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1. 发明专利

JP2014138590A Collagen biofabric and preparation method and use therefor 有权
标题翻译： COLLAGEN BIOFABRIC和制备方法及其应用
公开(公告)号：JP2014138590A
公开(公告)日：2014-07-31
申请号：JP2014016360
申请日：2014-01-31
申请人： Anthrogenesis Corp , アンスロジェネシスコーポレーション
发明人： HARIRI ROBERT J , KAPLUNOVSKY ALEKSANDR M , MURPHY PATRICIA A
IPC分类号： C12P21/00 , A61K31/5575 , A61K31/7008 , A61K33/00 , A61K38/00 , A61K38/22 , A61K38/43 , A61K39/00 , A61K45/00 , A61K47/32 , A61K47/34 , A61K47/36 , A61K47/42 , A61L27/00 , A61L27/36 , A61P17/00 , A61P17/02 , A61P27/02 , C12N5/00 , C12N5/071 , C12N5/074 , C12N5/0775 , C12N5/10
CPC分类号： C12N5/0068 , A61K35/50 , A61L27/3604 , A61L27/3683 , A61L27/3691 , A61L2430/40 , C12N2533/92 , Y10T442/2525
摘要： PROBLEM TO BE SOLVED: To provide collagenous membranes produced from amnion, and to provide a method for preparing a three-dimensional scaffold for forming a surgical graft.SOLUTION: A collagen biofabric of the invention has the structural integrity of the native non-treated amniotic membrane, i.e., the native tertiary and quaternary structure. The present invention provides a method for preparing the collagen biofabric from a placental membrane, preferably a human placental membrane, having a chorionic and amniotic membrane, by decellularizing the amniotic membrane. In a preferred embodiment, the amniotic membrane is completely decellularized. The collagen biofabric of the invention has numerous utilities in the medical and surgical field including for example, blood vessel repair, construction and replacement of a blood vessel, tendon and ligament replacement, wound-dressing, surgical grafts, ophthalmic uses, sutures and the like. The benefits of the biofabric are, in part, due to its physical properties such as biomechanical strength, flexibility, suturability, and low immunogenicity, particularly when derived from human placenta.
摘要翻译：要解决的问题：提供由羊膜制成的胶原膜，并提供一种制备用于形成手术移植物的三维支架的方法。解决方案：本发明的胶原生物制品具有天然未处理的羊膜的结构完整性膜，即天然三级和四级结构。本发明提供了通过使羊膜脱细胞从胎盘膜（优选人胎盘膜）制备具有绒毛膜和羊膜的胶原生物制剂的方法。在优选的实施方案中，羊膜完全脱细胞。本发明的胶原生物制剂在医疗和外科领域中具有许多用途，包括例如血管修复，血管的构造和替换，腱和韧带替代，伤口敷料，手术移植物，眼用途，缝合线等。生物制品的优点部分是由于其物理性质如生物力学强度，柔韧性，可渗透性和低免疫原性，特别是当衍生自人胎盘时。

2. 发明专利

JP2010265298A Collagen biofabric and method of preparation and use therefor 有权
标题翻译： COLLAGEN BIOFABRIC及其制备和使用方法
公开(公告)号：JP2010265298A
公开(公告)日：2010-11-25
申请号：JP2010156978
申请日：2010-07-09
申请人： Anthrogenesis Corp , アンスロジェネシスコーポレーション
发明人： HARIRI ROBERT J , KAPLUNOVSKY ALEKSANDR M , MURPHY PATRICIA A
IPC分类号： C07K14/78 , A61K38/17 , A61K47/42 , A61L27/00 , A61L27/36 , A61P13/02 , A61P17/00 , A61P17/02 , A61P27/02 , A61P41/00 , C07K1/14 , C12N5/00
CPC分类号： C12N5/0068 , A61K35/50 , A61L27/3604 , A61L27/3683 , A61L27/3691 , A61L2430/40 , C12N2533/92 , Y10T442/2525
摘要： PROBLEM TO BE SOLVED: To provide a method for preparing a collagen biofabric from a placental membrane (preferably human placental membrane) having a chorionic and amniotic membrane, by decellularizing the amniotic membrane. SOLUTION: There is provided a method for preparing a collagen biofabric from a placental membrane having a chorionic and amniotic membrane, wherein the method comprises (a) a step for isolating the amniotic membrane from the chorionic membrane; and (b) a step for decellularizing the amniotic membrane not to contact the amniotic membrane to the enzyme. The collagen biofabric has numerous utilities in the medical and surgical field including for example, blood vessel repair, construction and replacement of a blood vessel, tendon and ligament replacement, wound-dressing, surgical grafts, ophthalmic uses, sutures, and others. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：通过使羊膜脱细胞，提供从具有绒毛膜和羊膜的胎盘膜（优选人胎盘膜）制备胶原蛋白生物制剂的方法。提供了从具有绒毛膜和羊膜的胎盘膜制备胶原生物制剂的方法，其中所述方法包括（a）从绒毛膜分离羊膜的步骤; 和（b）用于使羊膜脱细胞不与羊膜接触的步骤。胶原蛋白生物制剂在医疗和外科领域中具有许多用途，包括例如血管修复，血管构造和置换，肌腱和韧带替代，伤口敷料，手术移植物，眼用途，缝合线等。版权所有（C）2011，JPO＆INPIT

3. 发明申请

WO03082201A2 COLLAGEN BIOFABRIC AND METHODS OF PREPARATION AND USE THEREFOR 审中-公开
标题翻译： COLLAGEN BIOFABRIC及其制备和使用方法
公开(公告)号：WO03082201A2
公开(公告)日：2003-10-09
申请号：PCT/US0309304
申请日：2003-03-26
申请人： ANTHROGENESIS CORP , HARIRI ROBERT J , KAPLUNOVSKY ALEKSANDR M , MURPHY PATRICIA A
发明人： HARIRI ROBERT J , KAPLUNOVSKY ALEKSANDR M , MURPHY PATRICIA A
IPC分类号： A61L27/36 , C12N5/00 , A61K
CPC分类号： C12N5/0068 , A61K35/50 , A61L27/3604 , A61L27/3683 , A61L27/3691 , A61L2430/40 , C12N2533/92 , Y10T442/2525
摘要： The present invention relates to collagenous membranes produced from amnion, herein referred to as a collagen biofabric. The collagen biofabric of the invention has the structural integrity of the native non-treated amniotic membrane, i.e., the native tertiary and quaternary structure. The present invention provides a method for preparing a collagen biofabric from a placental membrane, preferably a human placental membrane having a chorionic and amniotic membrane, by decellularizing the amniotic membrane. In a preferred embodiment, the amniotic membrane is completely decellularized. The collagen biofabric of the invention has numerous utilities in the medical and surgical field including for example, blood vessel repair, construction and replacement of a blood vessel, tendon and ligament replacement, wound-dressing, surgical grafts, ophthalmic uses, sutures, and others. The benefits of the biofabric are, in part, due to its physical properties such as biomechanical strength, flexibility, suturability, and low immunogenicity, particularly when derived from human placenta.
摘要翻译：本发明涉及由羊膜制成的胶原膜，本文称为胶原生物制品。本发明的胶原生物制品具有天然未处理的羊膜的结构完整性，即天然的三级和四级结构。本发明提供了通过使羊膜脱细胞从胎盘膜，优选具有绒毛膜和羊膜的人胎盘膜制备胶原蛋白生物制剂的方法。在优选的实施方案中，羊膜完全脱细胞。本发明的胶原蛋白生物制剂在医疗和外科领域中具有许多用途，包括例如血管修复，血管的构造和替换，腱和韧带置换术，伤口敷料，手术移植物，眼用途，缝合线等。生物制品的优点部分是由于其物理性质如生物力学强度，柔韧性，可渗透性和低免疫原性，特别是当衍生自人胎盘时。

4. 发明申请

WO2007005807A3 REPAIR OF TYMPANIC MEMBRANE USING PLACENTA DERIVED COLLAGEN BIOFABRIC 审中-公开
标题翻译：使用PLACENTA衍生的COLLAGEN BIOFABRIC修复典型膜
公开(公告)号：WO2007005807A3
公开(公告)日：2007-07-05
申请号：PCT/US2006025938
申请日：2006-06-29
申请人： ANTHROGENESIS CORP , SULNER JOSEPH W , SMIELL JANICE , BOURKE SHARON L , MURPHY PATRICIA A
发明人： SULNER JOSEPH W , SMIELL JANICE , BOURKE SHARON L , MURPHY PATRICIA A
IPC分类号： A61L27/24 , A61F2/18 , A61L31/04
CPC分类号： A61F2/18 , A61F2002/183 , A61L27/24 , A61L31/044 , A61L2430/14
摘要： The present invention provides a method of repairing a tympanic membrane deformity, such as a tympanic membrane perforation, commonly referred to as tympanoplasty or myringoplasty, using a collagen biofabric. The collagen biofabric is preferably laminated. The invention further provides kits comprising one or more pieces of collagen biofabric, for example laminated collagen biofabric, for the repair of a tympanic membrane.
摘要翻译：本发明提供了使用胶原生物制剂修复鼓膜变形（例如通常称为鼓膜成形术或鼓膜成形术）的鼓膜穿孔的方法。胶原生物制品优选层压。本发明还提供包含一种或多种胶原生物制品的试剂盒，例如用于修复鼓膜的层压胶原蛋白生物制剂。

5. 发明公开

EP1575572A4 COLLAGEN BIOFABRIC AND METHODS OF PREPARATION AND USE THEREFOR 有权转让
标题翻译：生物胶原组织及其制造方法和使用
公开(公告)号：EP1575572A4
公开(公告)日：2010-10-13
申请号：EP03745621
申请日：2003-03-26
申请人： ANTHROGENESIS CORP
发明人： HARIRI ROBERT J , KAPLUNOVSKY ALEKSANDR M , MURPHY PATRICIA A
IPC分类号： A61L27/36 , C12N5/00 , A01N27/00 , A61F2/00 , A61K35/54 , C12N5/08
CPC分类号： C12N5/0068 , A61K35/50 , A61L27/3604 , A61L27/3683 , A61L27/3691 , A61L2430/40 , C12N2533/92 , Y10T442/2525
摘要： The present invention relates to collagenous membranes produced from amnion, herein referred to as a collagen biofabric. The collagen biofabric of the invention has the structural integrity of the native non-treated amniotic membrane, i.e., the native tertiary and quaternary structure. The present invention provides a method for preparing a collagen biofabric from a placental membrane, preferably a human placental membrane having a chorionic and amniotic membrane, by decellularizing the amniotic membrane. In a preferred embodiment, the amniotic membrane is completely decellularized. The collagen biofabric of the invention has numerous utilities in the medical and surgical field including for example, blood vessel repair, construction and replacement of a blood vessel, tendon and ligament replacement, wound-dressing, surgical grafts, ophthalmic uses, sutures, and others. The benefits of the biofabric are, in part, due to its physical properties such as biomechanical strength, flexibility, suturability, and low immunogenicity, particularly when derived from human placenta.

6. 发明专利

CA2613548A1 REPAIR OF TYMPANIC MEMBRANE USING PLACENTA DERIVED COLLAGEN BIOFABRIC 未知
公开(公告)号：CA2613548A1
公开(公告)日：2007-01-11
申请号：CA2613548
申请日：2006-06-29
申请人： ANTHROGENESIS CORP
发明人： BOURKE SHARON L , MURPHY PATRICIA A , SULNER JOSEPH W , SMIELL JANICE
IPC分类号： A61L27/24 , A61F2/18 , A61L31/04
摘要： The present invention provides a method of repairing a tympanic membrane deformity, such as a tympanic membrane perforation, commonly referred to as tympanoplasty or myringoplasty, using a collagen biofabric. The collagen biofabric is preferably laminated. The invention further provides kits comprising one or more pieces of collagen biofabric, for example laminated collagen biofabric, for the repair of a tympanic membrane.

7. 发明专利

MX2007016268A REPARACION DE MEMBRANA TIMPANICA UTILIZANDO BIOTELA DE COLAGENO DERIVADO DE PLACENTA. 未知
公开(公告)号：MX2007016268A
公开(公告)日：2009-02-23
申请号：MX2007016268
申请日：2006-06-29
申请人： ANTHROGENESIS CORP
发明人： MURPHY PATRICIA A , SULNER JOSEPH W , SMIELL JANICE , BOURKE SHARON L
IPC分类号： A61F2/00
摘要： La presente invención proporciona un método para reparar una deformidad de la membrana timpánica, por ejemplo perforaciones de membrana timpánica, que se conoce comúnmente como tímpanoplastia o meringoplastia, utilizando una biotela de colágeno. La biotela de colágeno es preferentemente laminada. La invención proporciona además kits que comprenden una o varias piezas de biotela de colágeno, por ejemplo biotela de colágeno laminada, para la preparación de una membrana timpánica.

8. 发明专利

HK1085384A1 COLLAGEN BIOFABRIC AND METHODS OF PREPARATION AND USE THEREFOR 未知
公开(公告)号：HK1085384A1
公开(公告)日：2006-08-25
申请号：HK06103595
申请日：2006-03-21
申请人： ANTHROGENESIS CORP
发明人： HARIRI ROBERT J , KAPLUNOVSKY ALEKSANDR M , MURPHY PATRICIA A
IPC分类号： A61L20060101 , A61L27/36 , C12N5/00
摘要： The present invention provides a collagen biofabric comprising a dehydrated, decellularized and substrate-free amniotic membrane, wherein said amniotic membrane has a native tertiary and quaternary structure. Further, provided is a collagen biofabric from a placenta having an amniotic membrane and a chorionic membrane, wherein the collagen biofabric is prepared by a method comprising: (a) separating the amniotic membrane from the chorionic membrane; and (b) decellularizing the amniotic membrane so that the amniotic membrane is not contacted with an enzyme. The present invention also provides a three-dimensional scaffold comprising the collagen biofabric of the present invention, preferably wherein the three-dimensional scaffold is a tube, a sheet, a fiber, or a microsphere.

9. 发明专利

BRPI0612121A2 método de reparo de uma membrana timpânica que tenha uma deformidade, e, biotecido de colágeno 未知
公开(公告)号：BRPI0612121A2
公开(公告)日：2016-09-06
申请号：BRPI0612121
申请日：2006-06-29
申请人： ANTHROGENESIS CORP
发明人： SMIELL JANICE , SULNER JOSEPH W , MURPHY PATRICIA A , BOURKE SHARON L
IPC分类号： A61F2/18 , A61L27/24 , A61L31/04

10. 发明专利

CA2479903C COLLAGEN BIOFABRIC AND METHODS OF PREPARATION AND USE THEREFOR 未知
公开(公告)号：CA2479903C
公开(公告)日：2016-08-23
申请号：CA2479903
申请日：2003-03-26
申请人： ANTHROGENESIS CORP
发明人： HARIRI ROBERT J , KAPLUNOVSKY ALEKSANDR M , MURPHY PATRICIA A
IPC分类号： A61K38/39 , A61K35/50 , A61L15/32 , A61L27/24 , A61L27/36 , A61L27/38 , A61P17/02 , A61P27/02 , C12N5/00
摘要： The present invention relates to collagenous membranes produced from amnion, herein referred to as a collagen biofabric. The collagen biofabric of the invention has the structural integrity of the native non-treated amniotic membrane, i.e., the native tertiary and quaternary structure. The present invention provides a method for preparing a collagen biofabric from a placental membrane, preferably a human placental membrane having a chorionic and amniotic membrane, by decellularizing the amniotic membrane. In a preferred embodiment, the amniotic membrane is completely decellularized. The collagen biofabric of the invention has numerous utilities in the medical and surgical field including for example, blood vessel repair, construction and replacement of a blood vessel, tendon and ligament replacement, wound-dressing, surgical grafts, ophthalmic uses, sutures, and others. The benefits of the biofabric are, in part, due to its physical properties such as biomechanical strength, flexibility, suturability, and low immunogenicity, particularly when derived from human placenta.

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