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1. 发明授权

US08846411B2 Derivatives, reagents, and immunoassay for detecting levetiracetam 有权
标题翻译：用于检测左乙拉西坦的衍生物，试剂和免疫测定
公开(公告)号：US08846411B2
公开(公告)日：2014-09-30
申请号：US12797348
申请日：2010-06-09
申请人： Anlong Ouyang , Aniruddha Patwardhan , Lili Arabshahi
发明人： Anlong Ouyang , Aniruddha Patwardhan , Lili Arabshahi
IPC分类号： G01N33/53 , C07D207/09 , C07K2/00 , C07K16/44 , G01N33/94 , C07D207/16 , C07D207/27 , C07D403/12
CPC分类号： C07K16/44 , C07D207/16 , C07D207/27 , C07D403/12 , G01N33/9473
摘要： Levetiracetam (LEV) derivatives, methods for synthesizing LEV derivatives, and immunodiagnostic assays for LEV. The synthesis methods described herein include chirally-selective, liquid-phase synthesis steps to produce selected LEV derivatives in high-yield. LEV derivatives can include operative groups, such as: immunogenic moieties that can be used to prepare anti-LEV antibodies; antigenic moieties that can be used in immunodiagnostic assays for LEV; or tracer moieties that can be used in immunodiagnostic assays. Additionally, the LEV derivatives can be used in immunodiagnostic assays to compete with LEV for anti-LEV antibodies.
摘要翻译：左乙拉西坦（LEV）衍生物，LEV衍生物合成方法，LEV免疫诊断试验。本文所述的合成方法包括以高产率产生选定的LEV衍生物的手性选择性液相合成步骤。 LEV衍生物可以包括手术组，例如：可用于制备抗LEV抗体的免疫原性部分; 可用于LEV的免疫诊断测定中的抗原部分; 或可用于免疫诊断测定中的示踪剂部分。此外，LEV衍生物可用于免疫诊断测定，以与LEV竞争抗LEV抗体。

2. 发明申请

US20100317024A1 DERIVATIVES, REAGENTS, AND IMMUNOASSAY FOR DETECTING LEVETIRACETAM 有权
标题翻译：衍生物，试剂和免疫测定用于检测LEVETIRACETAM
公开(公告)号：US20100317024A1
公开(公告)日：2010-12-16
申请号：US12797348
申请日：2010-06-09
申请人： Anlong Ouyang , Aniruddha Patwardhan , Lili Arabshahi
发明人： Anlong Ouyang , Aniruddha Patwardhan , Lili Arabshahi
IPC分类号： G01N33/53 , C07D207/09 , C07D207/12 , C07K2/00 , C07H3/00 , C07H21/00 , C07H11/04 , C12N11/02
CPC分类号： C07K16/44 , C07D207/16 , C07D207/27 , C07D403/12 , G01N33/9473
摘要： Levetiracetam (LEV) derivatives, methods for synthesizing LEV derivatives, and immunodiagnostic assays for LEV. The synthesis methods described herein include chirally-selective, liquid-phase synthesis steps to produce selected LEV derivatives in high-yield. LEV derivatives can include operative groups, such as: immunogenic moieties that can be used to prepare anti-LEV antibodies; antigenic moieties that can be used in immunodiagnostic assays for LEV; or tracer moieties that can be used in immunodiagnostic assays. Additionally, the LEV derivatives can be used in immunodiagnostic assays to compete with LEV for anti-LEV antibodies.
摘要翻译：左乙拉西坦（LEV）衍生物，LEV衍生物合成方法，LEV免疫诊断试验。本文所述的合成方法包括以高产率产生选定的LEV衍生物的手性选择性液相合成步骤。 LEV衍生物可以包括手术组，例如：可用于制备抗LEV抗体的免疫原性部分; 可用于LEV的免疫诊断测定中的抗原部分; 或可用于免疫诊断测定中的示踪剂部分。此外，LEV衍生物可用于免疫诊断测定，以与LEV竞争抗LEV抗体。

3. 发明授权

US07655429B2 Immunoassays for topiramate 有权
标题翻译：托吡酯的免疫测定
公开(公告)号：US07655429B2
公开(公告)日：2010-02-02
申请号：US11858426
申请日：2007-09-20
申请人： Anlong Ouyang , Lili Arabshahi
发明人： Anlong Ouyang , Lili Arabshahi
IPC分类号： G01N33/53 , G01N33/573 , G01N33/532 , C07K16/00 , C07K1/04 , G01N33/533 , C07D321/10
CPC分类号： C07H5/04 , C07H9/04 , G01N33/9473 , Y10S436/815
摘要： Topiramate analogs have substituents at the sulfamate group, 9-position, or 10-position. Topiramate analogs may include immunogenic moieties to prepare anti-topiramate antibodies, or antigenic moieties for immunodiagnostic assays. Also, the topiramate analog can include tracer moieties for detecting the presence or amount of the analog during an immunodiagnostic assay. Additionally, the topiramate analogs can be used in immunodiagnostic assays to compete with topiramate for binding with anti-topiramate antibodies. Such an immunodiagnostic assay can be used for detecting the presence of topiramate in a sample obtained from a subject previously administered topiramate by the following: combining an anti-topiramate antibody and a topiramate analog with a sample to form a first composition; allowing any free topiramate from the sample and the topiramate analog to compete for binding with the antibody; detecting binding between the topiramate analog and the antibody.
摘要翻译：托吡酯类似物在氨基磺酸盐基团，9-位或10-位具有取代基。托吡酯类似物可以包括免疫原性部分以制备抗托吡酯抗体或用于免疫诊断测定的抗原部分。此外，托吡酯类似物可以包括用于在免疫诊断测定期间检测模拟物的存在或量的示踪剂部分。此外，托吡酯类似物可用于免疫诊断测定以与托吡酯竞争与抗托吡酯抗体结合。通过以下方法，这种免疫诊断测定可用于检测从先前施用托吡酯的受试者获得的样品中托吡酯的存在：将抗托吡酯与托吡酯类似物与样品结合以形成第一组合物; 允许来自样品和托吡酯类似物的任何游离托吡酯与抗体竞争结合; 检测托吡酯类似物和抗体之间的结合。

4. 发明授权

US08592564B2 Immunoassays for lamotrigine 有权
标题翻译：拉莫三嗪的免疫测定
公开(公告)号：US08592564B2
公开(公告)日：2013-11-26
申请号：US12693341
申请日：2010-01-25
申请人： Anlong Ouyang , Lili Arabshahi , Mark Roberts , Melissa Wall
发明人： Anlong Ouyang , Lili Arabshahi , Mark Roberts , Melissa Wall
IPC分类号： C07K16/00 , C07K1/04 , C07K1/13
CPC分类号： C07D253/075 , C07K16/44 , G01N33/6854 , G01N33/94 , G01N33/9473 , Y10S436/815 , Y10T436/13
摘要： Generally, the present invention relates to lamotrigine analogs that have substituents at the triazine 3-position and on the benzene 4-position and 5-position. The lamotrigine analogs can include immunogenic moieties that can be used to prepare anti-lamotrigine antibodies, or antigenic moieties that can be used in immunodiagnostic assays for lamotrigine. Also, the lamotrigine analog can include tracer moieties for detecting the presence or amount of the analog during an immunodiagnostic assay. Additionally, the lamotrigine analogs can be used in immunodiagnostic assays to compete with lamotrigine for binding with anti-lamotrigine antibodies.
摘要翻译：通常，本发明涉及在三嗪3-位和苯4-位和5-位具有取代基的拉莫三嗪类似物。拉莫三嗪类似物可以包括可用于制备抗拉莫三嗪抗体的免疫原性部分，或可用于拉莫三嗪的免疫诊断测定的抗原部分。此外，拉莫三嗪类似物可以包括用于在免疫诊断测定期间检测模拟物的存在或量的示踪剂部分。另外，拉莫三嗪类似物可用于免疫诊断测定以与拉莫三嗪竞争与抗拉莫三嗪抗体结合。

5. 发明申请

US20060088886A1 Topiramate analogs 审中-公开
标题翻译：托吡酯类似物
公开(公告)号：US20060088886A1
公开(公告)日：2006-04-27
申请号：US11254598
申请日：2005-10-20
申请人： Anlong Ouyang , Lili Arabshahi
发明人： Anlong Ouyang , Lili Arabshahi
IPC分类号： G01N33/53 , C07K14/47 , C07H5/04
CPC分类号： G01N33/9473 , C07H5/04
摘要： Generally, the present invention relates to topiramate analogs that have substituents at the sulfamate group or at the 9-position or 10-position. The topiramate analogs can include immunogenic moieties that can be used to prepare anti-topiramate antibodies, or antigenic moieties that can be used in immunodiagnostic assays for topiramate. Also, the topiramate analog can include tracer moieties for detecting the presence or amount of the analog during an immunodiagnostic assay. Additionally, the topiramate analogs can be used in immunodiagnostic assays to compete with topiramate for binding with anti-topiramate antibodies.
摘要翻译：通常，本发明涉及在氨基磺酸酯基或9-位或10-位具有取代基的托吡酯类似物。托吡酯类似物可以包括可用于制备抗托吡酯抗体的免疫原性部分，或可用于托吡酯的免疫诊断测定中的抗原部分。此外，托吡酯类似物可以包括用于在免疫诊断测定期间检测模拟物的存在或量的示踪剂部分。此外，托吡酯类似物可用于免疫诊断测定以与托吡酯竞争与抗托吡酯抗体结合。

6. 发明授权

US07678551B2 Immunoassays for lamotrigine 有权
标题翻译：拉莫三嗪的免疫测定
公开(公告)号：US07678551B2
公开(公告)日：2010-03-16
申请号：US11254637
申请日：2005-10-20
申请人： Anlong Ouyang , Lili Arabshahi , Mark Roberts , Melissa Wall
发明人： Anlong Ouyang , Lili Arabshahi , Mark Roberts , Melissa Wall
IPC分类号： G01N33/53 , G01N33/532 , G01N33/533 , C07K1/10 , C07K16/00
CPC分类号： C07D253/075 , C07K16/44 , G01N33/6854 , G01N33/94 , G01N33/9473 , Y10S436/815 , Y10T436/13
摘要： Generally, the present invention relates to lamotrigine analogs that have substituents at the triazine 3-position and on the benzene 4-position and 5-position. The lamotrigine analogs can include immunogenic moieties that can be used to prepare anti-lamotrigine antibodies, or antigenic moieties that can be used in immunodiagnostic assays for lamotrigine. Also, the lamotrigine analog can include tracer moieties for detecting the presence or amount of the analog during an immunodiagnostic assay. Additionally, the lamotrigine analogs can be used in immunodiagnostic assays to compete with lamotrigine for binding with anti-lamotrigine antibodies.
摘要翻译：通常，本发明涉及在三嗪3-位和苯4-位和5-位具有取代基的拉莫三嗪类似物。拉莫三嗪类似物可以包括可用于制备抗拉莫三嗪抗体的免疫原性部分，或可用于拉莫三嗪的免疫诊断测定的抗原部分。此外，拉莫三嗪类似物可以包括用于在免疫诊断测定期间检测模拟物的存在或量的示踪剂部分。另外，拉莫三嗪类似物可用于免疫诊断测定以与拉莫三嗪竞争与抗拉莫三嗪抗体结合。

7. 发明授权

US07638291B2 Immunoassays for topiramate 有权
标题翻译：托吡酯的免疫测定
公开(公告)号：US07638291B2
公开(公告)日：2009-12-29
申请号：US11254507
申请日：2005-10-20
申请人： Anlong Ouyang , Lili Arabshahi
发明人： Anlong Ouyang , Lili Arabshahi
IPC分类号： G01N33/53 , G01N33/573 , G01N33/532 , G01N33/533 , C07K16/00 , C07K1/04 , C07D321/10
CPC分类号： C07H5/04 , C07H9/04 , G01N33/9473 , Y10S436/815
摘要： Generally, the present invention relates to topiramate analogs that have substituents at the sulfamate group or at the 9-position or 10-position. The topiramate analogs can include immunogenic moieties that can be used to prepare anti-topiramate antibodies, or antigenic moieties that can be used in immunodiagnostic assays for topiramate. Also, the topiramate analog can include tracer moieties for detecting the presence or amount of the analog during an immunodiagnostic assay. Additionally, the topiramate analogs can be used in immunodiagnostic assays to compete with topiramate for binding with anti-topiramate antibodies.
摘要翻译：通常，本发明涉及在氨基磺酸酯基或9-位或10-位具有取代基的托吡酯类似物。托吡酯类似物可以包括可用于制备抗托吡酯抗体的免疫原性部分，或可用于托吡酯的免疫诊断测定中的抗原部分。此外，托吡酯类似物可以包括用于在免疫诊断测定期间检测模拟物的存在或量的示踪剂部分。此外，托吡酯类似物可用于免疫诊断测定以与托吡酯竞争与抗托吡酯抗体结合。

8. 发明申请

US20060115865A1 Lamotrigine analogs 审中-公开
标题翻译：拉莫三嗪类似物
公开(公告)号：US20060115865A1
公开(公告)日：2006-06-01
申请号：US11254650
申请日：2005-10-20
申请人： Anlong Ouyang , Lili Arabshahi , Mark Roberts
发明人： Anlong Ouyang , Lili Arabshahi , Mark Roberts
IPC分类号： G01N33/537 , C07D253/02 , C07K14/47
CPC分类号： C07D401/12 , C07D249/14 , C07D253/075
摘要： Generally, the present invention relates to lamotrigine analogs that have substituents at the triazine 3-position and on the benzene 4-position and 5-position. The lamotrigine analogs can include immunogenic moieties that can be used to prepare anti-lamotrigine antibodies, or antigenic moieties that can be used in immunodiagnostic assays for lamotrigine. Also, the lamotrigine analog can include tracer moieties for detecting the presence or amount of the analog during an immunodiagnostic assay. Additionally, the lamotrigine analogs can be used in immunodiagnostic assays to compete with lamotrigine for binding with anti-lamotrigine antibodies.
摘要翻译：通常，本发明涉及在三嗪3-位和苯4-位和5-位具有取代基的拉莫三嗪类似物。拉莫三嗪类似物可以包括可用于制备抗拉莫三嗪抗体的免疫原性部分，或可用于拉莫三嗪的免疫诊断测定的抗原部分。此外，拉莫三嗪类似物可以包括用于在免疫诊断测定期间检测模拟物的存在或量的示踪剂部分。另外，拉莫三嗪类似物可用于免疫诊断测定以与拉莫三嗪竞争与抗拉莫三嗪抗体结合。

9. 发明申请

US20060172356A1 Immunoassays for lamotrigine 有权
公开(公告)号：US20060172356A1
公开(公告)日：2006-08-03
申请号：US11254637
申请日：2005-10-20
申请人： Anlong Ouyang , Lili Arabshahi , Mark Roberts , Melissa Wall
发明人： Anlong Ouyang , Lili Arabshahi , Mark Roberts , Melissa Wall
IPC分类号： G01N33/537 , C07K16/18
CPC分类号： C07D253/075 , C07K16/44 , G01N33/6854 , G01N33/94 , G01N33/9473 , Y10S436/815 , Y10T436/13
摘要： Generally, the present invention relates to lamotrigine analogs that have substituents at the triazine 3-position and on the benzene 4-position and 5-position. The lamotrigine analogs can include immunogenic moieties that can be used to prepare anti-lamotrigine antibodies, or antigenic moieties that can be used in immunodiagnostic assays for lamotrigine. Also, the lamotrigine analog can include tracer moieties for detecting the presence or amount of the analog during an immunodiagnostic assay. Additionally, the lamotrigine analogs can be used in immunodiagnostic assays to compete with lamotrigine for binding with anti-lamotrigine antibodies.

10. 发明申请

US20060088885A1 Immunoassays for topiramate 有权
公开(公告)号：US20060088885A1
公开(公告)日：2006-04-27
申请号：US11254507
申请日：2005-10-20
申请人： Anlong Ouyang , Lili Arabshahi
发明人： Anlong Ouyang , Lili Arabshahi
IPC分类号： G01N33/53
CPC分类号： C07H5/04 , C07H9/04 , G01N33/9473 , Y10S436/815
摘要： Generally, the present invention relates to topiramate analogs that have substituents at the sulfamate group or at the 9-position or 10-position. The topiramate analogs can include immunogenic moieties that can be used to prepare anti-topiramate antibodies, or antigenic moieties that can be used in immunodiagnostic assays for topiramate. Also, the topiramate analog can include tracer moieties for detecting the presence or amount of the analog during an immunodiagnostic assay. Additionally, the topiramate analogs can be used in immunodiagnostic assays to compete with topiramate for binding with anti-topiramate antibodies.

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