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1. 发明授权

US5958427A Nitric oxide donor compounds and pharmaceutical compositions for pulmonary hypertension and other indications 失效
标题翻译：一氧化氮供体化合物和用于肺动脉高压等药物组合物
公开(公告)号：US5958427A
公开(公告)日：1999-09-28
申请号：US746431
申请日：1996-11-08
申请人： Andrew L. Salzman , Daniel J. Smith , Csaba Szabo , Richard J. Brilli , Brian Krafte-Jacobs
发明人： Andrew L. Salzman , Daniel J. Smith , Csaba Szabo , Richard J. Brilli , Brian Krafte-Jacobs
IPC分类号： A61K8/00 , A61K8/41 , A61K31/13 , A61K31/131 , A61K31/15 , A61P1/02 , A61P9/00 , A61P11/00 , A61P15/00 , A61P15/10 , A61P43/00 , A61Q11/00 , C07C243/42 , C07C291/04 , C08F8/30 , C08G73/02 , A61K9/00
CPC分类号： C07C291/04 , A61K31/131 , C08F8/30 , C08G73/0213 , Y10S514/929 , Y10S514/944 , Y10S514/946 , Y10S514/947
摘要： The invention is directed to nitric oxide (NO) donor compounds and to pharmaceutical compositions containing such nitric oxide (NO) donor compounds, for delivering NO to the apical surface of a mucosa, where the nitric oxide is released for passage across the epithelial monolayer of the mucous membrane. The NO donor compounds include polyalkyleneamine NO donors as well as tertiary and quaternary amino aliphatic NO donor compounds. The compounds and compositions of the invention are useful in any situation in which it is desirable to deliver NO across a mucosal surface. For example, the compounds and compositions of the invention are particularly useful in treating pulmonary hypertension, male impotence, and several other specific conditions.
摘要翻译：本发明涉及一氧化氮（NO）供体化合物和含有这种一氧化氮（NO）供体化合物的药物组合物，用于将NO递送至粘膜的顶端表面，其中一氧化氮被释放通过上皮单层粘膜。 NO供体化合物包括聚亚烷基亚胺NO供体以及叔氨基脂族NO供体化合物。本发明的化合物和组合物可用于期望通过粘膜表面递送NO的任何情况。例如，本发明的化合物和组合物特别可用于治疗肺动脉高压，男性阳ence以及其他几种特定病症。

2. 发明授权

US09801902B2 Debridement method using topical nitric oxide donor devices and compositions 有权
公开(公告)号：US09801902B2
公开(公告)日：2017-10-31
申请号：US12087837
申请日：2007-01-17
申请人： Daniel J. Smith , Patrick John Trotter , Mahesh Bhide
发明人： Daniel J. Smith , Patrick John Trotter , Mahesh Bhide
IPC分类号： A61K33/00 , A61K9/00 , A61K9/70 , A61K45/06 , A61K47/10 , A61K47/34 , A61L15/44 , A61L26/00
CPC分类号： A61K33/00 , A61K9/0014 , A61K9/7069 , A61K45/06 , A61K47/10 , A61K47/34 , A61L15/44 , A61L26/0066 , A61L2300/114
摘要： The present invention relates to methods for removal of dead tissue from wounds or skin using topical nitric oxide donor devices and/or compositions. In one embodiment, the present invention relates to a transdermal patch device that is designed to deliver nitric oxide. In another embodiment, the present invention relates to one or more devices and/or compositions that are designed to deliver nitric oxide and optionally one or more other compounds, where such devices/compositions include, without limitation, bandages, layered bandages, adhesive bandages, transdermal patches, creams, ointments, or a any combination of two or more thereof.

3. 发明授权

US08518362B2 Stabilization and ionic triggering of nitric oxide release 有权
标题翻译：一氧化氮释放的稳定和离子触发
公开(公告)号：US08518362B2
公开(公告)日：2013-08-27
申请号：US13234495
申请日：2011-09-16
申请人： Daniel J. Smith
发明人： Daniel J. Smith
IPC分类号： C01B21/24
CPC分类号： C01B21/24 , A61K9/0014 , A61K9/145 , A61K33/00 , A61K47/585 , B01J39/04 , B01J41/04
摘要： Provided is a method for producing nitric oxide that employs an ion exchange resin. Also provided is a method for producing nitric oxide that combines a salt with a gel or cream. A method is provided for producing nitric oxide that combines a pH adjuster with a diazeniumdiolate-containing compound or composition.
摘要翻译：提供采用离子交换树脂的一氧化氮的制造方法。还提供了一种将盐与凝胶或奶油组合的产生一氧化氮的方法。提供了一种用于生产一氧化氮的方法，其将pH调节剂与含二氮化萘二醇化合物或组合物结合。

4. 发明授权

US08303982B2 Self-locating, multiple application, and multiple location medical patch systems and methods therefor 有权
标题翻译：自定位，多应用和多位置医疗补丁系统及其方法
公开(公告)号：US08303982B2
公开(公告)日：2012-11-06
申请号：US12407840
申请日：2009-03-20
申请人： Daniel J. Smith , Jessica Liberatore
发明人： Daniel J. Smith , Jessica Liberatore
IPC分类号： A61F13/02 , A61F13/00 , A61F15/00
CPC分类号： A61F13/00063 , A61F13/023 , A61F13/025 , A61F2013/00553 , A61F2013/00646
摘要： A medical patch system has a first medical patch including an outer locating ring securable to a surface and an inner patch, separable from the outer locating ring, disposed within the outer locating ring. The medical patch system includes a second medical patch adapted for insertion into the central area bounded by the outer locating ring after the inner patch is separated from the outer locating ring. The second medical patch includes a second outer locating ring securable to the surface, and a second inner patch section, separable from the second outer locating ring, disposed within a second central area bounded by the second outer locating ring. The first and second outer locating rings have adhesive layers for securing the outer locating rings to a surface. The adhesive layers on the respective outer locating rings have different sizes, shapes or patterns to minimize skin irritation.
摘要翻译：医疗补片系统具有第一医疗补片，其包括可安装到表面的外定位环和设置在外定位环内的与外定位环可分离的内补片。医疗贴片系统包括第二医疗贴片，其适于在内贴片与外定位环分离之后插入到由外定位环限定的中心区域。第二医疗补片包括可固定到表面的第二外定位环和与第二外定位环分离的第二内补片部分，其设置在由第二外定位环限定的第二中心区域内。第一和第二外定位环具有用于将外定位环固定到表面的粘合剂层。相应的外定位环上的粘合剂层具有不同的尺寸，形状或图案以最小化皮肤刺激。

5. 再颁专利

USRE42769E1 Guitar body reinforcement 有权
标题翻译：吉他体增强
公开(公告)号：USRE42769E1
公开(公告)日：2011-10-04
申请号：US12893803
申请日：2010-09-29
申请人： Kevin M. Kroeger , Meaulnes Laberge , Timothy P. Shaw , Daniel J. Smith , Donald Scott Wade, Jr.
发明人： Kevin M. Kroeger , Meaulnes Laberge , Timothy P. Shaw , Daniel J. Smith , Donald Scott Wade, Jr.
IPC分类号： G10D3/00
CPC分类号： G10D3/02
摘要： A support for a body of a stringed instrument includes a brace structure having a plurality of legs radially disposed about a central body. The brace structure has a substantially flat first surface. A portion of the plurality of legs conforms to a soundhole opening which is integrated into the body of the stringed instrument. A brace for a body of a guitar includes a unitary structure adapted to mount to a soundboard of the guitar. The unitary structure has a plurality of arms radially disposed about a central body. A method of assembling a guitar includes mounting a brace structure to a soundboard of the guitar. Again, the brace structure has a plurality of legs radially disposed about a central body.
摘要翻译：用于弦乐器的主体的支撑件包括具有绕中心体径向设置的多个腿的支撑结构。支架结构具有基本平坦的第一表面。所述多个腿部的一部分符合整合到弦乐器的主体中的声孔开口。用于吉他身体的支架包括适于安装到吉他的音板的单一结构。单一结构具有围绕中心体径向设置的多个臂。一种组装吉他的方法包括将支架结构安装到吉他的音板上。同样，支架结构具有围绕中心体径向设置的多个腿。

6. 发明授权

US07765647B2 Non-woven fiber assemblies 有权
标题翻译：无纺布纤维集合体
公开(公告)号：US07765647B2
公开(公告)日：2010-08-03
申请号：US10510457
申请日：2003-04-04
申请人： Daniel J. Smith , Darrell H. Reneker
发明人： Daniel J. Smith , Darrell H. Reneker
IPC分类号： D01G13/00
CPC分类号： D04H3/16 , A61F13/0206 , A61F13/0209 , A61F13/0223 , A61F13/0226 , A61F13/0253 , A61L15/225 , A61L15/58 , A61L26/0052 , D04H1/728 , Y10T442/608 , Y10T442/642
摘要： In one embodiment, the present invention relates to a non-woven fiber assembly comprising one or more fibers wherein each fiber contains: a hydrophilic component; and an elastomeric component, and wherein the non-woven fiber assembly further comprises an adhesive component. In still another embodiment, the present invention relates to a non-woven fiber assembly comprising one or more fibers wherein each fiber contains: a hydrophilic component; an elastomeric component; and an adhesive component, wherein the hydrophilic component, the elastomeric component and the adhesive component are all contained within each fiber. Also disclosed is a method of making the afore-mentioned non-woven fiber assemblies. Additionally, a medical dressing made from the non-woven fiber assemblies of the present invention is disclosed.
摘要翻译：在一个实施方案中，本发明涉及包含一种或多种纤维的无纺纤维组合物，其中每种纤维包含：亲水性组分; 和弹性体组分，并且其中所述无纺纤维组合件还包含粘合剂组分。在另一个实施方案中，本发明涉及一种包含一种或多种纤维的无纺纤维组合物，其中每种纤维包含：亲水组分; 弹性体组分; 和粘合剂组分，其中亲水组分，弹性体组分和粘合剂组分都包含在每个纤维内。还公开了制造上述无纺纤维组件的方法。此外，公开了由本发明的无纺纤维组件制成的医用敷料。

7. 发明申请

US20090157117A1 PROCESS FOR TREATING METAL ALLOY SURGICAL NEEDLES TO IMPROVE BENDING STIFFNESS 有权
标题翻译：用于治疗金属合金手术针以改善弯曲硬度的方法
公开(公告)号：US20090157117A1
公开(公告)日：2009-06-18
申请号：US11957629
申请日：2007-12-17
申请人： Eugene D. Reynolds , Robert Maurer , Michael Nordmeyer , Frank R. Cichocki , Lester E. Schaible , Daniel J. Smith
发明人： Eugene D. Reynolds , Robert Maurer , Michael Nordmeyer , Frank R. Cichocki , Lester E. Schaible , Daniel J. Smith
IPC分类号： C22F1/16 , A61B17/06
CPC分类号： B21G1/08 , A61B17/06066 , A61B2017/0608 , B21G1/006 , Y10S72/702
摘要： A method of mechanically treating alloy metal surgical needles to improve bending strength is disclosed. The needles are curved and reverse-curved in this method to improve bending strength.
摘要翻译：公开了一种机械处理合金金属手术针以提高弯曲强度的方法。在这种方法中针是弯曲的和反向弯曲的，以提高弯曲强度。

8. 发明申请

US20090069449A1 ETHAMBUTOL BASED NITRIC OXIDE DONORS 有权
标题翻译：基于陶瓷基的氧化氮助剂
公开(公告)号：US20090069449A1
公开(公告)日：2009-03-12
申请号：US11817377
申请日：2006-03-03
申请人： Daniel J. Smith , Marcos Lopez
发明人： Daniel J. Smith , Marcos Lopez
IPC分类号： A61K47/32 , C07C245/24 , D01D5/00 , C08F8/30
CPC分类号： C07C291/04 , D01D5/0007 , D01F6/76
摘要： The present invention relates generally to nitric oxide releasing pharmaceutical compounds. More particularly, the present invention relates to pharmaceutical compositions that release nitric oxide under physiological conditions. In one embodiment, the present invention relates to new chemical compounds—diazeniumdiolates nitric oxide donors—that are based on ethambutol possessing physiological and biomedical activity.
摘要翻译：本发明一般涉及一氧化氮释放药物化合物。更具体地说，本发明涉及在生理条件下释放一氧化氮的药物组合物。在一个实施方案中，本发明涉及基于具有生理和生物医学活性的乙胺丁醇的新的化学化合物 - 二氮烯二硫化物一氧化氮供体。

9. 发明申请

US20070277665A1 Headblock and fingerboard support 有权
标题翻译：头块和指板支持
公开(公告)号：US20070277665A1
公开(公告)日：2007-12-06
申请号：US11446079
申请日：2006-06-01
申请人： Kevin M. Kroeger , Meaulnes Laberge , Timothy P. Shaw , Daniel J. Smith
发明人： Kevin M. Kroeger , Meaulnes Laberge , Timothy P. Shaw , Daniel J. Smith
IPC分类号： G10D3/00
CPC分类号： G10D3/06
摘要： A headblock and fingerboard support assembly for a stringed instrument includes a fingerboard support assembly for mounting to a neck and fingerboard of the stringed instrument. The fingerboard support assembly further includes a plate having an integrated rail structure. A headblock has an integrated channel for receiving the integrated rail structure. The headblock is adapted to secure to the fingerboard support assembly. A method of assembling a stringed instrument includes mounting a plate structure to a neck and fingerboard of the stringed instrument, where the plate includes an integrated rail, and mounting a headblock to an interior surface of a body of the stringed instrument, where the headblock has an integrated channel structure for receiving the integrated rail of the plate structure.
摘要翻译：用于弦乐器的头枕和指板支撑组件包括用于安装到弦乐器的颈部和指板的指板支撑组件。指板支撑组件还包括具有集成轨道结构的板。头块具有用于接收集成轨道结构的集成通道。头枕适于固定到指板支撑组件。组装弦乐器的方法包括将板结构安装到弦乐器的颈部和指板上，其中板包括集成导轨，并且将头块安装到弦乐器的主体的内表面，其中头带具有用于接收板结构的集成轨道的集成通道结构。

10. 发明授权

US07297102B2 Minimally invasive medical implant and insertion device and method for using the same 有权
标题翻译：微创医疗植入物和插入装置及其使用方法
公开(公告)号：US07297102B2
公开(公告)日：2007-11-20
申请号：US11190601
申请日：2005-07-27
申请人： Daniel J. Smith , Michael Tracey , Susanne Landgrebe
发明人： Daniel J. Smith , Michael Tracey , Susanne Landgrebe
IPC分类号： A61F2/00
CPC分类号： A61B17/06109 , A61B17/06066 , A61B17/062 , A61B2017/00805 , A61B2017/06042 , A61F2/0045 , A61F2250/0018
摘要： A medical implant and method for implantation of the same. One embodiment is an implant for use in the treatment of stress urinary incontinence that includes an implantable, elongated tape having a multiplicity of openings formed through the thickness thereof, the tape having a first end region and a second end region longitudinally opposite the first end region, and first and second bio-compatible fixation elements attached to the first and second end regions of the tape respectively. Each bio-compatible fixation element has a tissue adherence property greater than that of the tape.
摘要翻译：医疗植入物及其植入方法。一个实施例是用于治疗压力性尿失禁的植入物，其包括具有通过其厚度形成的多个开口的可植入的细长带，所述带具有第一端部区域和与第一端部区域纵向相对的第二端部区域以及分别附接到所述带的第一和第二端部区域的第一和第二生物相容性固定元件。每个生物相容的固定元件具有大于带的组织粘附性。

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