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1. 发明授权

US06373577B1 Surface plasmon resonance sensor for the simultaneous measurement of a plurality of samples in fluid form 失效
标题翻译：用于同时测量流体形式的多个样品的表面等离子体共振传感器
公开(公告)号：US06373577B1
公开(公告)日：2002-04-16
申请号：US09600670
申请日：2000-07-20
申请人： Andreas Bräuer , Norbert Danz , Kristina Schmidt , Dirk Vetter , Ralf Waldhausl
发明人： Andreas Bräuer , Norbert Danz , Kristina Schmidt , Dirk Vetter , Ralf Waldhausl
IPC分类号： G01N2155
CPC分类号： G01N21/253 , G01N21/553
摘要： The invention relates to a surface plasmon resonance sensor for the simultaneous measurement of a plurality of samples present in fluid form. The aim of the invention is to provide such a sensor which can be arranged into a defined array and where the surface plasmon resonance sensors can be produced using technology which is simpler and more economical than those produced according to the prior art. To this end several strip-like optical wave guides (2) are arranged on a planar support (1) at a defined distance to each other in such a way that their front faces (21, 22) are flush with opposite sides (11, 12) of the planar support (1). Each strip-like optical wave guide (2) in a section which is to be brought into contact with the fluid samples has at least one thin metal layer (3) which permits the excitation of surface plasmons. Means (14) are provided for which separate the measurement zones of the individual thin metal layers (3) from each other in such a way that each of the optical wave guides (2) can be assigned to only one sample.
摘要翻译：本发明涉及用于同时测量以流体形式存在的多个样品的表面等离子体共振传感器。本发明的目的是提供一种这样的传感器，其可以被布置成限定的阵列，并且其中可以使用比根据现有技术制造的那些更简单和更经济的技术来生产表面等离子体共振传感器。为此，几个带状光波导（2）以相互限定的距离布置在平面支撑件（1）上，使得它们的前表面（21,22）与相对侧（11， 12）。要与流体样品接触的部分中的每个带状光波导（2）具有允许表面等离子体激发的至少一个薄金属层（3）。提供了将各个薄金属层（3）的测量区域彼此分开的装置（14），使得每个光波导（2）只能分配给一个样品。

2. 发明授权

US07955638B2 Surface for the immobilization of ligands 失效
标题翻译：用于固定配体的表面
公开(公告)号：US07955638B2
公开(公告)日：2011-06-07
申请号：US11980015
申请日：2007-10-30
申请人： Stefan Dickopf , Holger Ottleben , Harald Rau , Renate Sekul , Kristina Schmidt , Dirk Vetter
发明人： Stefan Dickopf , Holger Ottleben , Harald Rau , Renate Sekul , Kristina Schmidt , Dirk Vetter
IPC分类号： G01N1/31
CPC分类号： B82Y30/00 , B82Y5/00 , B82Y15/00 , G01N33/54353 , G01N33/553
摘要： The present invention relates to binding surfaces for the immobilization of ligands, ligand surfaces and structured surface arrays which present a plurality of identical or different ligands. The invention further relates to a process for the production and the use of such surfaces and to specific binder molecules which can be used for the preparation thereof.
摘要翻译：本发明涉及用于固定配体，配体表面和呈现多个相同或不同配体的结构化表面阵列的结合表面。本发明还涉及一种用于制备和使用这些表面的方法以及可用于其制备的特定粘合剂分子。

3. 发明授权

US06752963B2 SPR sensor system 失效
标题翻译： SPR传感器系统
公开(公告)号：US06752963B2
公开(公告)日：2004-06-22
申请号：US09789015
申请日：2001-02-21
申请人： Stefan Dickopf , Kristina Schmidt , Dirk Vetter , Klaus Burkert
发明人： Stefan Dickopf , Kristina Schmidt , Dirk Vetter , Klaus Burkert
IPC分类号： G01N2155
CPC分类号： G01N21/253 , G01N21/553
摘要： The invention relates to an SPR sensor array comprising a plurality of SPR sensor surface areas (120) arranged on a substrate (10, 20) in a two-dimensional matrix located in a plane to which the SPR sensor surface areas (120) are parallel and whereby radiation capable of exciting surface plasmons in the SPR sensor surface areas (120) under specific physical conditions can be guided through the substrate (10, 20) to be reflected from the SPR sensor surface areas, as well as separating means (110) for separating each SPR sensor surface area (120) from its neighboring SPR sensor surface area (120), wherein the separating means (110) and SPR sensor surface areas (120) are provided such that at least outside of surface plasmon resonance occurring in the SPR sensor surface areas (120) the radiation (40) guided through the substrate (10, 20) is reflected in the region of the separating means to a different degree than in the region of the SPR sensor surface areas (120) to create a contrast between the separating means (110) and the SPR sensor surface areas (120) at least outside of surface plasmon resonance occurring in the SPR sensor surface areas (120) in the radiation reflected by the SPR sensor surface areas (120) and the separating means (110).
摘要翻译：本发明涉及一种SPR传感器阵列，其包括布置在位于SPR传感器表面区域（120）平行的平面中的二维矩阵中的衬底（10,20）上的多个SPR传感器表面区域（120）并且由此能够在特定物理条件下激发SPR传感器表面区域（120）中的表面等离子体激元的辐射能够被引导穿过衬底（10,20）以从SPR传感器表面区域反射，以及分离装置（110）用于将每个SPR传感器表面区域（120）与其相邻的SPR传感器表面区域（120）分离，其中分离装置（110）和SPR传感器表面区域（120）被设置成使得至少在表面等离子体共振引导穿过衬底（10,20）的辐射（40）的SPR传感器表面区域（120）在分离装置的区域中被反射到与SPR传感器表面区域（120）的区域不同的程度，以产生对比是在由SPR传感器表面区域（120）和分离装置（120）反射的辐射中至少在出现在SPR传感器表面区域（120）中的表面等离子体共振之外的分离装置（110）和SPR传感器表面区域（120）（110）。

4. 发明授权

US06795192B2 SPR sensor and SPR sensor array 失效
标题翻译： SPR传感器和SPR传感器阵列
公开(公告)号：US06795192B2
公开(公告)日：2004-09-21
申请号：US10223010
申请日：2002-08-19
申请人： Stefan Dickopf , Kristina Schmidt , Dirk Vetter
发明人： Stefan Dickopf , Kristina Schmidt , Dirk Vetter
IPC分类号： G01N2155
CPC分类号： G01N21/253 , G01N21/553
摘要： The invention relates to an an SPR surface plasmon resonance spectroscopy sensor for parallel measurement of a plurality of samples, comprising a body (1a) having several SPR sensor areas (2) for guiding radiation in order to carry out SPR measurements and which are coated with a material which is suitable for SPR in such a way that each SPR sensor area (2) can be exclusively associated with a single sample. The radiation conducting body (1a) forms a unit with the SPR sensor areas (2), whereby the path of the rays guided by the SPR sensor areas (2) can also extend through the radiation conducting body (1a).
摘要翻译：本发明涉及一种用于多个样本的并行测量的SPR表面等离子体共振光谱传感器，包括具有多个SPR传感器区域（2）的主体（1a），用于引导辐射以进行SPR测量并且涂覆有适合于SPR的材料，使得每个SPR传感器区域（2）可以与单个样品完全相关联。辐射导电体（1a）与SPR传感器区域（2）形成一个单元，由此由SPR传感器区域（2）引导的射线的路径也可以延伸穿过辐射导电体（1a）。

5. 发明授权

US06695369B2 Device and method for picking up and placing objects 失效
标题翻译：拾取和放置物体的装置和方法
公开(公告)号：US06695369B2
公开(公告)日：2004-02-24
申请号：US10086983
申请日：2002-02-28
申请人： Kristina Schmidt , Dirk Vetter
发明人： Kristina Schmidt , Dirk Vetter
IPC分类号： B25J1500
CPC分类号： B65G47/90 , B01J19/0046 , B01J2219/00315 , B01J2219/00387 , B01J2219/00468 , B01J2219/005 , B23P19/007 , C40B60/14
摘要： The invention relates to a device and a method for picking up individual objects or particles and placing them in containers or cavities filled with liquid. The invention allows in particular a simple handling of the objects and thus considerably reduces the operation costs of such a plant (FIG. 2). In this method and device, an adhesive is applied to an end portion of a transport structure. An object to be transported is held by the adhesive until it is delivered to the desired location.
摘要翻译：本发明涉及一种用于拾取单个物体或颗粒并将其放置在填充有液体的容器或空腔中的装置和方法。本发明特别地允许对象的简单处理，从而大大降低了这种植物的操作成本（图2）。在该方法和装置中，将粘合剂施加到运输结构的端部。要运输的物体由粘合剂保持，直到其被输送到期望的位置。

6. 发明授权

US06441906B2 Set-up of measuring instruments for the parallel readout of SPR sensors 失效
公开(公告)号：US06441906B2
公开(公告)日：2002-08-27
申请号：US09859677
申请日：2001-05-18
申请人： Stefan Dickopf , Kristina Schmidt , Dirk Vetter
发明人： Stefan Dickopf , Kristina Schmidt , Dirk Vetter
IPC分类号： G01N2155
CPC分类号： G01N21/253 , G01N21/553
摘要： The invention relates to a set-up of measuring instruments for the parallel readout of SPR sensors. The aim of the invention is to provide a measuring arrangement for the parallel readout of a plurality of SPR sensors, wherein the readout process should be terminated within an integration period of less than 30 minutes. To this end, a wavelength-selective component (5) and an optical imaging system (L2, L3) are arranged downstream of a light source (3). Said optical imaging system (L2, L3) is in such a manner that at a first wavelength it guarantees a parallel illumination of the light entrance sides of the waveguides (13) which are provided with SPR-compatible sensor zones, and that the light emerging from the individual light waveguides (13) may simultaneously be imaged onto a CCD chip (20) via an optical system (L4) in such a way that the light emerging from each individual light waveguide (13) is respectively detectable by several adjacent CCD pixels of the CCD chip (20), and from these pixel areas a respective light intensity value is calculable by means of image processing software, and, after data storage of an intensity value, a set wave length and coordinate in the waveguide array (10), an adjustment of the wavelength-selective assembly (5) to a second, arbitrarily providable, further light wavelength is performable by means of a computer (30) via a control line (31).

7. 发明申请

US20080167196A1 Surface for the immobilization of ligands 失效
标题翻译：用于固定配体的表面
公开(公告)号：US20080167196A1
公开(公告)日：2008-07-10
申请号：US11980015
申请日：2007-10-30
申请人： Stefan Dickopf , Holger Ottleben , Harald Rau , Renate Sekul , Kristina Schmidt , Dirk Vetter
发明人： Stefan Dickopf , Holger Ottleben , Harald Rau , Renate Sekul , Kristina Schmidt , Dirk Vetter
IPC分类号： C40B20/02 , C40B50/18 , C40B30/10
CPC分类号： B82Y30/00 , B82Y5/00 , B82Y15/00 , G01N33/54353 , G01N33/553
摘要： The present invention relates to binding surfaces for the immobilization of ligands, ligand surfaces and structured surface arrays which present a plurality of identical or different ligands. The invention further relates to a process for the production and the use of such surfaces and to specific binder molecules which can be used for the preparation thereof.
摘要翻译：本发明涉及用于固定配体，配体表面和存在多个相同或不同配体的结构化表面阵列的结合表面。本发明还涉及一种用于制备和使用这些表面的方法以及可用于其制备的特定粘合剂分子。

8. 发明授权

US06921514B1 Device for carrying out an almost simultaneous synthesis of a plurality of samples 失效
标题翻译：用于执行几个同时合成多个样品的装置
公开(公告)号：US06921514B1
公开(公告)日：2005-07-26
申请号：US09720284
申请日：1999-06-10
申请人： Dirk Vetter , Kristina Schmidt
发明人： Dirk Vetter , Kristina Schmidt
IPC分类号： B01J19/00 , B01L3/00 , B01L99/00 , C40B60/14 , G01N35/00
CPC分类号： B01J19/0046 , B01J2219/00369 , B01J2219/00427 , B01J2219/0043 , B01J2219/00468 , B01J2219/00527 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00619 , B01J2219/00621 , B01J2219/0063 , B01J2219/00637 , B01J2219/00659 , B01L3/0293 , B01L3/5027 , B01L3/502715 , B01L3/50273 , B01L2300/0636 , B01L2300/0819 , B01L2300/089 , B01L2400/0406 , C40B60/14 , G01N2035/00237 , Y10T436/25 , Y10T436/2575
摘要： The invention relates to a device for carrying out an almost simultaneous synthesis of a plurality of samples. The device is especially suitable for use in automated laboratory processes in the area of combinatorial chemistry. The aim of the invention is to provide a device of this type which enables the synthesis of a plurality of samples bonded to microbeads, said microbeads being provided in the cavities of a support plate. To this end, a plane support plate (1) is provided with a plurality of cavities (11) arranged regularly in an iterative grid. The cavities accommodate microbeads (12). A removable covering (2) is provided, said covering being provided with webs (21) which each cover at least one of a row of associated cavities (11) in such a way that a capillary gap (3) is formed between the microbeads (12) and the webs (21) and larger recesses (22) are left respectively between the adjacent webs (21). A dosed liquid dispenser (4) is allocated to each capillary gap (3).
摘要翻译：本发明涉及用于执行几乎同时合成多个样品的装置。该装置特别适用于组合化学领域的自动化实验室工艺。本发明的目的是提供这种类型的装置，其能够合成结合到微珠的多个样品，所述微珠设置在支撑板的空腔中。为此，平面支撑板（1）设置有以迭代网格规则排列的多个空腔（11）。空腔容纳微珠（12）。提供了可移除的覆盖物（2），所述覆盖物设置有腹板（21），每个腹板覆盖一排相关腔（11）中的至少一个，使得毛细孔隙（3）形成在微珠之间 12）和腹板（21）和较大的凹部（22）分别留在相邻的腹板（21）之间。给药液体分配器（4）分配给每个毛细管间隙（3）。

9. 发明授权

US07842242B2 Optical coupling device and method 失效
标题翻译：光耦合装置及方法
公开(公告)号：US07842242B2
公开(公告)日：2010-11-30
申请号：US10555818
申请日：2004-04-01
申请人： Stefan Dickopf , Thomas Perschke , Mladen Nedic , Kristina Schmidt
发明人： Stefan Dickopf , Thomas Perschke , Mladen Nedic , Kristina Schmidt
IPC分类号： G01N21/00 , G02B6/26 , G01N21/55
CPC分类号： G01N21/05 , G01N21/0303 , G01N21/553 , G01N2021/0346 , G01N2021/0389 , G01N2021/0396 , G01N2021/058 , G02B5/00
摘要： A device for optically coupling a first optical element to a second optical element comprises a first optical element with a first radiation penetration surface; a second optical element with a second radiation penetration surface located across from the first radiation penetration surface; and a chamber delimited by the first and second radiation penetration surfaces and a circumferentially closed side wall which connects the first and second radiation penetration surfaces. The circumferentially closed side wall defines a first sector in the first radiation penetration surface and a second sector in the second radiation penetration surface, the area of the first sector being smaller than the area of the first radiation penetration surface, and the area of the second sector being smaller than the area of the second radiation penetration surface. The device further comprises a feeding conduit to the chamber for delivering index-adjusting liquid; and a discharge conduit from the chamber for evacuating index-adjusting liquid or gas from the chamber.
摘要翻译：用于将第一光学元件光学耦合到第二光学元件的装置包括具有第一辐射穿透表面的第一光学元件; 第二光学元件，具有位于第一辐射穿透表面的第二辐射穿透表面; 以及由第一和第二辐射穿透表面限定的室和连接第一和第二辐射穿透表面的周向封闭的侧壁。周向封闭的侧壁限定了第一辐射穿透表面中的第一扇区和第二辐射穿透表面中的第二扇区，第一扇区的面积小于第一辐射穿透表面的面积，第二扇区的面积扇区小于第二辐射穿透表面的面积。该装置还包括一个用于输送折射率调节液体的输送管道，以及来自所述室的排出管道，用于从所述室排出折射率调节液体或气体。

10. 发明申请

US20130131321A1 LIGANDS FOR ANTIBODY AND Fc-FUSION PROTEIN PURIFICATION BY AFFINITY CHROMATOGRAPHY 审中-公开
标题翻译：通过亲和色谱法进行抗体和Fc融合蛋白纯化的配体
公开(公告)号：US20130131321A1
公开(公告)日：2013-05-23
申请号：US13813860
申请日：2011-08-03
申请人： Holger Bittermann , Klaus Burkert , Marc Arnold , Oliver Keil , Thomas Neumann , Inge Ott , Kristina Schmidt , Daniel Schwizer , Renate Sekul
发明人： Holger Bittermann , Klaus Burkert , Marc Arnold , Oliver Keil , Thomas Neumann , Inge Ott , Kristina Schmidt , Daniel Schwizer , Renate Sekul
IPC分类号： C07K1/22 , C07D405/04 , C07D409/04 , C07D231/14 , C07D231/56 , C07D213/82 , C07D403/04 , C07D209/42 , C07D261/20 , C07D307/87 , C07D217/26 , C07D513/04 , C07D471/04 , C07D417/04 , C07D413/04 , C07D235/24 , C07D487/04 , C07D261/18 , C07D271/06 , C07D277/68 , C07D277/56 , C08B37/00
CPC分类号： C07K1/22 , B01D15/3804 , B01J20/289 , B01J20/3251 , B01J20/3253 , B01J20/3255 , C07D209/42 , C07D213/82 , C07D217/26 , C07D231/14 , C07D231/56 , C07D235/24 , C07D261/18 , C07D261/20 , C07D271/06 , C07D277/46 , C07D277/56 , C07D277/68 , C07D277/82 , C07D307/87 , C07D403/04 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/04 , C07D417/14 , C07D471/04 , C07D487/04 , C07D513/04 , C07D519/00 , C07K16/00 , C08B37/0039
摘要： The present invention relates to the use for affinity purification of an antibody or an fragment of an antibody, of a ligand-substituted matrix comprising a support material and at least one ligand covalently bonded to the support material, the ligand being represented by formula (I) wherein Sp is a spacer group; v is 0 or 1; Am is an amide group —NR1—C(O)—, and wherein either NR1 is attached to Ar1 and —C(O)— is attached to Ar2, or —C(O)— is attached to Ar1 and NR1 is attached to Ar2; and R1 is hydrogen or C1 to C4 alkyl, preferably hydrogen or methyl; and more preferably hydrogen; Ar1 is a divalent 5- or 6-membered substituted or unsubstituted aromatic ring; Ar2 is 5- or 6-membered heterocyclic aromatic ring which is (a) attached to a further 5- or 6-membered aromatic ring via a single bond; or (b) fused to a further 5- or 6-membered aromatic ring as part of a multicyclic ring system; or (c) attached to at least one substituent selected from C1 to C4 alkyl; C2 to C4 alkenyl; C2 to C4 alkynyl; a halogen; C1 to C4 haloalkyl; hydroxyl-substituted C1 to C4 alkyl; C1 to C4 alkoxy; hydroxyl-substituted C1 to C4 alkoxy; C1 to C4 alkylamino; C1 to C4 alkylthio; and combinations thereof.
摘要翻译：本发明涉及用于亲和纯化抗体或抗体片段的配体取代基质，其包含载体材料和至少一种与载体材料共价结合的配体，所述配体由式（I ）其中Sp为间隔基; v为0或1; Am是酰胺基-NR1-C（O） - ，并且其中NR1与Ar1连接，-C（O） - 连接到Ar2上，或-C（O） - 连接到Ar1上，并且NR1连接到 Ar2; 并且R 1是氢或C 1至C 4烷基，优选氢或甲基; 更优选氢; Ar1是二价的5-或6-元取代或未取代的芳环; Ar 2是5-或6-元杂环芳环，其是（a）通过单键与另一个5-或6-元芳环相连; 或（b）作为多环系统的一部分与另一个5-或6-元芳环稠合; 或（c）连接至至少一个选自C 1至C 4烷基的取代基; C2至C4烯基; C2至C4炔基; 卤素 C1至C4卤代烷基; 羟基取代的C1至C4烷基; C1至C4烷氧基; 羟基取代的C1至C4烷氧基; C1至C4烷基氨基; C1〜C4烷硫基; 及其组合。

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