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1. 发明专利

JP2012025759A Medicinal composition for angiogenic therapy 有权
标题翻译：药物治疗用药物组合物
公开(公告)号：JP2012025759A
公开(公告)日：2012-02-09
申请号：JP2011190400
申请日：2011-09-01
申请人： Anges Mg Inc , Ryuichi Morishita , アンジェスMg株式会社 , 竜一森下
发明人： MORISHITA RYUICHI , KOIKE HIROMI , TANABE TADASHI , AOKI MOTOKUNI
IPC分类号： A61K45/00 , A61K48/00 , A61P7/02 , A61P9/10 , A61P9/14 , A61P43/00
摘要： PROBLEM TO BE SOLVED: To provide a new medicinal composition for angiogenic therapy.SOLUTION: The present invention discloses the medicinal composition for the angiogenic therapy containing, as effective components, at least one kind selected from the group comprising substances having a vasodilation effect and/or a platelet aggregation restraining effect, and substances generating the substances, and a gene encoding an angiogenesis factor. an enhancement agent for an angiogenic effect by a gene of encoding the angiogenesis factor, containing, as the effective components, at least one kind selected from the group comprising the substances having the vasodilation effect and/or the platelet aggregation restraining effect, and the substances generating the substances, an angiogenic medicine containing a prostacyclin synthetase gene as an active component, the medicinal composition for the angiogenic therapy containing an ets-1 gene and other gene encoding the angiogenesis factor as effective components, an enhancement agent for the angiogenic effect by the other gene encoding the angiogenesis factor, containing the ets-1 gene as the effective component, and an angiogenic medicine containing the ets-1 gene as an effective component.
摘要翻译：要解决的问题：提供用于血管生成治疗的新药物组合物。解决方案：本发明公开了用于血管生成治疗的药物组合物，其含有选自包含具有血管舒张作用和/或血小板聚集抑制作用的物质的组中的至少一种作为有效成分，以及产生该物质的物质，以及编码血管生成因子的基因。包含编码血管生成因子的基因的血管生成作用的增强剂，其含有选自包含具有血管舒张作用和/或血小板聚集抑制作用的物质的组中的至少一种作为有效成分，以及所述物质生成含有前列环素合成酶基因作为活性成分的血管生成药物，含有ets-1基因的血管发生疗法的药物组合物和编码血管生成因子的其他基因作为有效成分，作为血管生成作用的增效剂含有ets-1基因作为有效成分的编码血管生成因子的其他基因，以及含有ets-1基因作为有效成分的血管生成药。版权所有（C）2012，JPO＆INPIT

2. 发明专利

JP2009102428A Pharmaceutical compositions containing decoy and method of using the same 有权
标题翻译：含有DECOY的药物组合物及其使用方法
公开(公告)号：JP2009102428A
公开(公告)日：2009-05-14
申请号：JP2009026797
申请日：2009-02-06
申请人： Anges Mg Inc , アンジェスMg株式会社
发明人： MORISHITA RYUICHI , AOKI MOTOKUNI , OGIWARA TOSHIO , KANEDA YASUSHI , NAKAMURA HIROSHIGE
IPC分类号： A61K31/7088 , A61K9/06 , A61K31/711 , A61K38/17 , A61K47/06 , A61K47/10 , A61K47/44 , A61K48/00 , A61P1/04 , A61P17/00 , A61P17/02 , A61P17/04 , A61P17/06 , C12N15/09 , C12N15/113
CPC分类号： A61K31/711 , A61K38/1709 , C12N15/113 , C12N2310/13
摘要： PROBLEM TO BE SOLVED: To provide a method for effectively treating various kinds of diseases since a transcription factor including NF-κB is concerned in various kinds of diseases through expression of many genes which are under transcriptional control thereof and capable of efficaciously treating the diseases. SOLUTION: The invention is a pharmaceutical composition for treating skin diseases, comprises at least one decoy and a pharmaceutically acceptable carrier. These skin diseases may be atopic dermatitis, vulgar psoriasis, contact dermatitis, keloid, bedsore, ulcerative colitis, and Crohn's disease. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：待解决的问题：提供一种有效治疗各种疾病的方法，因为包括NF-κB的转录因子涉及各种疾病，通过表达许多在其转录控制下的基因并能够有效治疗疾病。解决方案：本发明是用于治疗皮肤疾病的药物组合物，包含至少一种诱饵和药学上可接受的载体。这些皮肤病可能是特应性皮炎，粗俗牛皮癣，接触性皮炎，瘢痕疙瘩，褥疮，溃疡性结肠炎和克罗恩病。版权所有（C）2009，JPO＆INPIT

3. 发明专利

JP2005306877A Pharmaceutical composition containing decoy and method for using the same 有权
标题翻译：含有DECOY的药物组合物及其使用方法
公开(公告)号：JP2005306877A
公开(公告)日：2005-11-04
申请号：JP2005128753
申请日：2005-04-26
申请人： Anges Mg Inc , アンジェスMg株式会社
发明人： MORISHITA RYUICHI , AOKI MOTOKUNI , OGIWARA TOSHIO , KANEDA YASUSHI , NAKAMURA HIROSHIGE
IPC分类号： C12N15/09 , A61K31/7088 , A61K45/00 , A61K47/10 , A61K47/44 , A61K48/00 , A61P1/04 , A61P17/00 , A61P17/02 , A61P17/06 , A61P37/08
摘要： PROBLEM TO BE SOLVED: To provide a pharmaceutical composition developed based on suggestion that a transcription factor, including NF-κB, is concerned in various kinds of diseases through expression of many genes which are under transcriptional control thereof and capable of efficaciously treating the diseases, especially skin diseases, including atopic dermatitis, vulgar psoriasis, contact dermatitis, keloid, bedsore, ulcerative colitis, and Crohn's disease.
SOLUTION: This pharmaceutical composition is used for treating the skin diseases, wherein the composition contains at least one decoy and a pharmaceutically acceptable carrier. An NF-κB decoy, an STAT-6 decoy, an AP-1 decoy, and an Ets decoy are especially used as the decoy. Further, an oligonucleotide combining with the decoys is used as the decoy. A petroleum jelly, or the petroleum jelly containing stearyl alcohol or a liquid paraffin, is used as the carrier.
COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：提供一种基于提示包括NF-κB在内的转录因子涉及各种疾病的药物组合物，其通过表达许多在其转录控制下并能够有效治疗的基因尤其是皮肤疾病，包括特应性皮炎，牛皮癣，接触性皮炎，瘢痕疙瘩，褥疮，溃疡性结肠炎和克罗恩病。解决方案：该药物组合物用于治疗皮肤疾病，其中组合物含有至少一种诱饵和药学上可接受的载体。 NF-κB诱饵，STAT-6诱饵，AP-1诱饵和Ets诱饵特别用作诱饵。此外，将与诱饵组合的寡核苷酸用作诱饵。使用含油硬脂或含有硬脂醇或液体石蜡的凡士林作为载体。版权所有（C）2006，JPO＆NCIPI

4. 发明专利

JP2009185064A Pharmaceutical composition containing decoy and method of using the same 有权
标题翻译：含有DECOY的药物组合物及其使用方法
公开(公告)号：JP2009185064A
公开(公告)日：2009-08-20
申请号：JP2009122580
申请日：2009-05-20
申请人： Anges Mg Inc , アンジェスMg株式会社
发明人： MORISHITA RYUICHI , AOKI MOTOKUNI , OGIWARA TOSHIO , KAWASAKI TOMIO
IPC分类号： A61K31/7088 , A61K9/70 , A61K47/30 , A61K48/00 , A61P9/14 , C12N15/09
摘要： PROBLEM TO BE SOLVED: To provide a pharmaceutical composition for treating diseases caused by expression of a gene controlled by NF-κB or ets, and a method of using the composition. SOLUTION: The pharmaceutical composition for treating or preventing the diseases caused by expression of the gene controlled by NF-κB or ets, contains at least one decoy and a pharmaceutically acceptable carrier. The invention discloses that, administration of a decoy of NF-κB or ets, or a chimera (double) decoy of NF-κB with ets, is effective on treating the diseases caused by expression of the gene controlled by NF-κB or ets. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：待解决的问题：提供用于治疗由NF-κB或ets控制的基因的表达引起的疾病的药物组合物，以及使用该组合物的方法。解决方案：用于治疗或预防由NF-κB或ets控制的基因的表达引起的疾病的药物组合物含有至少一种诱饵和药学上可接受的载体。本发明公开了用ets给予NF-κB或ets或NF-κB的嵌合体（双）诱饵的诱饵，对于治疗由NF-κB或ets控制的基因的表达引起的疾病是有效的。版权所有（C）2009，JPO＆INPIT

5. 发明专利

JP2002193813A PHARMACEUTICAL COMPOSITION CONTAINING DECOY AND METHOD FOR USING THE SAME 失效
公开(公告)号：JP2002193813A
公开(公告)日：2002-07-10
申请号：JP2000399613
申请日：2000-12-27
申请人： ANGES MG INC
发明人： MORISHITA RYUICHI , AOKI MOTOKUNI , OGIWARA TOSHIO , KAWASAKI TOMIO
IPC分类号： C12N15/09 , A61K31/7088 , A61K47/46 , A61P9/00 , A61P9/10 , A61P11/06 , A61P13/12 , A61P17/00 , A61P29/00 , A61P35/00
摘要： PROBLEM TO BE SOLVED: To provide a pharmaceutical composition for treating diseases caused from an expression of a gene controlled by NF-κB or ets and a method for using the composition. SOLUTION: This pharmaceutical composition is for therapy and prophylaxis of the diseases caused from the expression of the gene controlled by NF-κB or ets and comprises at least one decoy and pharmaceutically acceptable carrier.

6. 发明专利

CY1108165T1 ΤΟΠΙΚΗ ΧΡΗΣΗ ΔΟΛΩΜΑΤΟΣ NF-κΒ ΓΙΑ ΤΗΝ ΘΕΡΑΠΕΥΤΙΚΗ ΑΓΩΓΗ ΤΗΣ ΑΤΟΠΙΚΗΣ ΔΕΡΜΑΤΙΤΙΔΑΣ 未知
公开(公告)号：CY1108165T1
公开(公告)日：2014-02-12
申请号：CY081100682
申请日：2008-06-30
申请人： ANGES MG INC
发明人： MORISHITA RYUICHI , AOKI MOTOKUNI , OGIHARA TOSHIO , KANEDA YASUFUMI , NAKAMURA HIROSHIGE
IPC分类号： A61K48/00 , A61K9/06 , A61K31/711 , A61K38/17 , A61K47/06 , A61K47/10 , A61P17/00 , A61P17/04 , C12N15/113
摘要： Μίαφαρμακευτικήσύνθεσηγιατηνδιεξαγωγήθεραπευτικήςαγωγήςέναντιδερματοπαθειών, όπουη φαρμακευτικήσύνθεσηπεριλαμβάνειτουλάχιστονέναδόλωμακαιένανφαρμακευτικάπαραδεκτόφορέα. Τοτουλάχιστονέναδόλωμαμπορείναεπιλεγείαπότηνομάδαπουαποτελείταιαπόέναδόλωμα NF-κΒ, έναδόλωμα STAT-1, έναδόλωμα GATA-3, έναδόλωμα STAT-6, έναδόλωμαΑΡ-1 καιέναδόλωμα Ets. Τοτουλάχιστονέναδόλωμαμπορείναείναιέναολιγονουκλεοτίδιοπουπεριλαμβάνειτουλάχιστονδύοδολώματασυνδεδεμέναπροςαλλήλους, ενώτατουλάχιστονδύοδολώματαεπιλέγονταιαπότηνομάδαπουαποτελείταιαπόέναδόλωμα NF-κΒ, έναδόλωμα STAT-1, έναδόλωμα GATA-3, έναδόλωμα STAT-6, έναδόλωμαΑΡ-1 καιέναδόλωμα Ets. Ηδερματοπάθειαμπορείναείναιη ατοπικήδερματίτιδα, κοινήψωρίαση, δερματίτιδαεξεπαφής, χηλοειδήςακμή (kelcid), έλκωσηλόγωκατάκλισης, ελκώδηςκολίτιδαή ηασθένειατου Crohn.

7. 发明专利

AU2001266338B2 Medicinal compositions for angiogenic therapy 未知
公开(公告)号：AU2001266338B2
公开(公告)日：2006-11-09
申请号：AU2001266338
申请日：2001-06-27
申请人： ANGES MG INC , MORISHITA RYUICHI
发明人： AOKI MOTOKUNI , KOIKE HIROMI , TANABE TADASHI , MORISHITA RYUICHI
IPC分类号： A61K45/00 , A61K31/5585 , A61K31/711 , A61K38/17 , A61K38/52 , A61K48/00 , A61P9/00 , A61P9/10
摘要： The present invention provides: (1) pharmaceutical compositions for angiogenic therapy which contain, as the active ingredients, at least one substance selected from substances having vasodilating effect and/or platelet aggregation inhibitory effect, and substances producing them; and a gene encoding an angiogenesis factor; (2) agents for potentiating the angiogenic effect of a gene encoding an angiogenesis factor that contain, as the active ingredient, at least one substance selected from substances having vasodilating effect and/or platelet aggregation inhibitory effect and substances producing them; (3) an angiogenic agent which contains a prostacyclin synthase gene as the active ingredient; (4) pharmaceutical compositions for angiogenic therapy which contain ets-1 gene and another gene encoding an angiogenesis factor as the active ingredients; (4) an agent which contain ets-1 gene as the active ingredient for potentiating the angiogenic effect of another gene encoding an angiogenesis factor; and (5) an angiogenic agent which contains ets-1 gene as the active ingredient.

8. 发明专利

AT530197T 未知
公开(公告)号：AT530197T
公开(公告)日：2011-11-15
申请号：AT07021738
申请日：2001-06-27
申请人： ANGES MG INC , MORISHITA RYUICHI
发明人： MORISHITA RYUICHI , KOIKE HIROMI , TANABE TADASHI , AOKI MOTOKUNI
IPC分类号： A61K45/00 , A61K31/5585 , A61K31/711 , A61K38/16 , A61K38/17 , A61K38/18 , A61K38/52 , A61K48/00 , A61P9/00 , A61P9/10
摘要： The present invention provides: (1) pharmaceutical compositions for angiogenic therapy which contain, as the active ingredients, at least one substance selected from substances having vasodilating effect and/or platelet aggregation inhibitory effect, and substances producing them; and a gene encoding an angiogenesis factor; (2) agents for potentiating the angiogenic effect of a gene encoding an angiogenesis factor that contain, as the active ingredient, at least one substance selected from substances having vasodilating effect and/or platelet aggregation inhibitory effect and substances producing them; (3) an angiogenic agent which contains a prostacyclin synthase gene as the active ingredient; (4) pharmaceutical compositions for angiogenic therapy which contain ets-1 gene and another gene encoding an angiogenesis factor as the active ingredients; (4) an agent which contain ets-1 gene as the active ingredient for potentiating the angiogenic effect of another gene encoding an angiogenesis factor; and (5) an angiogenic agent which contains ets-1 gene as the active ingredient.

9. 发明专利

AU2003252493A1 PHARMACEUTICAL COMPOSITION CONTAINING DECOY AND METHOD OF USING THE SAME 未知
公开(公告)号：AU2003252493A1
公开(公告)日：2005-01-28
申请号：AU2003252493
申请日：2003-07-09
申请人： ANGES MG INC
发明人： MORISHITA RYUICHI , AOKI MOTOKUNI , OGIHARA TOSHIO , KAWASAKI TOMIO , MAKINO HIROFUMI
IPC分类号： A61K9/00 , A61K31/711 , A61K38/17 , A61K45/06 , A61P9/00 , A61P11/00 , A61P11/02 , A61P11/06 , A61P13/12 , A61P17/00 , A61P29/00 , A61P31/10 , A61P35/00 , A61P37/08 , A61K45/00 , A61K48/00 , A61K9/127
摘要： A pharmaceutical composition for treating and preventing diseases, disorders and/or conditions of airway inflammation, airway stenosis or nasal cavity inflammation caused by the expression of a gene regulated by NF-kappaB which contains an NF-kappaB decoy and a pharmaceutically acceptable carrier. The above diseases may be asthma, COPD or rhinitis. Moreover, the above diseases may be diseases caused by an eosinophil abnormality (for example, asthma, rhinitis and COPD). The pharmaceutically acceptable carrier may be a hydrophilic polymer, a liposome and so on.

10. 发明专利

CA2531629A1 MEDICINAL COMPOSITION CONTAINING NF-.KAPPA.B DECOY FOR TREATING AND PREVENTING RESPIRATORY DISEASES AND METHOD OF USING THE SAME 未知
公开(公告)号：CA2531629A1
公开(公告)日：2005-01-20
申请号：CA2531629
申请日：2004-07-09
申请人： ANGES MG INC
发明人： KAWASAKI TOMIO , MORISHITA RYUICHI , AOKI MOTOKUNI , OGIHARA TOSHIO , MAKINO HIROFUMI , KOYANAGI AKIHIRO , SHISHIKURA TAKASHI
IPC分类号： A61K45/00 , A61K9/00 , A61K9/08 , A61K9/12 , A61K9/127 , A61K9/14 , A61K9/72 , A61K31/7088 , A61K31/711 , A61K35/76 , A61K38/17 , A61K45/06 , A61K47/10 , A61K47/26 , A61K47/30 , A61K48/00 , A61P9/00 , A61P11/00 , A61P11/02 , A61P11/06 , A61P13/12 , A61P17/00 , A61P29/00 , A61P31/10 , A61P35/00 , A61P37/08
摘要： A medicinal composition for treating and preventing diseases, disorders and/ or conditions of airway inflammation, airway narrowing or nasal cavity inflammation caused by the expression of a gene regulated by NF-.kappa.B whi ch contains an NF-.kappa.B decoy and a pharmaceutically acceptable carrier. The above diseases may be asthma, COPD or rhinitis. Moreover, the above diseases may be diseases caused by abnormality in eosinophils (for example, asthma, rhinitis and COPD). The pharmaceutically acceptable carrier may be a hydrophilic polymer, a liposome and so on.

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