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1. 发明申请

US20140322327A1 DRUG DELIVERY SYSTEM FOR SUSTAINED DELIVERY OF BIOACTIVE AGENTS 审中-公开
标题翻译：用于持续输送生物剂的药物输送系统
公开(公告)号：US20140322327A1
公开(公告)日：2014-10-30
申请号：US14358141
申请日：2012-11-15
申请人： Antti Laukkanen , Ruzica Kolakovic , Leena Peltonen , Timo Laaksonen , Jouni Hirvonen , Heikki Lyytikainen , Harri Jukarainen , Prijo Kortesuo
发明人： Antti Laukkanen , Ruzica Kolakovic , Leena Peltonen , Timo Laaksonen , Jouni Hirvonen , Heikki Lyytikainen , Harri Jukarainen , Prijo Kortesuo
IPC分类号： A61K47/38 , A61K31/496 , A61K31/216 , A61K31/137 , A61K31/277 , A61K31/405 , A61K31/573
CPC分类号： A61K47/38 , A61K9/0019 , A61K9/0034 , A61K9/1652 , A61K9/5042 , A61K9/70 , A61K31/137 , A61K31/216 , A61K31/277 , A61K31/405 , A61K31/496 , A61K31/573
摘要： A drug delivery system for sustained delivery of bioactive agents, the system includes a matrix including nanofibrillated cellulose derived from plant based material and at least one bioactive agent, and at least one support selected from synthetic polymers, bio compounds and natural polymers. Also, methods for the manufacture of the system and methods of using it.
摘要翻译：一种用于持续递送生物活性剂的药物递送系统，该系统包括基质，其包含衍生自植物基材料的纳米纤维化纤维和至少一种生物活性剂，以及至少一种选自合成聚合物，生物化合物和天然聚合物的载体。而且，制造系统的方法和使用它的方法。

9. 发明申请

US20130131027A1 PARENTERAL PHARMACEUTICAL FORM WHICH RELEASES AROMATSE INHIBITOR AND GESTAGENS, FOR THE TREATMENT OF ENDOMETRIOSIS 审中-公开
公开(公告)号：US20130131027A1
公开(公告)日：2013-05-23
申请号：US13638243
申请日：2011-03-28
申请人： Arto Pakkalin , Rudolf Knauthe , Heinz Schmitz , Christine Talling , Harri Jukarainen , Henriikka Korolainen
发明人： Arto Pakkalin , Rudolf Knauthe , Heinz Schmitz , Christine Talling , Harri Jukarainen , Henriikka Korolainen
IPC分类号： A61K9/00 , A61K31/4196 , A61K31/56
CPC分类号： A61K31/567 , A61K9/0002 , A61K9/0036 , A61K31/00 , A61K31/4196 , A61K31/56 , A61K31/569 , A61K45/06 , A61K2300/00
摘要： The present invention for the treatment of endometriosis relates to providing a parenteral dosage form (delivery system) for the controlled release of an aromatase inhibitor (AI) in a daily release rate that does not induce stimulation of the ovaries by negative feed-back of the pituitary-ovarian-axis (which would cause secretion of gonadotropins and stimulation of ovarian follicular growth) and a gestagen in a daily release rate below the ovulation inhibition dose that provides contraceptive efficacy based on local effects (e.g. reducing and thickening of the cervical mucus impairing sperm ascension, effects on the endometrium and on tubal motility impairing implantation and egg transport).

10. 发明授权

US07294345B2 Otorhinological delivery device 有权
标题翻译：耳道输送装置
公开(公告)号：US07294345B2
公开(公告)日：2007-11-13
申请号：US10542420
申请日：2004-01-14
申请人： Timo Haapakumpu , Harri Jukarainen , Juha Ala-Sorvari , Henry Rankonen , Frederik E. Riphagen , Wolfgang Arnold
发明人： Timo Haapakumpu , Harri Jukarainen , Juha Ala-Sorvari , Henry Rankonen , Frederik E. Riphagen , Wolfgang Arnold
IPC分类号： A61F11/00
CPC分类号： A61K9/0046 , A61K9/0043 , A61L31/06 , A61L31/16 , Y10S514/953 , C08L83/04
摘要： The invention relates to an otorhinological delivery device comprising at least one pharmaceutically active agent. According to the invention the device comprises a core comprising said at least one pharmaceutically active agent wherein said core is made of an elastomer composition selected from the group consisting of poly(dimethylsiloxane), a siloxane-based elastomer comprising 3,3,3-trifluoropropyl groups attached to the Siatoms of the siloxane units, a siloxane-based elastomer comprising poly(alkylene oxide) groups and mixtures thereof, and a membrane encasing said core, said membrane being made of a same or a different elastomer composition than said core, said elastomer composition being selected from the group consisting of poly(dimethylsiloxane), a siloxane-based elastomer comprising 3,3,3-trifluoropropyl groups attached to the Siatoms of the siloxane units, a siloxane-based elastomer comprising poly(alkylene oxide) groups and mixtures thereof. The invention is characterized in that the pharmaceutically active agent is selected from the group comprising anti-allergic agents, anti-inflammatory agents, anti-fungicides, glucocorticoids and mixtures thereof.
摘要翻译：本发明涉及包含至少一种药物活性剂的运输装置。根据本发明，该装置包括一种包含所述至少一种药物活性剂的核心，其中所述核心由弹性体组合物制成，所述弹性体组合物选自聚（二甲基硅氧烷），包含3,3,3-三氟丙基连接到硅氧烷单元的硅原子的基团，包含聚（环氧烷）基团的硅氧烷基弹性体及其混合物，以及包围所述芯的膜，所述膜由与所述芯相同或不同的弹性体组合物制成，所述弹性体组合物选自聚（二甲基硅氧烷），包含连接到硅氧烷单元的硅原子上的3,3,3-三氟丙基的硅氧烷基弹性体，包含聚（氧化烯）基团的硅氧烷基弹性体和其混合物。本发明的特征在于药物活性剂选自抗过敏剂，抗炎剂，抗真菌剂，糖皮质激素及其混合物。

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