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1. 发明授权

US06197977B1 Process for the preparation of L-ascorbic acid 失效
标题翻译： L-抗坏血酸的制备方法
公开(公告)号：US06197977B1
公开(公告)日：2001-03-06
申请号：US09553896
申请日：2000-04-20
申请人： Andreas Böttcher , Hans Gurski , Thomas Kuntze , Karsten Kjaergaard
发明人： Andreas Böttcher , Hans Gurski , Thomas Kuntze , Karsten Kjaergaard
IPC分类号： C07D30762
CPC分类号： C07D307/62
摘要： The invention relates to a process for the preparation of L-ascorbic acid, which comprises lactonizing a melt of alkyl 2-keto-L-gulonate under acidic conditions.
摘要翻译：本发明涉及一种制备L-抗坏血酸的方法，该方法包括在酸性条件下将2-酮-L-古洛糖酸烷基酯的熔体内酯化。

2. 发明授权

US6121464A Preparation of salts of ascorbyl 2-phosphoric esters 失效
标题翻译：抗坏血酸2-磷酸酯的盐的制备
公开(公告)号：US6121464A
公开(公告)日：2000-09-19
申请号：US352139
申请日：1999-07-13
申请人： Andreas Bottcher , Hans Gurski
发明人： Andreas Bottcher , Hans Gurski
IPC分类号： C07F9/655 , C07F9/06
CPC分类号： C07F9/65515
摘要： A process for preparing salts of ascorbyl 2-phosphoric esters of the formula I, ##STR1## where the variables have the following meanings: M is sodium, potassium, magnesium, aluminum; ##STR2## k.sym. is the valence and m=equivalents, where the product of k.multidot.m can be from 3 to 5,comprisesa) dissolving calcium L-ascorbate-2-phosphate in an aqueous solution of ascorbyl 2-phosphoric esters at a pH of from 0.5 to 4,b) removing the calcium ions from the resulting solution,c) adjusting the pH of the solution which remains to from 7 to 11 by means of sodium, potassium, magnesium or aluminum salts andd) isolating the salts of the ascorbyl 2-phosphoric ester of the formula I.
摘要翻译：一种制备式I的抗坏血酸2-磷酸酯的方法，其中变量具有以下含义：M是钠，钾，镁，铝; k（+）是化合价，m =等价物，其中kxm的产物可以为3至5，包括：a）将L-抗坏血酸-2-磷酸酯溶解在抗坏血酸2-磷酸酯的水溶液中，pH为从0.5至4，b）从所得溶液中除去钙离子，c）通过钠，钾，镁或铝盐将溶液的pH调节至7至11，以及d）分离抗坏血酸2-磷酸酯。

3. 发明授权

US08673598B2 Microbial succinic acid producers and purification of succinic acid 有权
标题翻译：微生物琥珀酸生产商和琥珀酸的纯化
公开(公告)号：US08673598B2
公开(公告)日：2014-03-18
申请号：US13201547
申请日：2010-02-12
申请人： Hartwig Schroder , Stefan Haefner , Gregory Von Abendroth , Rajan Hollmann , Aline Raddatz , Hansgeorg Ernst , Hans Gurski
发明人： Hartwig Schroder , Stefan Haefner , Gregory Von Abendroth , Rajan Hollmann , Aline Raddatz , Hansgeorg Ernst , Hans Gurski
IPC分类号： C12N1/32 , C12P7/46 , C12P1/04 , C12P17/10 , C12P7/40
CPC分类号： C12P7/46 , C12N1/32 , C12N9/1029 , C12R1/01 , C12Y203/01054
摘要： The present invention relates to bacterial strains, capable of utilizing glycerol as a carbon source for the fermentative production of succinic acid, wherein said strains are genetically modified so that they comprise a deregulation of their endogenous pyruvate-formate-lyase enzyme activity, as well as to methods of producing organic acids, in particular succinic acid, by making use of such microorganism. The present invention also relates to the downstream processing of the produced organic acids by cation exchange chromatography.
摘要翻译：本发明涉及能够利用甘油作为发酵生产琥珀酸的碳源的细菌菌株，其中所述菌株被遗传修饰，使得它们包含其内源性丙酮酸 - 甲酸裂解酶活性的失调，以及涉及通过利用这种微生物生产有机酸，特别是琥珀酸的方法。本发明还涉及通过阳离子交换层析对所生产的有机酸的下游加工。

4. 发明申请

US20110300589A1 Novel Microbial Succinic Acid Producers and Purification of Succinic Acid 有权
标题翻译：新型微生物琥珀酸生产商和琥珀酸的纯化
公开(公告)号：US20110300589A1
公开(公告)日：2011-12-08
申请号：US13201547
申请日：2010-02-12
申请人： Hartwig Schroder , Stefan Haefner , Gregory Von Abendroth , Rajan Hollmann , Aline Raddatz , Hansgeorg Ernst , Hans Gurski
发明人： Hartwig Schroder , Stefan Haefner , Gregory Von Abendroth , Rajan Hollmann , Aline Raddatz , Hansgeorg Ernst , Hans Gurski
IPC分类号： C12P7/46 , C12P1/04 , C12P17/04 , C12P17/10 , C12N1/20 , C12P7/40
CPC分类号： C12P7/46 , C12N1/32 , C12N9/1029 , C12R1/01 , C12Y203/01054
摘要： The present invention relates to bacterial strains, capable of utilizing glycerol as a carbon source for the fermentative production of succinic acid, wherein said strains are genetically modified so that they comprise a deregulation of their endogenous pyruvate-formate-lyase enzyme activity, as well as to methods of producing organic acids, in particular succinic acid, by making use of such microorganism. The present invention also relates to the downstream processing of the produced organic acids by cation exchange chromatography.
摘要翻译：本发明涉及能够利用甘油作为发酵生产琥珀酸的碳源的细菌菌株，其中所述菌株被遗传修饰，使得它们包含其内源性丙酮酸 - 甲酸裂解酶活性的失调，以及涉及通过利用这种微生物生产有机酸，特别是琥珀酸的方法。本发明还涉及通过阳离子交换层析对所生产的有机酸的下游加工。

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