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1. 发明申请

US20140273125A1 PROCESSES FOR THE ANAEROBIC BIOCONVERSION OF SYNGAS TO OXYGENATED ORGANIC COMPOUND WITH IN SITU PROTECTION FROM HYDROGEN CYANIDE 有权
标题翻译：从氢氰化物处理到氧化有机化合物的无机生物反应过程
公开(公告)号：US20140273125A1
公开(公告)日：2014-09-18
申请号：US13828542
申请日：2013-03-14
申请人： Robert Hickey , Jianxin Du , Andrew Reeves , Richard E. Tobey
发明人： Robert Hickey , Jianxin Du , Andrew Reeves , Richard E. Tobey
IPC分类号： C12P7/16 , C12P7/04 , C12P7/06
CPC分类号： C12P7/16 , C12N1/20 , C12N1/38 , C12P7/04 , C12P7/06 , Y02E50/10 , Y02E50/17
摘要： Processes are disclosed for the anaerobic bioconversion of syngas to oxygenated organic compound that use an in situ method for protecting the microorganisms from hydrogen cyanide contained in the syngas that passes to the fermentation broth. The fermentation broth is maintained at a pH of between about 4 and 6, and dissolved metal cation of one or more of iron, cobalt, nickel and zinc is provided to the fermentation broth in an amount sufficient to form, under the conditions of the fermentation broth, a substantially insoluble metal complex with the metal cation and cyanide anion. The rate of formation of the insoluble complex is sufficiently high that that the amount of cyanide that is taken up by microorganisms does not result in an undue adverse effect on the population of microorganisms.
摘要翻译：公开了将合成气厌氧生物转化为含氧有机化合物的方法，其使用原位方法保护微生物免受通过发酵液的合成气中所含的氰化氢。发酵液的pH值保持在4〜6左右之间，并在发酵液中提供一种或多种铁，钴，镍，锌溶解的金属阳离子，其量足以在发酵条件下形成肉汤，与金属阳离子和氰化物阴离子基本不溶的金属络合物。不溶性络合物的形成速率足够高，使得微生物吸收的氰化物的量不会对微生物群体产生不适当的不利影响。

2. 发明申请

US20090311677A1 Identification of contaminating bacteria in industrial ethanol fermentations 审中-公开
标题翻译：工业乙醇发酵中污染细菌的鉴定
公开(公告)号：US20090311677A1
公开(公告)日：2009-12-17
申请号：US12157978
申请日：2008-06-13
申请人： Andrew Reeves , Richard E. Tobey
发明人： Andrew Reeves , Richard E. Tobey
IPC分类号： C12Q1/68 , C07H21/04
CPC分类号： C12Q1/689 , C12Q1/6841 , Y02E50/17
摘要： A method for determining the presence of a contaminating organism in a fermentation process includes initiating the fermentation process using a syngas and obtaining a first aliquot from the fermentation process. The method further includes subjecting said first aliquot to a polymerase chain reaction using at least one oligonucleotide primer capable of hybridizing to a target sequence of a genomic nucleic acid from a suspected contaminating organism, producing a first amplified product based on the polymerase chain reaction, separating the first amplified product based on size, and determining the presence of the suspected contaminating organism based on the first separated amplified product.
摘要翻译：用于确定发酵过程中污染生物体的存在的方法包括使用合成气启动发酵过程，并从发酵过程获得第一等分试样。该方法还包括使用至少一种能够与疑似污染生物体的基因组核酸的靶序列杂交的寡核苷酸引物对所述第一等分试样进行聚合酶链反应，基于聚合酶链反应产生第一扩增产物，分离基于大小的第一扩增产物，并且基于第一分离的扩增产物确定可疑污染生物体的存在。

3. 发明授权

US09045760B2 Genes encoding key catalyzing mechanisms for ethanol production from syngas fermentation 有权
标题翻译：编码合成气发酵乙醇生产关键催化机制的基因
公开(公告)号：US09045760B2
公开(公告)日：2015-06-02
申请号：US13655054
申请日：2012-10-18
申请人： Andrew Reeves , Rathin Datta
发明人： Andrew Reeves , Rathin Datta
IPC分类号： C12P7/06 , C12N9/00 , C12N1/20 , C12N15/00 , C07H21/04 , C12N15/74 , C12N15/52
CPC分类号： C12N15/74 , C12N15/52 , C12P7/065 , Y02E50/17
摘要： Gene sequences of key acetogenic clostridial species were sequenced and isolated. Genes of interest were identified, and functionality was established. Key genes of interest for metabolic catalyzing activity in clostridial species include a three-gene operon coding for CODH activity, a two-gene operon coding for PTA-ACK, and a novel acetyl coenzyme A reductase. The promoter regions of the two operons and the acetyl coA reductase are manipulated to increase ethanol production.
摘要翻译：对重要的乙型梭菌种的基因序列进行测序和分离。确定了感兴趣的基因，建立了功能。梭菌中代谢催化活性的关键基因包括编码CODH活性的三基因操纵子，编码PTA-ACK的双基因操纵子和新型乙酰辅酶A还原酶。操纵两个操纵子的启动子区域和乙酰辅酶A还原酶以增加乙醇生成。

4. 发明授权

US09734139B2 Auditing and tracking changes of data and code in spreadsheets and other documents 有权
公开(公告)号：US09734139B2
公开(公告)日：2017-08-15
申请号：US11461087
申请日：2006-07-31
申请人： Andrew Reeves , James Culverwell , Aaron Wittman
发明人： Andrew Reeves , James Culverwell , Aaron Wittman
IPC分类号： G06F17/00 , G06F17/24 , G06F17/22
CPC分类号： G06F17/246 , G06F17/2211 , G06F17/2288
摘要： A system for monitoring and auditing data in one or more spreadsheets comprises a file store within which files containing spreadsheet data can be stored, a database, and monitoring means. The monitoring means is operative to detect changes in spreadsheet data within the file store and to record the changes in the database. The system may comprise an entity selector for selecting entities in a spreadsheet, and a tracker for tracking the shift in position of entities. An offset determinator derives offset values representing the shift in position of the entities. An offset applicator applies the offset values to the spreadsheet data before comparing the spreadsheet data with a version of the spreadsheet data at a different time point. In a further aspect, the invention provides a system for processing and storing spreadsheets.

5. 发明授权

US08551746B2 Method for controlling undesirable byproducts formation caused by contaminating organisms in the production of ethanol from syngas 有权
标题翻译：用于控制由合成气生产乙醇中的污染生物引起的不希望的副产物形成的方法
公开(公告)号：US08551746B2
公开(公告)日：2013-10-08
申请号：US13239305
申请日：2011-09-21
申请人： Andrew Reeves , Rathin Datta
发明人： Andrew Reeves , Rathin Datta
IPC分类号： C12P7/52 , C12P7/06
CPC分类号： C12P7/04 , C12P7/065 , C12P7/08 , C12P7/14 , C12P7/52 , C12P7/54 , C12P39/00 , Y02E50/17
摘要： A method of operating a fermentation zone for the production of ethanol from syngas uses a crotonate derivative to prevent or reverse the effects of butyrigen contamination. The crotonate compound works in continuous fermentation processes to reduce or eliminate contamination from butyrate and butanol in the syngas derived ethanol product.
摘要翻译：操作从合成气生产乙醇的发酵区的方法使用巴豆酸衍生物来防止或逆转丁酰胺污染的作用。巴豆酸酯化合物在连续发酵过程中起作用，以减少或消除合成气衍生乙醇产物中丁酸和丁醇的污染。

6. 发明申请

US20130071896A1 METHOD FOR CONTROLLING UNDESIRABLE BYPRODUCTS FORMATION CAUSED BY CONTAMINATING ORGANISMS IN THE PRODUCTION OF ETHANOL FROM SYNGAS 有权
标题翻译：用于控制由SYNGAS生产乙醇中的污染组织引起的不可预测的副产物形成的方法
公开(公告)号：US20130071896A1
公开(公告)日：2013-03-21
申请号：US13239305
申请日：2011-09-21
申请人： Andrew Reeves , Rathin Datta
发明人： Andrew Reeves , Rathin Datta
IPC分类号： C12P7/54 , C12P7/04 , C12P7/52 , C12P7/06
CPC分类号： C12P7/04 , C12P7/065 , C12P7/08 , C12P7/14 , C12P7/52 , C12P7/54 , C12P39/00 , Y02E50/17
摘要： A method of operating a fermentation zone for the production of ethanol from syngas uses a crotonate derivative to prevent or reverse the effects of butyrigen contamination. The crotonate compound works in continuous fermentation processes to reduce or eliminate contamination from butyrate and butanol in the syngas derived ethanol product.
摘要翻译：操作从合成气生产乙醇的发酵区的方法使用巴豆酸衍生物来防止或逆转丁酰胺污染的作用。巴豆酸酯化合物在连续发酵过程中起作用，以减少或消除合成气衍生乙醇产物中丁酸和丁醇的污染。

7. 发明授权

US08039239B2 Recombinant microorganisms having modified production of alcohols and acids 有权
标题翻译：具有醇和酸改性产生的重组微生物
公开(公告)号：US08039239B2
公开(公告)日：2011-10-18
申请号：US12336278
申请日：2008-12-16
申请人： Andrew Reeves
发明人： Andrew Reeves
IPC分类号： C12P7/06 , C12P7/16 , C12N9/04 , C12N1/20 , C01B3/00
CPC分类号： C12P7/065 , C12P7/04 , C12P7/16 , Y02E50/10 , Y02E50/17
摘要： Recombinant acetogenic Clostridia are engineered to modulate production of aliphatic C2-C6 alcohols and aliphatic C2-C6 organic acids from synthetic gases. One aspect of the invention provides a method of producing an aliphatic C2-C6 alcohol using an acetogenic Clostridium micro-organism having at least one genetic modification that reduces or eliminates C2-C6 carboxylic acid production by the modified organism. Another aspect of the invention provides a method of producing an aliphatic C2-C6 alcohol using an acetogenic Clostridium micro-organism having one or more genetic modifications that cause increased enzyme activity of carbon monoxide dehydrogenase, aldehyde ferredoxin oxidoreductase, NADPH-dependent alcohol dehydrogenase, or alcohol dehydrogenase. Yet another aspect of the invention provides a method of producing aliphatic C2-C6 alcohols using acetogenic Clostridium micro-organisms that have been genetically modified to increase C2-C6 aliphatic alcohol formation and decrease the production of the corresponding C2-C6 aliphatic organic acid.
摘要翻译：工程改造重组乙型梭菌用于调控来自合成气体的脂族C 2 -C 6醇和脂族C 2 -C 6有机酸的生产。本发明的一个方面提供了使用具有减少或消除经修饰的生物体的C2-C6羧酸产生的至少一种遗传修饰的产乙酰梭菌微生物来生产脂族C 2 -C 6醇的方法。本发明的另一方面提供了一种使用具有一种或多种遗传修饰的乙酰酵母梭菌微生物来生产脂族C 2 -C 6醇的方法，所述遗传修饰引起一氧化碳脱氢酶，醛铁氧还蛋白氧化还原酶，NADPH依赖性醇脱氢酶的酶活性增加，或醇脱氢酶。本发明的另一方面提供了一种使用已经被遗传修饰以产生C2-C6脂族醇形成并降低对应的C 2 -C 6脂族有机酸的产生的乙酰酵母梭菌微生物来生产脂族C 2 -C 6醇的方法。

8. 发明申请

US20110008860A1 Genes encoding key catalyzing mechanisms for ethanol production from syngas fermentation 有权
标题翻译：编码合成气发酵乙醇生产关键催化机制的基因
公开(公告)号：US20110008860A1
公开(公告)日：2011-01-13
申请号：US12802560
申请日：2010-06-09
申请人： Andrew Reeves , Rathin Datta
发明人： Andrew Reeves , Rathin Datta
IPC分类号： C12P7/06 , C07H21/04 , C12N15/63 , C12N1/00 , C07H21/00
CPC分类号： C12N9/1029 , C12N9/1217 , C12N15/52 , C12N15/74 , C12P7/065 , Y02E50/17
摘要： Gene sequences of key acetogenic clostridial species were sequenced and isolated. Genes of interest were identified, and functionality was established. Key genes of interest for metabolic catalyzing activity in clostridial species include a three-gene operon coding for CODH activity, a two-gene operon coding for PTA-ACK, and a novel acetyl coenzyme A reductase. The promoter regions of the two operons and the acetyl coA reductase are manipulated to increase ethanol production.
摘要翻译：对重要的乙型梭菌种的基因序列进行测序和分离。确定了感兴趣的基因，建立了功能。梭菌中代谢催化活性的关键基因包括编码CODH活性的三基因操纵子，编码PTA-ACK的双基因操纵子和新型乙酰辅酶A还原酶。操纵两个操纵子的启动子区域和乙酰辅酶A还原酶以增加乙醇生成。

9. 发明申请

US20070122885A1 METHODS OF INCREASING PRODUCTION OF SECONDARY METABOLITES BY MANIPULATING METABOLIC PATHWAYS THAT INCLUDE METHYLMALONYL-COA 审中-公开
标题翻译：通过操作代谢途径增加二次代谢产物的方法，包括甲基亚油酸
公开(公告)号：US20070122885A1
公开(公告)日：2007-05-31
申请号：US11466364
申请日：2006-08-22
申请人： Andrew Reeves , J. Weber , Igor Brikun
发明人： Andrew Reeves , J. Weber , Igor Brikun
IPC分类号： C12P19/62 , C12N9/10 , C12N15/74 , C12N1/21
CPC分类号： C12P19/62 , C12N1/28 , C12N9/12 , C12N9/90 , C12R1/465
摘要： A process of increasing the cellular production of secondary metabolites, such as antibiotics, is provided. The process is particularly useful for increasing antibiotic production by bacterial cells, especially erythromycin. The process includes the step of increasing the activity of methylmalonyl-CoA mutase.
摘要翻译：提供了增加次级代谢物如抗生素的细胞产生的过程。该方法对于增加细菌细胞，特别是红霉素的抗生素生产特别有用。该方法包括增加甲基丙二酰辅酶A变位酶活性的步骤。

10. 发明申请

US20070011211A1 AUDITING AND TRACKING CHANGES OF DATA AND CODE IN SPREADSHEETS AND OTHER DOCUMENTS 审中-公开
标题翻译：审计和跟踪数据和代码在传播和其他文件中的变化
公开(公告)号：US20070011211A1
公开(公告)日：2007-01-11
申请号：US11461087
申请日：2006-07-31
申请人： Andrew Reeves , James Culverwell , Aaron Wittman
发明人： Andrew Reeves , James Culverwell , Aaron Wittman
IPC分类号： G06F17/30 , G06F17/00
CPC分类号： G06F17/246 , G06F17/2211 , G06F17/2288
摘要： In a first aspect, the invention provides a system for monitoring and auditing data in one or more spreadsheets. The system comprises a file store within which files containing spreadsheet data can be stored, a database, and monitoring means. The monitoring means is operative to detect changes in spreadsheet data within the file store and to record the changes in the database. Changes in a spreadsheet over time may thus be monitored and recorded. In another aspect the system comprises an entity selector for selecting one or more entities in a spreadsheet, and a tracker for tracking the shift in position of the selected entities between two time points. An offset determinator is arranged to derive one or more offset values from information received from the tracker, the offset values representing the shift in position of the entities in the spreadsheet. An offset applicator applies the offset values to the spreadsheet data before comparing the spreadsheet data with a version of the spreadsheet data at a different time point. Shifting of entities resulting from insertion or deletion of rows and columns or sorting are thus taken into account when comparing spreadsheets. In a further aspect, the invention provides a system for processing and storing spreadsheets. The system comprises a determining unit arranged to determine each unique formula occurring within a spreadsheet, a first store for storing each unique formula, a second store for storing a unique identification for each unique formula, and a replacing unit arranged to replace each formula occurring within the spreadsheet with its corresponding formula identification. More efficient storage of formulas is thus achieved.
摘要翻译：在第一方面，本发明提供了一种用于在一个或多个电子表格中监视和审计数据的系统。该系统包括一个文件存储器，可存储包含电子表格数据的文件，数据库和监视装置。监视装置用于检测文件存储内的电子表格数据的变化并记录数据库中的变化。因此可能会监控和记录电子表格随时间的变化。在另一方面，系统包括用于选择电子表格中的一个或多个实体的实体选择器，以及用于跟踪所选实体在两个时间点之间的位置偏移的跟踪器。偏移确定器被布置为从从跟踪器接收的信息中导出一个或多个偏移值，偏移值表示实体在电子表格中的位置偏移。在将电子表格数据与不同时间点的电子表格数据的版本进行比较之前，偏移量施加器将偏移值应用于电子表格数据。因此，在比较电子表格时，考虑插入或删除行和列或排序导致的实体的移位。在另一方面，本发明提供了一种用于处理和存储电子表格的系统。该系统包括确定单元，其被布置为确定在电子表格内出现的每个唯一公式，用于存储每个唯一公式的第一存储器，用于存储每个唯一公式的唯一标识的第二存储器，以及替换单元，该电子表格具有相应的公式识别。因此实现了更有效率的配方储存。

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