专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US5059591A Drug preparations of reduced toxicity 失效
标题翻译：药物制剂毒性降低
公开(公告)号：US5059591A
公开(公告)日：1991-10-22
申请号：US405623
申请日：1989-09-12
申请人： Andrew S. Janoff , Mircea C. Popescu , Carl R. Alving , Michael W. Fountain , Robert P. Lenk , Marc J. Ostro , Paul A. Tremblay , Alan L. Weiner
发明人： Andrew S. Janoff , Mircea C. Popescu , Carl R. Alving , Michael W. Fountain , Robert P. Lenk , Marc J. Ostro , Paul A. Tremblay , Alan L. Weiner
IPC分类号： A61K9/127 , A61K47/48
CPC分类号： A61K47/48215 , A61K47/48053 , A61K47/48123 , A61K9/127
摘要： Preparations of drugs in admixture with certain ligands are described which, when administered to animals or humans, are less toxic than conventional drug preparations. Although the toxicity of the drug-ligand preparations described is greatly reduced, the drug retains pharmacological activity.
摘要翻译：描述了与某些配体混合的药物的制备，其当施用于动物或人时比常规药物制剂毒性低。虽然所述药物 - 配体制剂的毒性大大降低，但药物保留药理活性。

2. 发明授权

US4897384A Drug preparations of reduced toxicity 失效
标题翻译：药物制剂毒性降低
公开(公告)号：US4897384A
公开(公告)日：1990-01-30
申请号：US844248
申请日：1986-03-24
申请人： Andrew S. Janoff , Carl R. Alving , Michael W. Fountain , Robert P. Lenk , Marc J. Ostro , Mircea C. Popescu , Paul A. Tremblay , Alan L. Weiner
发明人： Andrew S. Janoff , Carl R. Alving , Michael W. Fountain , Robert P. Lenk , Marc J. Ostro , Mircea C. Popescu , Paul A. Tremblay , Alan L. Weiner
IPC分类号： A61K20060101 , A61K9/127 , A61K31/00 , A61K31/66 , A61K31/665 , A61K31/70 , A61K47/00 , A61K47/48
CPC分类号： A61K9/127 , A61K47/48053 , A61K47/48123 , A61K47/48215
摘要： Preparations of drugs in admixture with certain ligands are described which, when administered to animals or humans, are less toxic than conventional drug preparations. Although the toxicity of the drug-ligand preparations described is greatly reduced, the drug retains pharmacological activity.
摘要翻译：描述了与某些配体混合的药物的制备，其当施用于动物或人时比常规药物制剂毒性低。虽然所述药物 - 配体制剂的毒性大大降低，但药物保留药理活性。

3. 发明授权

US5916588A Peptide-containing liposomes, immunogenic liposomes and methods of preparation and use 失效
标题翻译：含肽的脂质体，免疫原性脂质体及其制备和使用方法
公开(公告)号：US5916588A
公开(公告)日：1999-06-29
申请号：US452549
申请日：1995-05-25
申请人： Mircea C. Popescu , Alan L. Weiner , Marie S. Recine , Andrew S. Janoff , Leonard Estis , Lynn D. Keyes , Carl R. Alving
发明人： Mircea C. Popescu , Alan L. Weiner , Marie S. Recine , Andrew S. Janoff , Leonard Estis , Lynn D. Keyes , Carl R. Alving
IPC分类号： A61K9/00 , A61K9/127 , A61K39/39 , A61K39/00
CPC分类号： A61K39/39 , A61K9/1271 , A61K2039/55555
摘要： A high integrity liposome comprising at least one stabile lipid and at least one peptide-like therapeutic agent associated with the liposome, adapted for parenteral administration to an animal, including a human, and method according to manufacture and use.Immunizing dosage forms comprising a liposome and an immunogen, wherein the liposome and immunogen are present in an immunization dose. Additionally, a dosage form, including such form particularly adapted to producing an immune response, comprising a salt according to an organic acid derivative of a sterol and an immunogen are present in an immunization dose, and method according to uses is disclosed. Further, a dosage form, including such form particularly adapted to producing an immune response, comprising dimyristolyphosphatidylcholine (DMPC)/cholesterol liposomes, optionally in an aluminum hydroxide gel, and an immunogen wherein the DMPC/cholesterol and immunogen are present in an immunization dose, and method according to use.
摘要翻译：包含至少一种稳定脂质和至少一种与脂质体相关的肽样治疗剂的高完整性脂质体，其适于肠胃外给予动物，包括人类，以及根据制造和使用的方法。包含脂质体和免疫原的免疫剂型，其中所述脂质体和免疫原以免疫剂量存在。此外，包含特定适于产生免疫应答的形式的剂型，其包含根据固醇和免疫原的有机酸衍生物的盐，其以免疫剂量存在，并且公开了根据用途的方法。此外，包括特别适于产生免疫应答的剂型，包括任选在氢氧化铝凝胶中的二肉豆蔻基磷脂酰胆碱（DMPC）/胆固醇脂质体和免疫原，其中DMPC /胆固醇和免疫原以免疫剂量存在，和方法根据用途。

4. 发明授权

US6090406A Potentiation of immune responses with liposomal adjuvants 失效
标题翻译：用脂质体佐剂增强免疫反应
公开(公告)号：US6090406A
公开(公告)日：2000-07-18
申请号：US485388
申请日：1990-02-26
申请人： Mircea C. Popescu , Alan L. Weiner , Marie S. Recine , Andrew S. Janoff , Leonard Estis , Lynn D. Keyes , Carl R. Alving
发明人： Mircea C. Popescu , Alan L. Weiner , Marie S. Recine , Andrew S. Janoff , Leonard Estis , Lynn D. Keyes , Carl R. Alving
IPC分类号： A61K9/00 , A61K9/127 , A61K39/12 , A61K39/385 , B01J13/02
CPC分类号： A61K9/1271 , A61K9/1272 , A61K2039/55555 , Y10S424/812
摘要： A high integrity liposome comprising at least one stabile lipid and at least one peptide-like therapeutic agent associated with said liposome, adapted for parenteral administration to an animal, including a human, and method according to manufacture and use. Immunizing dosage forms comprising a liposome and an immunogen, wherein said liposome and immunogen are present in an immunization dose. Additionally, a dosage form, including such form particularly adapted to producing an immune response, comprising a salt according to an organic acid derivative of a sterol and an immunogen wherein said organic acid derivative of a sterol and immunogen are present in an immunization dose, and method according to use is disclosed. Further, a dosage form, including such form particularly adapted to producing an immune response, comprising dimyristoylphosphatidylcholine (DMPC)/cholesterol liposomes, optionally in an aluminum hydroxide gel, and an immunogen wherein said DMPC/cholesterol and immunogen are present in an immunization dose, and method according to use.
摘要翻译：包含至少一种稳定脂质和与所述脂质体相关联的至少一种肽样治疗剂的高完整性脂质体，适于肠胃外给予动物（包括人），以及根据制造和使用的方法。包含脂质体和免疫原的免疫剂型，其中所述脂质体和免疫原以免疫剂量存在。另外，包括特别适于产生免疫应答的剂型，其包含根据固醇和免疫原的有机酸衍生物的盐，其中所述固醇和免疫原的所述有机酸衍生物以免疫剂量存在，以及公开了根据使用的方法。此外，包括特别适于产生免疫应答的形式的剂型，包括二肉豆蔻酰磷脂酰胆碱（DMPC）/胆固醇脂质体，任选地在氢氧化铝凝胶中，以及免疫原，其中所述DMPC /胆固醇和免疫原以免疫剂量存在，和方法根据用途。

5. 发明授权

US06224902B1 Vaccines against sterols 失效
标题翻译：针对甾醇的疫苗
公开(公告)号：US06224902B1
公开(公告)日：2001-05-01
申请号：US09023256
申请日：1998-02-13
申请人： Carl R. Alving , Julie Kenner , Glenn M. Swartz, Jr. , John W. Madsen
发明人： Carl R. Alving , Julie Kenner , Glenn M. Swartz, Jr. , John W. Madsen
IPC分类号： A61K9127
CPC分类号： A61K31/575 , A61K9/127 , A61K9/1271 , A61K31/58 , A61K31/66 , A61K38/00 , A61K39/00 , A61K39/0002 , A61K39/0012 , A61K39/02 , A61K39/39 , A61K2039/55505 , A61K2039/5555 , A61K2039/55555 , A61K2039/55572 , B82Y5/00 , C07K14/445 , C07K16/1203 , C07K16/18 , C07K16/44 , G01N33/92 , G01N2800/044
摘要： The present invention relates to immunoreactive vaccine compositions for immunizing humans or animals against sterols, such as cholesterol and its derivatives, and their use in methods for reducing the serum cholesterol levels of the immunized individuals and to retard or reduce the severity of artherosclerosis or artherosclerosis plaques caused by ingestion of dietary cholesterol.
摘要翻译：本发明涉及用于免疫人或动物对抗甾醇（例如胆固醇及其衍生物）的免疫反应性疫苗组合物，以及它们在降低免疫个体的血清胆固醇水平的方法中的用途，并且用于延缓或降低动脉粥样硬化或动脉粥样硬化斑块的严重程度由摄入膳食胆固醇引起。

6. 发明授权

US5229376A Encapsulated plant-derived phosphatidylinositol (PI) compositions for the prevention of mitogenically induced cell proliferation 失效
标题翻译：用于预防有丝分裂诱导的细胞增殖的包封的植物衍生的磷脂酰肌醇（PI）组合物
公开(公告)号：US5229376A
公开(公告)日：1993-07-20
申请号：US667894
申请日：1991-03-12
申请人： Carl R. Alving , Earl C. Richardson
发明人： Carl R. Alving , Earl C. Richardson
IPC分类号： A61K9/127 , A61K31/66
CPC分类号： A61K31/685 , A61K31/66 , A61K9/127
摘要： Encapsulated PI compositions such as liposomes containing plant PI and th use to prevent mitogenic transformation of normal splenic lymphoid cells (including lymphocytes transformed induced by treatment of cells with lipid A) by exposing the cells thereto.
摘要翻译：包封的PI组合物如含有植物PI的脂质体及其用于通过将细胞暴露于其中来预防正常脾淋巴细胞（包括通过用脂质A处理细胞诱导的转化的淋巴细胞）的有丝分裂转化的用途。

7. 发明授权

US4999344A Phosphatidyl treatment of rapidly proliferating cells 失效
标题翻译：磷脂酰治疗快速增殖细胞
公开(公告)号：US4999344A
公开(公告)日：1991-03-12
申请号：US168079
申请日：1988-03-14
申请人： Marti Jett-Tilton , Carl R. Alving
发明人： Marti Jett-Tilton , Carl R. Alving
IPC分类号： A61K9/127 , A61K31/66
CPC分类号： A61K31/685 , A61K31/66 , A61K9/127
摘要： Diacyl phosphatides having a polyunsaturated carboxylic acid at the 2 position are found to have cytotoxic effect against tumor cells. Subject compositions may be employed in vivo or in vitro for inhibiting tumor cell growth, either by themselves or in combination with other cytotoxic drugs. The compositions may be administered as liposomes.
摘要翻译：发现在2位具有多不饱和羧酸的二酰基磷脂对肿瘤细胞具有细胞毒性作用。主题组合物可以在体内或体外用于抑制肿瘤细胞生长，无论是本身还是与其它细胞毒性药物组合。组合物可以作为脂质体施用。

8. 发明申请

US20110243979A1 Method of Transcutaneous Immunization Using Antigen 审中-公开
标题翻译：使用抗原经皮免疫的方法
公开(公告)号：US20110243979A1
公开(公告)日：2011-10-06
申请号：US13011071
申请日：2011-01-21
申请人： Gregory M. Glenn , Carl R. Alving
发明人： Gregory M. Glenn , Carl R. Alving
IPC分类号： A61K39/00 , A61K39/12 , A61K39/02 , A61K39/108 , A61K39/07 , A61P37/04 , A61P31/12 , A61P31/16 , A61P31/14 , A61P31/10 , A61P33/00 , A61P31/04 , A61M5/00 , A61M37/00 , A61N1/30
CPC分类号： A61K39/39 , A61K9/0019 , A61K9/0021 , A61K39/00 , A61K2039/54 , A61K2039/55544 , C12N2760/16134
摘要： Transcutaneous immunization can deliver antigen to the immune system through the stratum corneum without physical or chemical penetration to the dermis layer of the skin. This delivery system induces an antigen-specific immune response. Use of skin-active adjuvants is preferred. Although perforation of intact skin is not required, superficial penetration or micropenetration of the skin can act as an enhancer; similarly, hydration may enhance the immune response. This system can induce antigen-specific immune effectors after epicutaneous application of a formulation containing one or more antigen and adjuvant. The formulation may initiate processes such as antigen uptake, processing, and presentation; Langerhans cell activation, migration from the skin to other immune organs, and differentiation to mature dendritic cells; contacting antigen with lymphocytes bearing cognate antigen receptors on the cell surface and their stimulation; and combinations thereof. Systemic and/or regional immunity may be induced; immune responses that result in prophylaxis and/or therapeutic treatments are preferred. Antigen and adjuvant activities in the formulation may be found in the same molecule, two or more different molecules dissociated from each other, or multiple molecules in a complex formed by covalent or non-covalent bonds. For antigens and adjuvants which are proteinaceous, they may be provided in the formulation as a polynucleotide for transcutaneous genetic immunization. Besides simple application of a liquid formulation, patches or other medical devices may be used to deliver antigen for immunization.
摘要翻译：经皮免疫可以通过角质层将免疫系统的抗原递送到皮肤的真皮层，而不会物理或化学地渗透到真皮层。该递送系统诱导抗原特异性免疫应答。优选使用皮肤活性佐剂。虽然不需要完整皮肤的穿孔，但皮肤的表面渗透或微穿透可以作为增强剂; 类似地，水合可以增强免疫应答。该系统在表皮施用含有一种或多种抗原和佐剂的制剂后可以诱导抗原特异性免疫效应物。制剂可以引发诸如抗原摄取，加工和表达的过程; 朗格汉斯细胞活化，从皮肤迁移到其他免疫器官，并分化成成熟树突状细胞; 使抗原与淋巴细胞接触细胞表面的同源抗原受体及其刺激; 及其组合。可能诱发全身和/或区域免疫; 导致预防和/或治疗性治疗的免疫应答是优选的。制剂中的抗原和佐剂活性可以在相同的分子中发现，两个或更多个不同的分子彼此离解，或者是通过共价或非共价键形成的复合物中的多个分子。对于蛋白质的抗原和佐剂，它们可以作为经皮基因免疫的多核苷酸提供在制剂中。除了液体制剂的简单应用之外，可以使用贴片或其他医疗装置来递送用于免疫的抗原。

9. 发明授权

US06900025B2 Detection of antibodies to squalene in serum 失效
标题翻译：检测血清中角鲨烯的抗体
公开(公告)号：US06900025B2
公开(公告)日：2005-05-31
申请号：US09859389
申请日：2001-05-18
申请人： Carl R. Alving , Gary R. Matyas , Nabila M. Wassef , Mangala Rao
发明人： Carl R. Alving , Gary R. Matyas , Nabila M. Wassef , Mangala Rao
IPC分类号： C07K16/44 , C12N1/21 , C12N15/53 , G01N33/53
CPC分类号： G01N33/5308 , C07K16/44
摘要： The invention is a method for detecting squalene in sera.
摘要翻译：本发明是一种检测血清中角鲨烯的方法。

10. 发明授权

US5910306A Transdermal delivery system for antigen 失效
标题翻译：用于抗原的透皮递送系统
公开(公告)号：US5910306A
公开(公告)日：1999-06-08
申请号：US749164
申请日：1996-11-14
申请人： Carl R. Alving , Gregory M. Glenn
发明人： Carl R. Alving , Gregory M. Glenn
IPC分类号： A61K9/00 , A61K9/06 , A61K9/08 , A61K9/107 , A61K9/127 , A61K9/70 , A61K35/14 , A61K35/39 , A61K39/00 , A61K39/39 , A61P37/04 , A61K39/002 , A61K39/02 , A61K39/12
CPC分类号： A61K39/39 , A61K9/06 , A61K9/08 , A61K9/107 , A61K9/127 , A61K9/7023 , A61K2039/54 , A61K2039/55511 , A61K2039/55527 , A61K2039/55544 , A61K2039/55555 , A61K2039/55566 , Y10S424/81 , Y10S424/812
摘要： A transdermal liposome system delivers antigen to immune cells without perforation of the skin, and induces an immune response in an animal or human. The system uses liposomes to deliver a variety of antigens which can elicit an antigen-specific immune response (e.g., humoral and/or cellular effectors) after topical application of a formulation containing liposomes and antigen to intact skin of the animal or human.
摘要翻译：透皮脂质体系统将抗原递送到免疫细胞而不穿透皮肤，并在动物或人体中诱导免疫应答。在将包含脂质体和抗原的制剂局部施用于动物或人的完整皮肤之后，该系统使用脂质体递送各种能够引发抗原特异性免疫应答的抗原（例如体液和/或细胞效应物）。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式