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1. 发明授权

US5382514A In vivo angiogenesis assay 失效
标题翻译：体内血管生成测定
公开(公告)号：US5382514A
公开(公告)日：1995-01-17
申请号：US862622
申请日：1992-03-31
申请人： Antonino Passaniti , George R. Martin
发明人： Antonino Passaniti , George R. Martin
IPC分类号： A61K49/00 , G01N33/567 , G01N33/574
CPC分类号： A61K49/0004 , Y10S436/813
摘要： A method of performing in vivo angiogenesis assays which involves the use of a matrix material which can be maintained in an injectable solution form at a temperature below that of a host and which forms a gel matrix when injected into a host. The matrix material is an extract of murine basement membrane. Angiogenic factors, including inducers and inhibitors can be added to the matrix material prior to injection into a host. After a period of time within the host, the gel matrix is recovered and angiogenesis of the recovered matrix gel is quantitated. The procedure can be used to induce vascularization or inhibit vascularization at a tissue situs as desired.
摘要翻译：一种进行体内血管生成测定的方法，其涉及使用可以在低于主体温度的温度下保持在可注射溶液形式的基质材料，并且当注射入宿主时形成凝胶基质。基质材料是鼠基底膜的提取物。在注射入宿主之前，血管生成因子，包括诱导剂和抑制剂可以添加到基质材料中。在宿主内一段时间后，回收凝胶基质并定量回收的基质凝胶的血管生成。该方法可用于诱导血管形成或抑制组织部位的血管形成。

2. 发明申请

US20070041951A1 Differentiation of non-insulin producing cells into insulin producing cells by GLP-1 or exendin-4 and uses thereof 审中-公开
标题翻译：通过GLP-1或毒蜥外泌肽-4将非胰岛素生成细胞分化为产生胰岛素的细胞及其用途
公开(公告)号：US20070041951A1
公开(公告)日：2007-02-22
申请号：US11400715
申请日：2006-04-07
申请人： Josephine Egan , Riccardo Perfetti , Antonino Passaniti , Nigel Greig , Harold Holloway , Joel Habener , Doris Stoffers
发明人： Josephine Egan , Riccardo Perfetti , Antonino Passaniti , Nigel Greig , Harold Holloway , Joel Habener , Doris Stoffers
IPC分类号： A61K35/39 , C12N5/08
CPC分类号： C12N5/0676 , A61K35/39 , A61K38/00 , A61K38/26 , C07K14/57563 , C12N2501/335
摘要： The present invention relates to a population of insulin producing cells made by a process comprising contacting non-insulin producing cells with a growth factor selected from the group consisting of GLP-1 or Exendin-4, growth factors having amino acid sequences substantially homologous to GLP-1 or Exendin-4, and fragments thereof. The present invention also relates to methods of differentiating non-insulin producing cells into insulin producing cells and of enriching a population of cells for insulin-producing cells. The present invention also relates to methods of treating diabetes.
摘要翻译：本发明涉及通过包括使非胰岛素产生细胞与选自GLP-1或毒蜥外泌肽-4的生长因子接触的方法制备的胰岛素生产细胞群体，具有与GLP基本上同源的氨基酸序列的生长因子 -1或毒蜥外泌肽-4及其片段。本发明还涉及将非胰岛素生成细胞分化成胰岛素产生细胞并富集胰岛素生成细胞的细胞群的方法。本发明还涉及治疗糖尿病的方法。

3. 发明授权

US07056734B1 Differentiation of non-insulin producing cells into insulin producing cells by GLP-1 or exendin-4 and uses thereof 失效
标题翻译：通过GLP-1或毒蜥外泌肽-4将非胰岛素生成细胞分化为产生胰岛素的细胞及其用途
公开(公告)号：US07056734B1
公开(公告)日：2006-06-06
申请号：US09762538
申请日：1999-08-10
申请人： Josephine Egan , Riccardo Perfetti , Antonino Passaniti , Nigel Greig , Harold Holloway , Joel Habener , Doris Stoffers
发明人： Josephine Egan , Riccardo Perfetti , Antonino Passaniti , Nigel Greig , Harold Holloway , Joel Habener , Doris Stoffers
IPC分类号： C12N5/00
CPC分类号： C12N5/0676 , A61K35/39 , A61K38/00 , A61K38/26 , C07K14/57563 , C12N2501/335
摘要： The present invention relates to a population of insulin producing cells made by a process comprising contacting non-insulin producing cells with a growth factor selected from the group consisting of GLP-1 or Exendin-4, growth factors having amino acid sequences substantially homologous to GLP-1 or Exendin-4, and fragmets thereof. The present invention also relates to methods of differentiating non-insulin producing cells into insulin producing cells and of enriching a population of cells for insulin-producing cells. The present invention also relates to methods of treating diabetes.
摘要翻译：本发明涉及通过包括使非胰岛素产生细胞与选自GLP-1或毒蜥外泌肽-4的生长因子接触的方法制备的胰岛素生产细胞群体，具有与GLP基本上同源的氨基酸序列的生长因子 -1或毒蜥外泌肽-4及其片段。本发明还涉及将非胰岛素生成细胞分化成胰岛素产生细胞并富集胰岛素生成细胞的细胞群的方法。本发明还涉及治疗糖尿病的方法。

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