of gp300. Among these four glycoproteins, only gp80 and gp125 were associated with HIV-2 virions. As the other glycoproteins, gp8O was recognized by all HIV-2 positive sera. A murine polyclonal antibody raised against the purified gp300 recognized all four glycoproteins. On the other hand, a monoclonal antibody raised against a synthetic polypeptide deduced from the sequence of the transmembrane glycoprotein of HIV-2, recognized gp140, gp300 and gp80; thus indicating that gp80 should be related to the transmembrane protein of the envelope. Dimerization of envelope glycoprotein precursor and the transmembrane glycoprotein was also observed in cells infected with simian immunodeficiency virus (SIV), a virus closely related to HIV-2. Dimerization of the envelope precursors might be essential for the processing of these glycooroteins into the mature products, extracellular and transmembrane glycoproteins. Furthermore, the dimeric form of the transmembrane glycoproteins might be important for the optimal structure of the virus and thus for its infectivity.
摘要翻译：使用鼠多克隆和单克隆抗体或HIV-2蛋白特异性的患者血清进行人类免疫缺陷病毒2型（HIV-2）的包膜跨膜蛋白的表征。在HIV-2感染的细胞中产生80-Mr糖蛋白（gp80）以及最近报道的三种其他糖蛋白：细胞外糖蛋白（gp125），包膜糖蛋白前体（gp140）和gp140（gp140）的瞬时二聚体形式）。在gp140的合成和gp300的形成之后，gp125和gp80是可检测的。在这四种糖蛋白中，只有gp80和gp125与HIV-2病毒粒子相关。作为其他糖蛋白，gp8O被所有HIV-2阳性血清识别。针对纯化的gp300产生的鼠多克隆抗体识别所有四种糖蛋白。另一方面，从HIV-2的跨膜糖蛋白序列推断出的合成多肽产生的单克隆抗体，识别为gp140，gp300和gp80; 从而表明gp80应与信封的跨膜蛋白相关。在与HIV-2密切相关的猿猴免疫缺陷病毒（SIV）感染的细胞中也观察到包膜糖蛋白前体和跨膜糖蛋白的二聚体。包封前体的二聚化可能对于将这些糖宝蛋白加工成成熟产物，细胞外和跨膜糖蛋白是必需的。此外，跨膜糖蛋白的二聚形式对于病毒的最佳结构以及因此其感染性可能是重要的。

2. 发明授权

US06608179B1 Antibodies, that bind to HIV-2 transmembrane glycoprotein homodimer (gp 80) 失效
标题翻译：结合HIV-2跨膜糖蛋白同源二聚体的抗体（gp 80）
公开(公告)号：US06608179B1
公开(公告)日：2003-08-19
申请号：US09400909
申请日：1999-09-22
申请人： Ara G. Hovanessian , Marie-Anne Rey , Anne G. Laurent , Bernard Krust , Luc Montagnier
发明人： Ara G. Hovanessian , Marie-Anne Rey , Anne G. Laurent , Bernard Krust , Luc Montagnier
IPC分类号： C07K1600
CPC分类号： C07K14/005 , A61K39/00 , C07K16/1063 , C12N2740/15022 , C12N2740/16122 , C12N2740/16222 , Y10S435/974 , Y10S435/975 , Y10S530/826
摘要： Characterization of the envelope transmembrane protein of human immunodeficiency virus type 2 (HIV-2) was carried out using murine polyclonal and monoclonal antibodies or patient sera specific for HIV-2 proteins. A 80-Mr glycoprotein (gp80) was produced in HIV-2 infected cells along with three other glycoproteins that were recently reported: the extracellular glycoprotein (gp125), the envelope glycoprotein precursor (gp140), and the transient dimeric form of gp140 (gp300). The gp125 and gp80 were detectable after the synthesis of gp140 and the formation of gp300. Among these four glycoproteins, only gp80 and gp125 were associated with HIV-2 virions. As the other glycoproteins, gp80 was recognized by all HIV-2 positive sera. A murine polyclonal antibody raised against the purified gp300 recognized all four glycoproteins. On the other hand, a monoclonal antibody raised against a synthetic polypeptide deduced from the sequence of the transmembrane glycoprotein of HIV-2, recognized gp140, gp300 and gp80; thus indicating that gp80 should be related to the transmembrane protein of the envelope. Dimerization of envelope glycoprotein precursor and the transmembrane glycoprotein was also observed in cells infected with simian immunodeficiency virus (SIV), a virus closely related to HIV-2. Cimerization of the envelope precursors might be essential for the processing of these glycoproteins into the mature products, extracellular and transmembrane glycoproteins. Furthermore, the dimeric form of the transmembrane glycoproteins might be important for the optimal structure of the virus and thus for its infectivity.
摘要翻译：使用鼠多克隆和单克隆抗体或HIV-2蛋白特异性的患者血清进行人类免疫缺陷病毒2型（HIV-2）的包膜跨膜蛋白的表征。在HIV-2感染的细胞中产生80-Mr糖蛋白（gp80）以及最近报道的三种其他糖蛋白：细胞外糖蛋白（gp125），包膜糖蛋白前体（gp140）和gp140（gp140）的瞬时二聚体形式）。在gp140的合成和gp300的形成之后，gp125和gp80是可检测的。在这四种糖蛋白中，只有gp80和gp125与HIV-2病毒粒子相关。作为其他糖蛋白，gp80被所有HIV-2阳性血清识别。针对纯化的gp300产生的鼠多克隆抗体识别所有四种糖蛋白。另一方面，从HIV-2的跨膜糖蛋白序列推断出的合成多肽产生的单克隆抗体，识别为gp140，gp300和gp80; 从而表明gp80应与信封的跨膜蛋白相关。在与HIV-2密切相关的猿猴免疫缺陷病毒（SIV）感染的细胞中也观察到包膜糖蛋白前体和跨膜糖蛋白的二聚体。包膜前体的聚合可能对于将这些糖蛋白加工成成熟产物，细胞外和跨膜糖蛋白是必需的。此外，跨膜糖蛋白的二聚形式对于病毒的最佳结构以及因此其感染性可能是重要的。

3. 发明授权

US07507417B2 Immunogenic compositions comprising human immunodeficiency virus type 2 (HIV-2) glycosylated and unglycosylated envelope proteins and their methods of preparation 失效
标题翻译：包含人类免疫缺陷病毒2型（HIV-2）糖基化和非糖基化包膜蛋白的免疫原性组合物及其制备方法
公开(公告)号：US07507417B2
公开(公告)日：2009-03-24
申请号：US11235527
申请日：2005-09-27
申请人： Luc Montagnier , Anne G. Laurent-Crawford , Bernard Krust , Ara G. Hovanessian , Marie-Anne Rey-Cuillé
发明人： Luc Montagnier , Anne G. Laurent-Crawford , Bernard Krust , Ara G. Hovanessian , Marie-Anne Rey-Cuillé
IPC分类号： A61K39/21
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K39/21 , C07K16/1063 , C12N2740/15022 , C12N2740/16122 , C12N2740/16134 , C12N2740/16222
摘要： Four glycoproteins of apparent molecular weights 300,000, 140,000, 125,000, and 36,000 (gp300, gp140, gp125, and gp36) are detectable in human immunodeficiency virus type 2 (HIV-2) infected cells. The gp125 and gp36 are the external and transmembrane components, respectively, of the envelope glycoproteins of HIV-2 mature virions. The gp300, which is a dimeric form of gp140, the precursor of HIV-2 envelope glycoprotein, is probably formed by a pH dependent fusion in the endoplasmic reticulum. Such a doublet is also observed in cells infected with simian immunodeficiency virus (SIV), a virus closely related to HIV-2. On the other hand, the envelope glycoprotein precursor of HIV-1 does not form a dimer during its processing. Experiments carried out with various inhibitors of oligosaccharide trimming enzymes suggest that transient dimerization of the glycoprotein precursor is required for its efficient transport to the Golgi apparatus and for its processing. The gp300 is useful for detecting antibodies to HIV-2 antigens in human body fluids and for raising antibodies to gp300.
摘要翻译：在人类免疫缺陷病毒2型（HIV-2）感染细胞中可检测到四种表观分子量为30万，14万，125,000和36,000（gp300，gp140，gp125和gp36）的糖蛋白。 gp125和gp36分别是HIV-2成熟病毒粒子的包膜糖蛋白的外部和跨膜组分。作为HIV-2包膜糖蛋白前体的gp140的二聚体形式的gp300可能通过内质网中的pH依赖融合形成。在感染了与HIV-2密切相关的猿猴免疫缺陷病毒（SIV）的细胞中也观察到这样的双峰。另一方面，HIV-1的包膜糖蛋白前体在其加工过程中不形成二聚体。用各种寡糖修饰酶抑制剂进行的实验表明，糖蛋白前体的瞬时二聚需要其有效转运到高尔基体并进行加工。 gp300可用于检测人体液中HIV-2抗原的抗体和提高gp300的抗体。

4. 发明授权

US6056963A Immunogenic compositions comprising glycosylated and deglycosylated monomeric and dimeric forms of HIV-2 enveloped glycoproteins 失效
标题翻译：包含糖基化和去糖基化的单体和二聚体形式的HIV-2包膜糖蛋白的免疫原性组合物
公开(公告)号：US6056963A
公开(公告)日：2000-05-02
申请号：US477596
申请日：1995-06-07
申请人： Luc Montagnier , Anne G. Laurent-Crawford , Bernard Krust , Ara G. Hovanessian , Marie-Anne Rey Cuille
发明人： Luc Montagnier , Anne G. Laurent-Crawford , Bernard Krust , Ara G. Hovanessian , Marie-Anne Rey Cuille
IPC分类号： A61K39/00 , A61P31/18 , A61P37/04 , C07K14/155 , C07K14/16 , C07K16/10 , A61K39/21
CPC分类号： C07K14/005 , C07K16/1063 , A61K39/00 , C12N2740/15022 , C12N2740/16122 , C12N2740/16222
摘要： This invention is directed to a composition comprising one or more human immunodeficiency virus type 2 (HIV-2) envelope proteins and a pharmaceutically acceptable carrier. The proteins of the claimed invention are gp300, p200 and p90/80 of HIV-2. The composition is useful for the diagnostic assay of HIV-2 and as an antigen for the production of antibodies, for example.
摘要翻译：本发明涉及包含一种或多种人类免疫缺陷病毒2型（HIV-2）包膜蛋白和药学上可接受的载体的组合物。所要求保护的发明的蛋白质是HIV-2的gp300，p200和p90 / 80。例如，该组合物可用于HIV-2的诊断测定和用于产生抗体的抗原。

5. 发明授权

US06984721B2 Immunological reagents and diagnostic methods for the detection of human immunodeficiency virus type 2 utilizing multimeric forms of the envelope proteins GP300, P200, and P90/80 失效
标题翻译：使用多聚体形式的包膜蛋白GP300，P200和P90 / 80检测人类免疫缺陷病毒2型的免疫学试剂和诊断方法
公开(公告)号：US06984721B2
公开(公告)日：2006-01-10
申请号：US09739289
申请日：2000-12-19
申请人： Luc Montagnier , Anne G. Laurent-Crawford , Bernard Krust , Ara G. Hovanessian , Marie-Anne Rey-Cuillé
发明人： Luc Montagnier , Anne G. Laurent-Crawford , Bernard Krust , Ara G. Hovanessian , Marie-Anne Rey-Cuillé
IPC分类号： C07K16/00
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K39/21 , C07K16/1063 , C12N2740/15022 , C12N2740/16122 , C12N2740/16134 , C12N2740/16222
摘要： Immunological reagents obtained from multimeric forms of the HIV-2 and SIV envelope glycoproteins and their use in the detection of HIV-2, particularly, the HIV-2 proteins gp300, p200, p90, and p80, and gp300 of SIV.
摘要翻译：从HIV-2和SIV包膜糖蛋白的多聚体形式获得的免疫试剂及其在检测HIV-2，特别是SIV的HIV-2蛋白gp300，p200，p90和p80和gp300中的用途。

6. 发明授权

US06197496B1 Immunological reagents and diagnostic methods for the detection of human immunodeficiency virus type 2 utilizing multimeric forms of the envelope proteins gp300, p200, and p90/80 失效
标题翻译：使用包膜蛋白gp300，p200和p90 / 80的多聚体形式检测人类免疫缺陷病毒2型的免疫试剂和诊断方法
公开(公告)号：US06197496B1
公开(公告)日：2001-03-06
申请号：US08321566
申请日：1994-10-27
申请人： Luc Montagnier , Anne G. Laurent Crawford , Bernard Krust , Ara G. Hovanessian , Marie-Anne Rey Cuillé
发明人： Luc Montagnier , Anne G. Laurent Crawford , Bernard Krust , Ara G. Hovanessian , Marie-Anne Rey Cuillé
IPC分类号： C12Q170
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K39/21 , C07K16/1063 , C12N2740/15022 , C12N2740/16122 , C12N2740/16134 , C12N2740/16222
摘要： Immunological reagents obtained from multimeric forms of the HIV-2 and SIV envelope glycoproteins and their use in the detection of HIV-2 are disclosed. Particularly, the HIV-2 proteins, gp300, p200, p90, and p80, and gp300 of SIV are described.
摘要翻译：公开了从HIV-2和SIV包膜糖蛋白的多聚体形式获得的免疫试剂及其在HIV-2检测中的应用。特别地，描述了SIV的HIV-2蛋白，gp300，p200，p90和p80和gp300。

7. 发明授权

US06261571B1 Immunogenic compositions comprising dimeric forms of the human immunodeficiency virus type 2 (HIV-2) and simian immunodeficiency virus (SIV) envelope glycoproteins 失效
标题翻译：包含人类免疫缺陷病毒2型（HIV-2）和猿猴免疫缺陷病毒（SIV）包膜糖蛋白的二聚体形式的免疫原性组合物
公开(公告)号：US06261571B1
公开(公告)日：2001-07-17
申请号：US08364829
申请日：1994-12-27
申请人： Ara G. Hovanessian , Marie-Anne Rey , Anne G. Laurent , Bernard Krust , Luc Montagnier
发明人： Ara G. Hovanessian , Marie-Anne Rey , Anne G. Laurent , Bernard Krust , Luc Montagnier
IPC分类号： A61K3921
CPC分类号： C07K14/005 , A61K39/00 , C07K16/1063 , C12N2740/15022 , C12N2740/16122 , C12N2740/16222 , Y10S435/974 , Y10S435/975 , Y10S530/826
摘要： The invention relates to an isolated immune complex comprising a protein and an antibody that binds with said protein, wherein the protein is selected from the group consisting of gp80 of HIV-2 and gp65 of SIV, wherein said gp80 is a glycoprotein having an apparent molecular weight of 80 kDa, as determined by SDS-PAGE, and further wherein said gp65 is a glycoprotein having an apparent molecular weight of 65 kDa as determined by SDS-PAGE. Also provided are an immunogenic composition comprising an amount of gp80 protein of human immunodeficiency virus type 2 (HIV-2) sufficient to induce an immune response and a pharmaceutically acceptible carrier, and a composition comprising at least one antigen selected from the group consisting of gp80 protein of HIV-2 and gp65SIV.
摘要翻译：本发明涉及包含与所述蛋白质结合的蛋白质和抗体的分离的免疫复合物，其中所述蛋白质选自HIV-2的gp80和SIV的gp65，其中所述gp80是具有表观分子通过SDS-PAGE测定，其重量为80kDa，进一步其中所述gp65是通过SDS-PAGE测定的表观分子量为65kDa的糖蛋白。还提供了包含一定量的足以诱导免疫应答的人类免疫缺陷病毒2型（HIV-2）的gp80蛋白和药学上可接受的载体的免疫原性组合物，以及包含至少一种选自gp80的抗原的组合物 HIV-2和gp65SIV的蛋白质。

8. 发明授权

US5470702A HIV-2 transmembrane glycoprotein homodimer (gp 80) 失效
标题翻译： HIV-2跨膜糖蛋白同源二聚体（gp 80）
公开(公告)号：US5470702A
公开(公告)日：1995-11-28
申请号：US2756
申请日：1993-01-13
申请人： Ara G. Hovanessian , Marie-Anne Rey , Anne G. Laurent , Bernard Krust , Luc Montagnier
发明人： Ara G. Hovanessian , Marie-Anne Rey , Anne G. Laurent , Bernard Krust , Luc Montagnier
IPC分类号： A61K39/00 , A61P31/18 , A61P37/04 , C07K14/155 , C07K14/16 , C07K16/10 , C12Q1/70
CPC分类号： C07K14/005 , C07K16/1063 , A61K39/00 , C12N2740/15022 , C12N2740/16122 , C12N2740/16222 , Y10S435/974 , Y10S435/975 , Y10S530/826
摘要： Character of the envelope transmembrane protein of human immunodeficiency virus type 2 (HIV-2) was carried out using murine polyclonal and monoclonal antibodies or patient sera specific for HIV-2 proteins. A 80-Mr glycoprotein (gp80) was produced in HIV-2 infected cells along with three other glycoproteins that were recently reported: the extracellular glycoprotein (gp125), the envelope glycoprotein precursor (gp140), and the transient dimeric form of gp140 (gp300). The gp125 and gp80 were detectable after the synthesis of gp140 and the formation of gp300. Among these four glycoproteins, only gp80 and gp125 were associated with HIV-2 virions. As the other glycoproteins, gp80 was recognized by all HIV-2 positive sera. A murine polyclonal antibody raised against the purified gp300 recognized all four glycoproteins. On the other hand, a monoclonal antibody raised against a synthetic polypeptide deduced from the sequence of the transmembrane glycoprotein of HIV-2, recognized gp140, gp300 and gp80; thus indicating that gp80 should be related to the transmembrane protein of the envelope. Dimerization of envelope glycoprotein precursor and the transmebrane glycoprotein was also observed in cells infected with simian immunodeficiency virus (SIV), a virus closely related to HIV-2. Dimerization of the envelope precursors might be essential for the processing of these glycoproteins into the mature products, extracellular and transmembrane glycoproteins. Furthermore, the dimeric form of the transmembrane glycoproteins might be important for the optimal structure of the virus and thus for its infectivity.
摘要翻译：使用鼠多克隆和单克隆抗体或特异于HIV-2蛋白的患者血清进行人类免疫缺陷病毒2型（HIV-2）的包膜跨膜蛋白的特征。在HIV-2感染的细胞中产生80-Mr糖蛋白（gp80）以及最近报道的三种其他糖蛋白：细胞外糖蛋白（gp125），包膜糖蛋白前体（gp140）和gp140（gp140）的瞬时二聚体形式）。在gp140的合成和gp300的形成之后，gp125和gp80是可检测的。在这四种糖蛋白中，只有gp80和gp125与HIV-2病毒粒子相关。作为其他糖蛋白，gp80被所有HIV-2阳性血清识别。针对纯化的gp300产生的鼠多克隆抗体识别所有四种糖蛋白。另一方面，从HIV-2的跨膜糖蛋白序列推断出的合成多肽产生的单克隆抗体，识别为gp140，gp300和gp80; 从而表明gp80应与信封的跨膜蛋白相关。在与HIV-2密切相关的猿猴免疫缺陷病毒（SIV）感染的细胞中也观察到包膜糖蛋白前体和跨膜糖蛋白的二聚体。包膜前体的二聚化对于将这些糖蛋白加工成成熟产物，细胞外和跨膜糖蛋白可能是必需的。此外，跨膜糖蛋白的二聚形式对于病毒的最佳结构以及因此其感染性可能是重要的。

9. 发明授权

US5208321A HIV-2 transmembrane glycoprotein homodimer (GP 80) 失效
标题翻译： HIV-2跨膜糖蛋白同源二聚体（GP 80）
公开(公告)号：US5208321A
公开(公告)日：1993-05-04
申请号：US356459
申请日：1989-05-25
申请人： Ara G. Hovanessian , Marie-Anne Rey , Anne G. Laurent , Bernard Krust , Luc Montagnier
发明人： Ara G. Hovanessian , Marie-Anne Rey , Anne G. Laurent , Bernard Krust , Luc Montagnier
IPC分类号： A61K39/00 , A61P31/18 , A61P37/04 , C07K14/155 , C07K14/16 , C07K16/10
CPC分类号： C07K14/005 , C07K16/1063 , A61K39/00 , C12N2740/15022 , C12N2740/16122 , C12N2740/16222 , Y10S435/974 , Y10S435/975 , Y10S530/826
摘要： Characterization of the envelope transmembrane protein of human immunodeficiency virus type 2 (HIV-2) was carried out using murine polyclonal and monoclonal antibodies or patient sera specific for HIV-2 proteins. A 80-Mr glycoprotein (gp80) was produced in HIV-2 infected cells along with three other glycoproteins that were recently reported: the extracellular glycoprotein (gp125), the envelope glycoprotein precursor (gp140), and the transient dimeric form of gp140 (gp300). The gp125 and gp80 were detectable after the synthesis of gp140 and the formation of gp300. Among these four glycoproteins, only gp80 and gp125 were associated with HIV-2 virions. As the other glycoproteins, gp80 was recognized by all HIV-2 positive sera. A murine polyclonal antibody raised against the purified gp300 recognized all four glycoproteins. On the other hand, a monoclonal antibody raised against a synthetic polypeptide deduced from the sequence of the transmembrane glycoprotein of HIV-2, recognized gp140, gp300 and gp80; thus indicating that gp80 should be related to the transmembrane protein of the envelope. Dimerization of envelope glycoprotein precursor and the transmembrane glycoprotein was also observed in cells infected with simian immunodeficiency virus (SIV), a virus closely related to HIV-2. Dimerization of the envelope precursors might be essential for the processing of these glycoproteins into the mature products, extracellular and transmembrane glycoproteins. Furthermore, the dimeric form of the transmembrane glycoproteins might be important for the optimal structure of the virus and thus for its infectivity.
摘要翻译：使用鼠多克隆和单克隆抗体或HIV-2蛋白特异性的患者血清进行人类免疫缺陷病毒2型（HIV-2）的包膜跨膜蛋白的表征。在HIV-2感染的细胞中产生80-Mr糖蛋白（gp80）以及最近报道的三种其他糖蛋白：细胞外糖蛋白（gp125），包膜糖蛋白前体（gp140）和gp140（gp140）的瞬时二聚体形式）。在gp140的合成和gp300的形成之后，gp125和gp80是可检测的。在这四种糖蛋白中，只有gp80和gp125与HIV-2病毒粒子相关。作为其他糖蛋白，gp80被所有HIV-2阳性血清识别。针对纯化的gp300产生的鼠多克隆抗体识别所有四种糖蛋白。另一方面，从HIV-2的跨膜糖蛋白序列推断出的合成多肽产生的单克隆抗体，识别为gp140，gp300和gp80; 从而表明gp80应与信封的跨膜蛋白相关。在与HIV-2密切相关的猿猴免疫缺陷病毒（SIV）感染的细胞中也观察到包膜糖蛋白前体和跨膜糖蛋白的二聚体。包膜前体的二聚化对于将这些糖蛋白加工成成熟产物，细胞外和跨膜糖蛋白可能是必需的。此外，跨膜糖蛋白的二聚形式对于病毒的最佳结构以及因此其感染性可能是重要的。

10. 发明授权

US4210746A Nucleotide inhibitor of protein synthesis 失效
标题翻译：蛋白质合成的核苷酸抑制剂
公开(公告)号：US4210746A
公开(公告)日：1980-07-01
申请号：US932488
申请日：1978-08-10
申请人： Ian M. Kerr , Ronald E. Brown , Ara G. Hovanessian
发明人： Ian M. Kerr , Ronald E. Brown , Ara G. Hovanessian
IPC分类号： C07H21/00 , C12P19/34 , C07H17/00 , C07H15/12
CPC分类号： C07H21/00 , C12P19/34
摘要： Compounds having properties as inhibitors of protein synthesis are disclosed, of the general formula(p).sub.m --(5'--A--2'--p).sub.n --(A).sub.xwhereinp represents the phosphate group (orthophosphate),m is 0, 2, or 3A represents adenosine,n is from 2 to 5,x is 0 or 1,said compound containing at least three adenosine residues, the figures 5' and 2' signifying the carbon atoms of the ribose ring to which the respective phosphate groups p are attached.Compounds of particular interest are ApApA and its phosphorylated derivatives ppApApA and pppApApA. The substances may be prepared by chemical synthesis or enzymatic synthesis. They may be incorporated in liposomes.
摘要翻译：公开了具有蛋白质合成抑制剂性质的化合物，通式（p）m-（5'-A-2'-p）n-（A）x其中p表示磷酸基（正磷酸），m为0 ，2或3 A表示腺苷，n为2至5，x为0或1，所述化合物含有至少三个腺苷残基，图5'和2'表示核糖环的碳原子，磷酸基p连接。特别感兴趣的化合物是ApApA及其磷酸化衍生物ppApApA和pppApApA。物质可以通过化学合成或酶促合成来制备。它们可以并入脂质体中。

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