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1. 发明授权

US5364631A Tocopherol-based pharmaceutical systems 失效
标题翻译：基于生育酚的制药系统
公开(公告)号：US5364631A
公开(公告)日：1994-11-15
申请号：US18913
申请日：1993-02-17
申请人： Andrew S. Janoff , Lawrence Boni , Sharma R. Minchey , Lois E. Bolcsak , Steven J. Weiss
发明人： Andrew S. Janoff , Lawrence Boni , Sharma R. Minchey , Lois E. Bolcsak , Steven J. Weiss
IPC分类号： A61K9/127 , A61K31/415
CPC分类号： A61K31/415 , A61K9/1272 , Y10T428/2984
摘要： A method for making a pharmaceutical composition is described. The composition is comprised of an organic acid derivative of alpha tocopherol, and may additionally comprise other lipids. The composition may be in the form of liposomes, and as such are associated with or entrap a bioactive agent. Particularly suited for such systems are drugs stable at acidic pH, for example drugs having imidazole groups, such as pilocarpine. The composition requires a stabilizer to maintain the bilayer phase of the organic acid derivative of alpha tocopherol in a low pH environment. Such a stabilizer is for example a detergent. Upon in vivo administration of the system and concomitant increase of pH, viscosity of the preparation increases.
摘要翻译：描述制备药物组合物的方法。组合物由α-生育酚的有机酸衍生物组成，并且还可以包含其它脂质。组合物可以是脂质体的形式，因此与生物活性剂相关联或截留生物活性剂。特别适用于这种系统是在酸性pH下稳定的药物，例如具有咪唑基团的药物，如毛果芸香碱。该组合物需要稳定剂以在低pH环境中维持α-生育酚的有机酸衍生物的双相。这种稳定剂是例如洗涤剂。在系统的体内给药和伴随pH的增加时，制剂的粘度增加。

2. 发明授权

US5169637A Stable plurilamellar vesicles 失效
标题翻译：稳定的多层囊泡
公开(公告)号：US5169637A
公开(公告)日：1992-12-08
申请号：US679569
申请日：1991-04-02
申请人： Robert P. Lenk , Michael W. Fountain , Andrew S. Janoff , Mircea C. Popescu , Steven J. Weiss , Richard S. Ginsberg , Marc J. Ostro , Sol M. Gruner
发明人： Robert P. Lenk , Michael W. Fountain , Andrew S. Janoff , Mircea C. Popescu , Steven J. Weiss , Richard S. Ginsberg , Marc J. Ostro , Sol M. Gruner
IPC分类号： A61K9/127
CPC分类号： A61K9/127 , A61K9/1277
摘要： A new and substantially improved type of lipid vesicle, called stable plurilamellar vesicles (SPLVs), are described, as well as the process for making the same and X-ray diffraction methods for identifying the same. SPLVs are characterized by lipid bilayers enclosing aqueous compartments containing one or more entrapped solutes, the concentration of such solutes in each aqueous compartment being substantially equal to the emunization of solutes used to prepare the SPLVs. The bilayers of SPLVs are substantially non-compressed. SPLVs are stable during storage and can be used in vivo for the sustained release of compounds and in the treatment of disease.
摘要翻译：描述了称为稳定多层囊泡（SPLV）的新的和基本上改进的类型的脂质囊泡，以及制备相同的方法和用于鉴定其的X射线衍射方法。 SPLV的特征在于包裹含有一个或多个截留的溶质的水性隔室的脂质双层，每个水分隔室中的这种溶质的浓度基本上等于用于制备SPLV的溶质的排出。 SPLV的双层基本上是非压缩的。 SPLV在储存期间是稳定的，并且可以在体内用于化合物的持续释放和疾病的治疗。

3. 发明授权

US5030453A Stable plurilamellar vesicles 失效
标题翻译：稳定的多层囊泡
公开(公告)号：US5030453A
公开(公告)日：1991-07-09
申请号：US660573
申请日：1984-10-12
申请人： Robert P. Lenk , Michael W. Fountain , Andrew S. Janoff , Mircea C. Popescu , Steven J. Weiss , Richard S. Ginsberg , Marc J. Ostro , Sol M. Gruner
发明人： Robert P. Lenk , Michael W. Fountain , Andrew S. Janoff , Mircea C. Popescu , Steven J. Weiss , Richard S. Ginsberg , Marc J. Ostro , Sol M. Gruner
IPC分类号： A61K9/127
CPC分类号： A61K9/1277 , A61K9/127
摘要： A new and substantially improved type of lipid vesicle, called stable plurilamellar vesicles (SPLVs), are described, as well as the process for making the same and X-ray diffraction methods for identifying the same. SPLVs are characterized by lipid bilayers enclosing aqueous compartments containing one or more entrapped solutes, the concentration of such solutes in each aqueous compartment being substantially equal to the concentration of solutes used to prepare the SPLVs. The bilayers of SPLVs are substantially non-compressed. SPLVs are stable during storage and can be used in vivo for the sustained release of compounds and in the treatment of disease.
摘要翻译：描述了称为稳定多层囊泡（SPLV）的新的和基本上改进的类型的脂质囊泡，以及制备相同的方法和用于鉴定其的X射线衍射方法。 SPLV的特征在于包围含有一个或多个截留的溶质的水性隔室的脂质双层，每个水分隔室中的这种溶质的浓度基本上等于用于制备SPLV的溶质的浓度。 SPLV的双层基本上是非压缩的。 SPLV在储存期间是稳定的，并且可以在体内用于化合物的持续释放和疾病的治疗。

4. 发明授权

US07692592B2 High power two-patch array antenna system 有权
标题翻译：大功率双片阵列天线系统
公开(公告)号：US07692592B2
公开(公告)日：2010-04-06
申请号：US12178771
申请日：2008-07-24
申请人： Canh Ly , Steven J. Weiss , Arthur C. Harrison
发明人： Canh Ly , Steven J. Weiss , Arthur C. Harrison
IPC分类号： H01Q1/24 , H01Q1/38
CPC分类号： H01Q1/34 , H01Q1/42 , H01Q9/0407 , H01Q21/08
摘要： A patch array antenna is disclosed. The patch array antenna includes a ground plane with two patches. Each patch is supported from the ground plane only by metal posts. The patch array antenna further includes two-pin-feed probes, each pin-feed probe coupled to one patch, and a two-way high power divider attached to both pin-feed probes.
摘要翻译：公开了贴片阵列天线。贴片阵列天线包括具有两个贴片的接地平面。每个补丁只能通过金属柱从地平面支撑。贴片阵列天线还包括双引脚馈送探针，每个引脚馈送探针耦合到一个贴片，以及连接到两个引脚馈送探针的双向高功率分配器。

5. 发明授权

US5283969A Identification band 失效
标题翻译：识别带
公开(公告)号：US5283969A
公开(公告)日：1994-02-08
申请号：US921554
申请日：1992-07-29
申请人： Steven J. Weiss
发明人： Steven J. Weiss
IPC分类号： G09F3/00 , A61B5/103 , A44C5/00
CPC分类号： G09F3/005
摘要： An identification band having a pocket portion and a strap portion extending from the pocket portion. The pocket portion encloses identification information pertaining to the wearer. The periphery of the pocket portion is configured to convey a creative artistic impression, that is, a configuration resembling at least a portion of any one of a living being (alive now or in the past), cartoon character, a man-made functional article (such a transportation vehicle and a building), a natural object (such as a cloud or star) and a decoration (such as holiday decorations and artwork). The pocket portion may be relatively planar or be formed so that the artistic impression is three-dimensional.
摘要翻译：具有口袋部分和从口袋部分延伸的带部分的识别带。口袋部分包围有关佩戴者的识别信息。袖口部分的周边被配置为传达创造性的艺术印象，即，类似于生活（现在或过去存在），卡通人物，人造功能文章中的任何一个的至少一部分的配置（如运输车辆和建筑物），天然物体（如云或星星）和装饰品（如假日装饰品和艺术作品）。口袋部分可以是相对平面的或形成为使得艺术印象是三维的。

6. 发明申请

US20100019984A1 HIGH POWER TWO-PATCH ARRAY ANTENNA SYSTEM 有权
标题翻译：高功率双路阵列天线系统
公开(公告)号：US20100019984A1
公开(公告)日：2010-01-28
申请号：US12178771
申请日：2008-07-24
申请人： Canh Ly , Steven J. Weiss , Arthur C. Harrison
发明人： Canh Ly , Steven J. Weiss , Arthur C. Harrison
IPC分类号： H01Q9/04 , H01Q1/42
CPC分类号： H01Q1/34 , H01Q1/42 , H01Q9/0407 , H01Q21/08
摘要： A patch array antenna is disclosed. The patch array antenna includes a ground plane with two patches. Each patch is supported from the ground plane only by metal posts. The patch array antenna further includes two-pin-feed probes, each pin-feed probe coupled to one patch, and a two-way high power divider attached to both pin-feed probes.
摘要翻译：公开了贴片阵列天线。贴片阵列天线包括具有两个贴片的接地平面。每个补丁只能通过金属柱从地平面支撑。贴片阵列天线还包括双引脚馈送探针，每个引脚馈送探针耦合到一个贴片，以及连接到两个引脚馈送探针的双向高功率分配器。

7. 发明授权

US4610868A Lipid matrix carriers for use in drug delivery systems 失效
标题翻译：用于药物输送系统的脂质基质载体
公开(公告)号：US4610868A
公开(公告)日：1986-09-09
申请号：US591576
申请日：1984-03-20
申请人： Michael W. Fountain , Steven J. Weiss , John J. Kearns , Alan L. Weiner , Mircea C. Popescu
发明人： Michael W. Fountain , Steven J. Weiss , John J. Kearns , Alan L. Weiner , Mircea C. Popescu
IPC分类号： A61K9/127 , A61K43/00 , A61K49/00
CPC分类号： A61K9/127 , Y10T428/2984
摘要： Lipid matrix carriers are described which provide for the sustained release of bioactive agents in vivo or in vitro. The properties of the lipid matrix carriers of the present invention include high entrapment efficiencies; release of entrapped compounds in their active form; biodegradability and avoidance of vascular occlusion in vivo; and avoidance of sequestration of the bioactive agent in the liver and spleen.
摘要翻译：描述了脂质基质载体，其在体内或体外提供生物活性剂的持续释放。本发明的脂质基质载体的性质包括高的包埋效率; 以活性形式释放截留的化合物; 生物降解性和避免体内血管闭塞; 并避免肝脏和脾脏中生物活性剂的螯合。

8. 发明授权

US5000958A Enhancement of pharmaceutical activity 失效
标题翻译：增强药物活性
公开(公告)号：US5000958A
公开(公告)日：1991-03-19
申请号：US633481
申请日：1984-07-26
申请人： Michael W. Fountain , Steven J. Weiss , Robert P. Lenk , Mircea C. Popescu , Richard S. Ginsberg
发明人： Michael W. Fountain , Steven J. Weiss , Robert P. Lenk , Mircea C. Popescu , Richard S. Ginsberg
IPC分类号： A61K9/127
CPC分类号： A61K9/127
摘要： The invention encompasses mixtures of antimicrobial agents coencapsulated in liposomes which when administered in vivo exert an enhanced therapeutic effect. The therapeutic effectiveness of the coencapsulated antimocrobial agents is greater than that of the same combination administered either in solution or as a mixture of liposome populations each containing one of the antimicrobial agents.
摘要翻译：本发明包括在脂质体中包封的抗微生物剂的混合物，其在体内施用时发挥增强的治疗效果。胶囊化抗菌剂的治疗效果大于在溶液或作为每种含有一种抗微生物剂的脂质体群体的混合物中施用的相同组合。

9. 发明授权

US4588578A Lipid vesicles prepared in a monophase 失效
标题翻译：在单相制备的脂质囊泡
公开(公告)号：US4588578A
公开(公告)日：1986-05-13
申请号：US521176
申请日：1983-08-08
申请人： Michael W. Fountain , Steven J. Weiss , Mircea C. Popescu
发明人： Michael W. Fountain , Steven J. Weiss , Mircea C. Popescu
IPC分类号： A61K49/00 , A61K9/00 , A61K9/127 , A61K51/00 , B01J13/02 , A61K43/00
CPC分类号： A61K9/1277 , Y10S436/829 , Y10T428/2984
摘要： A process for the preparation in a monophasic solvent system of a new type of lipid vesicles, called monophasic lipid vesicles (MPVs). MPVs can be made to encapsulate one or more bioactive agents. MPVs are stable during storage and can be used in vivo in the treatment of disease.
摘要翻译：在单相溶剂系统中制备称为单相脂质囊泡（MPV）的新型脂质囊泡的方法。可以制备MPV以包封一种或多种生物活性剂。 MPV在储存过程中是稳定的，可用于体内治疗疾病。

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