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1. 发明申请

US20100135910A1 Modulation of Anergy and Methods for Isolating Anergy-Modulating Compounds 审中-公开
标题翻译：无症状调节和分离化学调节化合物的方法
公开(公告)号：US20100135910A1
公开(公告)日：2010-06-03
申请号：US12477622
申请日：2009-06-03
申请人： Anjana Rao , Patrick G. Hogan , Vigo Heissmeyer
发明人： Anjana Rao , Patrick G. Hogan , Vigo Heissmeyer
IPC分类号： A61K49/00 , G01N33/53 , A61P37/02
CPC分类号： C07K16/40 , G01N33/505 , G01N33/5052 , G01N2333/9015 , G01N2500/00
摘要： The present invention provides methods for identifying compounds capable of modulating anergy by inhibiting the production or activity of anergy associated E3 ubiquitin ligases or by altering the interaction between a ligase and its substrate.
摘要翻译：本发明提供了通过抑制相关的E3泛素连接酶的产生或活性或通过改变连接酶与其底物之间的相互作用来鉴定能够调节无反应性的化合物的方法。

2. 发明申请

US20090186422A1 SPECIFIC INHIBITORS OF NFAT ACTIVATION BY CALCINEURIN AND THEIR USE IN TREATING IMMUNE-RELATED DISEASES 有权
标题翻译：钙蛋白激酶的特异性抑制剂及其在治疗免疫相关疾病中的应用
公开(公告)号：US20090186422A1
公开(公告)日：2009-07-23
申请号：US12260049
申请日：2008-10-28
申请人： Patrick G. Hogan , Anjana Rao , Jose Aramburu
发明人： Patrick G. Hogan , Anjana Rao , Jose Aramburu
IPC分类号： G01N33/566 , C07K14/00 , C07K7/00
CPC分类号： C07K5/101 , A61K38/00
摘要： Isolated peptide fragments of the conserved regulatory domain of NFAT protein capable of inhibiting protein-protein interaction between calcineurin and NFAT, or a biologically active analog thereof are described. Isolated polynucleotides and gene therapy vectors encoding such peptide fragments are also described. In addition, methods for treating immune-related diseases or conditions and methods for high throughput screening of candidate agents are described. Pharmaceutical compositions are also provided.
摘要翻译：描述了能够抑制钙调神经磷酸酶和NFAT之间的蛋白质 - 蛋白质相互作用的NFAT蛋白质的保守调节结构域的分离的肽片段或其生物活性类似物。还描述了编码这种肽片段的分离的多核苷酸和基因治疗载体。此外，描述了用于治疗免疫相关疾病或病症的方法以及候选药物的高通量筛选方法。还提供药物组合物。

3. 发明授权

US07084241B2 Specific inhibitors of NFAT activation by calcineurin and their use in treating immune-related diseases 有权
公开(公告)号：US07084241B2
公开(公告)日：2006-08-01
申请号：US10066151
申请日：2002-01-31
申请人： Patrick G. Hogan , Anjana Rao , Jose Aramburu
发明人： Patrick G. Hogan , Anjana Rao , Jose Aramburu
IPC分类号： C07K7/00 , C07K7/06 , C07K7/08 , C07K14/00
CPC分类号： C07K5/101 , A61K38/00
摘要： Isolated peptide fragments of the conserved regulatory domain of NFAT protein capable of inhibiting protein—protein interaction between calcineurin and NFAT, or a biologically active analog thereof are described. Isolated polynucleotides and gene therapy vectors encoding such peptide fragments are also described. In addition, methods for treating immune-related diseases or conditions and methods for high throughput screening of candidate agents are described. Pharmaceutical compositions are also provided.

4. 发明授权

US07816490B2 Specific inhibitors of NFAT activation by calcineurin and their use in treating immune-related diseases 有权
标题翻译：钙调神经磷酸酶NFAT激活的特异性抑制剂及其在治疗免疫相关疾病中的应用
公开(公告)号：US07816490B2
公开(公告)日：2010-10-19
申请号：US12260049
申请日：2008-10-28
申请人： Patrick G. Hogan , Anjana Rao , Jose Aramburu
发明人： Patrick G. Hogan , Anjana Rao , Jose Aramburu
IPC分类号： C07K7/00 , C07K7/06 , C07K7/08 , C07K14/00
CPC分类号： C07K5/101 , A61K38/00
摘要： Isolated peptide fragments of the conserved regulatory domain of NFAT protein capable of inhibiting protein-protein interaction between calcineurin and NFAT, or a biologically active analog thereof are described. Isolated polynucleotides and gene therapy vectors encoding such peptide fragments are also described. In addition, methods for treating immune-related diseases or conditions and methods for high throughput screening of candidate agents are described. Pharmaceutical compositions are also provided.
摘要翻译：描述了能够抑制钙调神经磷酸酶和NFAT之间的蛋白质 - 蛋白质相互作用的NFAT蛋白质的保守调节结构域的分离的肽片段或其生物活性类似物。还描述了编码这种肽片段的分离的多核苷酸和基因治疗载体。此外，描述了用于治疗免疫相关疾病或病症的方法以及候选药物的高通量筛选方法。还提供药物组合物。

5. 发明申请

US20080311663A1 Gas Analyzer Apparatus and Method of Analyzing Gases 有权
标题翻译：气体分析装置及气体分析方法
公开(公告)号：US20080311663A1
公开(公告)日：2008-12-18
申请号：US11762891
申请日：2007-06-14
申请人： Ulrich Bonne , Patrick G. Hogan , Richard A. Gomy , Leslie T. Ivie
发明人： Ulrich Bonne , Patrick G. Hogan , Richard A. Gomy , Leslie T. Ivie
IPC分类号： G01N35/00 , B01J19/00
CPC分类号： G01N31/223 , Y10S435/807 , Y10T436/11
摘要： A gas analyzer apparatus includes a device or platform for supporting a predetermined quantity of a reagent capable of reacting with a predetermined gas to cause a detectable change in a characteristic of the reagent, a reservoir adapted to retain the reagent, a dispenser for dispensing a controlled quantity of the reagent from the reservoir to a predetermined position on the device for supporting the predetermined quantity of the reagent, and a detector that detects the presence of the predetermined gas upon the predetermined gas and the controlled quantity of reagent reacting to cause a detectable change in a characteristic of the reagent detectable by the detector, the detector adapted to detect a change in the controlled quantity of the reagent by detecting the change in the characteristic through the predetermined quantity of the reagent.
摘要翻译：一种气体分析仪装置包括一个装置或平台，用于支撑预定量的能够与预定气体反应的试剂，以引起试剂特性可检测到的变化，适于保持试剂的储存器，用于分配受控制的分配器用于支撑预定量的试剂的装置上从储存器到预定位置的试剂量;以及检测器，其检测预定气体上存在的预定气体，并且受控量的试剂反应以引起可检测的变化在检测器可检测的试剂的特性中，检测器适于通过检测预定量的试剂的特性变化来检测试剂受控量的变化。

6. 发明授权

US08003056B2 Gas analyzer apparatus and method of analyzing gases 有权
标题翻译：气体分析装置及气体分析方法
公开(公告)号：US08003056B2
公开(公告)日：2011-08-23
申请号：US11762891
申请日：2007-06-14
申请人： Ulrich Bonne , Patrick G. Hogan , Richard A. Gorny , Leslie T. Ivie
发明人： Ulrich Bonne , Patrick G. Hogan , Richard A. Gorny , Leslie T. Ivie
IPC分类号： G01N35/00
CPC分类号： G01N31/223 , Y10S435/807 , Y10T436/11
摘要： A gas analyzer apparatus includes a device or platform for supporting a predetermined quantity of a reagent capable of reacting with a predetermined gas to cause a detectable change in a characteristic of the reagent, a reservoir adapted to retain the reagent, a dispenser for dispensing a controlled quantity of the reagent from the reservoir to a predetermined position on the device for supporting the predetermined quantity of the reagent, and a detector that detects the presence of the predetermined gas upon the predetermined gas and the controlled quantity of reagent reacting to cause a detectable change in a characteristic of the reagent detectable by the detector, the detector adapted to detect a change in the controlled quantity of the reagent by detecting the change in the characteristic through the predetermined quantity of the reagent.
摘要翻译：一种气体分析仪装置包括一个装置或平台，用于支撑预定量的能够与预定气体反应的试剂，以引起试剂特性可检测到的变化，适于保持试剂的储存器，用于分配受控制的分配器用于支撑预定量的试剂的装置上从储存器到预定位置的试剂量;以及检测器，其检测预定气体上存在的预定气体，并且受控量的试剂反应以引起可检测的变化在检测器可检测的试剂的特性中，检测器适于通过检测预定量的试剂的特性变化来检测试剂受控量的变化。

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