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1. 发明申请

US20130136775A1 HYDROPHOBIC DRUG-DELIVERY MATERIAL, METHOD FOR MANUFACTURING THEREOF AND METHODS FOR DELIVERY OF A DRUG-DELIVERY COMPOSITION 有权
标题翻译：疏水性药物递送材料，其制造方法和用于递送药物组合物的方法
公开(公告)号：US20130136775A1
公开(公告)日：2013-05-30
申请号：US13307506
申请日：2011-11-30
申请人： Andreas Voigt , Jörg Kriwanek , Scott Hampton , Andreas Reiff , Sonja Ludwig
发明人： Andreas Voigt , Jörg Kriwanek , Scott Hampton , Andreas Reiff , Sonja Ludwig
IPC分类号： A61K47/44 , A61K47/26 , A61K47/42 , A61K47/36 , A61K47/34 , A61K9/00 , A61P31/00 , A61P25/24 , A61P31/10 , A61P23/00 , A61P37/08 , A61P9/06 , A61P9/10 , A61P25/08 , A61P29/00 , A61P9/12 , A61P7/02 , A61P37/06 , A61P37/04 , A61K39/395 , B82Y5/00
CPC分类号： A61K9/06 , A61K9/14 , A61K39/00 , A61K39/395 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/22 , A61K47/44 , A61K47/46 , A61K2039/505 , C07K16/00
摘要： A method for manufacturing a drug-delivery composition includes providing at least a pharmaceutically active composition, providing a hydrophobic matrix; and mixing the hydrophobic matrix and the pharmaceutically active composition to form a paste-like or semi-solid drug-delivery composition.
摘要翻译：制备药物递送组合物的方法包括提供至少一种药物活性组合物，提供疏水基质; 并混合疏水基质和药物活性组合物以形成糊状或半固体药物递送组合物。

2. 发明申请

US20130136774A1 POLYMERIC DRUG-DELIVERY MATERIAL, METHOD FOR MANUFACTURING THEREOF AND METHOD FOR DELIVERY OF A DRUG-DELIVERY COMPOSITION 有权
标题翻译：聚合物药物递送材料，其制造方法和递送药物组合物的方法
公开(公告)号：US20130136774A1
公开(公告)日：2013-05-30
申请号：US13307474
申请日：2011-11-30
申请人： Andreas Voigt , Jörg Kriwanek , Scott Hampton , Andreas Reiff , Sonja Ludwig
发明人： Andreas Voigt , Jörg Kriwanek , Scott Hampton , Andreas Reiff , Sonja Ludwig
IPC分类号： A61K39/395 , A61K31/7105 , A61K35/12 , A61K31/711 , A61K38/18 , A61K38/22 , A61K35/76 , A61K9/14 , A61K38/02 , A61K38/43
CPC分类号： A61K9/06 , A61K9/5036 , A61K47/36 , A61K47/38 , A61K47/42 , C07K16/00
摘要： A method for manufacturing a drug-delivery composition includes providing at least one pharmaceutically active compound, a dry powder comprising at least a polymer, and an aqueous solution. The dry powder, the pharmaceutically active compound and the aqueous solution are mixed to form a paste-like or semi-solid drug-delivery composition, wherein the aqueous solution is added in an amount of less than or equal to twice the total dry mass of the dry powder.
摘要翻译：制备药物递送组合物的方法包括提供至少一种药学活性化合物，至少包含聚合物的干粉和水溶液。将干燥粉末，药物活性化合物和水溶液混合以形成糊状或半固体药物递送组合物，其中水溶液的加入量小于或等于总干燥质量的两倍干粉。

3. 发明授权

US09474715B2 Polymeric drug-delivery material, method for manufacturing thereof and method for delivery of a drug-delivery composition 有权
标题翻译：高分子药物递送材料，其制造方法和递送药物递送组合物的方法
公开(公告)号：US09474715B2
公开(公告)日：2016-10-25
申请号：US13307474
申请日：2011-11-30
申请人： Andreas Voigt , Jörg Kriwanek , Scott Hampton , Andreas Reiff , Sonja Ludwig
发明人： Andreas Voigt , Jörg Kriwanek , Scott Hampton , Andreas Reiff , Sonja Ludwig
IPC分类号： A61K9/06 , A61K47/30 , A61K47/36 , A61K47/38 , A61K47/42 , A61K9/50
CPC分类号： A61K9/06 , A61K9/5036 , A61K47/36 , A61K47/38 , A61K47/42 , C07K16/00
摘要： A method for manufacturing a drug-delivery composition includes providing at least one pharmaceutically active compound, a dry powder comprising at least a polymer, and an aqueous solution. The dry powder, the pharmaceutically active compound and the aqueous solution are mixed to form a paste-like or semi-solid drug-delivery composition, wherein the aqueous solution is added in an amount of less than or equal to twice the total dry mass of the dry powder.
摘要翻译：制备药物递送组合物的方法包括提供至少一种药学活性化合物，至少包含一种聚合物的干粉和一种水溶液。将干燥粉末，药物活性化合物和水溶液混合以形成糊状或半固体药物递送组合物，其中水溶液的加入量小于或等于总干燥质量的两倍干粉。

4. 发明申请

US20170095419A1 Polymeric Drug-Delivery Material, Method for Manufacturing Thereof and Method for Delivery of a Drug-Delivery Composition 审中-公开
公开(公告)号：US20170095419A1
公开(公告)日：2017-04-06
申请号：US15277395
申请日：2016-09-27
申请人： Andreas Voigt , Jörg Kriwanek , Scott Hampton , Andreas Reiff , Sonja Ludwig
发明人： Andreas Voigt , Jörg Kriwanek , Scott Hampton , Andreas Reiff , Sonja Ludwig
IPC分类号： A61K9/06 , C07K16/00 , A61K47/36 , A61K47/42 , A61K47/38
CPC分类号： A61K9/06 , A61K9/5036 , A61K47/36 , A61K47/38 , A61K47/42 , C07K16/00
摘要： A method for manufacturing a drug-delivery composition includes providing at least one pharmaceutically active compound, a dry powder comprising at least a polymer, and an aqueous solution. The dry powder, the pharmaceutically active compound and the aqueous solution are mixed to form a paste-like or semi-solid drug-delivery composition, wherein the aqueous solution is added in an amount of less than or equal to twice the total dry mass of the dry powder.

5. 发明授权

US09364549B2 Hydrophobic drug-delivery material, method for manufacturing thereof and methods for delivery of a drug-delivery composition 有权
标题翻译：疏水性药物递送材料，其制造方法和递送药物递送组合物的方法
公开(公告)号：US09364549B2
公开(公告)日：2016-06-14
申请号：US13307506
申请日：2011-11-30
申请人： Andreas Voigt , Jörg Kriwanek , Scott Hampton , Andreas Reiff , Sonja Ludwig
发明人： Andreas Voigt , Jörg Kriwanek , Scott Hampton , Andreas Reiff , Sonja Ludwig
IPC分类号： A61K39/00 , A61K47/44 , A61K47/10 , A61K47/12 , A61K47/14 , C07K16/00 , A61K47/46 , A61K9/06 , A61K9/14 , A61K47/02 , A61K47/22
CPC分类号： A61K9/06 , A61K9/14 , A61K39/00 , A61K39/395 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/22 , A61K47/44 , A61K47/46 , A61K2039/505 , C07K16/00
摘要： A method for manufacturing a drug-delivery composition includes providing at least a pharmaceutically active composition, providing a hydrophobic matrix; and mixing the hydrophobic matrix and the pharmaceutically active composition to form a paste-like or semi-solid drug-delivery composition.
摘要翻译：制备药物递送组合物的方法包括提供至少一种药物活性组合物，提供疏水基质; 并混合疏水基质和药物活性组合物以形成糊状或半固体药物递送组合物。

6. 发明申请

US20170065579A1 Sustained Release Low Dose Formulations and Uses Thereof 审中-公开
标题翻译：持续释放低剂量配方及其用途
公开(公告)号：US20170065579A1
公开(公告)日：2017-03-09
申请号：US15258288
申请日：2016-09-07
申请人： Andreas Voigt , Annette Assogba-Zandt , Andreas Reiff , Scott Hampton
发明人： Andreas Voigt , Annette Assogba-Zandt , Andreas Reiff , Scott Hampton
IPC分类号： A61K31/485 , A61K47/36 , A61K9/00 , A61K9/16 , A61K9/10
CPC分类号： A61K31/485 , A61K9/0019 , A61K9/10 , A61K9/1617 , A61K9/1694 , A61K47/36
摘要： The present invention belongs to the field of sustained drug release, and provides drug delivery compositions and methods of manufacturing drug delivery compositions.
摘要翻译：本发明属于持续药物释放领域，并且提供药物递送组合物和制备药物递送组合物的方法。

7. 发明申请

US20160250146A1 Hydrophobic Drug-Delivery Material, Method for Manufacturing Thereof and Methods for Delivery of a Drug-Delivery Composition 审中-公开
标题翻译：疏水药物递送材料，其制造方法和递送组合物的方法
公开(公告)号：US20160250146A1
公开(公告)日：2016-09-01
申请号：US15083879
申请日：2016-03-29
申请人： Andreas Voigt , Scott Hampton , Andreas Reiff , Sonja Lehmann , Joerg Kriwanek
发明人： Andreas Voigt , Scott Hampton , Andreas Reiff , Sonja Lehmann , Joerg Kriwanek
IPC分类号： A61K9/06 , A61K47/10 , C07K16/00 , A61K47/12 , A61K47/14 , A61K39/395 , A61K47/44
CPC分类号： A61K9/06 , A61K9/14 , A61K39/00 , A61K39/395 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/22 , A61K47/44 , A61K47/46 , A61K2039/505 , C07K16/00
摘要： A method for manufacturing a drug-delivery composition includes providing at least a pharmaceutically active composition, providing a hydrophobic matrix; and mixing the hydrophobic matrix and the pharmaceutically active composition to form a paste-like or semi-solid drug-delivery composition.
摘要翻译：制备药物递送组合物的方法包括提供至少一种药物活性组合物，提供疏水基质; 并混合疏水基质和药物活性组合物以形成糊状或半固体药物递送组合物。

8. 发明申请

US20060110429A1 Implant for intraocular drug delivery 审中-公开
标题翻译：植入物用于眼内药物递送
公开(公告)号：US20060110429A1
公开(公告)日：2006-05-25
申请号：US11280377
申请日：2005-11-16
申请人： Andreas Reiff , Scott Hampton , Richard Payne
发明人： Andreas Reiff , Scott Hampton , Richard Payne
IPC分类号： A61K39/395 , A61F2/00
CPC分类号： A61K31/715 , A61F9/0017 , A61F2210/0004 , A61F2250/0068 , A61K9/0051 , C07K16/241
摘要： An implant for intraocular drug delivery for the treatment of inflammatory or degenerative diseases. In one embodiment, the implant includes a body portion having a first end portion and a second, opposite end portion and defining a cavity with a first opening at the first end portion, and a second, opposite opening at the second end portion, and a solid material received in the cavity, wherein the solid material comprises a depot material and an effective amount of at least one therapeutic compound or agent. When the implant is implanted in an eye of a living subject, the effective amount of at least one therapeutic compound or agent is released to the environment of the implant through at least one of the first opening and the second, opposite opening over an extended period of time.
摘要翻译：用于眼内药物递送的植入物用于治疗炎性或退行性疾病。在一个实施例中，植入物包括具有第一端部和第二相对端部并且在第一端部处限定具有第一开口的空腔的主体部分和在第二端部处的第二相对的开口，容纳在空腔中的固体材料，其中固体材料包含贮库材料和有效量的至少一种治疗化合物或药剂。当植入物植入生物体的眼睛中时，至少一种治疗化合物或药剂的有效量通过第一开口和第二相对开口中的至少一个在延长的时间段内释放到植入物的环境中的时间。

9. 发明申请

US20100028328A1 TOPICAL TREATMENT FOR DISEASES OF EYE SURFACE 审中-公开
标题翻译：用于眼睛表面疾病的局部治疗
公开(公告)号：US20100028328A1
公开(公告)日：2010-02-04
申请号：US12304381
申请日：2006-06-12
申请人： Andreas Reiff , Scott Hampton
发明人： Andreas Reiff , Scott Hampton
IPC分类号： A61K39/395 , A61K48/00 , A61K38/00 , A61P27/02
CPC分类号： A61K45/06 , A61K9/0048 , A61K38/2066 , A61K38/208
摘要： A topical eye solution for the treatment of corneal, scleral, or conjunctival diseases. In one embodiment of the present invention, the eye solution comprises a saline-based fluid, and an effective amount of at least one therapeutic compound or agent, wherein when at least one drop of the eye solution is applied to the surface of an eye, the therapeutic compound or agent is released to the cornea and conjunctiva of the eye.
摘要翻译：用于治疗角膜，巩膜或结膜疾病的局部眼部溶液。在本发明的一个实施方案中，眼液包含基于盐水的流体和有效量的至少一种治疗化合物或药剂，其中当至少一滴眼溶液施加到眼睛的表面时，治疗化合物或药剂释放到眼睛的角膜和结膜。

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