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1. 发明申请

US20070231239A1 Method for the Production of Hydrocyanic Acid 有权
标题翻译：生产氢氰酸的方法
公开(公告)号：US20070231239A1
公开(公告)日：2007-10-04
申请号：US11574064
申请日：2005-09-02
申请人： Andreas Deckers , Arnulf Lauterbach , Anton Negele , Thomas Schneider
发明人： Andreas Deckers , Arnulf Lauterbach , Anton Negele , Thomas Schneider
IPC分类号： C01C3/02
CPC分类号： C01C3/0204
摘要： Process for preparing hydrocyanic acid by catalytic dehydration of gaseous formamide, in which a formamide-containing recycle stream is obtained from the product mixture after the dehydration and is recirculated to the dehydration, wherein the formamide-containing recycle stream contains from 5 to 50% by weight of water.
摘要翻译：通过气态甲酰胺的催化脱水制备氢氰酸的方法，其中在脱水后从产物混合物获得含甲酰胺的再循环物流并再循环至脱水，其中含甲酰胺的循环物流含有5-50％水的重量。

2. 发明授权

US07514059B2 Method for the production of hydrocyanic acid 有权
标题翻译：生产氢氰酸的方法
公开(公告)号：US07514059B2
公开(公告)日：2009-04-07
申请号：US11574064
申请日：2005-09-02
申请人： Andreas Deckers , Arnulf Lauterbach , Anton Negele , Thomas Schneider
发明人： Andreas Deckers , Arnulf Lauterbach , Anton Negele , Thomas Schneider
IPC分类号： C01C3/02
CPC分类号： C01C3/0204
摘要： Process for preparing hydrocyanic acid by catalytic dehydration of gaseous formamide, in which a formamide-containing recycle stream is obtained from the product mixture after the dehydration and is recirculated to the dehydration, wherein the formamide-containing recycle stream contains from 5 to 50% by weight of water.
摘要翻译：通过气态甲酰胺的催化脱水制备氢氰酸的方法，其中在脱水后从产物混合物获得含甲酰胺的再循环物流并再循环至脱水，其中含甲酰胺的循环物流含有5-50％水的重量。

3. 发明申请

US20050080205A1 Method for producing polyoxyalkylene glycols 审中-公开
标题翻译：聚氧亚烷基二醇的制备方法
公开(公告)号：US20050080205A1
公开(公告)日：2005-04-14
申请号：US10503572
申请日：2003-12-19
申请人： Kai-Uwe Baldenius , Arnulf Lauterbach , Hans-Peter Seelmann-Eggebert
发明人： Kai-Uwe Baldenius , Arnulf Lauterbach , Hans-Peter Seelmann-Eggebert
IPC分类号： A23L29/00 , C08G65/20 , C08G65/26 , C08G59/14 , C07C41/03
CPC分类号： C08G65/2654 , C08G65/20
摘要： The present invention relates to a process for preparing polyoxyalkylene glycol of high purity and having a low color number from the corresponding alkylene glycol and a starter in the presence of a basic catalyst, wherein a reducing agent is present in the polymerization.
摘要翻译：本发明涉及在碱性催化剂存在下制备高纯度和相应的亚烷基二醇和起始物的低颜色数的聚氧亚烷基二醇的方法，其中在聚合反应中存在还原剂。

4. 发明申请

US20050009695A1 High-purity polyalkylene glycols and preparation thereof 有权
标题翻译：高纯度聚亚烷基二醇及其制备方法
公开(公告)号：US20050009695A1
公开(公告)日：2005-01-13
申请号：US10857915
申请日：2004-06-02
申请人： Markus Klumpe , Kai-Uwe Baldenius , Claus Hackmann , Arnulf Lauterbach , Hans-Peter Seelmann-Eggebert , Matthias Zipplies
发明人： Markus Klumpe , Kai-Uwe Baldenius , Claus Hackmann , Arnulf Lauterbach , Hans-Peter Seelmann-Eggebert , Matthias Zipplies
IPC分类号： C08G65/26 , C08G65/30 , B01J23/00
CPC分类号： C08G65/30 , C08G65/2609
摘要： A process is described for purifying polyalkylene glycols obtained by adding alkylene oxide to alkylene glycol, in which, after addition is complete, the resultant polyalkylene glycol is treated at a pH of >7 with a bleaching agent selected from the group consisting of peroxides, peracids, percarbonates, perborates, peroxodisulfates or oxygen, in each case with or without addition of a bleaching activator. The process is suitable in particular for preparing polyethylene glycol having molar weights from 196 to 203 g/mol which meets requirements of pharmacopeias.
摘要翻译：描述了用于纯化通过将亚烷基二醇加成烯化氧获得的聚亚烷基二醇的方法，其中在添加完成后，所得聚亚烷基二醇在pH> 7的条件下用漂白剂处理，所述漂白剂选自过氧化物，过酸，过碳酸盐，过硼酸盐，过氧二硫酸盐或氧气，在每种情况下都有或没有添加漂白活化剂。该方法特别适用于制备摩尔重量为196至203g / mol，满足药典要求的聚乙二醇。

5. 发明授权

US08728253B2 Method for handling aqueous methanesulfonic acid solutions 有权
标题翻译：甲磺酸水溶液处理方法
公开(公告)号：US08728253B2
公开(公告)日：2014-05-20
申请号：US12917796
申请日：2010-11-02
申请人： Stefan Faβbender , Peter Petersen , Arnulf Lauterbach , Günter Renz , Frieder Borgmeier , Peter Kolb
发明人： Stefan Faβbender , Peter Petersen , Arnulf Lauterbach , Günter Renz , Frieder Borgmeier , Peter Kolb
IPC分类号： C22C38/40 , C22C38/44 , C22C38/50
CPC分类号： C22C38/44 , C22C38/50 , Y10T137/0318
摘要： A method for handling aqueous solutions of methanesulfonic acid (MSA) having a concentration from 50 to 99% by weight of MSA and a total chlorine content of less than 50 mg/kg in apparatuses in which the aqueous MSA solution is in contact with steel surfaces. The steel comprises austenitic steels having a chromium content of from 15 to 22% by weight and a nickel content of from 9 to 15% by weight.
摘要翻译：在MSA溶液与钢表面接触的装置中处理浓度为MSA的50至99重量％和总氯含量小于50mg / kg的甲磺酸（MSA）的水溶液的方法。钢包含铬含量为15〜22重量％，镍含量为9〜15重量％的奥氏体钢。

6. 发明授权

US07279468B2 Integrin ligands 有权
标题翻译：整合素配体
公开(公告)号：US07279468B2
公开(公告)日：2007-10-09
申请号：US10311369
申请日：2001-06-15
申请人： Herve Geneste , Andreas Kling , Udo Lange , Werner Seitz , Claudia Isabella Graef , Thomas Subkoski , Wilfried Hornberger , Arnulf Lauterbach
发明人： Herve Geneste , Andreas Kling , Udo Lange , Werner Seitz , Claudia Isabella Graef , Thomas Subkoski , Wilfried Hornberger , Arnulf Lauterbach
IPC分类号： A01N43/00 , A61K31/55 , C07D513/00 , C07D487/00
CPC分类号： A61K45/06
摘要： The invention relates to novel compounds which bind to integrin receptors, their use as ligands of integrin receptors, in particular as ligands of the αvβ3 integrin receptor, their use, and pharmaceutical preparations comprising these compounds.
摘要翻译：本发明涉及结合整联蛋白受体的新型化合物，它们作为整联蛋白受体的配体，特别是作为α3β3整联蛋白受体的配体的用途，和包含这些化合物的药物制剂。

7. 发明授权

US09227915B2 Process for the preparation of a crystalline L-MGDA trialkali metal salt 有权
标题翻译：制备结晶L-MGDA三碱金属盐的方法
公开(公告)号：US09227915B2
公开(公告)日：2016-01-05
申请号：US13463446
申请日：2012-05-03
申请人： Alfred Oftring , Maxim Weber , Gerold Braun , Arnulf Lauterbach
发明人： Alfred Oftring , Maxim Weber , Gerold Braun , Arnulf Lauterbach
IPC分类号： C07C227/42
CPC分类号： C07C227/42 , C07C229/24
摘要： A process is proposed for the preparation of a crystalline L-MGDA trialkali metal salt by crystallization from an aqueous solution thereof which has been obtained by Strecker synthesis, starting from L-α-alanine, by reaction with formaldehyde and hydrocyanic acid to give L-α-alanine-N,N-diacetonitrile and subsequent alkaline saponification of the L-α-alanine-N,N-diacetonitrile to give the L-MGDA trialkali metal salt, wherein a temperature of 150° C. is not exceeded during the alkaline saponification.
摘要翻译：提出了通过从L-α-丙氨酸开始通过Strecker合成得到的水溶液，通过与甲醛和氢氰酸反应得到L-谷氨酰胺，从而得到结晶L-MGDA三碱金属盐的方法， α-丙氨酸-N，N-二乙腈和随后的L-α-丙氨酸-N，N-二乙腈碱性皂化，得到L-MGDA三碱金属盐，其中在碱性条件下不超过150℃的温度皂化

8. 发明申请

US20120283473A1 PROCESS FOR THE PREPARATION OF A CRYSTALLINE L-MGDA TRIALKALI METAL SALT 有权
标题翻译：制备结晶L-MGDA试制金属盐的方法
公开(公告)号：US20120283473A1
公开(公告)日：2012-11-08
申请号：US13463446
申请日：2012-05-03
申请人： Alfred OFTRING , Maxim Weber , Gerold Braun , Arnulf Lauterbach
发明人： Alfred OFTRING , Maxim Weber , Gerold Braun , Arnulf Lauterbach
IPC分类号： C07C227/42 , C07C229/24
CPC分类号： C07C227/42 , C07C229/24
摘要： A process is proposed for the preparation of a crystalline L-MGDA trialkali metal salt by crystallization from an aqueous solution thereof which has been obtained by Strecker synthesis, starting from L-α-alanine, by reaction with formaldehyde and hydrocyanic acid to give L-α-alanine-N,N-diacetonitrile and subsequent alkaline saponification of the L-α-alanine-N,N-diacetonitrile to give the L-MGDA trialkali metal salt, wherein a temperature of 150° C. is not exceeded during the alkaline saponification.
摘要翻译：提出了通过从L-α-丙氨酸开始通过Strecker合成得到的水溶液，通过与甲醛和氢氰酸反应得到L-谷氨酰胺，从而得到结晶L-MGDA三碱金属盐的方法， α-丙氨酸-N，N-二乙腈和随后的L-α-丙氨酸-N，N-二乙腈碱性皂化，得到L-MGDA三碱金属盐，其中在碱性条件下不超过150℃的温度皂化

9. 发明授权

US07105508B1 Integrin receptors antagonists 有权
标题翻译：整合素受体拮抗剂
公开(公告)号：US07105508B1
公开(公告)日：2006-09-12
申请号：US10049266
申请日：2000-08-01
申请人： Andreas Kling , Hervé Geneste , Udo Lange , Arnulf Lauterbach , Claudia Isabella Graef , Thomas Subkowski , Uta Holzenkamp , Helmut Mack , Jens Sadowski , Wilfried Hornberger , Volker Laux
发明人： Andreas Kling , Hervé Geneste , Udo Lange , Arnulf Lauterbach , Claudia Isabella Graef , Thomas Subkowski , Uta Holzenkamp , Helmut Mack , Jens Sadowski , Wilfried Hornberger , Volker Laux
IPC分类号： C07D401/12 , A61K31/55
CPC分类号： C07D401/06 , C07D223/20 , C07D243/38 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D409/12 , C07D409/14 , C07D417/06 , C07D417/12 , C07D417/14 , C07D471/04 , C07D495/04 , C07D495/14
摘要： The invention relates to novel compounds which bind to integrin receptors, and to the preparation thereof and the use thereof as drugs.
摘要翻译：本发明涉及结合整联蛋白受体的新化合物及其制备及其作为药物的用途。

10. 发明授权

US08802894B2 Process for the preparation of aqueous solutions of methylglycine-N,N-diacetic acid trialkali metal salts 有权
标题翻译：制备甲基甘氨酸-N，N-二乙酸三烷基金属盐水溶液的方法
公开(公告)号：US08802894B2
公开(公告)日：2014-08-12
申请号：US13431381
申请日：2012-03-27
申请人： Alfred Oftring , Gerold Braun , Arnulf Lauterbach
发明人： Alfred Oftring , Gerold Braun , Arnulf Lauterbach
IPC分类号： C07C227/18
CPC分类号： C07C253/00 , C07C227/26 , C07C255/25 , C07C229/12
摘要： A process for preparing an aqueous solution of a methylglycine-N,N-diacetic acid trialkali metal salt at a high yield and purity by Strecker synthesis, the process including: reacting an aqueous solution containing α-alanine with formaldehyde and hydrocyanic acid, to obtain α-alanine-N,N-diacetonitrile in one reaction unit; and saponification of the α-alanine-N,N-diacetonitrile with a base, to obtain the methylglycine-N,N-diacetic acid trialkali metal salt, wherein the α-alanine is partially neutralized and the addition of formaldehyde and hydrocyanic acid are controlled such that a concentration of free hydrocyanic acid in the liquid reaction mixture at any time is limited such that secondary reactions that produce formaldehyde cyanohydrin, consecutive reactions of formaldehyde cyanohydrin, and the polymerization of hydrocyanic acid, only occur insofar as the specification requirements, such as nitrilotriacetic acid content and color, for methylglycine-N,N-diacetic acid trialkali metal salts are observed.
摘要翻译：一种通过Strecker合成以高产率和纯度制备甲基甘氨酸-N，N-二乙酸三烷基金属盐的水溶液的方法，该方法包括：使含有α-丙氨酸的水溶液与甲醛和氢氰酸反应，得到 α-丙氨酸-N，N-二乙腈在一个反应单元中; 并用碱对α-丙氨酸-N，N-二乙腈进行皂化，得到甲基甘氨酸-N，N-二乙酸三碱金属盐，其中α-丙氨酸被部分中和，加入甲醛和氢氰酸被控制使得在任何时候液体反应混合物中的游离氢氰酸的浓度受到限制，使得产生甲醛氰醇的二次反应，甲醛氰醇的连续反应和氢氰酸的聚合仅发生在规范要求的范围内，例如观察到甲基甘氨酸-N，N-二乙酸三烷基金属盐的次氮基三乙酸含量和颜色。

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