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1. 发明授权

US07312223B2 Metabolite of xanthine Phosphodiesterase 5 inhibitor and derivatives thereof useful for treatment of erectile dysfunction 失效
标题翻译：黄嘌呤的代谢物磷酸二酯酶5抑制剂及其衍生物可用于治疗勃起功能障碍
公开(公告)号：US07312223B2
公开(公告)日：2007-12-25
申请号：US10901574
申请日：2004-07-29
申请人： Anima Ghosal , Wei Tong , Swapan K. Chowdhury , Shmuel Zbaida , Mark A. Wirth , Kevin B. Alton , James E. Patrick , Craig D. Boyle , Andrew Stamford
发明人： Anima Ghosal , Wei Tong , Swapan K. Chowdhury , Shmuel Zbaida , Mark A. Wirth , Kevin B. Alton , James E. Patrick , Craig D. Boyle , Andrew Stamford
IPC分类号： C07D473/06 , A61K31/522 , A61P9/10 , A61P9/12
CPC分类号： C07D473/06
摘要： The present invention is directed to a metabolite of a xanthine Phosphodiesterase type 5 inhibitor having the following structure derivatives, and formulations thereof, and processes for preparing the same. Further disclosed are methods of treating a physiological disorder, symptom or disease in a patient, comprising administering to the patient an effective amount of the above compound, wherein the physiological disorder, symptom or disease is a urogenital, cardiovascular, cerebrovascular or peripheral vascular disorder, angina pectoris, hypertension, restenosis post angioplasty, endarterectomy, stent introduction, cerebral stroke, a respiratory tract disorder such as an allergic condition associated with atopy, pulmonary hypertension, an ischemic heart disorder, impaired glucose tolerance, diabetes and its related complication, insulin resistance syndrome, hyperglycemia, polycystic ovarian syndrome, a glomerular disorder, renal insufficiency, nephritis, a tubular interstitial disorder, an autoimmune disorder, glaucoma, intestinal motility, cachexia or cancer.
摘要翻译：本发明涉及具有以下结构衍生物的黄嘌呤磷酸二酯酶5型抑制剂的代谢物及其制剂及其制备方法。进一步公开的是治疗患者的生理障碍，症状或疾病的方法，包括向患者施用有效量的上述化合物，其中所述生理障碍，症状或疾病是泌尿生殖系统，心血管，脑血管或外周血管疾病，心绞痛，高血压，血管成形术后再狭窄，内膜切除术，支架引入，脑中风，呼吸道疾病如与过敏相关的过敏性疾病，肺动脉高压，缺血性心脏病，糖耐量异常，糖尿病及其相关并发症，胰岛素抵抗综合征，高血糖症，多囊卵巢综合征，肾小球疾病，肾功能不全，肾炎，管状间质性疾病，自身免疫性疾病，青光眼，肠蠕动，恶病质或癌症。

2. 发明授权

US06982251B2 Substituted 2-azetidinones useful as hypocholesterolemic agents 失效
公开(公告)号：US06982251B2
公开(公告)日：2006-01-03
申请号：US10166942
申请日：2002-06-11
申请人： Anima Ghosal , Shmuel Zbaida , Swapan K. Chowdhury , Robert M. Iannucci , Wenqing Feng , Kevin B. Alton , James E. Patrick , Harry R. Davis
发明人： Anima Ghosal , Shmuel Zbaida , Swapan K. Chowdhury , Robert M. Iannucci , Wenqing Feng , Kevin B. Alton , James E. Patrick , Harry R. Davis
IPC分类号： A61K31/7056 , A61K31/397 , A61K31/675 , C07H17/02 , C07D25/08
CPC分类号： A61K31/70 , A61K45/06 , C07H15/26
摘要： Hypocholesterolemic substituted 2-azetidinone compounds of the formula: are disclosed, as well as a methods of lowering cholesterol by administering said compounds, pharmaceutical compositions containing them, and the combination of a substituted 2-azetidinone cholesterol-lowering agent and a cholesterol biosynthesis inhibitor for the treatment and prevention of atherosclerosis.

3. 发明授权

US07271174B2 Metabolites of tricyclic amides useful for inhibition of G-protein function and methods of treatment of proliferative diseases 失效
标题翻译：用于抑制G蛋白功能的三环酰胺的代谢物和治疗增殖性疾病的方法
公开(公告)号：US07271174B2
公开(公告)日：2007-09-18
申请号：US10874556
申请日：2004-06-23
申请人： Swapan K. Chowdhury , Anima Ghosal , Robert M. Iannucci , Wenqing Feng , Tze-Ming Chan , Shmuel Zbaida , Kevin B. Alton , Ronald J. Doll , Keith P. Minor
发明人： Swapan K. Chowdhury , Anima Ghosal , Robert M. Iannucci , Wenqing Feng , Tze-Ming Chan , Shmuel Zbaida , Kevin B. Alton , Ronald J. Doll , Keith P. Minor
IPC分类号： C07D221/06 , A61K31/435
CPC分类号： C07D401/14
摘要： The present invention relates to metabolites of tricyclic amides, and structurally related compounds, represented by the structural formula (I): and pharmaceutically acceptable isomers, salts, solvates or esters of the compound of formula (I), wherein: R1 is selected from the group consisting of H and ═O; R2-R5 can be the same or different, each being independently selected from the group consisting of H, —OH, halide, —NH2 and ═O; and, the combination solid-dashed lines independently represent either single bonds or double bonds, wherein the number of combination solid-dashed lines that are double bonds is not greater than 2, and when, the double bonds are not adjacent, and when 0, one of R1-R5 is not H. Also disclosed are methods of treatment of proliferative diseases and methods for inhibiting the abnormal growth of cells, and for inhibiting farnesyl protein transferase using the novel compounds.
摘要翻译：本发明涉及由结构式（I）表示的三环酰胺的代谢物和结构相关的化合物：和式（I）化合物的药学上可接受的异构体，盐，溶剂化物或酯，其中：R 1 选自H和-O; R 2 -R 5可以相同或不同，各自独立地选自H，-OH，卤化物，-NH 2， SUB>和-O; 并且，组合虚线独立地表示单键或双键，其中双键的组合实线的数目不大于2，当双键不相邻时，当为0时， R 1〜R 5之一不是H.还公开了治疗增殖性疾病的方法和抑制细胞异常生长的方法，以及用于抑制法呢基蛋白转移酶使用新型化合物。

4. 发明授权

US07825121B2 Piperazine derivatives useful as CCR5 antagonists 有权
标题翻译：哌嗪衍生物可用作CCR5拮抗剂
公开(公告)号：US07825121B2
公开(公告)日：2010-11-02
申请号：US11255643
申请日：2005-10-21
申请人： Ragulan Ramanathan , Anima Ghosal , Michael W. Miller , Swapan K. Chowdhury , Kevin B. Alton
发明人： Ragulan Ramanathan , Anima Ghosal , Michael W. Miller , Swapan K. Chowdhury , Kevin B. Alton
IPC分类号： A61K31/497 , A01N43/54 , C07D403/00 , C07D239/00
CPC分类号： C07D401/14 , C07D401/06 , C07H17/02
摘要： The use of CCR5 antagonists of the formula or a pharmaceutically acceptable salt thereof, wherein R is optionally substituted phenyl, pyridyl, thiophenyl or naphthyl; R1 is hydrogen or alkyl; R2 is substituted phenyl, substituted heteroaryl, naphthyl, fluorenyl, diphenylmethyl or optionally substituted phenyl- or heteroaryl-alkyl; R3 is hydrogen, alkyl, alkoxyalkyl, cycloalkyl, cycloalkylalkyl, or optionally substituted phenyl, phenylalkyl, naphthyl, naphthylalkyl, heteroaryl or heteroarylalkyl; R4, R5 and R7 are hydrogen or alkyl; R6 is hydrogen, alkyl or alkenyl; for the treatment of HIV, solid organ transplant rejection, graft v. host disease, arthritis, rheumatoid arthritis, inflammatory bowel disease, atopic dermatitis, psoriasis, asthma, allergies or multiple sclerosis is disclosed, as well as novel compounds, pharmaceutical compositions comprising them, and the combination of CCR5 antagonists of the invention in combination with antiviral agents useful in the treatment of HIV or agents useful in the treatment of inflammatory diseases.
摘要翻译：使用下式的CCR5拮抗剂或其药学上可接受的盐，其中R是任选取代的苯基，吡啶基，噻吩基或萘基; R1是氢或烷基; R 2是取代的苯基，取代的杂芳基，萘基，芴基，二苯基甲基或任选取代的苯基或杂芳基 - 烷基; R 3是氢，烷基，烷氧基烷基，环烷基，环烷基烷基或任选取代的苯基，苯基烷基，萘基，萘基烷基，杂芳基或杂芳基烷基; R4，R5和R7是氢或烷基; R6是氢，烷基或烯基; 公开了用于治疗HIV，实体器官移植排斥，移植物抗宿主病，关节炎，类风湿性关节炎，炎症性肠病，特应性皮炎，牛皮癣，哮喘，过敏或多发性硬化的新型化合物，以及包含它们的药物组合物，以及本发明的CCR5拮抗剂与可用于治疗HIV的抗病毒剂或可用于治疗炎性疾病的药剂的组合。

5. 发明申请

US20080173808A1 PROCESS AND DEVICE FOR RESPONSE NORMALIZED LIQUID CHROMATOGRAPHY NANOSPRAY IONIZATION MASS SPECTROMETRY (RNLC-NSI-MS) 审中-公开
标题翻译：响应正常化液相色谱法的过程和器件纳米粒子离子质谱（RNLC-NSI-MS）
公开(公告)号：US20080173808A1
公开(公告)日：2008-07-24
申请号：US12015953
申请日：2008-01-17
申请人： Ragulan Ramanathan , Swapan K. Chowdhury , Kevin B. Alton
发明人： Ragulan Ramanathan , Swapan K. Chowdhury , Kevin B. Alton
IPC分类号： H01J49/26
CPC分类号： G01N30/7266
摘要： Disclosed are a process and a device for the detection, identification, and quantification of chemical compounds or biomolecules using Response Normalized Liquid Chromatography NanoSpray Ionization Mass Spectrometry (RNLC-NSI-MS).
摘要翻译：公开了使用响应标准化液相色谱纳米喷雾电离质谱法（RNLC-NSI-MS）检测，鉴定和定量化学化合物或生物分子的方法和装置。

6. 发明授权

US5245186A Electrospray ion source for mass spectrometry 失效
标题翻译：电喷雾离子源进行质谱分析
公开(公告)号：US5245186A
公开(公告)日：1993-09-14
申请号：US879035
申请日：1992-05-06
申请人： Brian T. Chait , Swapan K. Chowdhury , Viswanatham Katta , Urooj A. Mirza
发明人： Brian T. Chait , Swapan K. Chowdhury , Viswanatham Katta , Urooj A. Mirza
IPC分类号： H01J49/04
CPC分类号： H01J49/165
摘要： A mass analyzer for the analysis of mass spectra of ions derived from organic molecules includes an electrospray ion source having means to transport the molecules of interest in a solvent of pure water free of organic solvents. The electrospray ion source sprays the water solution, under an imposed voltage, through a metal syringe needle having a sharp etched point and into a conductive capillary tube having a sharpened entrance orifice.
摘要翻译：用于分析源自有机分子的离子的质谱的质量分析器包括电喷雾离子源，其具有将目标分子输送到不含有机溶剂的纯水溶剂中的方法。电喷雾离子源通过具有尖锐蚀刻点的金属注射器针头在施加的电压下喷射水溶液并进入具有尖锐入口的导电毛细管中。

7. 发明授权

US4977320A Electrospray ionization mass spectrometer with new features 失效
标题翻译：具有新功能的电喷雾电离质谱仪
公开(公告)号：US4977320A
公开(公告)日：1990-12-11
申请号：US467978
申请日：1990-01-22
申请人： Swapan K. Chowdhury , Viswanatham Katta , Brian T. Chait
发明人： Swapan K. Chowdhury , Viswanatham Katta , Brian T. Chait
IPC分类号： H01J49/04 , H01J49/10
CPC分类号： H01J49/0404 , H01J49/044 , H01J49/0468 , H01J49/165
摘要： An electrospray ion source is designed for ready and simple plugging into commercial mass analyzers for mass spectrometric analysis of organic molecules. The electrospray is carried out is the ambient air and the ions and other charged species enter the mass analyuzer through a long metal capillary tube and three stages of differential pumping. The use of the long tube allows (a) convenient injection of the ions into the mass analyzer (b) optimization of the spray by direct visualization in the air (c) efficient and controlled heat transfer to the droplets and (d) efficient pumping of the region between the capillary exit and the skinner. Desolvation of the solvated ions is carried out using a combination of controlled heat transfer to the charged droplets during the transit through the tube and collisional activation in a region of reduced pressure. Desolvation with this system does not involve use of a strong countercurrent flow of heated gas. The system also may be used to obtain the collisional activated fragmentation spectra of molecule ions. The use of a metal capillary tube avoids complications from charging that arise from the use of dielectric capilliary tubes.
摘要翻译：电喷雾离子源设计用于准备和简单的插入商业质量分析仪，用于有机分子的质谱分析。进行电喷雾是环境空气，离子和其他带电物质通过长金属毛细管进入质量分析仪和三级差动泵送。使用长管允许（a）方便地将离子注入质量分析器中（b）通过在空气中直接可视化来优化喷雾（c）有效和可控制的热传递到液滴，以及（d）有效泵送毛细管出口与皮肤之间的区域。溶剂化离子的去溶剂使用在通过管的运输过程中受控的热传递到带电液滴和在减压区域中的碰撞活化的组合来进行。该系统的去溶剂不涉及使用强逆流的加热气体。该系统也可用于获得分子离子的碰撞激活的碎裂光谱。使用金属毛细管避免了使用电介质毛细管引起的充电并发症。

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