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1. 发明申请

US20130302399A1 ANTI-PCSK9 ANTIBODIES AND USE THEREOF 有权
标题翻译：抗PCSK9抗体及其用途
公开(公告)号：US20130302399A1
公开(公告)日：2013-11-14
申请号：US13795674
申请日：2013-03-12
申请人： Andrew Lawrence Feldhaus , Leon F. Garcia-Martinez , Benjamin H. Dutzar , Ethan Wayne Ojala , Brian Robert Kovacevich , Katie Olson , Pei Fan , Jens Billgren , Erica Ann Stewart , Corinne C. Akatsuka , Patricia Dianne McNeill , Danielle Marie Mitchell , Dan Scott Allison , John A. Latham
发明人： Andrew Lawrence Feldhaus , Leon F. Garcia-Martinez , Benjamin H. Dutzar , Ethan Wayne Ojala , Brian Robert Kovacevich , Katie Olson , Pei Fan , Jens Billgren , Erica Ann Stewart , Corinne C. Akatsuka , Patricia Dianne McNeill , Danielle Marie Mitchell , Dan Scott Allison , John A. Latham
IPC分类号： C07K16/40 , A61K45/06 , A61K39/395
CPC分类号： C07K16/40 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K2317/33 , C07K2317/76 , C07K2317/92 , G01N33/573 , G01N2333/96433
摘要： The present invention is directed to antibodies and fragments thereof having binding specificity for PCSK9. Another embodiment of this invention relates to the antibodies described herein, and binding fragments thereof, comprising the sequences of the VH, VL and CDR polypeptides described herein, and the polynucleotides encoding them. The invention also contemplates conjugates of anti-PCSK9 antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. The invention also contemplates methods of making said anti-PCSK9 antibodies and binding fragments thereof. Embodiments of the invention also pertain to the use of anti-PCSK9 antibodies, and binding fragments thereof, for the diagnosis, assessment and treatment of diseases and disorders associated with PCSK9.
摘要翻译：本发明涉及对PCSK9具有结合特异性的抗体及其片段。本发明的另一个实施方案涉及本文所述的抗体及其结合片段，其包含本文所述的VH，VL和CDR多肽的序列，以及编码它们的多核苷酸。本发明还考虑了抗PCSK9抗体和与一个或多个功能或可检测部分缀合的结合片段的缀合物。本发明还考虑制备所述抗PCSK9抗体及其结合片段的方法。本发明的实施方案还涉及抗PCSK9抗体及其结合片段用于诊断，评估和治疗与PCSK9相关的疾病和病症的用途。

2. 发明申请

US20130336975A1 ANTI-NGF COMPOSITIONS AND USE THEREOF 有权
标题翻译：抗NGF组合物及其用途
公开(公告)号：US20130336975A1
公开(公告)日：2013-12-19
申请号：US13833338
申请日：2013-03-15
申请人： Benjamin H. Dutzar , Brian R. Kovacevich , Patricia Dianne McNeill , Danielle M. Mitchell , Ethan W. Ojala , Pei Fan , Jens Billgren , Erica A. Stewart , Corinne C. Akatsuka , Betty Yu-Ching Chang , John A. Latham , Leon F. Garcia-Martinez
发明人： Benjamin H. Dutzar , Brian R. Kovacevich , Patricia Dianne McNeill , Danielle M. Mitchell , Ethan W. Ojala , Pei Fan , Jens Billgren , Erica A. Stewart , Corinne C. Akatsuka , Betty Yu-Ching Chang , John A. Latham , Leon F. Garcia-Martinez
IPC分类号： C07K16/22
CPC分类号： C07K16/22 , A61K39/3955 , A61K2039/505 , C07K16/2875 , C07K2317/24 , C07K2317/41 , C07K2317/55 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2317/94
摘要： The present invention is directed to antibodies and fragments thereof having binding specificity for NGF. Another embodiment of this invention relates to the antibodies described herein, and binding fragments thereof, comprising the sequences of the VH, VL and CDR polypeptides described herein, and the polynucleotides encoding them. The invention also contemplates conjugates of anti-NGF antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. The invention also contemplates methods of making said anti-NGF antibodies and binding fragments thereof. Embodiments of the invention also pertain to the use of anti-NGF antibodies, and binding fragments thereof, for the diagnosis, assessment and treatment of diseases and disorders associated with NGF.
摘要翻译：本发明涉及对NGF具有结合特异性的抗体及其片段。本发明的另一个实施方案涉及本文所述的抗体及其结合片段，其包含本文所述的VH，VL和CDR多肽的序列，以及编码它们的多核苷酸。本发明还考虑了抗NGF抗体和与一个或多个功能或可检测部分缀合的结合片段的缀合物。本发明还考虑制备所述抗NGF抗体及其结合片段的方法。本发明的实施方案还涉及抗NGF抗体及其结合片段用于诊断，评估和治疗与NGF相关的疾病和病症的用途。

3. 发明授权

US09499611B2 Anti-NGF compositions and use thereof 有权
公开(公告)号：US09499611B2
公开(公告)日：2016-11-22
申请号：US13309295
申请日：2011-12-01
申请人： Benjamin H. Dutzar , Brian R. Kovacevich , Patricia Dianne McNeill , Danielle M. Mitchell , Ethan W. Ojala , Pei Fan , Jens Billgren , Erica A. Stewart , Corinne C. Akatsuka , Betty Yu-Ching Chang , John A. Latham , Leon F. Garcia-Martinez
发明人： Benjamin H. Dutzar , Brian R. Kovacevich , Patricia Dianne McNeill , Danielle M. Mitchell , Ethan W. Ojala , Pei Fan , Jens Billgren , Erica A. Stewart , Corinne C. Akatsuka , Betty Yu-Ching Chang , John A. Latham , Leon F. Garcia-Martinez
IPC分类号： A61K39/395 , C07K16/22 , C07K16/28 , A61K45/06 , A61K39/00
摘要： The present invention is directed to antibodies and fragments thereof having binding specificity for NGF. Another embodiment of this invention relates to the antibodies described herein, and binding fragments thereof, comprising the sequences of the VH, VL and CDR polypeptides described herein, and the polynucleotides encoding them. The invention also contemplates conjugates of anti-NGF antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. The invention also contemplates methods of making said anti-NGF antibodies and binding fragments thereof. Embodiments of the invention also pertain to the use of anti-NGF antibodies, and binding fragments thereof, for the diagnosis, assessment and treatment of diseases and disorders associated with NGF.

4. 发明授权

US09783602B2 Anti-NGF compositions and use thereof 有权
公开(公告)号：US09783602B2
公开(公告)日：2017-10-10
申请号：US13309295
申请日：2011-12-01
申请人： Benjamin H. Dutzar , Brian R. Kovacevich , Patricia Dianne McNeill , Danielle M. Mitchell , Ethan W. Ojala , Pei Fan , Jens Billgren , Erica A. Stewart , Corinne C. Akatsuka , Betty Yu-Ching Chang , John A. Latham , Leon F. Garcia-Martinez
发明人： Benjamin H. Dutzar , Brian R. Kovacevich , Patricia Dianne McNeill , Danielle M. Mitchell , Ethan W. Ojala , Pei Fan , Jens Billgren , Erica A. Stewart , Corinne C. Akatsuka , Betty Yu-Ching Chang , John A. Latham , Leon F. Garcia-Martinez
IPC分类号： A61K39/395 , C07K16/22 , A61K45/06 , C07K16/28 , A61K39/00
CPC分类号： C07K16/22 , A61K39/3955 , A61K45/06 , A61K51/1021 , A61K2039/505 , C07K16/2875 , C07K2317/24 , C07K2317/41 , C07K2317/55 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2317/92 , C07K2317/94 , Y02A50/466
摘要： The present invention is directed to antibodies and fragments thereof having binding specificity for NGF. Another embodiment of this invention relates to the antibodies described herein, and binding fragments thereof, comprising the sequences of the VH, VL and CDR polypeptides described herein, and the polynucleotides encoding them. The invention also contemplates conjugates of anti-NGF antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. The invention also contemplates methods of making anti-NGF antibodies and binding fragments thereof. Embodiments of the invention also pertain to the use of anti-NGF antibodies, and binding fragments thereof, for the diagnosis, assessment and treatment of diseases and disorders associated with NGF.

5. 发明申请

US20120148490A1 ANTI-NGF COMPOSITIONS AND USE THEREOF 有权
标题翻译：抗NGF组合物及其用途
公开(公告)号：US20120148490A1
公开(公告)日：2012-06-14
申请号：US13309295
申请日：2011-12-01
申请人： Benjamin H. Dutzar , Brian R. Kovacevich , Patricia Dianne NcNeill , Danielle M. Mitchell , Ethan W. Ojala , Pei Fan , Jens Billgren , Erica A. Stewart , Corinne C. Akatsuka , Betty Yu-Ching Chang , John A. Latham , Leon F. Garcia-Martinez
发明人： Benjamin H. Dutzar , Brian R. Kovacevich , Patricia Dianne NcNeill , Danielle M. Mitchell , Ethan W. Ojala , Pei Fan , Jens Billgren , Erica A. Stewart , Corinne C. Akatsuka , Betty Yu-Ching Chang , John A. Latham , Leon F. Garcia-Martinez
IPC分类号： A61K39/395 , C12N15/13 , A61K49/00 , A61K51/10 , A61P29/00 , A61P25/00 , A61P19/10 , A61P35/00 , A61P1/16 , A61P25/06 , A61P31/04 , A61P21/00 , C12N15/63 , C12N5/10 , C12N1/21 , C12N1/15 , C12N1/19 , C12N9/96 , C12P21/02 , A61P37/08 , C07K16/22
CPC分类号： C07K16/22 , A61K39/3955 , A61K45/06 , A61K51/1021 , A61K2039/505 , C07K16/2875 , C07K2317/24 , C07K2317/41 , C07K2317/55 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2317/92 , C07K2317/94 , Y02A50/466
摘要： The present invention is directed to antibodies and fragments thereof having binding specificity for NGF. Another embodiment of this invention relates to the antibodies described herein, and binding fragments thereof, comprising the sequences of the VH, VL and CDR polypeptides described herein, and the polynucleotides encoding them. The invention also contemplates conjugates of anti-NGF antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. The invention also contemplates methods of making said anti-NGF antibodies and binding fragments thereof. Embodiments of the invention also pertain to the use of anti-NGF antibodies, and binding fragments thereof, for the diagnosis, assessment and treatment of diseases and disorders associated with NGF.
摘要翻译：本发明涉及对NGF具有结合特异性的抗体及其片段。本发明的另一个实施方案涉及本文所述的抗体及其结合片段，其包含本文所述的VH，VL和CDR多肽的序列，以及编码它们的多核苷酸。本发明还考虑了抗NGF抗体和与一个或多个功能或可检测部分缀合的结合片段的缀合物。本发明还考虑制备所述抗NGF抗体及其结合片段的方法。本发明的实施方案还涉及抗NGF抗体及其结合片段用于诊断，评估和治疗与NGF相关的疾病和病症的用途。

6. 发明授权

US08728473B2 Methods of preventing or treating pain using anti-NGF antibodies 有权
标题翻译：使用抗NGF抗体预防或治疗疼痛的方法
公开(公告)号：US08728473B2
公开(公告)日：2014-05-20
申请号：US13309153
申请日：2011-12-01
申请人： Leon F. Garcia-Martinez , John A. Latham , Ethan W. Ojala , Corinne C. Akatsuka , Pei Fan , Jeffrey T. L. Smith , Benjamin H. Dutzar
发明人： Leon F. Garcia-Martinez , John A. Latham , Ethan W. Ojala , Corinne C. Akatsuka , Pei Fan , Jeffrey T. L. Smith , Benjamin H. Dutzar
IPC分类号： A61K39/395 , C07K16/28
CPC分类号： C07K16/22 , A61K39/3955 , A61K45/06 , A61K51/1021 , A61K2039/505 , C07K16/2875 , C07K2317/24 , C07K2317/41 , C07K2317/55 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2317/92 , C07K2317/94 , Y02A50/466
摘要： Antibodies and antibody fragments thereof with binding specificity to human Nerve Growth Factor (NGF) and methods of use for treating pain. Methods of treating pain or eliciting an analgesic effect comprising administering an effective amount of an anti-human NGF antibody or antibody fragment thereof, which inhibits the association of NGF with TrkA, and/or p75. These methods may optionally further comprising administering an effective amount of a second anti-human NGF antibody or fragment thereof (e.g., one which inhibits the association of NGF with p75, or one that inhibits the association of NGF with TrkA.)
摘要翻译：具有对人神经生长因子（NGF）具有结合特异性的抗体及其抗体片段以及用于治疗疼痛的方法。治疗疼痛或引起镇痛作用的方法包括施用有效量的抑制NGF与TrkA缔合的抗人NGF抗体或其抗体片段和/或p75。这些方法可以任选地进一步包括施用有效量的第二抗人NGF抗体或其片段（例如，抑制NGF与p75缔合的抑制剂或抑制NGF与TrkA缔合的抑制剂）。

7. 发明申请

US20140004116A1 METHODS OF PREVENTING OR TREATING PAIN USING ANTI-NGF ANTIBODIES 有权
标题翻译：使用抗NGF抗体预防或治疗疼痛的方法
公开(公告)号：US20140004116A1
公开(公告)日：2014-01-02
申请号：US13834889
申请日：2013-03-15
申请人： Leon F. Garcia-Martinez , John A. Latham , Ethan W. Ojala , Corinne C. Akatsuka , Pei Fan , Jeffrey T.L. Smith , Benjamin H. Dutzar
发明人： Leon F. Garcia-Martinez , John A. Latham , Ethan W. Ojala , Corinne C. Akatsuka , Pei Fan , Jeffrey T.L. Smith , Benjamin H. Dutzar
IPC分类号： C07K16/22 , A61K45/06 , A61K39/395
CPC分类号： C07K16/22 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/2875 , C07K2317/24 , C07K2317/32 , C07K2317/52 , C07K2317/55 , C07K2317/565 , C07K2317/76
摘要： Antibodies and antibody fragments thereof with binding specificity to human Nerve Growth Factor (NGF) and methods of use for treating pain. Methods of treating pain or eliciting an analgesic effect comprising administering an effective amount of an anti-human NGF antibody or antibody fragment thereof, which inhibits the association of NGF with TrkA, and/or p75. These methods may optionally further comprising administering an effective amount of a second anti-human NGF antibody or fragment thereof (e.g., one which inhibits the association of NGF with p75, or one that inhibits the association of NGF with TrkA.)
摘要翻译：具有对人神经生长因子（NGF）具有结合特异性的抗体及其抗体片段以及用于治疗疼痛的方法。治疗疼痛或引起镇痛作用的方法包括施用有效量的抑制NGF与TrkA缔合的抗人NGF抗体或其抗体片段和/或p75。这些方法可以任选地进一步包括施用有效量的第二抗人NGF抗体或其片段（例如，抑制NGF与p75缔合的抑制剂或抑制NGF与TrkA缔合的抑制剂）。

8. 发明申请

US20120141485A1 METHODS OF PREVENTING OR TREATING PAIN USING ANTI-NGF ANTIBODIES 有权
标题翻译：使用抗NGF抗体预防或治疗疼痛的方法
公开(公告)号：US20120141485A1
公开(公告)日：2012-06-07
申请号：US13309153
申请日：2011-12-01
申请人： Leon F. Garcia-Martinez , John A. Latham , Ethan W. Ojala , Corinne C. Akatsuka , Pei Fan , Jeffrey T.L. Smith , Benjamin H. Dutzar
发明人： Leon F. Garcia-Martinez , John A. Latham , Ethan W. Ojala , Corinne C. Akatsuka , Pei Fan , Jeffrey T.L. Smith , Benjamin H. Dutzar
IPC分类号： A61K39/395 , A61P25/04 , A61K39/00 , A61P25/00 , B82Y5/00
CPC分类号： C07K16/22 , A61K39/3955 , A61K45/06 , A61K51/1021 , A61K2039/505 , C07K16/2875 , C07K2317/24 , C07K2317/41 , C07K2317/55 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2317/92 , C07K2317/94 , Y02A50/466
摘要： Antibodies and antibody fragments thereof with binding specificity to human Nerve Growth Factor (NGF) and methods of use for treating pain. Methods of treating pain or eliciting an analgesic effect comprising administering an effective amount of an anti-human NGF antibody or antibody fragment thereof, which inhibits the association of NGF with TrkA, and/or p75. These methods may optionally further comprising administering an effective amount of a second anti-human NGF antibody or fragment thereof (e.g., one which inhibits the association of NGF with p75, or one that inhibits the association of NGF with TrkA.)
摘要翻译：具有对人神经生长因子（NGF）具有结合特异性的抗体及其抗体片段以及用于治疗疼痛的方法。治疗疼痛或引起镇痛作用的方法包括施用有效量的抑制NGF与TrkA缔合的抗人NGF抗体或其抗体片段和/或p75。这些方法可以任选地进一步包括施用有效量的第二抗人NGF抗体或其片段（例如，抑制NGF与p75缔合的抑制剂或抑制NGF与TrkA缔合的抑制剂）。

9. 发明授权

US08430219B2 Power acquisition equipment for a gantry crane 有权
标题翻译：龙门起重机的采集设备
公开(公告)号：US08430219B2
公开(公告)日：2013-04-30
申请号：US12647440
申请日：2009-12-26
申请人： Aiguo Xiang , Haiming Xiong , Pei Fan
发明人： Aiguo Xiang , Haiming Xiong , Pei Fan
IPC分类号： B60L5/22
CPC分类号： B66C17/06 , B66C13/12
摘要： A power acquisition equipment, including at least: a power supplying portion, including at least: a pair of first posts, multiple second posts, multiple upper brackets, multiple lower brackets, multiple tightening devices, a cathode slide line, and an anode slide line, a power acquisition portion, including at least: a slide plate, a driving device, an adjusting device, a first base, and a linkage mechanism, and a control portion, including at least: a pair of front laser range sensors, a pair of back laser range sensors, multiple photoelectric detecting plates, a PLC controller, and an inverter driving system. The equipment features simple operation and high efficiency, and is retractable, stable, safe, cost-effective, and environmental friendly.
摘要翻译：一种电力采购设备，至少包括：供电部分，至少包括：一对第一柱，多个第二柱，多个上支架，多个下支架，多个紧固装置，阴极滑动线和阳极滑动线，功率获取部分，至少包括：滑板，驱动装置，调节装置，第一基座和联动机构，以及控制部分，至少包括：一对前激光范围传感器，一对背面激光测距传感器，多个光电检测板，PLC控制器和变频器驱动系统。设备操作简单，效率高，可伸缩，稳定，安全，经济高效，环保。

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