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1. 发明申请

US20100317727A1 ROSEMARY EXTRACTS, DIETARY AND PHARMACEUTICAL COMPOSTIONS CONTAINING THEM AND THEIR USES 审中-公开
标题翻译：含有它们的挥发性提取物，膳食和药物组合物及其用途
公开(公告)号：US20100317727A1
公开(公告)日：2010-12-16
申请号：US12515320
申请日：2007-11-22
申请人： Antoine De Saizieu , Ann Fowler , Regina Goralczyk , Claus Kilpert , Goede Schueler
发明人： Antoine De Saizieu , Ann Fowler , Regina Goralczyk , Claus Kilpert , Goede Schueler
IPC分类号： A61K31/352 , A61P25/00 , A61P25/24 , A61P25/18 , A61P25/20
CPC分类号： A61K36/53
摘要： The present invention refers to rosemary extracts for use as medicament for the treatment of a disorder connected to reduced neurotransmission, as well as to dietary and pharmaceutical compositions containing such rosemary extracts and their uses.
摘要翻译：本发明涉及用作治疗与减少的神经传递相关的病症的药物的迷迭香提取物，以及含有这种迷迭香提取物及其用途的饮食和药物组合物。

2. 发明申请

US20100099753A1 Dietary and pharmaceutical compositions containing tricyclic diterpenes and their derivates and their uses 失效
标题翻译：含有三环二萜及其衍生物及其用途的膳食和药物组合物
公开(公告)号：US20100099753A1
公开(公告)日：2010-04-22
申请号：US12654596
申请日：2009-12-23
申请人： Antoine De Saizieu , Ann Fowler , Regina Goralczyk , Claus Kilpert , Goede Schueler , Christof Wehrli
发明人： Antoine De Saizieu , Ann Fowler , Regina Goralczyk , Claus Kilpert , Goede Schueler , Christof Wehrli
IPC分类号： A61K31/335 , A61K31/215 , A61K31/19 , A61K31/122 , A61K31/05
CPC分类号： A61K31/192 , A23K20/105 , A23K50/40 , A23L33/10 , A23L33/105 , A23V2002/00 , A61K31/085 , A61K31/122 , A61K31/19 , A61K31/365 , A23V2200/322 , A23V2250/21
摘要： The present invention refers to tricyclic diterpenes and their derivatives of the formulae (I) and (II), wherein R1 is hydrogen or C1-6-alkyl; R2 is hydroxy, C3-5-acyloxy, hydroxymethyl, 1,3-dihydroxypropyl or C1-6-alkyl; R3 and R4 independently from each other are hydrogen, hydroxy, hydroxymethyl, C1-5-acyloxy or C1-6-alkoxy; R5 is C1-6-alkyl, hydroxymethyl carboxy or methoxycarbonyl; R9 is hydrogen, hydroxymethyl, methoxy, oxo or C1-5-acyloxy; R10 is hydrogen, or R5 and R9 taken together are —CH2—O— or —O—CH2—; or R5 and R10 taken together are —CO—O—, —O—CO—, —CH2—O— or —O—CH2—; R6 is hydrogen, or R5 and R6 together form a bond; R7 and R8 independently from each other are C1-6-alkyl, carboxy, x-hydroxy-Cx-alkyl (with x being an integer from 1 to 6), or C1-6-alkoxycarbonyl with the proviso that at least one of R7 and R8 is C1-6-alkyl; R11 and R12 are both hydrogen or R11 and R12 together are oxo, with the further proviso for formula (I) that if R2 is hydroxy R1 is C1-6-alkyl, for use as medicaments for the treatment of a disorder connected to impaired neurotransmission, as well as to dietary and pharmaceutical compositions and their uses.
摘要翻译：本发明涉及式（I）和（II）的三环二萜及其衍生物，其中R 1是氢或C 1-6 - 烷基; R2是羟基，C3-5-酰氧基，羟甲基，1,3-二羟基丙基或C1-6烷基; R 3和R 4彼此独立地是氢，羟基，羟甲基，C 1-5 - 酰氧基或C 1-6 - 烷氧基; R5是C1-6烷基，羟甲基羧基或甲氧基羰基; R9是氢，羟甲基，甲氧基，氧代或C1-5-酰氧基; R 10是氢，或者R 5和R 9一起是-CH 2 -O-或-O-CH 2 - ; 或R 5和R 10一起是-CO-O-，-O-CO-，-CH2-O-或-O-CH2-; R6是氢，或R5和R6一起形成键; R 7和R 8彼此独立地是C 1-6 - 烷基，羧基，x-羟基-C 1-6 - 烷基（x是1至6的整数）或C 1-6 - 烷氧基羰基，条件是R 7 并且R 8是C 1-6 - 烷基; R 11和R 12都是氢或R 11和R 12一起是氧代，进一步的条件是式（I），如果R 2是羟基，则R 1是C 1-6 - 烷基，用作治疗与神经传递受损有关的病症的药物，以及饮食和药物组合物及其用途。

3. 发明申请

US20100074976A1 NOVEL AGENTS FOR THE TREATMENT OF DISORDERS CONNECTED TO IMPAIRED NEUROTRANSMISSION 审中-公开
标题翻译：治疗与受神经衰弱有关的疾病的新药物
公开(公告)号：US20100074976A1
公开(公告)日：2010-03-25
申请号：US12375582
申请日：2007-08-09
申请人： Ann Fowler , Regina Goralczyk , Claus Kilpert , Goede Schueler
发明人： Ann Fowler , Regina Goralczyk , Claus Kilpert , Goede Schueler
IPC分类号： A61K36/53 , A61P25/00
CPC分类号： A61K36/53 , A23K10/30 , A23K50/40 , A23K50/50 , A23L2/52 , A23L7/126 , A23L33/105 , A23V2002/00 , A61K31/05 , A61K31/122 , A61K2300/00 , A23V2200/322 , A23V2250/21
摘要： The present invention relates to the use of oregano extracts and their volatile components for the treatment of disorders connected to impaired neurotransmission in animals including humans as well as to dietary supplements, food and feed or pharmaceutical compositions containing such extracts or their volatile components
摘要翻译：本发明涉及使用牛至提取物及其挥发性成分来治疗与包括人在内的动物以及膳食补充剂，食物和饲料或含有这些提取物或其挥发性成分的药物组合物相关的障碍性神经传递障碍

4. 发明授权

US08227508B2 Dietary and pharmaceutical compositions containing carnosol and/or rosmanol and their uses 有权
标题翻译：含有鼠尾草酚和/或罗斯曼醇的饮食和药物组合物及其用途
公开(公告)号：US08227508B2
公开(公告)日：2012-07-24
申请号：US12514881
申请日：2007-11-22
申请人： Ann Fowler , Regina Goralczyk , Claus Kilpert , Hasan Mohajeri , Daniel Raederstorff , Antoine De Saizieu , Goede Schueler , Ying Wang-Schmidt , Christof Wehrli
发明人： Ann Fowler , Regina Goralczyk , Claus Kilpert , Hasan Mohajeri , Daniel Raederstorff , Antoine De Saizieu , Goede Schueler , Ying Wang-Schmidt , Christof Wehrli
IPC分类号： A61K31/352 , C07D311/78
CPC分类号： A61K31/365 , A23K20/10 , A23K20/111 , A23L33/105 , A61K2300/00
摘要： The present invention refers to carnosol and rosmanol for use (as medicament) in the treatment of a disorder connected to reduced neurotransmission, cognitive dysfunction and/or symptoms caused by headache and/or migraine, as well as to dietary and pharmaceutical compositions and their uses.
摘要翻译：本发明涉及用于治疗与减少的神经传递，认知功能障碍和/或由头痛和/或偏头痛引起的症状相关的病症的鼠属溶胶和rosmanol，以及饮食和药物组合物及其用途。

5. 发明申请

US20120183635A1 ROSEMARY EXTRACTS, DIETARY AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USES 审中-公开
标题翻译：挥发性提取物，含有它们的食物和药物组合物及其用途
公开(公告)号：US20120183635A1
公开(公告)日：2012-07-19
申请号：US13433318
申请日：2012-03-29
申请人： Antoine De Saizieu , Ann Fowler , Regina Goralczyk , Claus Kilpert , Goede Schueler
发明人： Antoine De Saizieu , Ann Fowler , Regina Goralczyk , Claus Kilpert , Goede Schueler
IPC分类号： A61K36/53 , A61P25/00
CPC分类号： A61K36/53
摘要： Rosemary extracts are used in the treatment of disorders connected to reduced neurotransmission, as well as dietary and pharmaceutical compositions containing these rosemary extracts.
摘要翻译：迷迭香提取物用于治疗与减少的神经传递相关的疾病，以及含有这些迷迭香提取物的饮食和药物组合物。

6. 发明授权

US08552055B2 Dietary and pharmaceutical compositions containing tricyclic diterpenes and their derivates and their uses 失效
标题翻译：含三环二萜及其衍生物及其用途的膳食和药物组合物
公开(公告)号：US08552055B2
公开(公告)日：2013-10-08
申请号：US12654596
申请日：2009-12-23
申请人： Antoine De Saizieu , Ann Fowler , Regina Goralczyk , Claus Kilpert , Goede Schueler , Christof Wehrli
发明人： Antoine De Saizieu , Ann Fowler , Regina Goralczyk , Claus Kilpert , Goede Schueler , Christof Wehrli
IPC分类号： A01N43/02 , A01N37/10 , A61K31/235 , A61K31/19
CPC分类号： A61K31/192 , A23K20/105 , A23K50/40 , A23L33/10 , A23L33/105 , A23V2002/00 , A61K31/085 , A61K31/122 , A61K31/19 , A61K31/365 , A23V2200/322 , A23V2250/21
摘要： The present invention refers to tricyclic diterpenes and their derivatives of the formulae (I) and (II), wherein R1 is hydrogen or C1-6-alkyl; R2 is hydroxy, C3-5-acyloxy, hydroxymethyl, 1,3-dihydroxypropyl or C1-6-alkyl; R3 and R4 independently from each other are hydrogen, hydroxy, hydroxymethyl, C1-5-acyloxy or C1-6-alkoxy; R5 is C1-6-alkyl, hydroxymethyl carboxy or methoxycarbonyl; R9 is hydrogen, hydroxymethyl, methoxy, oxo or C1-5-acyloxy; R10 is hydrogen, or R5 and R9 taken together are —CH2—O— or —O—CH2—; or R5 and R10 taken together are —CO—O—, —O—CO—, —CH2—O— or —O—CH2—; R6 is hydrogen, or R5 and R6 together form a bond; R7 and R8 independently from each other are C1-6-alkyl, carboxy, x-hydroxy-Cx-alkyl (with x being an integer from 1 to 6), or C1-6-alkoxycarbonyl with the proviso that at least one of R7 and R8 is C1-6-alkyl; R11 and R12 are both hydrogen or R11 and R12 together are oxo, with the further proviso for formula (I) that if R2 is hydroxy R1 is C1-6-alkyl, for use as medicaments for the treatment of a disorder connected to impaired neurotransmission, as well as to dietary and pharmaceutical compositions and their uses.
摘要翻译：本发明涉及式（I）和（II）的三环二萜及其衍生物，其中R 1是氢或C 1-6 - 烷基; R2是羟基，C3-5-酰氧基，羟甲基，1,3-二羟基丙基或C1-6烷基; R 3和R 4彼此独立地是氢，羟基，羟甲基，C 1-5 - 酰氧基或C 1-6 - 烷氧基; R5是C1-6烷基，羟甲基羧基或甲氧基羰基; R9是氢，羟甲基，甲氧基，氧代或C1-5-酰氧基; R 10是氢，或者R 5和R 9一起是-CH 2 -O-或-O-CH 2 - ; 或R 5和R 10一起是-CO-O-，-O-CO-，-CH2-O-或-O-CH2-; R6是氢，或R5和R6一起形成键; R 7和R 8彼此独立地是C 1-6 - 烷基，羧基，x-羟基-C 1-6 - 烷基（x是1至6的整数）或C 1-6 - 烷氧基羰基，条件是R 7 并且R 8是C 1-6 - 烷基; R 11和R 12都是氢或R 11和R 12一起是氧代，进一步的条件是式（I），如果R 2是羟基，则R 1是C 1-6 - 烷基，用作治疗与神经传递受损有关的病症的药物，以及饮食和药物组合物及其用途。

7. 发明申请

US20110070326A1 OREGANO EXTRACT AND ITS COMPONENTS FOR ENHANCING VIGILANCE 审中-公开
标题翻译： OREGANO提取物及其用于增强动物的组分
公开(公告)号：US20110070326A1
公开(公告)日：2011-03-24
申请号：US12847543
申请日：2010-07-30
申请人： Ann Fowler , Regina Goralczyk , Claus Kilpert , Hasan Hohajeri , Goede Schueler , Jonas Wittwer
发明人： Ann Fowler , Regina Goralczyk , Claus Kilpert , Hasan Hohajeri , Goede Schueler , Jonas Wittwer
IPC分类号： A23L1/30 , A23K1/00
CPC分类号： A23K50/48 , A23K20/10 , A23K20/105 , A23K50/40 , A23K50/42 , A23L33/105 , A61K36/53
摘要： Oregano extract can act as a stimulant, yet it does not interfere with sleep patterns or induce nervousness the way many stimulants such as caffeine can. It also has the benefits of promoting improved vigilance, improving attention and ability to focus on a task, and improving general alertness.
摘要翻译：牛至提取物可以作为兴奋剂，但它不会干扰睡眠模式或引起紧张，许多兴奋剂如咖啡因可以使用。提高警惕，提高注意力和集中精力开展工作的能力，提高一般警觉性，具有好处。

8. 发明申请

US20100048688A1 DIETARY AND PHARMACEUTICAL COMPOSITIONS CONTAINING CARNOSOL AND/OR ROSMANOL AND THEIR USES 有权
标题翻译：含有卡罗糖醇和/或罗莫诺的膳食和药物组合物及其用途
公开(公告)号：US20100048688A1
公开(公告)日：2010-02-25
申请号：US12514881
申请日：2007-11-22
申请人： Ann Fowler , Regina Goralczyk , Claus Kilpert , Hasan Mohajeri , Daniel Raederstorff , Antoine De Saizieu , Goede Schueler , Ying Wang-Schmidt , Christof Wehrli
发明人： Ann Fowler , Regina Goralczyk , Claus Kilpert , Hasan Mohajeri , Daniel Raederstorff , Antoine De Saizieu , Goede Schueler , Ying Wang-Schmidt , Christof Wehrli
IPC分类号： A61K31/352 , C07D311/78 , A61P25/00
CPC分类号： A61K31/365 , A23K20/10 , A23K20/111 , A23L33/105 , A61K2300/00
摘要： The present invention refers to carnosol and rosmanol for use (as medicament) in the treatment of a disorder connected to reduced neurotransmission, cognitive dysfunction and/or symptoms caused by headache and/or migraine, as well as to dietary and pharmaceutical compositions and their uses.
摘要翻译：本发明涉及用于治疗与减少的神经传递，认知功能障碍和/或由头痛和/或偏头痛引起的症状相关的病症的鼠属溶胶和rosmanol，以及饮食和药物组合物及其用途。

9. 发明申请

US20090099251A1 DIETARY AND PHARMACEUTICAL COMPOSITIONS CONTAINING TRICYCLIC DITERPENES AND THEIR DERIVATIVES AND THEIR USES 审中-公开
标题翻译：含有三聚磷酸酯及其衍生物及其用途的膳食和药物组合物
公开(公告)号：US20090099251A1
公开(公告)日：2009-04-16
申请号：US12297416
申请日：2007-11-22
申请人： Antoine De Saizieu , Ann Fowler , Regina Goralczyk , Claus Kilpert , Goede Schueler , Christof Wehrli
发明人： Antoine De Saizieu , Ann Fowler , Regina Goralczyk , Claus Kilpert , Goede Schueler , Christof Wehrli
IPC分类号： A61K31/335 , C07C61/22 , A61K31/19 , C07C39/12 , A61K31/05 , A61K31/122 , A61P25/00 , C07C49/543 , C07C69/74 , A61K31/215 , C07D315/00
CPC分类号： A61K31/192 , A23K20/105 , A23K50/40 , A23L33/10 , A23L33/105 , A23V2002/00 , A61K31/085 , A61K31/122 , A61K31/19 , A61K31/365 , A23V2200/322 , A23V2250/21
摘要： The present invention refers to tricyclic diterpenes and their derivatives of the formulae (I) and (II), wherein R1 is hydrogen or C1-6-alkyl; R2 is hydroxy, C3-5-acyloxy, hydroxymethyl, 1,3-dihydroxypropyl or C1-6-alkyl; R3 and R4 independently from each other are hydrogen, hydroxy, hydroxymethyl, C1-5-acyloxy or C1-6-alkoxy; R5 is C1-6-alkyl, hydroxymethyl carboxy or methoxycarbonyl; R9 is hydrogen, hydroxymethyl, methoxy, oxo or C1-5-acyloxy; R10 is hydrogen, or R5 and R9 taken together are —CH2—O— or —O—CH2—; or R5 and R10 taken together are —CO—O—, —O—CO—, —CH2—O— or —O—CH2—; R6 is hydrogen, or R5 and R6 together form a bond; R7 and R8 independently from each other are C1-6-alkyl, carboxy, x-hydroxy-Cx-alkyl (with x being an integer from 1 to 6), or C1-6-alkoxycarbonyl with the proviso that at least one of R7 and R8 is C1-6-alkyl; R11 and R12 are both hydrogen or R11 and R12 together are oxo, with the further proviso for formula (I) that if R2 is hydroxy R1 is C1-6-alkyl, for use as medicaments for the treatment of a disorder connected to impaired neurotransmission, as well as to dietary and pharmaceutical compositions and their uses.
摘要翻译：本发明涉及式（I）和（II）的三环二萜及其衍生物，其中R 1是氢或C 1-6 - 烷基; R2是羟基，C3-5-酰氧基，羟甲基，1,3-二羟基丙基或C1-6烷基; R 3和R 4彼此独立地是氢，羟基，羟甲基，C 1-5 - 酰氧基或C 1-6 - 烷氧基; R5是C1-6烷基，羟甲基羧基或甲氧基羰基; R9是氢，羟甲基，甲氧基，氧代或C1-5-酰氧基; R 10是氢，或者R 5和R 9一起是-CH 2 -O-或-O-CH 2 - ; 或R 5和R 10一起是-CO-O-，-O-CO-，-CH2-O-或-O-CH2-; R6是氢，或R5和R6一起形成键; R 7和R 8彼此独立地是C 1-6 - 烷基，羧基，x-羟基-C 1-6 - 烷基（x是1至6的整数）或C 1-6 - 烷氧基羰基，条件是R 7 并且R 8是C 1-6 - 烷基; R 11和R 12都是氢或R 11和R 12一起是氧代，进一步的条件是式（I），如果R 2是羟基，则R 1是C 1-6 - 烷基，用作治疗与神经传递受损有关的病症的药物，以及饮食和药物组合物及其用途。

10. 发明申请

US20110038957A1 NOVEL NUTRACEUTICAL COMPOSITIONS CONTAINING STEVIA EXTRACT OR STEVIA EXTRACT CONSTITUENTS AND USES THEREOF 审中-公开
标题翻译：含有维生素提取物或维生素提取物的新型营养组合物及其用途
公开(公告)号：US20110038957A1
公开(公告)日：2011-02-17
申请号：US12745421
申请日：2008-12-03
申请人： Ann Fowler , Regina Goralczyk , Claus Kilpert , Annis Olivia Mayne-Mechan , Bernd Mussler , Adrian Wyss
发明人： Ann Fowler , Regina Goralczyk , Claus Kilpert , Annis Olivia Mayne-Mechan , Bernd Mussler , Adrian Wyss
IPC分类号： A61K31/19 , A61K36/28 , A61P25/00
CPC分类号： A61K31/704 , A23K20/10 , A23K20/163 , A23K50/40 , A23L27/36 , A23L33/105 , A61K36/28
摘要： The invention relates to a novel nutraceutical composition containing Stevia extract or its constituents, such as steviol and stevioside, as active ingredient(s). The term “nutraceutical” as used herein denotes usefulness in nutritional, pharmaceutical and veterinary fields of application. The compositions are useful for improvement of cognitive functions, such as learning, memory and alertness, and psychotic stability.
摘要翻译：本发明涉及含有甜叶菊提取物或其成分如甜菊醇和甜菊苷作为活性成分的新型营养组合物。本文所用的术语“营养制品”表示在营养，药物和兽医领域的有用性。该组合物可用于改善认知功能，例如学习，记忆和警觉性以及精神稳定性。

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