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1. 发明授权

US06427084B2 Multi-site hybrid hardware-based cardiac pacemaker 有权
标题翻译：多站点混合硬件心脏起搏器
公开(公告)号：US06427084B2
公开(公告)日：2002-07-30
申请号：US09514813
申请日：2000-02-28
申请人： Kenneth L. Baker , Doug M. Birkholz , David L. Perschbacher , Andrew P. Kramer , Gary T. Seim
发明人： Kenneth L. Baker , Doug M. Birkholz , David L. Perschbacher , Andrew P. Kramer , Gary T. Seim
IPC分类号： A61N1362
CPC分类号： A61N1/368 , A61N1/3622 , A61N1/3684
摘要： A hybrid cardiac pacemaker in which the operation of the device is controlled by hardware-based controller as supervised by a microprocessor-based controller. The hardware-based controller comprises a plurality of timers that expire when they reach timer limit values stored in registers updatable by the microprocessor, and a combinational logic array for causing the device to generate pace outputs in accordance with timer expirations and sense signals. The combinational logic array may operate the pacemaker in a number of programmed modes in accordance with a mode value stored in a mode control register by the microprocessor.
摘要翻译：一种混合心脏起搏器，其中由基于微处理器的控制器监控的由基于硬件的控制器控制该设备的操作。基于硬件的控制器包括多个定时器，当它们达到存储在可由微处理器更新的寄存器中的定时器限制值时，该定时器到期，以及组合逻辑阵列，用于使该设备根据定时器期满和感测信号产生步进输出。组合逻辑阵列可以根据由微处理器存储在模式控制寄存器中的模式值，以多种编程模式操作起搏器。

2. 发明授权

US07257442B2 Mode switching algorithm for AV block 失效
标题翻译： AV块的模式切换算法
公开(公告)号：US07257442B2
公开(公告)日：2007-08-14
申请号：US10854736
申请日：2004-05-26
申请人： Andrew P. Kramer , Gary T. Seim
发明人： Andrew P. Kramer , Gary T. Seim
IPC分类号： A61N1/00
CPC分类号： A61N1/368
摘要： An apparatus and method is presented for treating patients with sinus node dysfunction who have apparently normal intrinsic AV conduction and thus do not require ventricular pacing unless there is an unexpected AV conduction failure. In one embodiment, a cardiac device with dual-chamber pacing capability is programmed to operate in a primary DDI (or DDI(R)) mode adjusted to pace only the atria if intrinsic AV conduction is intact and switch to a secondary DDD (or DDD(R)) mode upon detection of AV block.
摘要翻译：提出了一种用于治疗窦房结功能障碍患者的装置和方法，其具有明显正常的内在AV传导，因此除非出现意外的AV传导衰竭，否则不需要心室起搏。在一个实施例中，具有双室起搏能力的心脏装置被编程为在主要DDI（或DDI））模式下操作，其被调整为仅在内部AV传导完整的情况下仅调节心房，并切换到次级DDD（或DDD （R））模式。

3. 发明授权

US06920355B2 Multi-site hybrid hardware-based cardiac pacemaker 有权
标题翻译：多站点混合硬件心脏起搏器
公开(公告)号：US06920355B2
公开(公告)日：2005-07-19
申请号：US10150297
申请日：2002-05-17
申请人： Kenneth L. Baker , Doug M. Birkholz , David L. Perschbacher , Andrew P. Kramer , Gary T. Seim
发明人： Kenneth L. Baker , Doug M. Birkholz , David L. Perschbacher , Andrew P. Kramer , Gary T. Seim
IPC分类号： A61N1/362 , A61N1/368
CPC分类号： A61N1/368 , A61N1/3622 , A61N1/3684
摘要： A hybrid cardiac pacemaker in which the operation of the device is controlled by hardware-based controller as supervised by a microprocessor-based controller. The hardware-based controller comprises a plurality of timers that expire when they reach timer limit values stored in registers updatable by the microprocessor, and a combinational logic array for causing the device to generate pace outputs in accordance with timer expirations and sense signals. The combinational logic array may operate the pacemaker in a number of programmed modes in accordance with a mode value stored in a mode control register by the microprocessor.
摘要翻译：一种混合心脏起搏器，其中由基于微处理器的控制器监控的由基于硬件的控制器控制该设备的操作。基于硬件的控制器包括多个定时器，当它们达到存储在可由微处理器更新的寄存器中的定时器限制值时，该定时器到期，以及组合逻辑阵列，用于使该设备根据定时器期满和感测信号产生步进输出。组合逻辑阵列可以根据由微处理器存储在模式控制寄存器中的模式值，以多种编程模式操作起搏器。

4. 发明授权

US09409025B2 Cardiac rhythm management device with neural sensor 有权
公开(公告)号：US09409025B2
公开(公告)日：2016-08-09
申请号：US12840449
申请日：2010-07-21
申请人： Imad Libbus , Andrew P. Kramer , Julia Moffitt
发明人： Imad Libbus , Andrew P. Kramer , Julia Moffitt
IPC分类号： A61N1/36 , A61N1/362
CPC分类号： A61N1/3627 , A61N1/36114 , A61N1/36117
摘要： Various aspects of the present subject matter relate to a device. In various embodiments, the device comprises at least one port adapted to connect at least one lead, a CRM functions module connected to the port and adapted to provide at least one CRM function using the lead, a neural function module, and a controller connected to the CRM functions module and the neural function module. The at least one CRM function includes a function to provide an electrical signal to the lead to capture cardiac tissue. The neural function module includes a signal processing module connected to the port and adapted to receive and process a nerve traffic signal from the lead into a signal indicative of the nerve traffic. The controller is adapted to implement a CRM therapy based on the signal indicative of the nerve traffic. Other aspects are provided herein.

5. 发明申请

US20130211471A1 METHOD AND APPARATUS FOR CONTROLLING AUTONOMIC BALANCE USING NEURAL STIMULATION 有权
公开(公告)号：US20130211471A1
公开(公告)日：2013-08-15
申请号：US13841593
申请日：2013-03-15
申请人： Imad Libbus , Andrew P. Kramer , Julio C. Spinelli
发明人： Imad Libbus , Andrew P. Kramer , Julio C. Spinelli
IPC分类号： A61N1/365
CPC分类号： A61N1/36057 , A61N1/36114 , A61N1/36139 , A61N1/3621 , A61N1/3627 , A61N1/36585
摘要： A neural stimulation system senses autonomic activities and applies neural stimulation to sympathetic and parasympathetic nerves to control autonomic balance. The neural stimulation system is capable of delivering neural stimulation pulses for sympathetic excitation, sympathetic inhibition, parasympathetic excitation, and parasympathetic inhibition.

6. 发明申请

US20130165998A1 SYSTEM AND METHOD FOR CLOSED-LOOP NEURAL STIMULATION 审中-公开
标题翻译：闭环神经刺激的系统和方法
公开(公告)号：US20130165998A1
公开(公告)日：2013-06-27
申请号：US13709271
申请日：2012-12-10
申请人： Imad Libbus , Andrew P. Kramer , Julia Moffitt
发明人： Imad Libbus , Andrew P. Kramer , Julia Moffitt
IPC分类号： A61N1/36
CPC分类号： A61N1/36053 , A61N1/36117
摘要： Various device embodiments comprise a pulse generator, a signal processing module and a controller. The pulse generator is adapted to provide a neural stimulation signal to be applied at a neural simulation site within an autonomic nervous system (ANS). The signal processing module is adapted to receive and process sensed neural traffic at a neural sensing site within the ANS. The controller is connected to the pulse generator and adapted to provide a neural stimulation control signal to the pulse generator to generate the neural stimulation signal, and to the signal processing module to receive a feedback control signal indicative of the sensed neural traffic. The controller is adapted to adjust the neural stimulation control signal to adjust at least one parameter of the neural stimulation signal to converge on desired sensed neural traffic at the neural sensing site. Other aspects and embodiments are provided herein.
摘要翻译：各种装置实施例包括脉冲发生器，信号处理模块和控制器。脉冲发生器适于提供在自主神经系统（ANS）内的神经模拟部位应用的神经刺激信号。信号处理模块适于在ANS内的神经感测部位接收和处理感测到的神经流量。控制器连接到脉冲发生器并且适于向脉冲发生器提供神经刺激控制信号以产生神经刺激信号，并且向信号处理模块接收指示所感测的神经流量的反馈控制信号。控制器适于调整神经刺激控制信号以调整神经刺激信号的至少一个参数以收敛于神经感测位置处的期望感测的神经交通。本文提供了其它方面和实施例。

7. 发明授权

US08457734B2 System and method for neural stimulation 有权
公开(公告)号：US08457734B2
公开(公告)日：2013-06-04
申请号：US11468135
申请日：2006-08-29
申请人： Imad Libbus , Andrew P. Kramer , Anthony V. Caparso , Kristofer J. James , Stephen Ruble , Weiying Zhao
发明人： Imad Libbus , Andrew P. Kramer , Anthony V. Caparso , Kristofer J. James , Stephen Ruble , Weiying Zhao
IPC分类号： A61N1/365
CPC分类号： A61N1/365 , A61N1/36053 , A61N1/36114
摘要： Various aspects provide an implantable device. In various embodiments, the device comprises at least one port, where each port is adapted to connect a lead with an electrode to the device. The device further includes a stimulation platform, including a sensing circuit connected to the at least one port to sense an intrinsic cardiac signal and a stimulation circuit connected to the at least one port via a stimulation channel to deliver a stimulation signal through the stimulation channel to the electrode. The stimulation circuit is adapted to deliver stimulation signals through the stimulation channel for both neural stimulation therapy and CRM therapy. The sensing and stimulation circuits are adapted to perform CRM functions. The device further includes a controller connected to the sensing circuit and the stimulation circuit to control the neural stimulation therapy and the CRM therapy. Other aspects and embodiments are provided herein.

8. 发明授权

US08452401B2 Method and device for comprehensive anti-tachyarrhythmia therapy 有权
标题翻译：综合性抗心律失常治疗方法和装置
公开(公告)号：US08452401B2
公开(公告)日：2013-05-28
申请号：US13287842
申请日：2011-11-02
申请人： Imad Libbus , Andrew P. Kramer , William J. Linder , Jeffrey E. Stahmann
发明人： Imad Libbus , Andrew P. Kramer , William J. Linder , Jeffrey E. Stahmann
IPC分类号： A61N1/36
CPC分类号： A61N1/3622 , A61N1/36114 , A61N1/3962
摘要： A method and apparatus for delivering therapy to treat ventricular tachyarrhythmias is described. In one embodiment, neural stimulation, anti-tachycardia pacing, and shock therapy are employed in a progressive sequence upon detection of a ventricular tachycardia.
摘要翻译：描述了用于递送治疗以治疗室性快速性心律失常的方法和装置。在一个实施例中，在检测到室性心动过速时，采用进行性顺序的神经刺激，抗心动过速起搏和休克疗法。

9. 发明授权

US08396560B2 System and method for closed-loop neural stimulation 有权
标题翻译：闭环神经刺激的系统和方法
公开(公告)号：US08396560B2
公开(公告)日：2013-03-12
申请号：US10992319
申请日：2004-11-18
申请人： Imad Libbus , Andrew P. Kramer , Julia Moffitt
发明人： Imad Libbus , Andrew P. Kramer , Julia Moffitt
IPC分类号： A61N1/18
CPC分类号： A61N1/36117 , A61N1/08 , A61N1/36171
摘要： Various aspects of the present subject matter provide a device. In various embodiments, the device comprises a port adapted to connect a lead, a pulse generator connected to the port and adapted to provide a neural stimulation signal to the lead, and a signal processing module connected to the port and adapted to receive and process a nerve traffic signal from the lead into a signal indicative of the nerve traffic. The device includes a controller connected to the pulse generator and the signal processing module. The controller is adapted to implement a stimulation protocol to provide the neural stimulation signal with desired neural stimulation parameters based on the signal indicative of the nerve traffic. Other aspects are provided herein.
摘要翻译：本主题的各个方面提供了一种装置。在各种实施例中，该装置包括适于连接引线的端口，连接到端口的脉冲发生器，并适于向引线提供神经刺激信号，以及信号处理模块，连接到端口并且适于接收和处理神经交通信号从引导到指示神经交通的信号。该装置包括连接到脉冲发生器和信号处理模块的控制器。控制器适于实现刺激方案，以基于指示神经交通的信号向神经刺激信号提供期望的神经刺激参数。本文提供了其他方面。

10. 发明授权

US08369949B2 Pace counter isolation for cardiac resynchronization pacing 有权
标题翻译：心脏再同步起搏的步调隔离
公开(公告)号：US08369949B2
公开(公告)日：2013-02-05
申请号：US12724021
申请日：2010-03-15
申请人： Jeffrey E. Stahmann , Rene H. Wentkowski , Andrew P. Kramer , James Kalgren
发明人： Jeffrey E. Stahmann , Rene H. Wentkowski , Andrew P. Kramer , James Kalgren
IPC分类号： A61N1/368
CPC分类号： A61N1/36507 , A61N1/3627 , A61N1/3684
摘要： A system and method for recording sensing and pacing events in a cardiac rhythm management device. The method may be particularly useful in assessment of pacing parameters for ventricular resynchronization therapy.
摘要翻译：用于在心律管理装置中记录感测和起搏事件的系统和方法。该方法在评价心室再同步治疗的起搏参数方面特别有用。

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