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1. 发明授权

US06723718B2 Substituted &agr;, &bgr;-anellated butyrolactones 失效
标题翻译：取代的α，β-蒽醌丁内酯
公开(公告)号：US06723718B2
公开(公告)日：2004-04-20
申请号：US10206166
申请日：2002-07-25
申请人： Andreas Stolle , Horst-Peter Antonicek , Stephen Lensky , Arnd Voerste , Thomas Müller , Jörg Baumgarten , Karsten von dem Bruch , Gerhard Müller , Udo Stropp , Ervin Horváth , Jean-Marie-Viktor de Vry , Rudy Schreiber
发明人： Andreas Stolle , Horst-Peter Antonicek , Stephen Lensky , Arnd Voerste , Thomas Müller , Jörg Baumgarten , Karsten von dem Bruch , Gerhard Müller , Udo Stropp , Ervin Horváth , Jean-Marie-Viktor de Vry , Rudy Schreiber
IPC分类号： A61K315377
CPC分类号： C07D401/10 , C07D307/88 , C07D401/12 , C07D405/06 , C07D405/10 , C07D405/12 , C07D407/12 , C07D409/06 , C07D409/12 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/10 , C07D417/12
摘要： The present invention relates to novel substituted &agr;,&bgr;-fused butyrolactones, to processes for their preparation and to their use for the prevention and/or treatment of disorders caused by hyper- or hypofunction of the glutamatergic system, in particular of cerebral ischaemias, craniocerebral trauma, states of pain or CNS-mediated spasms.
摘要翻译：本发明涉及新的取代的α，β-稠合的丁内酯，其制备方法及其用于预防和/或治疗由谷氨酸能系统，特别是脑缺血性脑血管病，颅脑缺血创伤，疼痛状态或CNS介导的痉挛状态。

2. 发明授权

US06433004B1 Substituted &bgr;,&ggr;-anellated lactones 失效
标题翻译：取代的β，γ-安息内酯
公开(公告)号：US06433004B1
公开(公告)日：2002-08-13
申请号：US09600430
申请日：2000-07-14
申请人： Andreas Stolle , Horst-Peter Antonicek , Stephen Lensky , Arnd Voerste , Thomas Müller , Jörg Baumgarten , Karsten von dem Bruch , Gerhard Müller , Udo Stropp , Ervin Horváth , Jean-Marie-Viktor de Vry , Rudy Schreiber
发明人： Andreas Stolle , Horst-Peter Antonicek , Stephen Lensky , Arnd Voerste , Thomas Müller , Jörg Baumgarten , Karsten von dem Bruch , Gerhard Müller , Udo Stropp , Ervin Horváth , Jean-Marie-Viktor de Vry , Rudy Schreiber
IPC分类号： A61K31381
CPC分类号： C07D307/935 , C07D409/06
摘要： The present invention relates to novel substituted &bgr;,&ggr;-fused lactones, to processes for their preparation and to their use for the prevention and/or treatment of disorders caused by hyper- or hypofunction of the glutamatergic system, in particular of cerebral ischaemias, craniocerebral trauma, states of pain or CNS-mediated spasms.
摘要翻译：本发明涉及新的取代的β，γ-融合的内酯，其制备方法及其用于预防和/或治疗由谷氨酸能系统的过度功能或功能不全引起的疾病，特别是脑缺血性颅脑损伤创伤，疼痛状态或CNS介导的痉挛状态。

3. 发明授权

US06462074B1 Substituted &agr;, &bgr;-anellated butyrolactones 失效
标题翻译：取代的α，β-蒽醌丁内酯
公开(公告)号：US06462074B1
公开(公告)日：2002-10-08
申请号：US09600355
申请日：2000-07-14
申请人： Andreas Stolle , Horst-Peter Antonicek , Stephen Lensky , Arnd Voerste , Thomas Müller , Jörg Baumgarten , Karsten von dem Bruch , Gerhard Müller , Udo Stropp , Ervin Horváth , Jean-Marie-Viktor de Vry , Rudy Schreiber
发明人： Andreas Stolle , Horst-Peter Antonicek , Stephen Lensky , Arnd Voerste , Thomas Müller , Jörg Baumgarten , Karsten von dem Bruch , Gerhard Müller , Udo Stropp , Ervin Horváth , Jean-Marie-Viktor de Vry , Rudy Schreiber
IPC分类号： A61K31343
CPC分类号： C07D401/10 , C07D307/88 , C07D401/12 , C07D405/06 , C07D405/10 , C07D405/12 , C07D407/12 , C07D409/06 , C07D409/12 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/10 , C07D417/12
摘要： The present invention relates to novel substituted (&agr;,&bgr;-fused butyrolactones, to processes for their preparation and to their use for the prevention and/or treatment of disorders caused by hyper- or hypofunction of the glutamatergic system, in particular of cerebral ischaemias, craniocerebral trauma, states of pain or CNS-mediated spasms.
摘要翻译：本发明涉及新的取代的（α，β-稠合丁内酯，其制备方法及其用于预防和/或治疗由谷氨酸能系统，特别是脑缺血性系统的过度功能或功能不全引起的疾病的用途，颅脑创伤，疼痛状态或CNS介导的痉挛状态。

4. 发明授权

US06376539B1 Substituted bicyclic lactones 失效
标题翻译：取代的双环内酯
公开(公告)号：US06376539B1
公开(公告)日：2002-04-23
申请号：US09600395
申请日：2000-07-14
申请人： Andreas Stolle , Horst-Peter Antonicek , Stephen Lensky , Arnd Voerste , Thomas Müller , Jörg Baumgarten , Karsten von dem Bruch , Gerhard Müller , Udo Stropp , Ervin Horváth , Jean-Marie-Viktor de Vry , Rudy Schreiber
发明人： Andreas Stolle , Horst-Peter Antonicek , Stephen Lensky , Arnd Voerste , Thomas Müller , Jörg Baumgarten , Karsten von dem Bruch , Gerhard Müller , Udo Stropp , Ervin Horváth , Jean-Marie-Viktor de Vry , Rudy Schreiber
IPC分类号： A61K3134
CPC分类号： C07D493/10 , C07D307/93 , C07D495/10
摘要： The present invention relates to novel substituted bicyclic lactones, to processes for their preparation and to their use for the prevention and/or treatment of disorders caused by hyper- or hypofunction of the glutamatergic system, in particular of cerebral ischaemias, cranial cerebral trauma, states of pain or CNS-mediated spasms.
摘要翻译：本发明涉及新的取代的双环内酯，其制备方法及其用于预防和/或治疗由谷氨酸能系统的过度功能或功能不全引起的疾病，特别是脑缺血性颅脑创伤，状态的疼痛或CNS介导的痉挛。

5. 发明授权

US5583035A HIV antisense expression vectors 失效
标题翻译： HIV反义表达载体
公开(公告)号：US5583035A
公开(公告)日：1996-12-10
申请号：US338355
申请日：1994-11-14
申请人： Axel Kretschmer , Horst-Peter Antonicek , Jorg Baumgarten , Antonius Loebberding , Burkhard Mielke , Wolfgang Springer , Udo Stropp , Mark-Michael Struck , Lothar Biesert , Helga Rubsamen-Waigmann , Hary Suhartono , Thomas-Peter Hausner
发明人： Axel Kretschmer , Horst-Peter Antonicek , Jorg Baumgarten , Antonius Loebberding , Burkhard Mielke , Wolfgang Springer , Udo Stropp , Mark-Michael Struck , Lothar Biesert , Helga Rubsamen-Waigmann , Hary Suhartono , Thomas-Peter Hausner
IPC分类号： C12N15/113 , C12H5/22 , C12H15/85
CPC分类号： C12N15/1132 , C12N2310/111 , C12N2799/021
摘要： The present invention relates to the targeted blocking of the genetic information of the viral messenger ribonucleic acid (mRNA) for virus replication (e.g. of HIV) in transfected, haematopoietic cells with particularly suitable expression systems, which express a complementary "antisense RNA".
摘要翻译：本发明涉及具有表达互补的“反义RNA”的特别合适的表达系统的转染的造血细胞中用于病毒复制的病毒信使核糖核酸（mRNA）的遗传信息的靶向阻断。

6. 发明申请

US20110166838A1 ALGORITHMS FOR OUTCOME PREDICTION IN PATIENTS WITH NODE-POSITIVE CHEMOTHERAPY-TREATED BREAST CANCER 审中-公开
标题翻译：患有结直肠癌治疗乳腺癌的患者的预后预测方法
公开(公告)号：US20110166838A1
公开(公告)日：2011-07-07
申请号：US12999522
申请日：2009-06-16
申请人： Mathias Gehrmann , Ralf Kronenwett , Udo Stropp , Christian Von Törne , Karsten Weber
发明人： Mathias Gehrmann , Ralf Kronenwett , Udo Stropp , Christian Von Törne , Karsten Weber
IPC分类号： G06F7/60
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/158 , G16B20/00 , G16B25/00 , G16B40/00
摘要： The invention relates to methods for predicting an outcome of cancer in a patient suffering from cancer, said patient having been previously diagnosed as node positive and treated with cytotoxic chemotherapy, said method comprising determining in a biological sample from said patient an expression level of a plurality of genes selected from the group consisting of ACTG1, CAl2, CALM2, CCND1, CHPT1, CLEC2B, CTSB, CXCL13, DCN, DHRS2, EIF4B, ERBB2, ESR1, FBXO28, GABRP, GAPDH, H2AFZ, IGFBP3, IGHG1, IGKC, KCTD3, KIAA0101, KRT17, MLPH, MMP1, NAT1, NEK2, NR2F2, OAZ1, PCNA, PDLIM5, PGR, PPIA, PRC1, RACGAP1, RPL37A, SOX4, TOP2A, UBE2C and VEGF; ABCB1, ABCG2, ADAM15, AKR1C1, AKR1C3, AKT1, BANF1, BCL2, BIRC5, BRMS1, CASP10, CCNE2, CENPJ, CHPT1, EGFR, CTTN, ERBB3, ERBB4, FBLN1, FIP1L1, FLT1, FLT4, FNTA, GATA3, GSTP1, Herstatin, IGF1R, IGHM, KDR, KIT, CKRT5, SLC39A6, MAPK3, MAPT, MKI67, MMP7, MTA1, FRAP1, MUC1, MYC, NCOA3, NFIB, OLFM1, TP53, PCNA, PI3K, PPERLD1, RAB31, RAD54B, RAF1, SCUBE2, STAU, TINF2, TMSL8, VGLL1, TRA@, TUBA1, TUBB, TUBB2A.
摘要翻译：本发明涉及用于预测患有癌症的患者的癌症结果的方法，所述患者先前被诊断为淋巴结阳性并用细胞毒性化疗治疗，所述方法包括在来自所述患者的生物样品中确定多个表达水平选自ACTG1，CA2，CALM2，CCND1，CHPT1，CLEC2B，CTSB，CXCL13，DCN，DHRS2，EIF4B，ERBB2，ESR1，FBXO28，GABRP，GAPDH，H2AFZ，IGFBP3，IGHG1，IGKC，KCTD3， KIAA0101，KRT17，MLPH，MMP1，NAT1，NEK2，NR2F2，OAZ1，PCNA，PDLIM5，PGR，PPIA，PRC1，RACGAP1，RPL37A，SOX4，TOP2A，UBE2C和VEGF; ABCB1，ABCG2，ADAM15，AKR1C1，AKR1C3，AKT1，BANF1，BCL2，BIRC5，BRMS1，CASP10，CCNE2，CENPJ，CHPT1，EGFR，CTTN，ERBB3，ERBB4，FBLN1，FIP1L1，FLT1，FLT4，FNTA，GATA3，GSTP1， Herbatin，IGF1R，IGHM，KDR，KIT，CKRT5，SLC39A6，MAPK3，MAPT，MKI67，MMP7，MTA1，FRAP1，MUC1，MYC，NCOA3，NFIB，OLFM1，TP53，PCNA，PI3K，PPERLD1，RAB31，RAD54B，RAF1， SCUBE2，STAU，TINF2，TMSL8，VGLL1，TRA @，TUBA1，TUBB，TUBB2A。

7. 发明授权

US5849893A Nucleic acid-binding oligomers possessing C-branching for therapy and diagnostics 失效
标题翻译：具有C支化的核酸结合寡聚体用于治疗和诊断
公开(公告)号：US5849893A
公开(公告)日：1998-12-15
申请号：US719048
申请日：1996-09-24
申请人： Antonius Lobberding , Burkhard Mielke , Christoph Schwemler , Eckhard Schwenner , Udo Stropp , Wolfgang Springer , Axel Kretschmer , Thorsten Potter
发明人： Antonius Lobberding , Burkhard Mielke , Christoph Schwemler , Eckhard Schwenner , Udo Stropp , Wolfgang Springer , Axel Kretschmer , Thorsten Potter
IPC分类号： C12N15/09 , A61K31/40 , A61K31/495 , A61K31/505 , A61K38/00 , A61K38/10 , A61P31/12 , C07C271/22 , C07C309/66 , C07D207/16 , C07D239/46 , C07D239/47 , C07D239/54 , C07D403/04 , C07D403/12 , C07D473/18 , C07D473/30 , C07D473/34 , C07K5/00 , C07K5/062 , C07K5/078 , C07K5/097 , C07K5/117 , C07K7/06 , C07K7/08 , C07K14/00 , C07H21/04
CPC分类号： C07D239/47 , C07C309/66 , C07D239/54 , C07D403/04 , C07K14/003 , C07K7/06 , C07K7/08 , A61K38/00
摘要： The invention relates to nucleic acid-binding oligomers possessing C-branching of the general formula (I) ##STR1## and to the corresponding monomers, whose radicals have the meaning given in the description, and to their use as medicaments or diagnostic aids.
摘要翻译：本发明涉及具有通式（I）C支化的核酸结合低聚物（I）和相应的单体，其基团具有说明书中给出的含义，以及它们作为药物或诊断用途艾滋病。

8. 发明授权

US5623049A Nucleic acid-binding oligomers possessing N-branching for therapy and diagnostics 失效
标题翻译：具有N-支化用于治疗和诊断的核酸结合寡聚体
公开(公告)号：US5623049A
公开(公告)日：1997-04-22
申请号：US300884
申请日：1994-09-06
申请人： Antonius L obberding , Burkhard Mielke , Christoph Schwemler , Eckhard Schwenner , Udo Stropp , Wolfgang Springer , Axel Kretschmer , Thorsten P otter
发明人： Antonius L obberding , Burkhard Mielke , Christoph Schwemler , Eckhard Schwenner , Udo Stropp , Wolfgang Springer , Axel Kretschmer , Thorsten P otter
IPC分类号： C07D239/47 , A61K31/195 , A61K31/40 , A61K31/401 , A61K38/00 , A61K38/10 , A61P31/12 , C07D239/54 , C07D403/06 , C07D403/12 , C07D473/18 , C07D473/30 , C07D473/34 , C07K5/00 , C07K5/06 , C07K5/062 , C07K7/06 , C07K14/00 , C07K19/00 , C07K7/00 , C07D239/00 , C07H5/04 , C07H21/04
CPC分类号： C07D239/54 , C07D403/06 , C07D473/18 , C07D473/30 , C07D473/34 , C07K14/003 , C07K5/06026 , A61K38/00
摘要： The invention relates to nucleic acid-binding oligomers possessing N-branching of the general formula (I), ##STR1## and their monomers, where the individual radicals have the meaning given in the description, and to their use as medicaments or as aids in diagnostics.
摘要翻译：本发明涉及具有通式（I）的N-支化的核酸结合寡聚体及其单体，其中各个基团具有说明书中给出的含义，以及它们作为药物或作为诊断的辅助工具。

9. 发明申请

US20110172928A1 MOLECULAR MARKERS FOR CANCER PROGNOSIS 审中-公开
标题翻译：癌症预防分子标记
公开(公告)号：US20110172928A1
公开(公告)日：2011-07-14
申请号：US12999406
申请日：2009-06-16
申请人： Mathias Gehrmann , Udo Stropp , Karsten Weber , Christian Von Törne , Marcus Schmidt
发明人： Mathias Gehrmann , Udo Stropp , Karsten Weber , Christian Von Törne , Marcus Schmidt
IPC分类号： G06F19/00
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , G16B20/00 , G16B25/00 , G16B40/00
摘要： The present invention relates to methods for prediction of an outcome of neoplastic disease or cancer. More specifically, the present invention relates to a method for the prediction of breast cancer by determining in a biological sample from said patient an expression level of a plurality of genes selected from the group consisting of ACTG1, CA12, CALM2, CCND1, CHPT1, CLEC2B, CTSB, CXCL13, DCN, DHRS2, EIF4B, ERBB2, ESR1, FBXO28, GABRP, GAPDH, H2AFZ, IGFBP3, IGHG1, IGKC, KCTD3, KIAA0101, KRT17, MLPH, MMP1, NAT1, NEK2, NR2F2, OAZ1, PCNA, PDLIM5, PGR, PPIA, PRC1, RACGAP1, RPL37A, SOX4, TOP2A, UBE2C and VEGF.
摘要翻译：本发明涉及用于预测肿瘤性疾病或癌症的结果的方法。更具体地，本发明涉及通过在来自所述患者的生物样品中测定多种选自ACTG1，CA12，CALM2，CCND1，CHPT1，CLEC2B的多种基因的表达水平来预测乳腺癌的方法，CTSB，CXCL13，DCN，DHRS2，EIF4B，ERBB2，ESR1，FBXO28，GABRP，GAPDH，H2AFZ，IGFBP3，IGHG1，IGKC，KCTD3，KIAA0101，KRT17，MLPH，MMP1，NAT1，NEK2，NR2F2，OAZ1，PCNA，PDLIM5 ，PGR，PPIA，PRC1，RACGAP1，RPL37A，SOX4，TOP2A，UBE2C和VEGF。

10. 发明申请

US20110166845A1 METHOD FOR THE QUALITY ASSESSMENT OF NUCLEIC ACID AMPLIFICATION REACTIONS 审中-公开
标题翻译：核酸扩增反应质量评估方法
公开(公告)号：US20110166845A1
公开(公告)日：2011-07-07
申请号：US13061797
申请日：2009-07-16
申请人： Christian Von Törne , Mareike Assink , Udo Stropp
发明人： Christian Von Törne , Mareike Assink , Udo Stropp
IPC分类号： G06G7/58
CPC分类号： C12Q1/6851 , G16B40/00 , C12Q2537/165
摘要： The invention relates to a method for the quality assessment of nucleic acid amplification reactions which is based on a mathematical approach for the quality assessment of complete nucleic acid amplification reactions and comprises the following steps: a) Carrying out an amplification reaction for at least one nucleic acid target molecule, b)Collecting time-related data reflecting the course of the amplification reaction, c) Fitting these time-related data with a growth model equation comprising at least one parameter, d) Obtaining, from said fitting process, at least one value for the at least one parameter.
摘要翻译：本发明涉及一种核酸扩增反应质量评估方法，该方法基于完整核酸扩增反应的质量评估的数学方法，包括以下步骤：a）对至少一个核酸进行扩增反应酸性靶分子，b）收集反映扩增反应过程的时间相关数据，c）使用包含至少一个参数的生长模型方程拟合这些时间相关数据，d）从所述拟合过程获得至少一个至少一个参数的值。

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