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1. 发明专利

JP2007185192A Statistical analysis of regulatory factor binding site of differentially expressed gene 审中-公开
标题翻译：不同表达基因的调节因子结合位点的统计分析
公开(公告)号：JP2007185192A
公开(公告)日：2007-07-26
申请号：JP2007023601
申请日：2007-02-01
申请人： Anesiva Inc , アネシヴァ, インコーポレイテッドCorgentech, Inc.
发明人： ZHANG JIE , WEI HSIU-YING , MCEVOY LESLIE MARGARET
IPC分类号： C12N15/09 , C12Q1/68 , G01N33/48 , G01N33/50 , G06F19/00
CPC分类号： G06F19/18 , G06F19/20 , G06F19/22 , Y02A90/26
摘要： PROBLEM TO BE SOLVED: To provide a means for developing therapeutic strategy for treating disease accompanied by a differentially expressed gene. SOLUTION: The method of statistical analysis of the differentially expressed gene is provided. The method comprises (a) a step for obtaining a set of differentially expressed genes, (b) a step for screening genomic sequences including the regulatory regions of the differentially expressed genes for the presence of regulatory factor binding sites, and (c) a step for identifying at least one regulatory factor binding site enriched within the set of differentially expressed genes relative to a genome-scale or tissue-scale background. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供一种开发用于治疗伴随差异表达基因的疾病的治疗策略的手段。解决方案：提供差异表达基因的统计学分析方法。该方法包括（a）获得一组差异表达基因的步骤，（b）筛选基因组序列的步骤，所述基因组序列包括调节因子结合位点存在的差异表达基因的调节区，和（c）步骤用于鉴定相对于基因组规模或组织尺度背景，富含差异表达基因的集合中的至少一个调节因子结合位点。版权所有（C）2007，JPO＆INPIT

2. 发明专利

JP2008293505A Genomic profiling of regulatory factor binding site 审中-公开
标题翻译：监管因素绑定网站的基本概况
公开(公告)号：JP2008293505A
公开(公告)日：2008-12-04
申请号：JP2008147319
申请日：2008-06-04
申请人： Anesiva Inc , アネシバ・インコーポレイテッドAnesiva,Inc.
发明人： ZHANG JIE , WEI HSIU-YING , MCEVOY LESLIE MARGARET
IPC分类号： C12N15/00 , G06F19/00 , C12Q1/68 , G01N33/48 , G01N33/50 , G06F17/30
CPC分类号： G06F19/18 , G06F19/22 , G06F19/28
摘要： PROBLEM TO BE SOLVED: To provide a method for genomic profiling of regulatory factor binding sites. SOLUTION: A computer execution system for characterizing the regulatory factor binding sites includes instructions for implementing processes for retrieving one or more complete genes of one organism species from one or more data files according to one of scripts, wherein the data file includes transcription starting site (TSS) information and genetic information including genomic sequences of the organism species, retrieving the genomic sequences of the organism, mapping the positions of the TSSs regarding the complete genes on the genomic sequences, comparing all the positions of the mapped TSSs to identify the most 5' side position regarding each of the complete genes, and specifying the regulatory factor binding site based on the TSS having the most 5' side position regarding each of the complete genes. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供调节因子结合位点的基因组谱学方法。用于表征调节因子结合位点的计算机执行系统包括用于根据脚本之一从一个或多个数据文件中实现从一个或多个数据文件检索一个或多个完整基因的过程的指令，其中所述数据文件包括转录起始位点（TSS）信息和遗传信息，包括生物物种的基因组序列，检索生物体的基因组序列，映射关于基因组序列上的完整基因的TSS的位置，比较所映射的TSS的所有位置以鉴定关于每个完整基因的最多5'侧位置，并且基于关于每个完整基因具有最多5'侧位置的TSS来指定调节因子结合位点。版权所有（C）2009，JPO＆INPIT

3. 发明专利

DE602004018115D1 未知
公开(公告)号：DE602004018115D1
公开(公告)日：2009-01-15
申请号：DE602004018115
申请日：2004-03-24
申请人： ANESIVA INC
发明人： ZHANG JIE , WEI HSIU-YING , MCEVOY LESLIE MARGARET
IPC分类号： C12N15/00 , C12Q1/68 , G01N33/48 , G01N33/50 , G06F17/30 , G06F19/00
摘要： A method is provided for profiling regulatory factor binding sites. A complete gene is located on genome for mapping gene regulatory regions. Genomic sequences of gene regulatory regions are defined and retrieved. DNA sequence information of each retrieved gene regulatory region is screened for identifying putative regulatory factor binding sites. The putative regulatory factor binding sites are profiled.

4. 发明专利

AU2004225536A1 Statistical analysis of regulatory factor binding sites of differentially expressed genes 未知
公开(公告)号：AU2004225536A1
公开(公告)日：2004-10-14
申请号：AU2004225536
申请日：2004-03-24
申请人： ANESIVA INC
发明人： WEI HSIU-YING , ZHANG JIE , MCEVOY LESLIE MARGARET
IPC分类号： C12N15/09 , C12Q1/68 , G01N33/48 , G01N33/50 , G06F19/00
摘要： The invention concerns the statistical analysis of regulatory factor binding sites of differentially expressed genes. More particularly, the invention concerns methods for identifying and characterizing regulatory factor, e.g. transcription factor binding sites in differentially expressed genes in order to develop therapeutic strategies for the treatment of diseases which are accompanied by differential gene expression, or to study biological processes.

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