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1. 发明申请

US20110038805A1 COMPOUNDS COMPRISING PARAMAGNETIC CHELATES ARRANGED AROUND A CENTRAL CORE AND THEIR USE IN MAGNETO RESONANCE IMAGING AND SPECTROSCOPY 审中-公开
标题翻译：包含在中心核心附近的参考粒子的化合物及其在磁共振成像和光谱中的使用
公开(公告)号：US20110038805A1
公开(公告)日：2011-02-17
申请号：US12937719
申请日：2009-04-17
申请人： Andreas Meijer , Oskar Axelsson , Anders Brathe , Andreas Olsson , John Henrik Johansen , Duncan George Wynn
发明人： Andreas Meijer , Oskar Axelsson , Anders Brathe , Andreas Olsson , John Henrik Johansen , Duncan George Wynn
IPC分类号： A61B5/055 , C07D257/02 , A61K31/555
CPC分类号： C07D257/02 , A61K49/124
摘要： The present invention relates to novel compounds of formula (I) and (II), compositions comprising compounds of formula (II) and their use as contrast agents in magnetic resonance (MR) imaging (MRI) and MR spectroscopy (MRS).
摘要翻译：本发明涉及式（I）和（II）的新化合物，包含式（II）化合物的组合物及其作为磁共振（MR）成像（MRI）和MR光谱学（MRS）中的造影剂的用途。

2. 发明申请

US20100008864A1 AROMATIC MULTIMERS 审中-公开
公开(公告)号：US20100008864A1
公开(公告)日：2010-01-14
申请号：US12499281
申请日：2009-07-08
申请人： Andreas Meijer , Harry John Wadsworth , Ian Martin Newington , Clare L. Jones , Amanda Ewan , Dennis O'Shea , Oskar Axelsson , Anders Brathe , Andreas Olsson , John Henrik Johansen , Duncan George Wynn
发明人： Andreas Meijer , Harry John Wadsworth , Ian Martin Newington , Clare L. Jones , Amanda Ewan , Dennis O'Shea , Oskar Axelsson , Anders Brathe , Andreas Olsson , John Henrik Johansen , Duncan George Wynn
IPC分类号： A61K49/10 , C07F15/00
CPC分类号： A61K49/124
摘要： The present invention relates to novel compounds of formula (I) and (II), compositions comprising compounds of formula (II) and their use as contrast agents in magnetic resonance (MR) imaging (MRI) and MR spectroscopy (MRS).
摘要翻译：本发明涉及式（I）和（II）的新化合物，包含式（II）化合物的组合物及其作为磁共振（MR）成像（MRI）和MR光谱学（MRS）中的造影剂的用途。

3. 发明申请

US20130064770A1 RADIOLABELED COMPOUNDS AND METHODS THEREOF 审中-公开
标题翻译：放射性化合物及其方法
公开(公告)号：US20130064770A1
公开(公告)日：2013-03-14
申请号：US13699155
申请日：2011-05-26
申请人： Ian Martin Newington , Duncan George Wynn , Robert James Domett Nairne , Benedicte Guilbert , Subrata Mandal , Jinto Jose , Sunderaraman Varadarajan , Chitralekha Rangaswamy , Helen Betts , Rebecca Davis
发明人： Ian Martin Newington , Duncan George Wynn , Robert James Domett Nairne , Benedicte Guilbert , Subrata Mandal , Jinto Jose , Sunderaraman Varadarajan , Chitralekha Rangaswamy , Helen Betts , Rebecca Davis
IPC分类号： A61K51/04 , C07D403/06 , C07D327/04 , C07D401/14 , C07D417/14 , B01J19/00 , C07D295/096 , C07D417/04 , C07D403/12 , C07D417/12 , C07D401/04 , C07D403/04
CPC分类号： C07D401/04 , A61K51/0459 , A61K51/0461 , B01J19/00 , C07D209/14 , C07D211/96 , C07D213/74 , C07D213/75 , C07D217/06 , C07D233/88 , C07D239/88 , C07D249/04 , C07D253/075 , C07D263/46 , C07D263/58 , C07D277/36 , C07D277/64 , C07D277/74 , C07D295/096 , C07D295/125 , C07D327/04 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/04
摘要： The present invention relates to radiodiagnostic compounds, methods of making those compounds, and methods of use thereof as imaging agents for preferably a HA serotonin 5-HT1A receptor for use in PET or SPECT, preferably PET. Compositions comprising an imaging-effective amount of radiolabeled compounds are also disclosed. The present invention also relates to non-radiolabeled compounds, methods of making those compounds, and methods of use thereof to treat various neurological and/or psychiatric disorders.
摘要翻译：本发明涉及放射诊断化合物，制备这些化合物的方法及其用作优选用于PET或SPECT，优选PET的HA血清素5-HT1A受体的显像剂。还公开了包含成像有效量的放射性标记化合物的组合物。本发明还涉及非放射性标记的化合物，制备这些化合物的方法及其用于治疗各种神经和/或精神疾病的方法。

4. 发明申请

US20100233097A1 CONTRAST AGENTS 失效
标题翻译：对比剂
公开(公告)号：US20100233097A1
公开(公告)日：2010-09-16
申请号：US12739989
申请日：2008-11-06
申请人： Veronique Morrison-Iverson , Duncan George Wynn
发明人： Veronique Morrison-Iverson , Duncan George Wynn
IPC分类号： A61K49/04 , C07C237/46 , A61P43/00
CPC分类号： C07C237/46 , A61K49/0433
摘要： Compounds of formula (I) RA—CO—N(R2)—(CR12)n—N(R5)—RB and salts or optical active isomers thereof, wherein each R1 independently are the same or different and denotes a hydrogen atom, a hydroxyl group, a C1 to C4 straight of branched alkyl group or a C1 to C4 straight of branched oxyalkyl group; R2 denotes a hydrogen atom or a C1 to C4 straight of branched alkyl group; R5 independently are the same or different and denotes a acyl moiety; RA and RB independently are the same or different and denote a triiodinated phenyl group, preferably a 2,4,6-triiodinated phenyl group further substituted by two groups R3 in the 3 and 5 positions wherein each R3 are the same or different and denote a hydrogen atom or a non-ionic hydrophilic moiety, provided that at least one R3 group in the compound of formula (I) is a hydrophilic moiety; and n denotes a positive integer of 1 to 6. The invention also relates to the use of such diagnostic compositions as contrast agents in diagnostic imaging and in particular in X-ray imaging, and to contrast media containing such compounds.
摘要翻译：式（I）化合物RA-CO-N（R2） - （CR12）n-N（R5）-RB及其盐或光学活性异构体，其中每个R 1各自独立地相同或不同，表示氢原子，羟基，支链烷基的C1〜C4直链或支链烷氧基的C1〜C4直链; R2表示氢原子或支链烷基的C1〜C4直链; R5独立地相同或不同，表示酰基部分; RA和RB独立地相同或不同，表示三碘代苯基，优选2,4,6-三碘代苯基，其进一步被3和5位的R3基团取代，其中每个R 3相同或不同，表示氢原子或非离子亲水部分，条件是式（I）化合物中的至少一个R 3基团是亲水部分; 并且n表示1至6的正整数。本发明还涉及这种诊断组合物作为造影剂在诊断成像中，特别是在X射线成像中的用途，以及含有这些化合物的造影剂。

5. 发明申请

US20100260685A1 CONTRAST AGENTS 失效
标题翻译：对比剂
公开(公告)号：US20100260685A1
公开(公告)日：2010-10-14
申请号：US12739977
申请日：2008-10-29
申请人： Duncan George Wynn , Ian Martin Newington , Harry John Wadsworth
发明人： Duncan George Wynn , Ian Martin Newington , Harry John Wadsworth
IPC分类号： A61K49/04 , C07C275/40 , C07D413/14
CPC分类号： A61K49/04 , A61K49/0438 , C07C237/46
摘要： The present invention relates to a class of compounds and to diagnostic compositions containing such compounds where the compounds are iodine containing compounds of the formula R—Y—X—Z—R where each R denotes a triiodinated phenyl residue further substituted by hydrophilic moieties, Y and Z are urea and urethane groups and X is a alkylene group which may be further substituted. The invention also relates to the use of such diagnostic compositions as contrast agents in diagnostic imaging and in particular in X-ray imaging, and to contrast media containing such compounds.
摘要翻译：本发明涉及一类化合物和含有这种化合物的诊断组合物，其中化合物是含碘的式R-Y-X-Z-R化合物，其中每个R表示进一步被亲水部分取代的三碘化苯基残基，Y Z为脲和氨基甲酸酯基，X为可进一步取代的亚烷基。本发明还涉及这种诊断组合物作为造影剂在诊断成像中，特别是在X射线成像中的用途，以及含有这些化合物的造影剂。

6. 发明申请

US20100221189A1 CONTRAST AGENTS 失效
标题翻译：对比剂
公开(公告)号：US20100221189A1
公开(公告)日：2010-09-02
申请号：US12682298
申请日：2008-10-10
申请人： Ian Martin Newington , Duncan George Wynn , Veronique Morisson-Iveson , Joanna Marie Passmore
发明人： Ian Martin Newington , Duncan George Wynn , Veronique Morisson-Iveson , Joanna Marie Passmore
IPC分类号： A61K49/04 , C07C233/15 , C07D241/04 , C07D211/56
CPC分类号： A61K49/0438 , C07C237/46 , C07C2601/14 , C07D211/58 , C07D295/108
摘要： The present invention relates to a class of compounds and to diagnostic compositions containing such compounds where the compounds are iodine containing compounds. More specifically the iodine containing compounds are chemical compounds containing two linked iodinated phenyl groups of the general formula (I) and salts or optical active isomers thereof, wherein each R1 independently are the same or different and denotes a hydrogen atom or a C1 to C4 straight or branched alkyl group which is optionally substituted by 1 to 4 —OH groups; each of R2 independently are the same or different and denote a hydrogen atom or a C1 to C4 straight or branched alkyl group; each R3 independently are the same or different and denotes a hydrogen atom or a C1 to C4 straight or branched alkyl group which is optionally substituted by 1 to 4 —OH groups; each R4 independently are the same or different and denote C1 to C6 straight or branched alkyl moieties substituted by up to 6 —OH groups; and each R5 independently are the same or different and denote C1 to C6 straight or branched alkyl moieties substituted by up to 6 —OH groups; and X denotes a straight chain alkylene moiety with 3 to 10 carbon atoms, a 1,4-cyclohexylene group, or X together with the adjacent —NR1 groups forms a 1,4-piperazine group or a 4-aminopiperidine group. The invention also relates to the use of such diagnostic compositions as contrast agents in diagnostic imaging and in particular in X-ray imaging, and to contrast media containing such compounds.
摘要翻译：本发明涉及一类化合物和含有这些化合物的诊断组合物，其中化合物是含碘化合物。更具体地说，含碘化合物是含有通式（I）的两个连接的碘化苯基和其盐或光学活性异构体的化合物，其中每个R 1独立地相同或不同，表示氢原子或C1至C4直链或任选被1至4个-OH基团取代的支链烷基; R2各自相同或不同，表示氢原子或C1〜C4直链或支链烷基; 每个R 3独立地相同或不同，表示氢原子或任选被1至4个-OH基团取代的C 1至C 4直链或支链烷基; 每个R 4独立地相同或不同，表示被至多6个-OH基团取代的C1至C6直链或支链烷基部分; 并且每个R 5独立地相同或不同，表示被至多6个-OH基团取代的C 1至C 6直链或支链烷基部分; X表示具有3至10个碳原子的直链亚烷基部分，1,4-亚环己基或X与相邻的-NR1基团一起形成1,4-哌嗪基团或4-氨基哌啶基团。本发明还涉及这种诊断组合物作为造影剂在诊断成像中，特别是在X射线成像中的用途，以及含有这些化合物的造影剂。

7. 发明授权

US08551449B2 Contrast agents 失效
标题翻译：对比剂
公开(公告)号：US08551449B2
公开(公告)日：2013-10-08
申请号：US12739977
申请日：2008-10-29
申请人： Duncan George Wynn , Ian Martin Newington , Harry John Wadsworth
发明人： Duncan George Wynn , Ian Martin Newington , Harry John Wadsworth
IPC分类号： A61K49/04 , A61K49/00
CPC分类号： A61K49/04 , A61K49/0438 , C07C237/46
摘要： The present invention relates to a class of compounds and to diagnostic compositions containing such compounds where the compounds are iodine containing compounds of the formula R—Y—X—Z—R where each R denotes a triiodinated phenyl residue further substituted by hydrophilic moieties, Y and Z are urea and urethane groups and X is a alkylene group which may be further substituted. The invention also relates to the use of such diagnostic compositions as contrast agents in diagnostic imaging and in particular in X-ray imaging, and to contrast media containing such compounds.
摘要翻译：本发明涉及一类化合物和含有这种化合物的诊断组合物，其中化合物是含碘的式RYXZR化合物，其中每个R表示进一步被亲水部分取代的三碘代苯基，Y和Z是脲和氨基甲酸酯基团， X是可以被进一步取代的亚烷基。本发明还涉及这种诊断组合物作为造影剂在诊断成像中，特别是在X射线成像中的用途，以及含有这些化合物的造影剂。

8. 发明授权

US08323619B2 Contrast agents 失效
标题翻译：对比剂
公开(公告)号：US08323619B2
公开(公告)日：2012-12-04
申请号：US12739989
申请日：2008-11-06
申请人： Veronique Morisson-Iveson , Duncan George Wynn
发明人： Veronique Morisson-Iveson , Duncan George Wynn
IPC分类号： A61K49/04
CPC分类号： C07C237/46 , A61K49/0433
摘要： Compounds of formula (I) RA—CO—N(R2)—(CR12)n—N(R5)—RB and salts or optical active isomers thereof, wherein each R1 independently are the same or different and denotes a hydrogen atom, a hydroxyl group, a C1 to C4 straight of branched alkyl group or a C1 to C4 straight of branched oxyalkyl group; R2 denotes a hydrogen atom or a C1 to C4 straight of branched alkyl group; R5 independently are the same or different and denotes a acyl moiety; RA and RB independently are the same or different and denote a triiodinated phenyl group, preferably a 2,4,6-triiodinated phenyl group further substituted by two groups R3 in the 3 and 5 positions wherein each R3 are the same or different and denote a hydrogen atom or a non-ionic hydrophilic moiety, provided that at least one R3 group in the compound of formula (I) is a hydrophilic moiety; and n denotes a positive integer of 1 to 6. The invention also relates to the use of such diagnostic compositions as contrast agents in diagnostic imaging and in particular in X-ray imaging, and to contrast media containing such compounds.
摘要翻译：式（I）化合物RA-CO-N（R2） - （CR12）n-N（R5）-RB及其盐或光学活性异构体，其中每个R 1各自独立地相同或不同，表示氢原子，羟基，支链烷基的C1〜C4直链或支链烷氧基的C1〜C4直链; R2表示氢原子或支链烷基的C1〜C4直链; R5独立地相同或不同，表示酰基部分; RA和RB独立地相同或不同，表示三碘代苯基，优选2,4,6-三碘代苯基，其进一步被3和5位的R3基团取代，其中每个R 3相同或不同，表示氢原子或非离子亲水部分，条件是式（I）化合物中的至少一个R 3基团是亲水部分; 并且n表示1至6的正整数。本发明还涉及这种诊断组合物作为造影剂在诊断成像中，特别是在X射线成像中的用途，以及含有这些化合物的造影剂。

9. 发明授权

US08202511B2 Contrast agents 失效
标题翻译：对比剂
公开(公告)号：US08202511B2
公开(公告)日：2012-06-19
申请号：US12682298
申请日：2008-10-10
申请人： Ian Martin Newington , Duncan George Wynn , Veronique Morisson-Iveson , Joanna Marie Passmore
发明人： Ian Martin Newington , Duncan George Wynn , Veronique Morisson-Iveson , Joanna Marie Passmore
IPC分类号： A61K49/04
CPC分类号： A61K49/0438 , C07C237/46 , C07C2601/14 , C07D211/58 , C07D295/108
摘要： The present invention relates to a class of compounds and to diagnostic compositions containing such compounds where the compounds are iodine containing compounds. The invention also relates to the use of such diagnostic compositions as contrast agents in diagnostic imaging and in particular in X-ray imaging, and to contrast media containing such compounds.
摘要翻译：本发明涉及一类化合物和含有这些化合物的诊断组合物，其中化合物是含碘化合物。本发明还涉及这种诊断组合物作为造影剂在诊断成像中，特别是在X射线成像中的用途，以及含有这些化合物的造影剂。

10. 发明申请

US20100221192A1 CONTRAST AGENTS 审中-公开
标题翻译：对比剂
公开(公告)号：US20100221192A1
公开(公告)日：2010-09-02
申请号：US12682070
申请日：2008-10-10
申请人： Duncan George Wynn , Lars-Goran Wistrand
发明人： Duncan George Wynn , Lars-Goran Wistrand
IPC分类号： A61K49/04 , C07C233/15
CPC分类号： A61K49/0438 , C07C237/46
摘要： The present invention relates to a class of compounds and to diagnostic compositions containing such compounds where the compounds are iodine containing compounds. More specifically the iodine containing compounds are chemical compounds containing two linked iodinated phenyl groups of the general formula and salts or optical active isomers thereof, wherein each of R1, R2 and R3 independently are the same or different and denote a hydrogen atom or a C1 to C4 straight of branched alkyl group; each R4 independently are the same or different and denote C1 to C6 straight of branched alkyl moieties substituted by up to 6 —OH groups; and each R5 independently are the same or different and denote C1 to C6 straight or branched alkyl moieties substituted by up to 6 —OH groups. The invention also relates to the use of such diagnostic compositions as contrast agents in diagnostic imaging and in particular in X-ray imaging, and to contrast media containing such compounds.
摘要翻译：本发明涉及一类化合物和含有这些化合物的诊断组合物，其中化合物是含碘化合物。更具体地说，含碘化合物是含有通式的两个连接的碘化苯基和其盐或光活性异构体的化合物，其中R1，R2和R3各自独立地相同或不同，表示氢原子或C1至 C4直链的支链烷基; 每个R 4独立地相同或不同，并且表示被至多6个-OH基团取代的支链烷基部分的C1至C6直链; 并且每个R 5独立地相同或不同，并且表示被至多6个-OH基团取代的C 1至C 6直链或支链烷基部分。本发明还涉及这种诊断组合物作为造影剂在诊断成像中，特别是在X射线成像中的用途，以及含有这些化合物的造影剂。

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