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1. 发明申请

US20100062463A1 IN VITRO MULTIPARAMETER DETERMINATION METHOD FOR THE DIAGNOSIS AND EARLY DIAGNOSIS OF NEURODEGENERATIVE DISORDERS 有权
标题翻译：用于诊断和早期诊断神经损伤性疾病的体外多重测定方法
公开(公告)号：US20100062463A1
公开(公告)日：2010-03-11
申请号：US12305088
申请日：2007-06-15
申请人： Andreas Bergmann , Andrea Ernst , Harald Hampel
发明人： Andreas Bergmann , Andrea Ernst , Harald Hampel
IPC分类号： G01N33/53
CPC分类号： G01N33/6896 , G01N2800/28 , G01N2800/2814 , G01N2800/2821 , Y10S436/811
摘要： In vitro multiparameter method for the diagnosis and early diagnosis, for determination of the severity and for assessing the course and prognosis of neurodegenerative disorders, in which the concentrations of at least two different vasotropic peptides are determined in a biological fluid from a person suffering from subjective or objectively detectable cognitive impairments, the resulting person-specific measurements are combined computationally to give a person-specific complex reference value, and conclusions are drawn concerning the presence of a neurodegenerative disorder in the person on the basis of the person-specific complex reference value found.
摘要翻译：用于诊断和早期诊断的体外多参数方法，用于确定严重性并评估神经变性疾病的过程和预后，其中在来自患有主观的人的生物液体中确定至少两种不同的吸水肽的浓度或客观可检测的认知障碍，所得到的人特异性测量结合计算来给出特定于人的复杂参考值，并且基于人特异性复杂参考值对人的神经变性疾病的存在得出结论发现。

2. 发明申请

US20090263822A1 In Vitro Procedure for Diagnosis and Early Diagnosis of Neurodegenerative Diseases 有权
标题翻译：体外诊断和早期诊断神经退行性疾病的方法
公开(公告)号：US20090263822A1
公开(公告)日：2009-10-22
申请号：US12300747
申请日：2007-05-15
申请人： Andreas Bergmann , Andrea Ernst , Harald Hampel
发明人： Andreas Bergmann , Andrea Ernst , Harald Hampel
IPC分类号： G01N33/53
CPC分类号： G01N33/6896 , G01N2800/28
摘要： An in vitro process for the detection and early detection of neurodegenerative diseases, for determination of the severity, and to evaluate the progression of and render a prognoses of neurogenerative diseases, in a patient suffering from a subjectively or objectively detectable cognitive impairment, by determining the concentration of an analyte selected from natriuretic peptides, in particular ANP, and, if necessary, BNP and/or CNP in a biological fluid of the patient, whereby the determination of the analyte is performed directly and/or indirectly as the determination of a relevant co-peptide generated from a mutual propeptide, and is based upon the measured concentration of the determined analyte thus making it possible to form conclusions about a neurodegenerative disease or an early form typical of such a disease or the course of the disease and/or the success of the efforts to relieve or prevent the disease.
摘要翻译：一种用于检测和早期检测神经变性疾病，用于确定严重程度并评估患有主观或客观可检测的认知障碍的患者中神经生殖疾病的进展和预测神经生殖疾病的体外方法，通过确定选自利尿钠肽，特别是ANP的分析物的浓度，以及如果需要，BNP和/或CNP在患者的生物液体中的浓度，由此分析物的测定直接和/或间接地作为相关的测定由相互前肽产生的共肽，并且基于所测定的分析物的测量浓度，从而可以形成关于神经变性疾病或这种疾病典型的早期形式或疾病过程和/或成功地减轻或预防疾病的努力。

3. 发明授权

US08298784B2 In vitro procedure for diagnosis and early diagnosis of neurodegenerative diseases 有权
标题翻译：诊断和早期诊断神经变性疾病的体外方法
公开(公告)号：US08298784B2
公开(公告)日：2012-10-30
申请号：US12300747
申请日：2007-05-15
申请人： Andreas Bergmann , Andrea Ernst , Harald Hampel
发明人： Andreas Bergmann , Andrea Ernst , Harald Hampel
IPC分类号： G01N33/53 , G01N33/537 , G01N33/567
CPC分类号： G01N33/6896 , G01N2800/28
摘要： An in vitro process for the detection and early detection of neurodegenerative diseases, for determination of the severity, and to evaluate the progression of and render a prognoses of neurogenerative diseases, in a patient suffering from a subjectively or objectively detectable cognitive impairment, by determining the concentration of an analyte selected from natriuretic peptides, in particular ANP, and, if necessary, BNP and/or CNP in a biological fluid of the patient, whereby the determination of the analyte is performed directly and/or indirectly as the determination of a relevant co-peptide generated from a mutual propeptide, and is based upon the measured concentration of the determined analyte thus making it possible to form conclusions about a neurodegenerative disease or an early form typical of such a disease or the course of the disease and/or the success of the efforts to relieve or prevent the disease.
摘要翻译：一种用于检测和早期检测神经变性疾病，用于确定严重程度并评估患有主观或客观可检测的认知障碍的患者中神经生殖疾病的进展和预测神经生殖疾病的体外方法，通过确定选自利尿钠肽，特别是ANP的分析物的浓度，以及如果需要，BNP和/或CNP在患者的生物液体中的浓度，由此分析物的测定直接和/或间接地作为相关的测定由相互前肽产生的共肽，并且基于所测定的分析物的测量浓度，从而可以形成关于神经变性疾病或这种疾病典型的早期形式或疾病过程和/或成功地减轻或预防疾病的努力。

4. 发明授权

US07547553B2 In vitro method for the diagnosis of neurodegenerative diseases 有权
标题翻译：用于诊断神经变性疾病的体外方法
公开(公告)号：US07547553B2
公开(公告)日：2009-06-16
申请号：US11997250
申请日：2006-07-24
申请人： Andreas Bergmann , Andrea Ernst , Harald Hampel
发明人： Andreas Bergmann , Andrea Ernst , Harald Hampel
IPC分类号： G01N33/68 , G01N33/00 , G01N33/566 , G01N33/543 , G01N33/536 , G01N33/53
CPC分类号： G01N33/6896 , G01N2333/575 , G01N2800/2814 , G01N2800/2821 , Y10S436/811 , Y10S436/815
摘要： An in vitro method for the detection, determination of severity and monitoring and prognosis of neurodegenerative diseases is disclosed. The presence and/or concentration of the physiologically inactive proadrenomedullin (proADM) partial peptide, in particular, the midregional proADM partial peptide, is determined in a biological fluid of a patient who is suffering from a neurodegenerative disease or is suspected of having such a disease. Conclusions about the presence, course, severity or success of a treatment of the neurodegenerative disease are drawn on the basis of the presence and/or concentration of the specific partial peptide in the biological sample.
摘要翻译：公开了用于检测，确定严重程度并监测和预测神经变性疾病的体外方法。在患有神经变性疾病或被怀疑患有这种疾病的患者的生物流体中测定生理上无活性的肾上腺髓质素（proADM）部分肽，特别是中期proADM部分肽的存在和/或浓度。基于生物样品中特异性部分肽的存在和/或浓度来绘制关于神经变性疾病的治疗的存在，过程，严重性或成功的结论。

5. 发明申请

US20080199966A1 Vitro Method For the Diagnosis of Neurodegenerative Diseases 有权
标题翻译：用于诊断神经退行性疾病的体外方法
公开(公告)号：US20080199966A1
公开(公告)日：2008-08-21
申请号：US11997250
申请日：2006-07-24
申请人： Andreas Bergmann , Andrea Ernst , Harald Hampel
发明人： Andreas Bergmann , Andrea Ernst , Harald Hampel
IPC分类号： G01N33/68
CPC分类号： G01N33/6896 , G01N2333/575 , G01N2800/2814 , G01N2800/2821 , Y10S436/811 , Y10S436/815
摘要： An in vitro method for the detection, determination of severity and monitoring and prognosis of neurodegenerative diseases is disclosed. The presence and/or concentration of the physiologically inactive proadrenomedullin (proADM) partial peptide, in particular, the midregional proADM partial peptide, is determined in a biological fluid of a patient who is suffering from a neurodegenerative disease or is suspected of having such a disease. Conclusions about the presence, course, severity or success of a treatment of the neurodegenerative disease are drawn on the basis of the presence and/or concentration of the specific partial peptide in the biological sample.
摘要翻译：公开了用于检测，确定严重程度并监测和预测神经变性疾病的体外方法。在患有神经变性疾病或被怀疑患有这种疾病的患者的生物流体中测定生理上无活性的肾上腺髓质素（proADM）部分肽，特别是中期proADM部分肽的存在和/或浓度。基于生物样品中特异性部分肽的存在和/或浓度来绘制关于神经变性疾病的治疗的存在，过程，严重性或成功的结论。

6. 发明授权

US08013123B2 Use of precursors of enkephalins and/or their fragments in medical diagnostics 有权
标题翻译：在医学诊断中使用脑啡肽和/或其片段的前体
公开(公告)号：US08013123B2
公开(公告)日：2011-09-06
申请号：US11569023
申请日：2005-05-11
申请人： Andreas Bergmann , Andrea Ernst
发明人： Andreas Bergmann , Andrea Ernst
IPC分类号： C07K16/00 , A61K39/395 , G01N33/53
CPC分类号： C07K16/26 , G01N2333/70
摘要： The invention relates to the diagnosis of disease based on the presence of biochemical components in human or animal body fluids, tissues and/or biomaterials. More specifically the invention relates to the use of precursors of enkephalins and/or its fragments isolated from body fluids, tissues or other biomaterials as a marker peptide for detection of a number of diseases/disorders including diseases/disorders of the central nervous system, neurodegenerative diseases, Parkinson's disease, Alzheimer's disease, Huntington's disease, ischemia including myocardiac ishcemica, schizophrenia, disease/disorders of the immune system, diseases/conditions of pain, chronic pain, migraine, tension type headache, tumor diseases/cancer including lymphoblastic leukaemia, malignant brain tumors, adenomas, in particular human pituitary adenomas, disorders of the blood brain barrier, multiple sclerosis, inflammation, chronic arthritis, infectious diseases, bacterial and viral infections, in particular infections of Gram-positive bacteria, borna diseases virus infections, peritonitis, intoxication, AIDS, stress, trauma comprising head trauma, infarction, in particular cerebral infarction, heart and cardiovascular diseases including coronary heart disease, bone and skin disorders, malaria chronic/obstructive pulmonary disease and cerebral damage. The invention further provides antibodies that bind to proenkephalin and its fragments. In accordance with the invention, a kit useful for the above mentioned diagnosis is also provided.
摘要翻译：本发明涉及基于人或动物体液，组织和/或生物材料中生化成分的存在的疾病诊断。更具体地，本发明涉及使用脑啡肽和/或其体外分离体液，组织或其他生物材料的片段的前体作为用于检测多种疾病/病症的标记肽，包括中枢神经系统的疾病/病症，神经变性疾病，帕金森病，阿尔茨海默病，亨廷顿病，缺血，包括心肌异常，精神分裂症，免疫系统疾病/病症，疾病/疼痛状况，慢性疼痛，偏头痛，紧张型头痛，肿瘤疾病/癌症，包括淋巴细胞白血病，恶性肿瘤脑肿瘤，腺瘤，特别是人垂体腺瘤，血脑屏障障碍，多发性硬化，炎症，慢性关节炎，感染性疾病，细菌和病毒感染，特别是革兰氏阳性细菌感染，发生疾病病毒感染，腹膜炎，中毒，艾滋病，压力，创伤，包括头部创伤，梗死，在标准脑梗塞，心脏和心血管疾病，包括冠心病，骨骼和皮肤病，疟疾慢性/阻塞性肺病和脑损伤。本发明还提供结合前脑啡肽及其片段的抗体。根据本发明，还提供了用于上述诊断的试剂盒。

7. 发明申请

US20100035286A1 IN VITRO METHOD FOR THE DIAGNOSIS AND EARLY DIAGNOSIS OF NEURODEGENERATIVE DISORDERS 审中-公开
标题翻译：用于诊断和早期诊断神经损伤性疾病的体外方法
公开(公告)号：US20100035286A1
公开(公告)日：2010-02-11
申请号：US12516851
申请日：2007-11-28
申请人： Andreas Bergmann , Andrea Ernst , Harald Hampel
发明人： Andreas Bergmann , Andrea Ernst , Harald Hampel
IPC分类号： G01N33/535 , G01N33/92
CPC分类号： G01N33/6896 , G01N2800/2821
摘要： In vitro method for the detection and early detection of, for the determination of the degree of severity of, and for the assessment of the course of and prognosis of neurodegenerative disorders, in which an immunodiagnostic determination method is used to determine the apolipoprotein C-1 (Apo C-1) immunoreactivity in a serum or plasma sample from a patient suffering from subjective or objectively verifiable cognitive disorders.
摘要翻译：用于检测和早期检测用于确定神经变性疾病的过程和预后的程度和用于评估神经变性疾病的体外方法，其中使用免疫诊断测定方法来测定载脂蛋白C-1 （Apo C-1）在患有主观或可客观验证的认知障碍的患者的血清或血浆样品中的免疫反应性。

8. 发明申请

US20080261232A1 Use of Precursors of Enkephalins and/or Their Fragments in Medical Diagnostics 有权
标题翻译：使用脑啡肽和/或其片段的前体进行医学诊断
公开(公告)号：US20080261232A1
公开(公告)日：2008-10-23
申请号：US11569023
申请日：2005-05-11
申请人： Andreas Bergmann , Andrea Ernst
发明人： Andreas Bergmann , Andrea Ernst
IPC分类号： G01N33/53 , C07K16/00
CPC分类号： C07K16/26 , G01N2333/70
摘要： The invention relates to the diagnosis of disease based on the presence of biochemical components in human or animal body fluids, tissues and/or biomaterials. More specifically the invention relates to the use of precursors of enkephalins and/or its fragments isolated from body fluids, tissues or other biomaterials as a marker peptide for detection of a number of diseases/disorders including diseases/disorders of the central nervous system, neurodegenerative diseases, Parkinson's disease, Alzheimer's disease, Huntington's disease, ischemia including myocardiac ishcemica, schizophrenia, disease/disorders of the immune system, diseases/conditions of pain, chronic pain, migraine, tension type headache, tumor diseases/cancer including lymphoblastic leukaemia, malignant brain tumors, adenomas, in particular human pituitary adenomas, disorders of the blood brain barrier, multiple sclerosis, inflammation, chronic arthritis, infectious diseases, bacterial and viral infections, in particular infections of Gram-positive bacteria, borna diseases virus infections, peritonitis, intoxication, AIDS, stress, trauma comprising head trauma, infarction, in particular cerebral infarction, heart and cardiovascular diseases including coronary heart disease, bone and skin disorders, malaria chronic/obstructive pulmonary disease and cerebral damage. The invention further provides antibodies that bind to proenkephalin and its fragments. In accordance with the invention, a kit useful for the above mentioned diagnosis is also provided.
摘要翻译：本发明涉及基于人或动物体液，组织和/或生物材料中生化成分的存在的疾病诊断。更具体地，本发明涉及使用脑啡肽和/或其体外分离体液，组织或其他生物材料的片段的前体作为用于检测多种疾病/病症的标记肽，包括中枢神经系统的疾病/病症，神经变性疾病，帕金森病，阿尔茨海默病，亨廷顿病，缺血，包括心肌异常，精神分裂症，免疫系统疾病/病症，疾病/疼痛状况，慢性疼痛，偏头痛，紧张型头痛，肿瘤疾病/癌症，包括淋巴细胞白血病，恶性肿瘤脑肿瘤，腺瘤，特别是人垂体腺瘤，血脑屏障障碍，多发性硬化，炎症，慢性关节炎，感染性疾病，细菌和病毒感染，特别是革兰氏阳性细菌感染，发生疾病病毒感染，腹膜炎，中毒，艾滋病，压力，创伤，包括头部创伤，梗死，在标准脑梗塞，心脏和心血管疾病，包括冠心病，骨骼和皮肤病，疟疾慢性/阻塞性肺病和脑损伤。本发明还提供结合前脑啡肽及其片段的抗体。根据本发明，还提供了可用于上述诊断的试剂盒。

9. 发明授权

US09188591B2 Use of precursors of tachykinins and/or their fragments in medical diagnostic 有权
标题翻译：速激肽和/或其片段的前体在医学诊断中的应用
公开(公告)号：US09188591B2
公开(公告)日：2015-11-17
申请号：US12939390
申请日：2010-11-04
申请人： Andreas Bergmann , Andrea Ernst
发明人： Andreas Bergmann , Andrea Ernst
IPC分类号： G01N33/68
CPC分类号： G01N33/68 , G01N33/6872 , G01N2410/06 , G01N2500/04
摘要： The present invention relates to the use of protachykinin and/or fragments thereof that can be isolated from body fluids, tissues or other biological samples and therefore, serves as a marker peptide for medical diagnosis of diseases/disorders of the central nervous system, including Alzheimer's disease, Parkinson's disease, depression and/or conditions of pain, neurological, endocrinological, cerebral, muscular, local, systemic, chronic, inflammatory diseases, infectious diseases comprising bacterial and viral infections, meningitis, sepsis, Crohn's disease, colitis ulcerosa, sickle cell anemia, ischemia, amyotrophic lateral sclerosis, arthritis comprising rheumatoid arthritis, bronchitis, hyperalgesia, asthma, intoxication comprising bacterial intoxication, immunological disorders, poly/-trauma comprising cranio-cerebral trauma, tumors/cancer, stroke, stress, atopis dermatitis, HIV, Huntington's disease, burns, schizophrenia, Hirschsprung's disease, allergies, familial dysautononmia (Riley Day syndrome), hematopoietic disorders, gliomas comprising glioblastomas and astrocytomas, disorders of the blood brain barrier. The invention further provides antibodies for binding to certain proteins and their fragments, more specifically protachykinin and protachykinin peptides. In accordance with the invention, a kit useful for the above-mentioned diagnosis is also provided.
摘要翻译：本发明涉及可以从体液，组织或其他生物学样品中分离的维拉霉素和/或其片段的用途，因此用作医学诊断中枢神经系统疾病/病症的标记肽，包括阿尔茨海默病疾病，帕金森病，抑郁症和/或疼痛状况，神经系统，内分泌学，脑，肌肉，局部，全身，慢性，炎性疾病，包括细菌和病毒感染的传染病，脑膜炎，败血症，克罗恩病，溃疡性结肠炎，镰状细胞贫血，缺血，肌萎缩性侧索硬化，包括类风湿性关节炎的关节炎，支气管炎，痛觉过敏，哮喘，中毒，包括细菌中毒，免疫学障碍，包含头颅脑创伤，肿瘤/癌症，中风，压力，特应性皮炎，HIV，亨廷顿氏病，烧伤，精神分裂症，赫氏症，过敏，家族性失眠症（Riley Day综合征），造血障碍，包含成胶质细胞瘤和星形细胞瘤的胶质瘤，血脑屏障障碍。本发明进一步提供用于结合某些蛋白质及其片段的抗体，更具体地说是抗曲奇激肽和维拉霉素肽。根据本发明，还提供了可用于上述诊断的试剂盒。

10. 发明授权

US07838245B2 Use of precursors of tachykinins and/or their fragments in medical diagnostic 有权
标题翻译：速激肽和/或其片段的前体在医学诊断中的应用
公开(公告)号：US07838245B2
公开(公告)日：2010-11-23
申请号：US11568146
申请日：2005-04-20
申请人： Andreas Bergmann , Andrea Ernst
发明人： Andreas Bergmann , Andrea Ernst
IPC分类号： G01N33/553
CPC分类号： G01N33/68 , G01N33/6872 , G01N2410/06 , G01N2500/04
摘要： The present invention relates to the use of protachykinin and/or fragments thereof that can be isolated from body fluids, tissues or other bioiological samples and therefore, serves as a marker peptide for medical diagnosis of diseases/disorders of the central nervous system, including Alzheimer's disease, Parkinson's disease, depression and/or conditions of pain, neurological, endocrinological, cerebral, muscular, local, systemic, chronic, inflammatory diseases, infectious diseases comprising bacterial and viral infections, meningitis, sepsis, Crohn's disease, colitis ulcerosa, sickle cell anemia, ischemia, amyotrophic lateral sclerosis, arthritis comprising rheumatoid arthritis, bronchitis, hyperalgesia, asthma, intoxication comprising bacterial intoxication, immunological disorders, poly/-trauma comprising cranio-cerebral trauma, tumors/cancer, stroke, stress, atopis dermatitis, HIV, Huntington's disease, burns, schizophrenia, Hirschsprung's disease, allergies, familial dysautononmia (Riley Day syndrome), hematopoietic disorders, gliomas comprising glioblastomas and astrocytomas, disorders of the blood brain barrier. The invention further provides antibodies for binding to certain proteins and their fragments, more specifically protachykinin and protachykinin peptides. In accordance with the invention, a kit useful for the above-mentioned diagnosis is also provided.
摘要翻译：本发明涉及可以从体液，组织或其他生物样品中分离出的维拉霉素和/或其片段的用途，因此，用作用于医学诊断中枢神经系统疾病/病症的标记肽，包括阿尔茨海默病疾病，帕金森病，抑郁症和/或疼痛状况，神经系统，内分泌学，脑，肌肉，局部，全身，慢性，炎性疾病，包括细菌和病毒感染的传染病，脑膜炎，败血症，克罗恩病，溃疡性结肠炎，镰状细胞贫血，缺血，肌萎缩性侧索硬化，包括类风湿性关节炎的关节炎，支气管炎，痛觉过敏，哮喘，中毒，包括细菌中毒，免疫学障碍，包含头颅脑创伤，肿瘤/癌症，中风，压力，特应性皮炎，HIV，亨廷顿氏病，烧伤，精神分裂症，赫氏症，过敏，家族性嗜睡（Riley Day综合征），造血障碍，胶质母细胞瘤和星形细胞瘤的神经胶质瘤，血脑屏障障碍。本发明进一步提供用于结合某些蛋白质及其片段的抗体，更具体地说是抗曲奇激肽和维拉霉素肽。根据本发明，还提供了可用于上述诊断的试剂盒。

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