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1. 发明申请

US20100298392A1 Isoindoline Derivatives For The Treatment Of Arrhythmias 审中-公开
标题翻译：异二氢吲哚衍生物治疗心律失常
公开(公告)号：US20100298392A1
公开(公告)日：2010-11-25
申请号：US12373065
申请日：2007-07-12
申请人： Annika Bjore , Jonas Bostrom , Ojvind Davidsson , Hans Emtenas , Ulrik Gran , Tommy Iliefski , Johan Kajanus , Roine Olsson , Lars Sandberg , Gert Strandlund , Johan Sundell , Zhong-Qing Yuan
发明人： Annika Bjore , Jonas Bostrom , Ojvind Davidsson , Hans Emtenas , Ulrik Gran , Tommy Iliefski , Johan Kajanus , Roine Olsson , Lars Sandberg , Gert Strandlund , Johan Sundell , Zhong-Qing Yuan
IPC分类号： A61K31/4035 , C07D413/12 , C07D209/46 , C07D405/12 , A61K31/422 , A61P9/06
CPC分类号： C07D209/46 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/10 , C07D403/12 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/06 , C07D409/12 , C07D413/06 , C07D413/12 , C07D413/14
摘要： There is provided compounds of formula I, wherein R1 to R7 have meanings given in the description, which are useful in the prophylaxis and in the treatment of arrhythmias, in particular atrial and ventricular arrhythmias.
摘要翻译：提供式I化合物，其中R 1至R 7具有在描述中给出的含义，其可用于预防和治疗心律失常，特别是心房和室性心律失常。

2. 发明申请

US20080015237A1 NEW COMPOUNDS I/418 审中-公开
标题翻译：新化合物I / 418
公开(公告)号：US20080015237A1
公开(公告)日：2008-01-17
申请号：US11776250
申请日：2007-07-11
申请人： Annika Bjore , Jonas Bostrom , Ojvind Davidsson , Hans Emtenas , Ulrik Gran , Tommy Iliefski , Johan Kajanus , Roine Olsson , Gert Strandlund , Johan Sundell , Zhong-Qing Yuan , Lars Sandberg
发明人： Annika Bjore , Jonas Bostrom , Ojvind Davidsson , Hans Emtenas , Ulrik Gran , Tommy Iliefski , Johan Kajanus , Roine Olsson , Gert Strandlund , Johan Sundell , Zhong-Qing Yuan , Lars Sandberg
IPC分类号： A61K31/4035 , A61K31/421 , A61K31/422 , A61P9/06 , C07D209/44 , C07D263/00 , C07D413/02
CPC分类号： C07D209/46 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/10 , C07D403/12 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/06 , C07D409/12 , C07D413/06 , C07D413/12 , C07D413/14
摘要： There is provided compounds of formula I, wherein R1 to R7 have meanings given in the description, which are useful in the prophylaxis and in the treatment of arrhythmias, in particular atrial and ventricular arrhythmias.
摘要翻译：提供式I化合物，其中R 1至R 7具有在描述中给出的含义，其可用于预防和治疗心律失常，特别是心房和室性心律失常。

3. 发明申请

US20130345248A1 Cyclohexane-1,2'-Naphthalene-1',2"-Imidazol Compounds and Their Use as Bace 有权
标题翻译：环己烷-1,2'-萘-1'，2“ - 咪唑化合物及其作为Bace的用途
公开(公告)号：US20130345248A1
公开(公告)日：2013-12-26
申请号：US13916731
申请日：2013-06-13
申请人： Sofia Karlstrom , Lars Sandberg , Peter Soderman , Karin Kolmodin , Liselotte Ohberg
发明人： Sofia Karlstrom , Lars Sandberg , Peter Soderman , Karin Kolmodin , Liselotte Ohberg
IPC分类号： C07D235/02 , A61K45/06 , A61K31/4439 , A61K31/4184 , C07D401/04
CPC分类号： C07D235/02 , A61K31/4184 , A61K31/4439 , A61K45/06 , C07D401/02 , C07D401/04 , C07D491/107
摘要： Cyclohexane-1,2′-naphthalene-1′,2″-imidazole compounds, therapeutically acceptable salts thereof, processes for preparation thereof, therapeutic uses of such compounds for treating Aβ-related pathologies such as Down's syndrome, β-amyloid angiopathy, Alzheimer's disease, memory loss, attention deficit symptoms associated with Alzheimer's disease, neurodegeneration associated with diseases such as Alzheimer's disease or dementia including dementia of mixed vascular and degenerative origin, pre-senile dementia, senile dementia and dementia associated with Parkinson's disease, progressive supranuclear palsy or cortical basal degeneration, methods of therapy using such compounds, and pharmaceutical compositions containing such compounds.
摘要翻译：环己烷-1,2'-萘-1'，2“ - 咪唑化合物，其治疗上可接受的盐，其制备方法，这些化合物治疗Abeta相关病症如唐氏综合征，β-淀粉样血管病，阿尔茨海默病，记忆丧失，与阿尔茨海默病相关的注意力缺陷症状，与诸如阿尔茨海默病或痴呆的疾病相关的神经变性，包括混合血管和退行性起源的痴呆，老年痴呆，老年痴呆和与帕金森病相关的痴呆，进行性核上性麻痹或皮层基底变性，使用这些化合物的治疗方法，以及含有这些化合物的药物组合物。

4. 发明申请

US20120238579A1 New Compounds 806 审中-公开
标题翻译：新化合物806
公开(公告)号：US20120238579A1
公开(公告)日：2012-09-20
申请号：US13427981
申请日：2012-03-23
申请人： Yevgeni Besidki , Inger Kers , Martin Nylôf , Lars Sandberg , Karin Skogholm
发明人： Yevgeni Besidki , Inger Kers , Martin Nylôf , Lars Sandberg , Karin Skogholm
IPC分类号： C07D405/10 , C07D405/14 , A61P25/00 , A61K31/497 , A61K31/498 , A61K31/501 , A61K31/4433 , A61K31/506
CPC分类号： C07D405/14
摘要： The present invention relates to new compounds of formula (I) and to pharmaceutical composition containing said compounds and to the use of said compounds in therapy. The present invention further relates to processes for the preparation of said compounds and to new intermediates useful in the preparation thereof.
摘要翻译：本发明涉及新的式（I）化合物和含有所述化合物的药物组合物和所述化合物在治疗中的用途。本发明还涉及制备所述化合物的方法和可用于其制备的新中间体。

5. 发明授权

US08143408B2 N-(8-heteroaryltetrahydronaphtalene-2yl) or N-(5-heteroarylchromane-3-yl) carboxamide derivatives for the treatment of pain 失效
标题翻译：用于治疗疼痛的N-（8-杂芳基四氢萘-2-基）或N-（5-杂芳基苯并二氢吡喃-3-基）甲酰胺衍生物
公开(公告)号：US08143408B2
公开(公告)日：2012-03-27
申请号：US12596878
申请日：2008-04-22
申请人： Yevgeni Besidski , Inger Kers , Martin Nylöf , Lars Sandberg , Karin Skogholm
发明人： Yevgeni Besidski , Inger Kers , Martin Nylöf , Lars Sandberg , Karin Skogholm
IPC分类号： C07D401/00
CPC分类号： C07D405/14
摘要： The present invention relates to new compounds of formula (I) and to pharmaceutical composition containing said compounds and to the use of said compounds in therapy. The present invention further relates to processes for the preparation of said compounds and to new intermediates useful in the preparation thereof.
摘要翻译：本发明涉及新的式（I）化合物和含有所述化合物的药物组合物和所述化合物在治疗中的用途。本发明还涉及制备所述化合物的方法和可用于其制备的新中间体。

6. 发明授权

US07389875B2 Locking sleeve package and blank therefor 有权
标题翻译：锁紧套筒包装和空白
公开(公告)号：US07389875B2
公开(公告)日：2008-06-24
申请号：US11019398
申请日：2004-12-23
申请人： Lars Sandberg , Marcus Dehlin , Antje Rosentreter
发明人： Lars Sandberg , Marcus Dehlin , Antje Rosentreter
IPC分类号： B65D83/04
CPC分类号： B65D83/0463 , B65D5/38 , B65D2215/02
摘要： A package includes a top panel, a bottom panel, a first side panel connecting the top panel and the bottom panel to each other and a second side panel also connecting the top panel and the bottom panel to each other. The bottom panel, the first side panel, the top panel and the second side panel form a sleeve having a cross-section essentially formed as a rectangle. The sleeve is adapted to slidably receive an insert along a sliding direction normal to the rectangle. The package includes a locking member which includes an arch-shaped portion extending into the rectangular cross section to releasably retain the insert. The present disclosure also relates to a blank for forming the package.
摘要翻译：包装包括顶板，底板，将顶板和底板彼此连接的第一侧板以及将顶板和底板相互连接的第二侧板。底板，第一侧板，顶板和第二侧板形成具有基本上形成为矩形的横截面的套筒。套筒适于沿着垂直于矩形的滑动方向可滑动地接收插入件。该包装包括锁定构件，该锁定构件包括延伸到矩形横截面中以可释放地保持插入件的拱形部分。本公开还涉及用于形成包装的坯料。

7. 发明授权

US06543397B2 Limitation of controllable operating parameters in an engine 失效
公开(公告)号：US06543397B2
公开(公告)日：2003-04-08
申请号：US09682799
申请日：2001-10-19
申请人： Lars Sandberg , Martin Litorell
发明人： Lars Sandberg , Martin Litorell
IPC分类号： F02D4102
CPC分类号： F02D41/0235 , F02D41/1495 , F02D41/187 , F02D2011/102 , F02D2041/389
摘要： The invention relates to a method for limitation of at least one controllable operating parameter that can cause ageing of at least one component or one material in connection with an engine. The method includes the steps of determination of a maximum limit value allowed regarding the operating parameter and control of the engine so that the limit value is not exceeded, thereby limiting ageing of the component or material. The invention includes continuous determination of a measure that corresponds to the degree of impairment of the component that depends on ageing, wherein said determination of the limit value is made depending on the measure. The invention also relates to an arrangement for accomplishing this method. By means of the invention, an improved method and arrangement is provided for limitation of ageing of components and materials that, in particular, are arranged in connection with a combustion engine in a vehicle, thereby providing improved fuel consumption, improved emissions and improved performance of the vehicle.

8. 发明申请

US20190152943A1 TETRAHYDROINDAZOLES AND MEDICAL USES THEREOF 审中-公开
公开(公告)号：US20190152943A1
公开(公告)日：2019-05-23
申请号：US15772650
申请日：2016-11-11
申请人： Sonia Lain , Catherine Drummond , Ingeborg van Leeuwen , Martin Haraldsson , Lars Johansson , Lars Sandberg , Ulrika Yngve
发明人： Sonia Lain , Catherine Drummond , Ingeborg van Leeuwen , Martin Haraldsson , Lars Johansson , Lars Sandberg , Ulrika Yngve
IPC分类号： C07D401/12 , A61P35/00 , A61P31/14 , A61K45/06 , A61K31/4439 , C07D417/12 , A61K31/427 , C07D413/12 , A61K31/422 , C07D403/12 , A61K31/497 , C07D405/12 , A61K31/416 , C07D409/12 , C07D471/04 , A61K31/437 , A61K31/5377 , A61K31/506
摘要： There is herein provided a compound of formula I (I) or a pharmaceutically acceptable salt thereof, for use in the treatment of cancer and/or the treatment or prevention of a viral infection, wherein A1, A2, L1, R1, R2 and n have meanings as provided in the description.

9. 发明申请

US20130345246A1 2H-Imidazol-4-Amine Compounds and Their Use as Bace Inhibitors 有权
标题翻译： 2H-咪唑-4-胺化合物及其作为抑制剂的用途
公开(公告)号：US20130345246A1
公开(公告)日：2013-12-26
申请号：US13916690
申请日：2013-06-13
申请人： Sofia Karlstrom , Gabor Csjernyik , Britt-Marie Swahn , Lars Sandberg , Karin Kolmodin , Peter Soderman , Liselotte Ohberg
发明人： Sofia Karlstrom , Gabor Csjernyik , Britt-Marie Swahn , Lars Sandberg , Karin Kolmodin , Peter Soderman , Liselotte Ohberg
IPC分类号： C07D235/02 , A61K45/06 , A61K31/4439 , C07D401/04 , A61K31/4184
CPC分类号： C07D235/02 , A61K31/4184 , A61K31/4439 , A61K45/06 , C07D401/02 , C07D401/04
摘要： 2H-imidazol-4-amine compounds, therapeutically acceptable salts thereof, processes for preparation thereof, therapeutic uses of such compounds for treating Aβ-related pathologies such as Down's syndrome, β-amyloid angiopathy, Alzheimer's disease, memory loss, attention deficit symptoms associated with Alzheimer's disease, neurodegeneration associated with diseases such as Alzheimer's disease or dementia including dementia of mixed vascular and degenerative origin, pre-senile dementia, senile dementia and dementia associated with Parkinson's disease, progressive supranuclear palsy or cortical basal degeneration. methods of therapy, and pharmaceutical compositions containing such compounds.
摘要翻译： 2H-咪唑-4-胺化合物，其治疗上可接受的盐，其制备方法，这些化合物治疗Abeta相关病症如唐氏综合征，β-淀粉样血管病，阿尔茨海默病，记忆丧失，注意力缺陷症状相关的治疗用途阿尔茨海默病，与阿尔茨海默病或痴呆等疾病相关的神经变性，包括混合血管和退行性痴呆，老年痴呆，老年性痴呆和与帕金森病相关的痴呆，进行性核上性麻痹或皮质基底变性。治疗方法和含有这些化合物的药物组合物。

10. 发明申请

US20130210837A1 Compounds and Their Use as BACE Inhibitors 有权
标题翻译：化合物及其用作BACE抑制剂
公开(公告)号：US20130210837A1
公开(公告)日：2013-08-15
申请号：US13833221
申请日：2013-03-15
申请人： Gabor Csjernyik , Sofia Karlstrom , Annika Kers , Karin Kolmodin , Martin Nylof , Liselotte Ohberg , Laszlo Rakos , Lars Sandberg , Fernando Sehgelmeble , Peter Soderman , Britt-Marie Swahn , Stefan Von Berg
发明人： Gabor Csjernyik , Sofia Karlstrom , Annika Kers , Karin Kolmodin , Martin Nylof , Liselotte Ohberg , Laszlo Rakos , Lars Sandberg , Fernando Sehgelmeble , Peter Soderman , Britt-Marie Swahn , Stefan Von Berg
IPC分类号： C07D491/107 , C07D491/20 , C07D471/04 , C07D235/02
CPC分类号： A61K31/497 , A61K31/4184 , A61K31/4188 , A61K31/437 , A61K31/4439 , A61K31/506 , A61K45/06 , A61K2300/00 , C07D235/02 , C07D401/04 , C07D401/12 , C07D403/12 , C07D405/12 , C07D471/04 , C07D491/107 , C07D491/20
摘要： The present invention relates to compounds of formula (I) and their pharmaceutical compositions. In addition, the present invention relates to therapeutic methods for the treatment and/or prevention of Aβ-related pathologies such as Down's syndrome, β-amyloid angiopathy such as but not limited to cerebral amyloid angiopathy or hereditary cerebral hemorrhage, disorders associated with cognitive impairment such as but not limited to MCI (“mild cognitive impairment”), Alzheimer's disease, memory loss, attention deficit symptoms associated with Alzheimer's disease, neurodegeneration associated with diseases such as Alzheimer's disease or dementia including dementia of mixed vascular and degenerative origin, pre-senile dementia, senile dementia and dementia associated with Parkinson's disease, progressive supranuclear palsy or cortical basal degeneration.
摘要翻译：本发明涉及式（I）化合物及其药物组合物。此外，本发明涉及用于治疗和/或预防与Abeta相关的病理学的治疗方法，例如唐氏综合征，β-淀粉样变性血管病，例如但不限于脑淀粉样血管病或遗传性脑出血，与认知障碍相关的疾病例如但不限于MCI（“轻度认知障碍”），阿尔茨海默病，记忆丧失，与阿尔茨海默病相关的注意力缺陷症状，与诸如阿尔茨海默病或痴呆的疾病相关的神经变性，包括混合血管和退行性起源的痴呆，老年性痴呆，老年性痴呆和与帕金森病相关的痴呆，进行性核上性麻痹或皮质基底变性。

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