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1. 发明专利

JP2015057478A 芳香族置換キサンテン色素审中-公开
标题翻译：芳香取代的XANTHENE DYE
公开(公告)号：JP2015057478A
公开(公告)日：2015-03-26
申请号：JP2014203629
申请日：2014-10-02
申请人：アプライドバイオシステムズリミテッドライアビリティーカンパニー , Applied Biosystems Llc , アプライドバイオシステムズリミテッドライアビリティーカンパニー
发明人： BENSON SCOTT CONRAD , MENCHEN STEVEN MICHAEL , THEISEN PETER DAVID , UPADHYA KRISHNA GAJANAN , HAUSER JOAN DALE
IPC分类号： C09B11/28 , G01N21/64 , C07D311/82 , C07D407/14 , C07D493/04 , C07D493/14 , C07H19/04 , C07H19/06 , C07H19/10 , C07H19/14 , C07H19/16 , C07H19/20 , C07H21/00 , C09B11/08 , C09K11/06 , C12N15/09 , C12Q1/68 , G01N21/78 , G01N33/533 , G01N33/58
CPC分类号： C07H21/00 , C07H19/04 , C09B11/08
摘要：【課題】混合物中の複数の空間的に重複した分析物の独立した検出、例えば、単一管の多重DNAプローブアッセイ、イムノアッセイ、多色DNA配列決定法などに使用する有用な化合物の提供。【解決手段】下式で表される芳香族置換キサンテン化合物。(Y1及びY2は、各々独立に、ヒドロキシル、酸素、イミニウム、連結基或いはアミン;又はY1はR2と一緒になって、環状イミン或いはY2はR3と一緒になって、環状アミン;R2、R3、R5およびR7は、各々独立に、H、F、Cl、低級アルキル、低級アルケン、低級アルキン、スルホネート、スルホン、アミノ、イミニウム、アミド、ニトリル、低級アルコキシ、フェニル又は連結基;R1は単環又は多環式芳香族等;R4はH,F、アルキル、アミノ等;R6はアセチレン、低級アルキル等)【選択図】なし
摘要翻译：要解决的问题：提供用于混合物中多重空间重叠分析物的独立检测的有用化合物，例如单管多重DNA探针测定，免疫测定，多色DNA测序方法等。解决方案：提供了一种芳香取代的呫吨染料由下式表示。（Yand Yeach独立地表示羟基，氧，亚胺，连接基团或胺; Y与环烷基一起形成环状胺和R; R，R，R，Rand Reach独立地表示H，F，Cl，低级烷基低级烯烃，磺酸盐，砜，亚胺，酰胺，腈，低级烷氧基，苯基或连接基团; R表示单环或多环芳族等; R表示H，F，烷基，氨基等; R代表乙炔，低级烷基等）

2. 发明专利

JP2011168787A Aromatic-substituted xanthene dye 审中-公开
标题翻译：芳香取代的XANTHENE DYE
公开(公告)号：JP2011168787A
公开(公告)日：2011-09-01
申请号：JP2011063420
申请日：2011-03-22
申请人： Applied Biosystems Llc , アプライドバイオシステムズリミテッドライアビリティーカンパニー
发明人： BENSON SCOTT CONRAD , MENCHEN STEVEN MICHAEL , THEISEN PETER DAVID , UPADHYA KRISHNA GAJANAN , HAUSER JOAN DALE
IPC分类号： C09B67/20 , G01N21/64 , C07D311/82 , C07D407/14 , C07D493/04 , C07D493/14 , C07H19/04 , C07H19/06 , C07H19/10 , C07H19/14 , C07H19/16 , C07H19/20 , C07H21/00 , C09B11/08 , C09B11/28 , C09B67/42 , C09K11/06 , C12N15/09 , C12Q1/68 , G01N21/78 , G01N27/447 , G01N33/533 , G01N33/58
CPC分类号： C07H21/00 , C07H19/04 , C09B11/08
摘要： PROBLEM TO BE SOLVED: To provide the independent detection of multiple spatially overlapping analytes in a mixture, e.g., single-tube multiplex DNA probe assays, immunoassays, multicolor DNA sequencing methods, and the like, as required in many important applications. SOLUTION: A class of aromatic-substituted xanthene compounds useful as fluorescent dyes is disclosed, the compounds having the general structure (I) where Y 1 and Y 2 taken separately are selected from the group consisting of hydroxyl, oxygen, iminium, linking group, and amine, or Y 1 taken together with R 2 is cyclic imine, or Y 2 taken together with R 3 is cyclic amine; R 2 , R 3 , R 5 , and R 7 are independently selected from the group consisting of hydrogen, fluorine, chlorine, lower alkyl, lower alkene, lower alkyne, sulfonate, sulfone, amino, iminium, amido, nitrile, lower alkoxy, phenyl, and linking group. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：待解决的问题：根据许多重要应用的要求，提供混合物中多重空间重叠分析物的独立检测，例如单管多重DNA探针测定，免疫测定，多色DNA测序方法等。解决方案：公开了一类用作荧光染料的芳香族取代的呫吨化合物，其中具有Y 1 和Y 2 的一般结构（I）的化合物分别选自羟基，氧，亚胺，连接基和胺，或与R SB一起使用的Y SB 1是环状亚胺，或Y 2 与R SB 3一起是环胺; R SB 2，R SB 3，R SB 5，R SB 7，R 7独立地选自氢，氟，氯，低级烷基，低级烯，低级炔，磺酸，砜，氨基，亚氨基，酰胺基，腈，低级烷氧基，苯基和连接基。版权所有（C）2011，JPO＆INPIT

3. 发明专利

JP2011178999A Aromatic-substituted xanthene dye 审中-公开
标题翻译：芳香取代的XANTHENE DYE
公开(公告)号：JP2011178999A
公开(公告)日：2011-09-15
申请号：JP2011063421
申请日：2011-03-22
申请人： Applied Biosystems Llc , アプライドバイオシステムズリミテッドライアビリティーカンパニー
发明人： BENSON SCOTT CONRAD , MENCHEN STEVEN MICHAEL , THEISEN PETER DAVID , UPADHYA KRISHNA GAJANAN , HAUSER JOAN DALE
IPC分类号： C09B11/28 , G01N21/64 , C07D311/82 , C07D407/14 , C07D493/04 , C07D493/14 , C07H19/04 , C07H19/06 , C07H19/10 , C07H19/14 , C07H19/16 , C07H19/20 , C07H21/00 , C09B11/08 , C09K11/06 , C12N15/09 , C12Q1/68 , G01N21/78 , G01N33/533 , G01N33/58
CPC分类号： C07H21/00 , C07H19/04 , C09B11/08
摘要： PROBLEM TO BE SOLVED: To provide novel aromatic-substituted xanthene dyes useful as fluorescent labeling reagents, and to provide independent detection of multiple spatially overlapping analytes in a mixture using the dyes, such as single-tube multiplex DNA probe assays, immunoassays, multicolor DNA sequencing methods, and the like.
SOLUTION: There are provided classes of aromatic-substituted xanthene compounds useful as fluorescent dyes. The compounds have general formula (I), wherein Y
1 and Y
2 taken separately are selected from the group consisting of hydroxyl, oxygen, imminium, linking group and amine, or Y
1 taken together with R
2 is cyclic imine, or Y
2 taken together with R
3 is cyclic amine; R
2 , R
3 , R
5 , and R
7 taken separately are selected from the group consisting of hydrogen, fluorine, chlorine, lower alkyl, lower alkene, lower alkyne, sulfonate, sulfone, amino, imminium, amido, nitrile, lower alkoxy, phenyl, and linking group.
COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供用作荧光标记试剂的新型芳族取代的呫吨染料，并使用染料提供混合物中多种空间重叠的分析物的独立检测，例如单管多重DNA探针测定法，免疫测定法，多色DNA测序方法等。
解决方案：提供了用作荧光染料的芳香族取代的呫吨化合物。化合物具有通式（I），其中分别取代的Y 1 和Y 2 选自羟基，氧，氨，连接基和胺，或与R SB 2一起使用的Y 1 是环状亚胺，或与R SB 3一起使用的Y SB 2是环状胺 ; R SB 2，R SB 3，R SB 3，R SB 7，和R SB 7，分别选自氢，氟，氯，低级烷基，低级烯，低级炔，磺酸酯，砜，氨基，咪唑，酰氨基，腈，低级烷氧基，苯基和连接基。版权所有（C）2011，JPO＆INPIT

4. 发明专利

JP2010159420A Dibenzorhodamine dye useful as fluorescent labeling reagent 有权
标题翻译：二苯甲酮染料可用作荧光标签试剂
公开(公告)号：JP2010159420A
公开(公告)日：2010-07-22
申请号：JP2010025761
申请日：2010-02-08
申请人： Applied Biosystems Llc , アプライドバイオシステムズ, エルエルシー
发明人： BENSON SCOTT C , LAM JOE Y L , UPADHYA KRISHNA GAJANAN , RADEL PEGGY ANN , ZHEN WEIGUO , MENCHEN STEVEN MICHAEL
IPC分类号： C09B11/28 , G01N21/78 , C07C215/86 , C07D209/60 , C07D221/10 , C07D311/78 , C07D311/92 , C07D491/14 , C07D491/147 , C07H19/06 , C07H19/10 , C07H19/14 , C07H19/16 , C07H19/20 , C07H21/00 , C07H21/04 , C09B11/02 , C09B11/24 , C09K11/06 , C12N15/09 , C12Q1/68
CPC分类号： C09B11/24 , C07D209/60 , C07D221/10 , C07D311/78 , C07D491/14 , C07D491/147 , C07H19/10 , C07H19/20 , C07H21/00 , C07H21/04 , C09B11/02 , C12Q1/6869 , Y10T436/143333 , C12Q2563/107 , C12Q2527/125
摘要： PROBLEM TO BE SOLVED: To provide dye compounds suitable for the creation of sets of spectrally-resolvable fluorescent labels useful for multi-color fluorescent detection. SOLUTION: The invention relates to the use of dibenzorhodamine compounds represented in the structural formula (1), (including nitrogen- and aryl-substituted forms thereof). The subject dye compounds are particularly well suited for use in automated 4-color DNA sequencing systems using an excitation light source having a wavelength greater than about 630 nm, (e.g., a helium-neon gas laser or a solid state diode laser). COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供适合于创建可用于多色荧光检测的光谱可分辨荧光标记的组的染料化合物。解决方案：本发明涉及结构式（1）所示的二苯并佛胺化合物（包括其氮和芳基取代形式）的用途。主题染料化合物特别适用于使用波长大于约630nm的激发光源（例如氦氖气体激光器或固态二极管激光器）的自动化4色DNA测序系统。版权所有（C）2010，JPO＆INPIT

5. 发明专利

AU9493598A Aromatic-substituted xanthene dyes 未知
公开(公告)号：AU9493598A
公开(公告)日：1999-04-23
申请号：AU9493598
申请日：1998-09-18
申请人： APPLIED BIOSYSTEMS LLC
发明人： BENSON SCOTT CONRAD , MENCHEN STEVEN MICHAEL , THEISEN PETER DAVID , UPADHYA KRISHNA GAJANAN , HAUSER JOAN DALE
IPC分类号： G01N21/64 , C07D311/82 , C07D407/14 , C07D493/04 , C07D493/14 , C07H19/04 , C07H19/06 , C07H19/10 , C07H19/14 , C07H19/16 , C07H19/20 , C07H21/00 , C09B11/08 , C09B11/28 , C09K11/06 , C12N15/09 , C12Q1/68 , G01N21/78 , G01N33/533 , G01N33/58 , C09B11/24
摘要： A class of aromatic-substituted xanthene compounds useful as fluorescent dyes is disclosed, the compounds having general structure (I), where Y1 and Y2 taken separately are selected from the group consisting of hydroxyl, oxygen, imminium, linking group and amine, or Y1 taken together with R2 is cyclic imine, or Y2 taken together with R3 is cyclic amine; R2, R3, R5, and R7 taken separately are selected from the group consisting of hydrogen, fluorine, chlorine, lower alkyl, lower alkene, lower alkyne, sulfonate, sulfone, amino, imminium, amido, nitrile, lower alkoxy, phenyl, and linking group; R1 taken separately is selected from the group consisting of phenyl, substituted phenyl, polycyclic aromatic, substituted polycyclic aromatic, linking-group and electron-rich heterocycle, or when taken together with R7 is selected from the group consisting of electron-rich heterocycle and indene; R4 taken separately is selected from the group consisting of amino, amido, phenyl, substituted phenyl, polycyclic aromatic, substituted polycyclic aromatic, indene, linking group and electron-rich heterocycle, or when taken together with R5 is selected from the group consisting of phenyl, substituted phenyl, polycyclic aromatic, substituted polycyclic aromatic, indene, and electron rich heterocycle; and R6 is selected from the group consisting of acetylene, lower alkyl, lower alkene, cyano, phenyl, substituted phenyl, and heterocyclic aromatic. In another aspect, the invention includes methods for synthesizing the above dye compounds and intermediates. In yet another aspect, the present invention includes reagents labelled with the asymmetric benzoxanthene dye compounds, including deoxynucleotides, dideoxynucleotides, phosphoramidites, and polynucleotides. In an additional aspect, the invention includes methods utilising such dye compounds and reagents including dideoxy polynucleotide sequencing and fragment analysis methods.

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