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1. 发明申请

US20120040853A1 REAL TIME MULTIPLEX PCR DETECTION ON SOLID SURFACES USING DOUBLE STRANDED NUCLEIC ACID SPECIFIC DYES 审中-公开
标题翻译：使用双重棒状核酸特异性染料对固体表面进行实时多重PCR检测
公开(公告)号：US20120040853A1
公开(公告)日：2012-02-16
申请号：US13131333
申请日：2009-11-17
申请人： Anke Pierik , Derk Jan Wilfred Klunder , Marius Losif Boamfa , Richard Joseph Marinus Schroedes , Hendrik Roelof Stapert , Danielle Elisa Willemine Clout
发明人： Anke Pierik , Derk Jan Wilfred Klunder , Marius Losif Boamfa , Richard Joseph Marinus Schroedes , Hendrik Roelof Stapert , Danielle Elisa Willemine Clout
IPC分类号： C40B30/04
CPC分类号： C12Q1/6851 , C12Q2565/519 , C12Q2565/101 , C12Q2561/113
摘要： The present invention provides method allowing for real time detection of a multitude of target nucleic acids of interest in one reaction (multiplexing) using dyes that are specific for double stranded nucleic acids.
摘要翻译：本发明提供允许使用对双链核酸特异性的染料的一次反应（多重）中实时检测大量目标核酸的方法。

2. 发明申请

US20120035075A1 CARTRIDGE FOR AN AMPLIFICATION PROCESS 有权
标题翻译：用于放大过程的盒
公开(公告)号：US20120035075A1
公开(公告)日：2012-02-09
申请号：US13264187
申请日：2010-04-13
申请人： Derk Jan Wilfred Klunder , Anke Pierik , Richard Joseph Marinus Schroeders , Marius Iosif Boamfa
发明人： Derk Jan Wilfred Klunder , Anke Pierik , Richard Joseph Marinus Schroeders , Marius Iosif Boamfa
IPC分类号： C40B30/04 , B23P11/00 , B01L3/00 , C40B60/14 , C40B60/12
CPC分类号： B01L3/5027 , B01J2219/00608 , B01L7/52 , B01L9/52 , B01L9/527 , B01L2200/025 , B01L2200/141 , B01L2300/0609 , B01L2300/0636 , B01L2300/0816 , B01L2300/0819 , B01L2300/0858 , B01L2300/0887 , G01N2035/00158 , Y10T29/49826
摘要： The invention relates to real-time array PCR cartridges. The cartridge (100) has a fluid chamber (101) for a fluid bath (102) and a first support element (200) for fixing a microarray (103) in the fluid chamber (101). Thereby the first support element (200) fixes the microarray (103) in such a way that a change of a size of the microarray (103) due to thermal expansion of the microarray (103) is possible without inducing substantial mechanical stress to the cartridge (100). Thereby the cartridge materials chosen independently from thermal expansion coefficients of different microarrays that are to be inserted and fixed into the cartridge (100).
摘要翻译：本发明涉及实时阵列PCR盒。盒（100）具有用于流体槽（102）的流体室（101）和用于将微阵列（103）固定在流体室（101）中的第一支撑元件（200）。因此，第一支撑元件（200）以这样的方式固定微阵列（103），使得由于微阵列（103）的热膨胀而导致的微阵列（103）的尺寸变化是可能的，而不会对盒子造成实质的机械应力（100）。由此，盒材料独立于不同微阵列的热膨胀系数而被选择，其将被插入和固定到盒（100）中。

3. 发明申请

US20110086361A1 AMPLIFICATION OF NUCEIC ACIDS USING TEMPERATURE ZONES 审中-公开
标题翻译：使用温度区的核酸增殖
公开(公告)号：US20110086361A1
公开(公告)日：2011-04-14
申请号：US12999641
申请日：2009-06-16
申请人： Derk Jan Wilfred Klunder , Anke Pierik , Aleksey Kolesnychenko , Marius Iosif Boamfa , Richard Joseph Marinus Schroeders
发明人： Derk Jan Wilfred Klunder , Anke Pierik , Aleksey Kolesnychenko , Marius Iosif Boamfa , Richard Joseph Marinus Schroeders
IPC分类号： C12Q1/68 , C12M1/34
CPC分类号： C12Q1/6834 , B01L7/525 , B01L7/54 , B01L2300/088 , B01L2300/0883 , C12Q1/686 , C12Q2565/519 , C12Q2561/113 , C12Q2527/101
摘要： The present invention relates to the amplification and detection of amplified nucleic acid sequences employing methods and devices with distinct temperature zones. The methods and devices of the present invention may be used for quantitative analysis of target nucleic acid sequences, for simultaneous quantitative analysis of multiple target nucleic acid sequences or for analyzing a sample for the presence of a target nucleic acid.
摘要翻译：本发明涉及使用具有不同温度区的方法和装置扩增和检测扩增的核酸序列。本发明的方法和装置可用于靶核酸序列的定量分析，用于同时定量分析多个靶核酸序列或用于分析样品中靶核酸的存在。

4. 发明授权

US09114395B2 Cartridge for an amplification process 有权
标题翻译：用于放大过程的墨盒
公开(公告)号：US09114395B2
公开(公告)日：2015-08-25
申请号：US13264187
申请日：2010-04-13
申请人： Derk Jan Wilfred Klunder , Anke Pierik , Richard Joseph Marinus Schroeders , Marius Iosif Boamfa
发明人： Derk Jan Wilfred Klunder , Anke Pierik , Richard Joseph Marinus Schroeders , Marius Iosif Boamfa
IPC分类号： B01L3/00 , B23P11/00 , B01L7/00 , C40B60/12 , G01N35/00 , B01L9/00
CPC分类号： B01L3/5027 , B01J2219/00608 , B01L7/52 , B01L9/52 , B01L9/527 , B01L2200/025 , B01L2200/141 , B01L2300/0609 , B01L2300/0636 , B01L2300/0816 , B01L2300/0819 , B01L2300/0858 , B01L2300/0887 , G01N2035/00158 , Y10T29/49826
摘要： The invention relates to real-time array PCR cartridges. The cartridge (100) has a fluid chamber (101) for a fluid bath (102) and a first support element (200) for fixing a microarray (103) in the fluid chamber (101). Thereby the first support element (200) fixes the microarray (103) in such a way that a change of a size of the microarray (103) due to thermal expansion of the microarray (103) is possible without inducing substantial mechanical stress to the cartridge (100). Thereby the cartridge materials chosen independently from thermal expansion coefficients of different microarrays that are to be inserted and fixed into the cartridge (100).
摘要翻译：本发明涉及实时阵列PCR盒。药筒（100）具有用于流体浴（102）的流体室（101）和用于将微阵列（103）固定在流体室（101）中的第一支撑元件（200）。因此，第一支撑元件（200）以这样的方式固定微阵列（103），使得由于微阵列（103）的热膨胀而导致的微阵列（103）的尺寸变化是可能的，而不会对盒子造成实质的机械应力（100）。由此，盒材料独立于不同微阵列的热膨胀系数而被选择，其将被插入和固定到盒（100）中。

5. 发明申请

US20110319275A1 METHOD FOR IMMOBILIZING NUCLEIC ACIDS ON A SUPPORT 有权
标题翻译：用于在支持物上固定核酸的方法
公开(公告)号：US20110319275A1
公开(公告)日：2011-12-29
申请号：US13121206
申请日：2009-09-22
申请人： Anke Pierik , Hendrik Roelof Stapert
发明人： Anke Pierik , Hendrik Roelof Stapert
IPC分类号： C40B20/08 , C40B50/18 , C40B40/06
CPC分类号： C12Q1/6837 , C12Q2525/173
摘要： The present invention relates to a method for immobilizing nucleic acids on a support, comprising the provision of a nucleic acid with a stretch of nucleotides of only one basetype and the immobilization of said nucleic acid on a support by crosslinking by light, wherein said crosslinking by light is performed at a wavelength of about 300-500 nm, preferably at a wavelength of 365 nm. The present invention further relates to a method for the analysis of nucleic acids immobilized according to the invention, which comprises the hybridization of the immobilized nucleic acid with complementary and mismatch segments. Furthermore, the present invention relates to immobilized nucleic acids obtainable by the method of the invention, the use of accordingly immobilized nucleic acids for the production of nucleic acid arrays and a diagnostic kit, comprising an array of nucleic acids which are immobilized according to the present invention.
摘要翻译：本发明涉及用于将核酸固定在载体上的方法，其包括提供具有仅一种碱基类型的核苷酸序列的核酸和通过光交联将所述核酸固定在载体上，其中所述交联通过光在约300-500nm的波长处进行，优选在365nm的波长下进行。本发明还涉及用于分析根据本发明固定的核酸的方法，其包括将固定的核酸与互补和错配片段杂交。此外，本发明涉及通过本发明的方法可获得的固定化核酸，使用相应地固定的核酸来生产核酸阵列和诊断试剂盒，其包含根据本发明固定的核酸阵列发明。

6. 发明申请

US20090203544A1 METHOD AND USE OF A PRINTER DEVICE FOR PRODUCING BIOLOGICAL TEST ARRAYS 审中-公开
标题翻译：用于生产生物测试阵列的打印机的方法和用途
公开(公告)号：US20090203544A1
公开(公告)日：2009-08-13
申请号：US12306289
申请日：2007-07-03
申请人： Anke Pierik , Johan Frederik Dijksman , Hendrik Roelof Stapert , Roy Gerardus Franciscus Antonius Verbeek , Aleksey Kolesnychenko
发明人： Anke Pierik , Johan Frederik Dijksman , Hendrik Roelof Stapert , Roy Gerardus Franciscus Antonius Verbeek , Aleksey Kolesnychenko
IPC分类号： C40B60/14 , C40B50/14 , C40B40/00
CPC分类号： G01N35/1074 , B01J19/0046 , B01J2219/0036 , B01J2219/00378 , B01J2219/00527 , B01J2219/00659 , B01J2219/00693 , G01N35/1016 , G01N2035/1076
摘要： The invention relates to a printer device for producing biological test arrays by depositing an array of biofluids onto a substrate. The invention further relates to the use of such a device in the production of biological test arrays. The invention also relates to a method for producing a biological test array. The invention moreover relates to a biological test array. The method according to the invention is failure-proof, and results in biological test arrays of superior quality.
摘要翻译：本发明涉及一种用于通过将生物流体阵列沉积到基底上来生产生物测试阵列的打印机装置。本发明还涉及这种装置在生物测试阵列生产中的应用。本发明还涉及一种用于生产生物测试阵列的方法。本发明还涉及生物测试阵列。根据本发明的方法是无故障的，并且导致具有优良品质的生物测试阵列。

7. 发明申请

US20090264308A1 BIOSENSOR SOLID SUBSTRATE WITH INTEGRATED TEMPERATURE CONTROL AND A METHOD TO MAKE THE SAME 审中-公开
标题翻译：具有集成温度控制的生物传感器固体基板及其制造方法
公开(公告)号：US20090264308A1
公开(公告)日：2009-10-22
申请号：US12301645
申请日：2007-05-22
申请人： Dirk Jan Broer , Roel Penterman , Ralph Kurt , Emiel Peeters , Hendrik Roelof Stapert , Anke Pierik , Aleksey Kolesnychenko , Hendrik De Koning
发明人： Dirk Jan Broer , Roel Penterman , Ralph Kurt , Emiel Peeters , Hendrik Roelof Stapert , Anke Pierik , Aleksey Kolesnychenko , Hendrik De Koning
IPC分类号： C40B30/04 , C12Q1/68 , C12M1/34 , C40B40/06
CPC分类号： G01K11/16 , B01L3/508 , B01L2200/147 , B01L2300/0636 , B01L2300/0663
摘要： This invention provides a biosensor solid or hydrogel substrate comprising one or more temperature indicating agents, each of said one or more temperature indicating agents operating by changing its optical properties and being deposited in and/or at the surface of the biosensor solid or hydrogel substrate as one or more layers and/or spots
摘要翻译：本发明提供了包含一种或多种温度指示剂的生物传感器固体或水凝胶基质，所述一种或多种温度指示剂中的每一种通过改变其光学性质并沉积在生物传感器固体或水凝胶基质的表面和/ 一个或多个层和/或点

8. 发明申请

US20090033690A1 INK JET DEVICE AND METHOD FOR RELEASING A PLURALITY OF SUBSTANCES ONTO A SUBSTRATE 审中-公开
标题翻译：油墨喷射装置和将多种物质释放到基底上的方法
公开(公告)号：US20090033690A1
公开(公告)日：2009-02-05
申请号：US12160222
申请日：2007-01-11
申请人： Anke Pierik , Johan Frederik Dijksman , Hendrik Roelof Stapert
发明人： Anke Pierik , Johan Frederik Dijksman , Hendrik Roelof Stapert
IPC分类号： B41J3/00 , B41J2/145
CPC分类号： B01L3/0268 , B01J2219/00378 , B01J2219/00659 , B01L2200/025 , B01L2200/143 , B01L2300/0819 , B01L2400/0439 , G01N35/1011 , G01N2035/1041
摘要： The invention provides an ink jet device for releasing a plurality of substances onto a substrate, the device comprising at least one print head, which is positionable relative to the substrate, and which comprises at least one nozzle, provided to eject a droplet. The ink jet device is designed such that the plurality of substances can be deposited onto the substrate in a predefined pattern in a limited amount of moves of the at least one print head relative to the substrate.
摘要翻译：本发明提供了一种用于将多种物质释放到基底上的喷墨装置，该装置包括至少一个可相对于基底定位的打印头，并且包括至少一个用于喷射液滴的喷嘴。喷墨装置被设计成使得多个物质可以以相对于基底的至少一个打印头的有限量的移动中的预定图案沉积到基底上。

9. 发明申请

US20080309701A1 Ink Jet Device for Releasing Controllably a Plurality of Substances Onto a Substrate, Method of Discrimination Between a Plurality of Substances and Use of an Ink Jet Device 审中-公开
标题翻译：用于将基底上的多种物质可释放的喷墨装置，多种物质之间的歧视方法和喷墨装置的使用
公开(公告)号：US20080309701A1
公开(公告)日：2008-12-18
申请号：US12095047
申请日：2006-11-24
申请人： Anke Pierik , Johan Frederik Dijksman , Hendrik Roelof Stapert
发明人： Anke Pierik , Johan Frederik Dijksman , Hendrik Roelof Stapert
IPC分类号： B41J29/393
CPC分类号： B41J2/04581 , B41J2/04571 , B41J2002/14354
摘要： The invention provides an ink jet device for releasing controllably a plurality of substances onto a substrate, the device comprising at least a print head comprising a nozzle, the device comprising at least a transducer provided to eject a droplet out of the nozzle, wherein a detection means is assigned to the ink jet device such that the substances are discriminable from each other by means of the detection of the behaviour of the transducer.
摘要翻译：本发明提供了一种用于将多个物质可控地释放到基底上的喷墨装置，该装置至少包括一个包括喷嘴的打印头，该装置至少包括一个用于将墨滴从喷嘴喷出的换能器，其中检测装置被分配给喷墨装置，使得物质可以通过检测换能器的行为而彼此区分开。

10. 发明申请

US20110207630A1 METHOD FOR TESTING AND QUALITY CONTROLLING OF NUCLEIC ACIDS ON A SUPPORT 审中-公开
标题翻译：用于支持核酸的测试和质量控制的方法
公开(公告)号：US20110207630A1
公开(公告)日：2011-08-25
申请号：US13121195
申请日：2009-09-29
申请人： Anke Pierik , Hendrik Roelof Stapert
发明人： Anke Pierik , Hendrik Roelof Stapert
IPC分类号： C40B30/04 , C40B40/06 , C07H21/04
CPC分类号： C12Q1/6837 , C12Q2565/518 , C12Q2525/173
摘要： The present invention relates to a method for testing nucleic acids on a support, comprising the immobilization of one or more nucleic acids via crosslinking, wherein each of the immobilized nucleic acids includes a stretch of nucleotides of only one basetype, the provision of labeled oligonucleotides complementary to said stretch of nucleotides, and the determination of a value indicative for the condition of said nucleic acids. The present invention further relates to a kit for testing nucleic acids on a support comprising an array of nucleic acids immobilized on a solid support, wherein each of the immobilized nucleic acids includes a stretch of nucleotides of only one basetype and a labeled oligonucleotide complementary to said stretch of nucleotides. The invention additionally concerns the use of a labeled oligonucleotide complementary to a stretch of nucleotides of only one basetype for testing the condition of nucleic acids immobilized on a solid support.
摘要翻译：本发明涉及一种用于在载体上测试核酸的方法，其包括通过交联固定一种或多种核酸，其中每个固定化的核酸包括仅一种碱基类型的一段核苷酸，提供标记的寡核苷酸互补到所述核苷酸区段，以及确定指示所述核酸条件的值。本发明还涉及一种用于在载体上测试核酸的试剂盒，其包含固定在固体支持物上的核酸阵列，其中每个固定化核酸包括仅一种碱基类型的核苷酸片段和与所述核苷酸延伸。本发明还涉及使用与仅一种碱基类型的一段核苷酸互补的标记的寡核苷酸来测试固定在固体支持物上的核酸的状态。

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