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1. 发明授权

US09403901B2 Anti-pseudomonas Psl binding molecules and uses thereof 有权
标题翻译：抗假单胞菌Ps1结合分子及其用途
公开(公告)号：US09403901B2
公开(公告)日：2016-08-02
申请号：US14125073
申请日：2012-06-08
申请人： Antonio Digiandomenico , Paul G. Warrener , Charles K. Stover , Brett Sellman , Sandrine Guillard , Ralph Minter , Steven Rust , Mladen Tomich
发明人： Antonio Digiandomenico , Paul G. Warrener , Charles K. Stover , Brett Sellman , Sandrine Guillard , Ralph Minter , Steven Rust , Mladen Tomich
IPC分类号： A61K39/40 , A61K39/395 , C12P21/08 , C07K16/00 , C07K16/12 , A61K47/48 , A61K38/00 , A61K39/00 , C07K16/18
CPC分类号： C07K16/1214 , A61K38/00 , A61K47/6811 , A61K47/6835 , A61K2039/505 , C07K2317/21 , C07K2317/622 , C07K2317/64 , C07K2317/71 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： The disclosure relates to an anti-Pseudomonas PSL binding molecule and uses thereof, in particular, in prevention and treatment of Pseudomonas infection. Furthermore, the disclosure provides compositions and methods for preventing and treating Pseudomonas infection.
摘要翻译：本公开涉及抗假单胞菌属PSL结合分子及其用途，特别是预防和治疗假单胞菌属感染。此外，本公开提供了预防和治疗假单胞菌属感染的组合物和方法。

2. 发明申请

US20140227285A1 ANTI-PSEUDOMONAS PSL BINDING MOLECULES AND USES THEREOF 有权
标题翻译：抗PSEUDOMONAS PSL结合分子及其用途
公开(公告)号：US20140227285A1
公开(公告)日：2014-08-14
申请号：US14125073
申请日：2012-06-08
申请人： Antonio Digiandomenico , Paul G. Warrener , Charles K. Stover , Brett Sellman , Sandrine Gullard , Ralph Minter , Steven Rust , Mladen Tomich
发明人： Antonio Digiandomenico , Paul G. Warrener , Charles K. Stover , Brett Sellman , Sandrine Gullard , Ralph Minter , Steven Rust , Mladen Tomich
IPC分类号： C07K16/12
CPC分类号： C07K16/1214 , A61K38/00 , A61K47/6811 , A61K47/6835 , A61K2039/505 , C07K2317/21 , C07K2317/622 , C07K2317/64 , C07K2317/71 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： The disclosure relates to an anti-Pseudomonas PSL binding molecule and uses thereof, in particular, in prevention and treatment of Pseudomonas infection. Furthermore, the disclosure provides compositions and methods for preventing and treating Pseudomonas infection.
摘要翻译：本公开涉及抗假单胞菌属PSL结合分子及其用途，特别是预防和治疗假单胞菌属感染。此外，本公开提供了预防和治疗假单胞菌属感染的组合物和方法。

3. 发明申请

US20110190199A1 Combination Therapy for Tuberculosis 审中-公开
标题翻译：结核病联合治疗
公开(公告)号：US20110190199A1
公开(公告)日：2011-08-04
申请号：US13061233
申请日：2009-08-31
申请人： Steven J. Brickner , Eric Nuermberger , Charles K. Stover
发明人： Steven J. Brickner , Eric Nuermberger , Charles K. Stover
IPC分类号： A61K31/541 , A61K31/7036 , A61K31/606 , A61K38/12 , A61P31/06
摘要： The present invention relates to methods of treating tuberculosis, including multi-drug resistant varieties and latent tuberculosis. More particularly, the present invention relates to a method of treating tuberculosis in a mammal comprising administering to said mammal in need thereof an effective amount of a compound of formula (I), (S)—N-[[3-[3-fluoro-4-(4-thiomorpholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]acetamide, or a pharmaceutically acceptable salt thereof in combination with at least two agents useful in the treatment of tuberculosis. The present invention also relates to a pharmaceutical composition comprising a therapeutically effective amount of a compound of formula (I) or a pharmaceutically acceptable salt or solvate thereof, (ii) a therapeutically effective amount of at least one agent useful in the treatment of tuberculosis and (iii) one or more pharmaceutically acceptable carriers or vehicles.
摘要翻译：本发明涉及治疗结核病的方法，包括多药耐药品种和潜伏性结核病。更具体地说，本发明涉及一种治疗哺乳动物结核病的方法，其包括向有需要的哺乳动物施用有效量的式（I），（S）-N - [[3- [3-氟 -4-（4-硫代吗啉基）苯基] -2-氧代-5-恶唑烷基]甲基]乙酰胺或其药学上可接受的盐与至少两种可用于治疗结核病的药物组合。本发明还涉及包含治疗有效量的式（I）化合物或其药学上可接受的盐或溶剂化物的药物组合物，（ii）治疗有效量的至少一种可用于治疗结核病的药剂和（iii）一种或多种药学上可接受的载体或载体。

4. 发明授权

US06180111B2 Vaccine delivery system 失效
标题翻译：疫苗输送系统
公开(公告)号：US06180111B2
公开(公告)日：2001-01-30
申请号：US09081576
申请日：1998-05-19
申请人： Daniel C. Stein , Charles K. Stover
发明人： Daniel C. Stein , Charles K. Stover
IPC分类号： A61K39095
CPC分类号： C07K14/22 , A61K39/00 , A61K39/095 , A61K39/39 , A61K2039/55555 , A61K2039/55594 , Y02A50/401 , Y10S530/812
摘要： The invention relates to a hyperblebbing strain of Neisseria gonorrhoeae which produces large amounts of blebs useful for production of blebosomes containing antigens for use as a vaccine delivery vehicle or as a diagnostic reagent. The invention also relates to a method for producing high levels of a desired protein in purified form using the hyperblebbing strain of N. gonorrhoeae, and to a vaccine delivery systems containing the blebosomes expressing the desired antigen.
摘要翻译：本发明涉及淋病奈瑟氏球菌的超高度吸附菌株，其产生大量可用于产生含有用作疫苗递送载体或作为诊断试剂的抗原的含有抗体的泡沫的泡沫。本发明还涉及使用淋病奈瑟氏球菌的超耐热菌株以及包含表达所需抗原的小泡的疫苗递送系统来产生高水平的纯化形式的所需蛋白质的方法。

5. 发明授权

US5736367A Vectors and prokaryotes which autocatalytically delete antibiotic resistance 失效
标题翻译：载体和原核生物自身催化删除抗生素抗性
公开(公告)号：US5736367A
公开(公告)日：1998-04-07
申请号：US425380
申请日：1995-04-20
申请人： Shirley L. Haun , Charles K. Stover , Graham Hatfull , Mark S. Hanson , William R. Jacobs
发明人： Shirley L. Haun , Charles K. Stover , Graham Hatfull , Mark S. Hanson , William R. Jacobs
IPC分类号： A61K39/00 , A61K39/04 , A61K39/39 , C07K14/35 , C12N15/74 , C12N15/00 , C12N1/20 , C12N15/09 , C12N15/63
CPC分类号： A61K39/04 , A61K39/39 , C07K14/35 , C12N15/74 , C12R1/34 , A61K2039/523 , A61K39/00
摘要： A vector and a prokaryote transformed therewith which includes nucleic acid sequences which make possible the autocatalytic deletion of nucleotide sequences encoding an antibiotic resistance phenotype. The prokaryote can be a bacterium, and in particular a mycobacterium. Such transformed mycobacteria may be employed in vaccines, thereby eliminating the attendant risk of vaccines including antibiotic resistance markers.
摘要翻译：载体和由其转化的原核生物，其包括使编码抗生素抗性表型的核苷酸序列的自动催化缺失成为可能的核酸序列。原核生物可以是细菌，特别是分枝杆菌。这种转化的分枝杆菌可以用于疫苗中，从而消除了包括抗生素抗性标记在内的疫苗的伴随风险。

6. 发明授权

US5583038A Bacterial expression vectors containing DNA encoding secretion signals of lipoproteins 失效
标题翻译：含有编码脂蛋白分泌信号的DNA的细菌表达载体
公开(公告)号：US5583038A
公开(公告)日：1996-12-10
申请号：US977630
申请日：1992-11-17
申请人： Charles K. Stover
发明人： Charles K. Stover
IPC分类号： C12N15/09 , A61K39/00 , A61K39/04 , A61K39/395 , A61P31/04 , C07K14/20 , C07K14/315 , C07K14/35 , C12N1/21 , C12N15/62 , C12N15/74 , C12P21/02 , C12R1/32
CPC分类号： C07K14/3156 , C07K14/20 , C07K14/35 , C12N15/625 , C12N15/74 , A61K39/00 , C07K2319/035 , C07K2319/40 , C07K2319/915
摘要： An expression vector for expressing a protein or polypeptide in a bacterium, which comprises a first DNA sequence encoding at least a secretion signal of a lipoprotein, and a second DNA sequence encoding a protein or fragment thereof, or polypeptide or peptide heterologous to the bacterium which expresses the protein or fragment thereof, or polypeptide or peptide. The bacterium expresses a fusion protein a lipoprotein or lipoprotein segment and the protein or fragment thereof, or polypeptide or peptide heterologous to the bacterium which expresses the protein or fragment thereof, or polypeptide or peptide. Such expression vectors increase the immunogenicity of the protein or fragment thereof, or polypeptide or peptide by enabling the protein or fragment thereof, or polypeptide or peptide to be expressed on the surface of the bacterium. Bacteria which may be transformed with the expression vector include mycobacteria such as BCG. The expression vectors of the present invention may be employed in the formation of live bacterial vaccines against Lyme disease wherein the bacteria express a surface protein of Borrelia burgdorferi, the causative agent of Lyme disease.
摘要翻译：用于在细菌中表达蛋白质或多肽的表达载体，其包含编码脂蛋白的至少一种分泌信号的第一DNA序列和编码其蛋白质或其片段的第二DNA序列，或与该细菌异源的多肽或肽表达蛋白质或其片段，或多肽或肽。该细菌表达融合蛋白质的脂蛋白或脂蛋白片段及其与表达其蛋白质或片段，或多肽或肽的细菌异源的蛋白质或片段，或多肽或肽。这种表达载体通过使蛋白质或其片段或多肽或肽在细菌表面上表达而增加蛋白质或其片段或多肽或肽的免疫原性。可用表达载体转化的细菌包括分枝杆菌如BCG。本发明的表达载体可以用于形成针对莱姆病的活细菌疫苗，其中细菌表达布氏疏螺旋体的表面蛋白，其是莱姆病的致病因子。

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