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1. 发明授权

US5597933A Process for the preparation of N-acetyl neuraminic acid derivatives 失效
标题翻译：制备N-乙酰神经氨酸衍生物的方法
公开(公告)号：US5597933A
公开(公告)日：1997-01-28
申请号：US549820
申请日：1996-03-08
申请人： Andrew D. Searle , Christopher Williamson
发明人： Andrew D. Searle , Christopher Williamson
IPC分类号： B01J23/44 , B01J23/62 , C07B61/00 , C07D309/28
CPC分类号： C07D309/28 , Y02P20/55
摘要： The invention provides a method for the preparation of the compound of formula(I) ##STR1## which comprises catalytic hydrogenolysis of a compound of formula (II) ##STR2## (wherein R is H or a C.sub.1-4 alkyl group and R.sup.1 is H or a hydroxyl protecting group for example an acyl group such as acetyl) in aqueous formic acid followed, where necessary, by hydrolysis.
摘要翻译： PCT No.PCT / EP94 / 01940 Sec。 371日期：1996年3月8日 102（e）1996年3月8日PCT 1994年6月15日PCT公布。公开号WO95 / 00503 日期1 9 9 5年1月5日本发明提供了制备式（I）化合物的方法，其包括式（II）化合物（II）的催化氢解（其中R为H 或C 1-4烷基，R 1为H或羟基保护基，例如酰基如乙酰基）在甲酸水溶液中，然后根据需要通过水解。

2. 发明授权

US08099555B2 Systems and methods for memory management on print devices 有权
标题翻译：打印设备上的内存管理系统和方法
公开(公告)号：US08099555B2
公开(公告)日：2012-01-17
申请号：US12358816
申请日：2009-01-23
申请人： Christopher Williamson
发明人： Christopher Williamson
IPC分类号： G06F12/00 , G06F13/00 , G06F13/28
CPC分类号： G06F12/0802 , G06F12/121 , G06K15/02 , G06K15/1828
摘要： Systems and methods disclosed permit flexible optimization of printer cache memories by specify criteria for determining cache membership for objects derived from a print data streams, wherein the objects may be associated with distinct reference counts. In some embodiments, the method may comprise the steps of: assigning an initial value to the reference count associated with an object, if the object is not present in the cache; incrementing the reference count by a first weight, if the object is already present in the cache; decrementing the reference count by a second weight, in response to an end-of-page event; and removing the object from the cache if the reference count is below a threshold.
摘要翻译：所公开的系统和方法允许通过指定用于确定从打印数据流导出的对象的高速缓存成员资格的标准来灵活地优化打印机高速缓存存储器，其中对象可以与不同的参考计数相关联。在一些实施例中，该方法可以包括以下步骤：如果对象不存在于高速缓存中，则将初始值分配给与对象相关联的引用计数; 如果对象已经存在于缓存中，则将引用计数递增第一权重; 响应于页面结束事件，将引用计数减去第二权重; 并且如果引用计数低于阈值，则从缓存中移除该对象。

3. 发明申请

US20100191912A1 Systems and Methods for Memory Management on Print Devices 有权
标题翻译：打印设备内存管理的系统和方法
公开(公告)号：US20100191912A1
公开(公告)日：2010-07-29
申请号：US12358816
申请日：2009-01-23
申请人： Christopher Williamson
发明人： Christopher Williamson
IPC分类号： G06F12/08
CPC分类号： G06F12/0802 , G06F12/121 , G06K15/02 , G06K15/1828
摘要： Systems and methods disclosed permit flexible optimization of printer cache memories by specify criteria for determining cache membership for objects derived from a print data streams, wherein the objects may be associated with distinct reference counts. In some embodiments, the method may comprise the steps of: assigning an initial value to the reference count associated with an object, if the object is not present in the cache; incrementing the reference count by a first weight, if the object is already present in the cache; decrementing the reference count by a second weight, in response to an end-of-page event; and removing the object from the cache if the reference count is below a threshold.
摘要翻译：所公开的系统和方法允许通过指定用于确定从打印数据流导出的对象的高速缓存成员资格的标准来灵活地优化打印机高速缓存存储器，其中对象可以与不同的参考计数相关联在一些实施例中，该方法可以包括以下步骤：如果对象不存在于高速缓存中，则将初始值分配给与对象相关联的引用计数; 如果对象已经存在于缓存中，则将引用计数递增第一权重; 响应于页面结束事件，将引用计数减去第二权重; 并且如果引用计数低于阈值，则从缓存中移除该对象。

4. 发明授权

US08887499B2 Electronic high hydraulic pressure cutoff to improve system efficiency 有权
标题翻译：电子高压液压切断，提高系统效率
公开(公告)号：US08887499B2
公开(公告)日：2014-11-18
申请号：US13172320
申请日：2011-06-29
申请人： Brad Edler , Viral S. Mehta , Lawrence Tognetti , Christopher Williamson
发明人： Brad Edler , Viral S. Mehta , Lawrence Tognetti , Christopher Williamson
IPC分类号： F16D31/02 , F15B11/05
CPC分类号： F15B11/055 , F15B2211/20553 , F15B2211/20576 , F15B2211/27 , F15B2211/613 , F15B2211/625 , F15B2211/6346 , F15B2211/7053
摘要： A method for overpressure control in a hydraulic system having multiple hydraulic pumps, with each hydraulic pump being connected by a respective hydraulic circuit for actuating a single respective hydraulic actuator, includes actuating a first variable displacement hydraulic pump, the first hydraulic pump being fluidly linked by a first hydraulic circuit to a first hydraulic actuator for powering the first hydraulic actuator. Upon detecting a pressure that exceeds a predetermined threshold pressure, the flow rate of the first hydraulic pump is electronically modified to a second flow rate lower than the first flow rate whereby the pressure in the first hydraulic circuit is reduced to a pressure that is below the predetermined threshold pressure.
摘要翻译：一种用于具有多个液压泵的液压系统中的超压控制的方法，每个液压泵通过相应的液压回路连接，用于致动单个相应的液压致动器，包括致动第一可变排量液压泵，第一液压泵通过向第一液压致动器供给第一液压致动器的第一液压回路。在检测到超过预定阈值压力的压力时，第一液压泵的流量被电子地修改为低于第一流量的第二流量，由此第一液压回路中的压力降低到低于预定阈值压力。

5. 发明申请

US20120180677A1 METHOD AND SYSTEM FOR PAD PRINTING WITH REMOVABLE PRE-FILLED INK CUP 有权
标题翻译：用可拆卸预填充墨盒打印纸盘的方法和系统
公开(公告)号：US20120180677A1
公开(公告)日：2012-07-19
申请号：US13434402
申请日：2012-03-29
申请人： Samuel Peterson , Christopher Schaafsma , Sigi Knappik , Christopher Williamson
发明人： Samuel Peterson , Christopher Schaafsma , Sigi Knappik , Christopher Williamson
IPC分类号： B41F31/04
CPC分类号： B41F17/001
摘要： A doctor assembly for a pad printing system includes a body and a doctor blade. The body has an outer surface and an opposite inner surface that defines a passageway through the body. The inner surface engages a removable pre-filled ink cup to secure the ink cup to the body. The inner surface directs ink from the ink cup through the passageway toward an ink-receiving surface of a cliché device. The doctor blade is coupled with the body and engages the cliché device. The doctor blade wipes the ink along the cliché device as the body laterally moves relative to the cliché device. The doctor blade is coupled with the body such that the doctor blade is laterally spaced apart from the inner surface of the body.
摘要翻译：用于移印系统的刮刀组件包括主体和刮刀。主体具有外表面和相对的内表面，其限定穿过主体的通道。内表面接合可移除的预先填充的墨水杯以将墨水杯固定到身体上。内表面将油墨从墨杯引导通过通道朝向陈设装置的墨接收表面。刮刀与主体联接并与陈词滥调装置接合。当身体相对于陈设装置横向移动时，刮刀沿着陈腔装置擦拭墨水。刮刀与主体联接，使得刮刀与主体的内表面横向间隔开。

6. 发明授权

US06180639B2 1,3-oxathiolane nucleoside analogues 失效
标题翻译： 1,3-氧硫杂环戊烷核苷类似物
公开(公告)号：US06180639B2
公开(公告)日：2001-01-30
申请号：US07835964
申请日：1992-02-20
申请人： Jonathan Allan Coates , Ian Martin Mutton , Charles Richard Penn , Christopher Williamson , Richard Storer
发明人： Jonathan Allan Coates , Ian Martin Mutton , Charles Richard Penn , Christopher Williamson , Richard Storer
IPC分类号： A61K31505
CPC分类号： A61K31/7068 , A61K31/505 , A61K31/506 , A61K31/70 , A61K45/06 , C07D411/04 , A61K2300/00
摘要： (−)-4-amino-1-(2-hydroxymethyl-1,3-oxathiolan-5-yl)-(1H)-pyrimidin-2-one, its pharmaceutically acceptable derivatives, pharmaceutical formulation thereof, methods for its preparation and its uses as an antiviral agent are described.
摘要翻译：（ - ） - 4-氨基-1-（2-羟甲基-1,3-氧硫杂环戊烷-5-基） - （1H） - 嘧啶-2-酮，其药学上可接受的衍生物，其药物制剂，其制备方法和描述其作为抗病毒剂的用途。

7. 发明授权

US08484015B1 Entity pages 有权
标题翻译：实体页面
公开(公告)号：US08484015B1
公开(公告)日：2013-07-09
申请号：US12780651
申请日：2010-05-14
申请人： Stephen Wolfram , Christopher Williamson , Oyvind Tafjord
发明人： Stephen Wolfram , Christopher Williamson , Oyvind Tafjord
IPC分类号： G06F17/27 , G06F17/21 , G06F17/20 , G06F17/30
CPC分类号： G06F17/30693 , G06F17/30654
摘要： An answer engine determines an entity related to a query from a user in a system designed for computation, search, or other activities involving the processing of queries. The system determines whether an entity page for the entity is stored in an answers database and, if so, retrieves and displays the stored entity page. If there is no stored entity page for the entity, the answer engine generates and displays an answer to the query and may optionally store the answer as an entity page. Additionally, the answer engine may pre-generate and store entity pages according to algorithmic variation of received queries and/or according to information received from external sources.
摘要翻译：答案引擎在用于计算，搜索或涉及处理查询的其他活动的系统中确定与来自用户的查询相关的实体。系统确定实体的实体页面是否存储在答案数据库中，如果是，则检索并显示存储的实体页面。如果实体没有存储的实体页面，则答案引擎生成并显示对查询的答案，并且可以可选地将答案存储为实体页面。此外，应答引擎可以根据接收到的查询的算法变化和/或根据从外部源接收的信息来预生成和存储实体页面。

8. 发明授权

US4650800A Substituted pyrimidin-2-ones, the salts thereof, pharmaceutical compositions containing them and a method therefor 失效
标题翻译：取代的嘧啶-2-酮，其盐，含有它们的药物组合物及其方法
公开(公告)号：US4650800A
公开(公告)日：1987-03-17
申请号：US496093
申请日：1983-05-19
申请人： Gordon H. Phillipps , Christopher Williamson , Ian P. Steeples , Brian M. Bain , Raymond A. Borella
发明人： Gordon H. Phillipps , Christopher Williamson , Ian P. Steeples , Brian M. Bain , Raymond A. Borella
IPC分类号： A61K31/505 , A61P35/00 , A61P35/02 , C07D401/06 , C07D403/06 , C07D405/06 , C07D409/06 , C07D413/06 , C07D417/06
CPC分类号： C07D409/06 , C07D401/06 , C07D403/06 , C07D405/06 , C07D413/06
摘要： Compounds of the general formula: ##STR1## wherein X represents a halogen atom or a trifluoromethyl group; R.sup.1 represents a hydrogen atom or a lower alkyl group and Het represents an optionally substituted C-attached 5-7 membered aromatic heterocyclic ring which ring contains one or more heteroatoms selected from O, N and S and optionally carries a fused ring and where an acidic or basic group is present, the salts thereof have been found to possess excellent metaphase arresting ability and are of use in combating abnormal cell proliferation. Thus a knowledge of the cell division cycles of the normal and abnormal cells enables a cytotoxic drug to be administered while the abnormal cells are in a phase susceptible to attack and while the normal cells are in a non-susceptible phase.The compounds of the invention are prepared by alkylation, deprotection of a protected keto group, oxidation or electrophilic halogenation.
摘要翻译：通式的化合物：其中X表示卤素原子或三氟甲基; R1表示氢原子或低级烷基，Het表示任选取代的C连接的5-7元芳族杂环，该环含有一个或多个选自O，N和S的杂原子，并且任选地带有稠环，并且其中酸性或碱性基团，其盐被发现具有优异的中期阻滞能力，并且可用于对抗异常细胞增殖。因此，正常和异常细胞的细胞分裂周期的知识使得能够施用细胞毒性药物，同时异常细胞处于易受攻击的阶段，而正常细胞处于非易感相。本发明的化合物是通过烷基化，保护的酮基的脱保护，氧化或亲电卤化来制备的。

9. 发明授权

US4636509A Substituted pyrimidin-2-ones, the salts thereof, processes for their preparation, pharmaceutical compositions containing them and a method therefor 失效
标题翻译：取代的嘧啶-2-酮，其盐，其制备方法，含有它们的药物组合物及其方法
公开(公告)号：US4636509A
公开(公告)日：1987-01-13
申请号：US498723
申请日：1983-05-27
申请人： Gordon H. Phillipps , Christopher Williamson
发明人： Gordon H. Phillipps , Christopher Williamson
IPC分类号： A61K31/505 , A61P35/00 , A61P35/02 , C07D239/36
CPC分类号： C07D239/36
摘要： Compounds of the general formula: ##STR1## (wherein X represents a halogen atom or a trifluoromethyl group; R.sup.1 represents an optionally substituted C.sub.6-10 carbocyclic aromatic group; and R.sup.2 represents a hydrogen atom or a lower alkyl, C.sub.7-16 aralkyl or C.sub.6-10 aryl group or the group COR.sup.1a, in which R.sup.1a is as defined for R.sup.1, R.sup.1 and R.sup.1a being the same or different) and where an acidic or basic group is present, the salts thereof have been found to possess excellent metaphase arresting ability and are of use in combating abnormal cell proliferation. Thus a knowledge of the cell division cycles of the normal and abnormal cells enables a cytotoxic drug to be administered while the abnormal cells are in a phase susceptible to attack and while the normal cells are in a non-susceptible phase.The compounds of the invention are prepared by alkylation, deprotection of a protected keto group, oxidation or electrophilic halogenation.Pharmaceutical compositions containing the compounds of formula I, and where appropriate, the physiologically compatible salts thereof; and methods for the use of the compounds are described and claimed.
摘要翻译：通式为的化合物：其中X表示卤原子或三氟甲基; R 1表示任选取代的C 6-10碳环芳基; R 2表示氢原子或低级烷基，C 7-16芳烷基或 C6-10芳基或COR1a基团，其中R1a如R1所定义，R1和R1a相同或不同），并且其中存在酸性或碱性基团时，其盐被发现具有优异的中期阻滞能力并且可用于对抗异常细胞增殖。因此，正常和异常细胞的细胞分裂周期的知识使得能够施用细胞毒性药物，同时异常细胞处于易受攻击的阶段，而正常细胞处于非易感相。本发明的化合物是通过烷基化，保护的酮基的脱保护，氧化或亲电卤化来制备的。含有式I化合物和适当时其生理上相容的盐的药物组合物; 并描述和要求保护化合物的使用方法。

10. 发明授权

US4335121A Androstane carbothioates 失效
标题翻译：雄甾烷硫代磷酸酯
公开(公告)号：US4335121A
公开(公告)日：1982-06-15
申请号：US234113
申请日：1981-02-13
申请人： Gordon H. Phillipps , Brian M. Bain , Ian P. Steeples , Christopher Williamson
发明人： Gordon H. Phillipps , Brian M. Bain , Ian P. Steeples , Christopher Williamson
IPC分类号： A61K31/56 , A61K31/58 , A61P29/00 , C07J3/00 , C07J31/00 , C07J41/00 , C07J71/00 , C07J7/00
CPC分类号： C07J71/0031 , C07J3/005 , C07J31/006 , C07J41/0038 , C07J71/001 , C07J71/0015
摘要： Compounds of the formula ##STR1## wherein R.sup.1 represents a fluoro-, chloro- or bromo-methyl group or a 2'-fluoroethyl group, R.sup.2 represents a group COR.sup.6 where R.sup.6 is a C.sub.1-3 alkyl group or OR.sup.2 and R.sup.3 together form a 16.alpha.,17.alpha.-isopropylidenedioxy group; R.sup.3 represents a hydrogen atom, a methyl group (which may be in either the .alpha.- or .beta.-configuration) or a methylene group; R.sup.4 represents a hydrogen, chlorine or fluorine atom; R.sup.5 represents a hydrogen or fluorine atom and symbol represents a single or double bond have good anti-inflammatory activity, particularly on topical applications.The compounds of formula I are prepared by esterification, halogenation, reduction, deprotection and reaction at a 9,11-double bond to form a 9.alpha.-halo-11.beta.-hydroxy grouping.Pharmaceutical compositions containing the compounds of formula I and methods for the use of the compounds are described and claimed.
摘要翻译：式（I）的化合物其中R 1表示氟，氯或溴甲基或2'-氟乙基，R 2表示基团COR 6，其中R 6是C 1-3烷基或OR 2和R 3 一起形成16α，17α-异亚丙基二氧基; R 3表示氢原子，甲基（其可以是α或β构型）或亚甲基; R4表示氢，氯或氟原子; R5表示氢或氟原子，符号表示单键或双键具有良好的抗炎活性，特别是局部应用。式I的化合物通过在9,11-双键进行酯化，卤化，还原，脱保护和反应来制备，以形成9α-卤代-11β-羟基。描述并要求保护含有式I化合物的药物组合物和使用该化合物的方法。

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