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1. 发明授权

US5670489A Oligonucleotide analogues 失效
标题翻译：寡核苷酸类似物
公开(公告)号：US5670489A
公开(公告)日：1997-09-23
申请号：US463139
申请日：1995-06-02
申请人： Anthony David Baxter , Eric Keith Baylis , Stephen Paul Collingwood , Roger John Taylor , Alain De Mesmaeker , Chantal Schmit
发明人： Anthony David Baxter , Eric Keith Baylis , Stephen Paul Collingwood , Roger John Taylor , Alain De Mesmaeker , Chantal Schmit
IPC分类号： G01N33/569 , A61K31/665 , A61K31/70 , A61K31/7042 , A61K31/7052 , A61K31/7064 , A61K31/7072 , A61K31/7076 , A61P31/12 , A61P31/16 , C07F9/6512 , C07F9/655 , C07F9/6561 , C07H19/04 , C07H19/06 , C07H19/16 , C07H21/00 , C07H21/04
CPC分类号： C07H21/00 , C07H19/04
摘要： A dinucleotide analogue of formula ##STR1## where B.sup.1 and B.sup.2 are each independently a monovalent nucleoside base radical; R.sup.1 is R.sup.1.sub.a or Z; R.sup.1.sub.a, R.sup.2, R.sup.3 and R.sup.4 are each independently hydrogen, halogen or hydroxy; R.sup.5 is R.sup.5.sub.a or Z; R.sup.6 is hydrogen or R.sup.6.sub.a ; R.sup.7 is hydrogen, alkyl-N,N-dialkylphosphoramidyl or R.sup.7.sub.a, R.sup.8 is R.sup.8.sub.a or Z, or the indicated R.sup.7 O and R.sup.8 together denote an isopropylidenedioxy group; R.sup.5.sub.a and R.sup.8.sub.a are each independently hydrogen, halogen, hydroxy, --OR.sup.10, --OCOR.sup.10 or silyloxy substituted by three C.sub.1 -C.sub.5 hydrocarbyl groups; R.sup.6.sub.a and R.sup.7.sub.a are each independently a C.sub.1 -C.sub.10 aliphatic radical, a C.sub.6 -C.sub.15 aromatic radical, a C.sub.7 -C.sub.30 araliphatic radical, --COR.sup.11, --SO.sub.2 R.sup.11 or silyl substituted by three C.sub.1 -C.sub.15 hydrocarbyl groups; R.sup.9 is hydrogen, a C.sub.1 -C.sub.8 aliphatic radical, a C.sub.3 -C.sub.8 cycloaliphatic radical, a C.sub.6 -C.sub.15 aromatic radical, a C.sub.7 -C.sub.13 araliphatic radical, an alkali metal ion or an ammonium ion; R.sup.10 and R.sup.11 are each independently a C.sub.1 -C.sub.10 aliphatic radical, a C.sub.3 -C.sub.8 cycloaliphatic radical, a C.sub.6 -C.sub.15 aromatic radical or a C.sub.7 -C.sub.16 araliphatic radical; R.sup.x and R.sup.y are independently hydrogen, halogen, hydroxy, a C.sub.1 -C.sub.10 alkyl, C.sub.2 -C.sub.10 alkenyl, C.sub.3 -C.sub.8 cycloalkyl, C.sub.6 -C.sub.15 aryl, C.sub.7 -C.sub.16 aralkyl, C.sub.1 -C.sub.10 alkoxy, C.sub.2 -C.sub.10 alkenoxy, C.sub.6 -C.sub.10 aryloxy or C.sub.7 -C.sub.16 aralkyloxy group, which is substituted or unsubstituted, or --OCOR.sub.z ; R.sup.z is a substituted or unsubstituted C.sub.1 -C.sub.10 alkyl, C.sub.2 -C.sub.10 alkenyl, C.sub.3 -C.sub.8 cycloalkyl, C.sub.6 -C.sub.15 aryl or C.sub.7 -C.sub.16 aralkyl group; and Z is C.sub.6 -C.sub.10 aryloxythiocarbonyloxy, the C.sub.6 -C.sub.10 aryl group being substituted or unsubstituted.
摘要翻译：式Ⅰ的二核苷酸类似物，其中B1和B2各自独立地是一价核苷碱基; R1为R1a或Z; R1a，R2，R3和R4各自独立地为氢，卤素或羟基; R5为R5a或Z; R6是氢或R6a; R7是氢，烷基-N，N-二烷基磷酰胺基或R7a，R8是R8a或Z，或者所指示的R7O和R8一起表示异丙烯二氧基; R5a和R8a各自独立地为氢，卤素，羟基，-OR10，-OCOR10或被三个C1-C5烃基取代的甲硅烷氧基; R6a和R7a各自独立地为C1-C10脂族基团，C6-C15芳族基团，C7-C30芳脂族基团，-COR11，-SO2R11或被三个C1-C15烃基取代的甲硅烷基基团; R9是氢，C1-C8脂族基团，C3-C8脂环族基团，C6-C15芳族基团，C7-C13芳脂族基团，碱金属离子或铵离子; R 10和R 11各自独立地为C 1 -C 10脂族基团，C 3 -C 8脂环族基团，C 6 -C 15芳族基团或C 7 -C 16芳脂族基团; Rx和Ry独立地是氢，卤素，羟基，C1-C10烷基，C2-C10烯基，C3-C8环烷基，C6-C15芳基，C7-C16芳烷基，C1-C10烷氧基，C2-C10链烯氧基，C6-C10 取代或未取代的芳氧基或C7-C16芳烷氧基，或-OCORz; Rz是取代或未取代的C1-C10烷基，C2-C10烯基，C3-C8环烷基，C6-C15芳基或C7-C16芳烷基; Z为C6-C10芳氧基硫代羰氧基，C6-C10芳基为取代或未取代的。

2. 发明授权

US6087490A Dinucleotide and oligonucleotide analogues 失效
标题翻译：二核苷酸和寡核苷酸类似物
公开(公告)号：US6087490A
公开(公告)日：2000-07-11
申请号：US155198
申请日：1998-10-08
申请人： Anthony David Baxter , Eric Keith Baylis , Stephen Paul Collingwood , Robin Alec Fairhurst , Roger John Taylor
发明人： Anthony David Baxter , Eric Keith Baylis , Stephen Paul Collingwood , Robin Alec Fairhurst , Roger John Taylor
IPC分类号： C07H19/06 , C07H21/00 , C07H19/00 , C07H21/02 , C07H21/04
CPC分类号： C07H19/06 , C07H21/00 , Y02P20/55
摘要： A compound which is a dinucleotide analogue of formula ##STR1## or a salt thereof, where B.sup.1 and B.sup.2 are each independently a monovalent nucleoside base radical,R.sup.1 is hydrogen or Y.sup.1,R.sup.2 and R.sup.3 are each independently hydrogen, halogen, hydroxy or --OY.sup.2,R.sup.4 is hydrogen, halogen, hydroxy, --OY.sup.3 or R.sup.7,R.sup.5 is hydrogen, halogen or R.sup.8,R.sup.6 is hydrogen, Y.sup.4 or a phosphoramidyl group,Z is a group of formula II, III or IV ##STR2## where R.sup.9 is hydrogen, halogen, hydroxy, --OY.sup.5 or R.sup.13, R.sup.10 is hydrogen, halogen or R.sup.14, R.sup.11 is hydroxy, R.sup.15 or --OR.sup.15 where R.sup.15 is a C.sub.1 to C.sub.10 aliphatic group, a C.sub.3 to C.sub.8 cycloaliphatic group, a C.sub.6 to C.sub.10 aromatic group or a C.sub.7 to C.sub.13 araliphatic group, and R.sup.12 is hydrogen, R.sup.12.sub.a or --OCOR.sup.12.sub.a where R.sup.12.sub.a is a C.sub.1 to C.sub.10 aliphatic group, a C.sub.3 to C.sub.8 cycloaliphatic group, a C.sub.6 to C.sub.10 aromatic group or a C.sub.7 to C.sub.13 araliphatic group, Y.sup.1, Y.sup.2, Y.sup.3, Y.sup.4 and Y.sup.5 are each indpendently a hydroxy-protecting group, and R.sup.7, R.sup.8, R.sup.13 and R.sup.14 are each independently a C.sub.1 to C.sub.10 aliphatic group, a C.sub.3 to C.sub.8 cycloaliphatic group, a C.sub.6 to C.sub.10 aromatic group or a C.sub.7 to C.sub.13 araliphatic group.
摘要翻译： PCT No.PCT / GB97 / 00651 Sec。 371日期：1998年10月8日 102（e）日期1998年10月8日PCT 1997年11月3日PCT PCT。公开号WO97 / 35869 日期1997年10月2日为式或二价核苷酸类似物的化合物或其盐，其中B1和B2各自独立地为一价核苷碱基，R1为氢或Y1，R2和R3各自独立地为氢，卤素，羟基或 -OY2，R4是氢，卤素，羟基，-OY3或R7，R5是氢，卤素或R8，R6是氢，Y4或磷酰胺基，Z是式II，III或IV的基团，其中R9是氢，卤素，羟基，-OY5或R13，R10为氢，卤素或R14，R11为羟基，R15或-OR15，其中R15为C1至C10脂族基团，C3至C8脂环族基团，C6至C10芳族基团或 C7至C13芳脂族基团，R12为氢，R12a或-OCOR12a，其中R12a为C1至C10脂族基团，C3至C8脂环族基团，C6至C10芳族基团或C7至C13芳脂族基团，Y1，Y2， Y3，Y4和Y5各自独立地为羟基保护基，R7，R8，R13和R14各自独立地为C1至C10脂族基团，C3t C 8脂环族基团，C 6至C 10芳族基团或C 7至C 13芳脂基基团。

3. 发明授权

US3932505A Hydrazide salts 失效
标题翻译：酰肼盐
公开(公告)号：US3932505A
公开(公告)日：1976-01-13
申请号：US430843
申请日：1974-01-04
申请人： Wilfred Pickles , Eric Keith Baylis
发明人： Wilfred Pickles , Eric Keith Baylis
IPC分类号： C22B15/00 , C22B3/26 , C22B3/32 , C07C103/26
CPC分类号： C22B3/0022 , Y02P10/234 , Y02P20/582 , Y10S423/14
摘要： A compound having the general formula ##SPC1##In which R.sup.1 , R.sup.2, R.sup.3 and R.sup.4 may be the same or different and represent hydrogen, a straight or branched chain alkyl radical having 1 to 20 carbon atoms, an aralkyl radical having 7 to 20 carbon atoms which may be substituted by one or more alkyl groups having 1 to 4 carbon atoms, or may be of the type: ##SPC2##Wherein R.sup.5 and R.sup.6 are each a hydrogen atom or a methyl group, and each R represents the others of R.sup.1, R.sup.2, R.sup.3 and R.sup.4, an alkenyl radical having 2 to 20 carbon atoms; a cycloalkyl radical having 5 to 12 carbon atoms which may be substituted by one or more alkyl groups having 1 to 4 carbon atoms; an aryl radical having 6 to 10 carbon atoms; an alkaryl radical having 7 to 12 carbon atoms; a cyclohexyl alkyl radical in which the alkyl moiety has 2 or 3 carbon atoms and the cyclohexenyl ring may contain a methyl group as substituent; an alkenyl cyclohexyl radical in which the alkenyl moiety has 2 or 3 carbon atoms and the cyclohexyl ring may also contain a methyl group as substituent; or a group -OR.sup.7 wherein R.sup.7 represents an alkyl radical having 1 to 20 carbon atoms, a cycloalkyl radical having 5 to 12 carbon atoms, optionally substituted by one or more alkyl groups having 1 to 4 carbon atoms, an aryl radical having 6 to 10 carbon atoms or an alkenyl radical having 3 to 20 carbon atoms; or any two adjacent radicals R.sup.1, R.sup.2, R.sup.3 and R.sup.4 may be joined together to form an aryl ring which may be substituted by one or more alkyl groups having 1 to 20 carbon atoms; X represents an anion; and n is the valency of X, is useful for the extraction of metals from aqueous solutions.
摘要翻译：具有通式I 1，R 1，R 3和R 4的化合物可以相同或不同，表示氢，具有1-20个碳原子的直链或支链烷基，可以具有7至20个碳原子的芳烷基，被一个或多个具有1至4个碳原子的烷基取代，或者可以是以下类型：其中R 5和R 6各自是氢原子或甲基，并且每个R表示其它的R 1，R 2，R 3和R 4 具有2-20个碳原子的烯基; 可以被一个或多个具有1至4个碳原子的烷基取代的具有5至12个碳原子的环烷基; 具有6至10个碳原子的芳基; 具有7至12个碳原子的烷芳基; 其中烷基部分具有2或3个碳原子的环己基烷基，环己烯环可以含有甲基作为取代基; 其中烯基部分具有2或3个碳原子的烯基环己基，环己基环也可以含有甲基作为取代基; 或基团-OR 7，其中R 7表示具有1至20个碳原子的烷基，具有5至12个碳原子的环烷基，任选被一个或多个具有1至4个碳原子的烷基取代，芳基具有6至10个碳原子或碳原子数3〜20的烯基; 或任意两个相邻基团R 1，R 2，R 3和R 4可以连接在一起形成可被一个或多个具有1至20个碳原子的烷基取代的芳基环; X表示阴离子; 并且n是X的化合价，可用于从水溶液中萃取金属。

4. 发明授权

US5693799A Method of synthesizing an organophosphorus compound 失效
标题翻译：合成有机磷化合物的方法
公开(公告)号：US5693799A
公开(公告)日：1997-12-02
申请号：US676990
申请日：1996-07-08
申请人： Eric Keith Baylis
发明人： Eric Keith Baylis
IPC分类号： C07F9/32 , C07F9/48 , C07H7/02 , C07H9/04 , C07H19/10 , C07F9/02
CPC分类号： C07H19/10 , C07F9/3211 , C07F9/4816 , C07H7/02 , C07H9/04
摘要： A compound of formula ##STR1## where R.sup.1 and R.sup.2 are independently a C.sub.1 -C.sub.10 aliphatic radical, or R.sup.1 is a C.sub.1 -C.sub.10 aliphatic radical and R.sup.2 is a C.sub.6 -C.sub.10 aromatic radical, and R.sup.3 is a C.sub.1 -C.sub.8 aliphatic radical, a C.sub.3 -C.sub.8 cycloaliphatic radical, a C.sub.6 -C.sub.15 aromatic radical or a C.sub.7 -C.sub.13 araliphatic radical, provided that R.sup.3 is not methyl when R.sup.1 and R.sup.2 are each methyl, that R.sup.3 is not ethyl when R.sup.1 and R.sup.2 are each methyl and that R.sup.2 is not p-aminophenyl when R.sup.1 is methyl and R.sup.3 is ethyl with an organic compound having at least one group reactive with a P--H bond.
摘要翻译：其中R 1和R 2独立地是C 1 -C 10脂族基团，或者R 1是C 1 -C 10脂族基团，R 2是C 6 -C 10芳族基团，R 3是C 1 -C 8脂族基团， C3-C8脂环族基团，C6-C15芳族基团或C7-C13芳脂族基团，条件是当R 1和R 2各自为甲基时，R 3不是甲基，当R 1和R 2各自是甲基时，R 3不是乙基，并且R 2 当R1为甲基且R3为具有至少一个与PH键反应的基团的有机化合物的乙基时，其不是对氨基苯基。

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