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1. 发明授权

US6034229A BMP-15 compositions 失效
标题翻译： BMP-15组合物
公开(公告)号：US6034229A
公开(公告)日：2000-03-07
申请号：US982987
申请日：1997-12-02
申请人： Anthony J. Celeste , Jennifer L. Dube , Karen M. Lyons , Brigid Hogan
发明人： Anthony J. Celeste , Jennifer L. Dube , Karen M. Lyons , Brigid Hogan
IPC分类号： C12N15/09 , A61K38/00 , A61K38/17 , A61L27/22 , A61L27/36 , A61P43/00 , C07K14/51 , C07K16/22 , C07K19/00 , C12N5/10 , C12N15/12 , C12P21/02 , C07H21/04
CPC分类号： C07K14/51 , A61L27/227 , A61K38/00 , C07K2319/00
摘要： Purified BMP-15-related proteins and processes for producing them are disclosed. DNA molecules encoding the BMP-15-related proteins are also disclosed. The proteins may be used in the treatment of bone and cartilage and/or other connective tissue defects and in wound healing and related tissue repair.
摘要翻译：公开了纯化的BMP-15相关蛋白质及其生产方法。还公开了编码BMP-15相关蛋白的DNA分子。蛋白质可用于治疗骨和软骨和/或其他结缔组织缺陷以及伤口愈合和相关组织修复。

2. 发明授权

US5635372A BMP-15 compositions 失效
标题翻译： BMP-15组合物
公开(公告)号：US5635372A
公开(公告)日：1997-06-03
申请号：US446924
申请日：1995-05-18
申请人： Anthony J. Celeste , Jennifer L. Dube , Karen M. Lyons , Brigid Hogan
发明人： Anthony J. Celeste , Jennifer L. Dube , Karen M. Lyons , Brigid Hogan
IPC分类号： C12N15/09 , A61K38/00 , A61K38/17 , A61L27/22 , A61L27/36 , A61P43/00 , C07K14/51 , C07K16/22 , C07K19/00 , C12N5/10 , C12N15/12 , C12P21/02 , C12P21/06 , C07H21/04 , C12N5/00 , C12N15/00
CPC分类号： C07K14/51 , A61L27/227 , A61K38/00 , C07K2319/00
摘要： Purified BMP-15-related proteins and processes for producing them are disclosed. DNA molecules encoding the BMP-15-related proteins are also disclosed. The proteins may be used in the treatment of bone and cartilage and/or other connective tissue defects and in wound healing and related tissue repair.
摘要翻译：公开了纯化的BMP-15相关蛋白质及其生产方法。还公开了编码BMP-15相关蛋白的DNA分子。蛋白质可用于治疗骨和软骨和/或其他结缔组织缺陷以及伤口愈合和相关组织修复。

3. 发明授权

US5728679A BMP-15 compositions 失效
公开(公告)号：US5728679A
公开(公告)日：1998-03-17
申请号：US798665
申请日：1997-02-11
申请人： Anthony J. Celeste , Jennifer L. Dube , Karen M. Lyons , Brigid Hogan
发明人： Anthony J. Celeste , Jennifer L. Dube , Karen M. Lyons , Brigid Hogan
IPC分类号： C12N15/09 , A61K38/00 , A61K38/17 , A61L27/22 , A61L27/36 , A61P43/00 , C07K14/51 , C07K16/22 , C07K19/00 , C12N5/10 , C12N15/12 , C12P21/02 , A61K9/14 , C07K1/00 , C07K16/00
CPC分类号： C07K14/51 , A61L27/227 , A61K38/00 , C07K2319/00
摘要： Purified BMP-15-related proteins and processes for producing them are disclosed. DNA molecules encoding the BMP-15-related proteins are also disclosed. The proteins may be used in the treatment of bone and cartilage and/or other connective tissue defects and in wound healing and related tissue repair.

4. 发明申请

US20070178590A1 PLURIPOTENTIAL EMBRYONIC STEM CELLS AND METHODS OF MAKING SAME 审中-公开
标题翻译：胚胎干细胞及其制备方法
公开(公告)号：US20070178590A1
公开(公告)日：2007-08-02
申请号：US11550713
申请日：2006-10-18
申请人： Brigid Hogan
发明人： Brigid Hogan
IPC分类号： C12N5/06 , C12N5/08
CPC分类号： C12N5/0611 , C12N5/0606 , C12N2501/115 , C12N2501/125 , C12N2501/235 , C12N2502/99 , C12N2503/02 , C12N2506/04 , C12N2510/00
摘要： The present invention provides a non-mouse, including human, pluripotential embryonic stem cell which can: (a) be maintained on feeder layers for at least 20 passages; and (b) give rise to embryoid bodies and multiple differentiated cell phenotypes in monolayer culture. The invention further provides a method of making a pluripotential embryonic stem cell comprising culturing germs cells and germ cell progenitors in a composition comprising a growth enhancing amount of basic fibroblast growth factor, leukemia inhibitory factor, membrane associated steel factor, and soluble steel factor to primordial germ cells under cell growth conditions, thereby making a pluripotential embryonic stem cell. Also provided are composition useful to produce the pluripotent embryonic stem cells and methods of screening associated with the method of making the embryonic stem cell.
摘要翻译：本发明提供了一种非小鼠，其包括人多能胚胎干细胞，其可以：（a）保持在饲养层上至少20代; 和（b）在单层培养物中产生类胚体和多种分化细胞表型。本发明还提供了一种制备多能胚胎干细胞的方法，包括在包含生长增加量的碱性成纤维细胞生长因子，白血病抑制因子，膜相关钢因子和可溶性钢因子的组合物中培养细菌和生殖细胞祖细胞至原始细胞生长条件下的生殖细胞，从而形成多能胚胎干细胞。还提供了可用于产生多能胚胎干细胞的组合物和与制备胚胎干细胞的方法相关的筛选方法。

5. 发明申请

US20060275898A1 Compositions and Methods for Making Embryonic Stem Cells 审中-公开
标题翻译：胚胎干细胞的组成和方法
公开(公告)号：US20060275898A1
公开(公告)日：2006-12-07
申请号：US11423676
申请日：2006-06-12
申请人： Brigid Hogan , Guang-Quan Zhao
发明人： Brigid Hogan , Guang-Quan Zhao
IPC分类号： C12N5/06 , C12N5/08
CPC分类号： G01N33/5073 , A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/03 , A61K38/1875 , C07K14/51 , C12N5/061 , C12N15/8509 , C12N2501/115 , C12N2501/125 , C12N2501/155 , C12N2501/235 , G01N33/5008 , G01N33/5017 , G01N33/5044 , G01N33/689 , G01N2510/00 , G01N2800/367
摘要： The invention relates to cell proliferation, cell differentiation, male infertility, male fertility and to compositions and methods involved therein.
摘要翻译：本发明涉及细胞增殖，细胞分化，男性不育症，男性生殖力以及涉及其中的组合物和方法。

6. 发明授权

US07041801B1 Antibodies binding to polypeptides encoded by developmentally-regulated endothelial cell locus-1 失效
标题翻译：结合由发育调节的内皮细胞基因座-1编码的多肽的抗体
公开(公告)号：US07041801B1
公开(公告)日：2006-05-09
申请号：US09237981
申请日：1999-01-25
申请人： Thomas Quertermous , Brigid Hogan , H. Ralph Snodgrass , Thomas Joel Zupancic
发明人： Thomas Quertermous , Brigid Hogan , H. Ralph Snodgrass , Thomas Joel Zupancic
IPC分类号： C07K16/00
CPC分类号： C07K14/475 , C07K16/22 , G01N2333/71
摘要： The present invention relates to a member of a novel gene family referred to as developmentally-regulated endothelial cell locus-1 (del-1). In particularly, the invention related to del-1 nucleotide sequences, Del-1 amino acid sequences, methods of expressing a functional gene product, and methods of using the gene and gene product. Since del-1 is expressed in endothelial cells and certain cancer cells, it may be useful as an endothelial cell and tumor marker. In addition, anti-Del-1 antibodies for immunological assessment of Del-1 protein expression as well as for inhibiting or stimulating Del-1 function are provided.
摘要翻译：本发明涉及称为发育调节内皮细胞基因座-1（del-1）的新型基因家族的成员。特别地，本发明涉及del-1核苷酸序列，Del-1氨基酸序列，表达功能性基因产物的方法，以及使用该基因和基因产物的方法。由于del-1在内皮细胞和某些癌细胞中表达，因此可能作为内皮细胞和肿瘤标志物有用。此外，提供了用于免疫评估Del-1蛋白表达以及抑制或刺激Del-1功能的抗Del-1抗体。

7. 发明授权

US5877281A Developmentally-regulated endothelial cell locus-1 失效
标题翻译：发育调节内皮细胞基因座-1
公开(公告)号：US5877281A
公开(公告)日：1999-03-02
申请号：US659235
申请日：1996-06-05
申请人： Thomas Quertermous , Brigid Hogan , H. Ralph Snodgrass , Thomas Joel Zupancic
发明人： Thomas Quertermous , Brigid Hogan , H. Ralph Snodgrass , Thomas Joel Zupancic
IPC分类号： C12N15/09 , A61K38/00 , C07K14/475 , C07K14/485 , C07K14/745 , C07K16/22 , C07K16/36 , C12N5/10 , C12N15/12 , C12P21/02 , C12P21/08 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/574 , C07K14/435 , C07K14/755 , C12N15/11
CPC分类号： G01N33/5091 , A01K67/0275 , C07K14/475 , G01N33/5008 , G01N33/5011 , G01N33/5064 , G01N33/57484 , A01K2217/05 , A01K2227/105 , A01K2267/0375 , A61K38/00 , G01N2500/00
摘要： The present invention relates to a member of a novel gene family referred to as developmentally-regulated endothelial cell locus-1 (del-1). In particular, the invention relates to del-1 nucleotide sequences, Del-1 amino acid sequences, methods of expressing a functional gene product, and methods of using the gene and gene product.
摘要翻译：本发明涉及称为发育调节内皮细胞基因座-1（del-1）的新型基因家族的成员。特别地，本发明涉及del-1核苷酸序列，Del-1氨基酸序列，表达功能性基因产物的方法，以及使用该基因和基因产物的方法。

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