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1. 发明申请

US20130005790A1 INORGANIC SALT COMPLEXES OF VILDAGLIPTIN 有权
标题翻译：维拉胶的无机盐复合物
公开(公告)号：US20130005790A1
公开(公告)日：2013-01-03
申请号：US13500356
申请日：2010-10-07
申请人： Andras Mravik , Imre Koehegyi , Laszlo Pongo , Balazs Volk , Gabor Nemeth , Jozsef Barkoczy , Kalman Nagy , Gyoergy Ruzsics , Judit Broda , Andras Dancso , Adrienn Keszthelyi , Jozsef Debreczeni
发明人： Andras Mravik , Imre Koehegyi , Laszlo Pongo , Balazs Volk , Gabor Nemeth , Jozsef Barkoczy , Kalman Nagy , Gyoergy Ruzsics , Judit Broda , Andras Dancso , Adrienn Keszthelyi , Jozsef Debreczeni
IPC分类号： C07D207/16 , A61P3/10 , A61K31/40
CPC分类号： C07D207/16
摘要： The present invention relates to the use of novel vildagliptin complexes for the manufacture of high purity vildagliptin of Formula I and/or pharmaceutical acceptable salts thereof. Further objects of the present invention are pharmaceutically acceptable complexes of vildagliptin and/or amorphous and crystalline forms, anhydrous forms, amorphous and crystalline hydrates, amorphous and crystalline solvates of the complexes and a process for the preparation thereof. Another object of the present invention is the high purity vildagliptin and pharmaceutically acceptable salts thereof prepared form the vildagliptin complexes of the present invention, a process for the preparation thereof and pharmaceutical compositions containing vildagliptin base, pharmaceutically acceptable salts and/or complexes and use thereof for the treatment of type 2 diabetes (NIDDM). The present invention provides pharmaceutically advantageous high purity vildagliptin complexes.
摘要翻译：本发明涉及新型维格列汀复合物用于制备式I的高纯度维格列汀和/或其药学上可接受的盐。本发明的另外的目的是维格列汀和/或无定形和结晶形式，无水形式，无定形和结晶水合物，络合物的无定形和结晶溶剂合物的药学上可接受的复合物及其制备方法。本发明的另一个目的是从本发明的维格列汀复合物制备的高纯度维格列汀及其药学上可接受的盐，其制备方法和含有维格列汀碱，药学上可接受的盐和/或配合物的药物组合物及其用途治疗2型糖尿病（NIDDM）。本发明提供药学上有利的高纯度维格列汀复合物。

2. 发明授权

US08877799B2 Inorganic salt complexes of vildagliptin 有权
标题翻译：维格列汀的无机盐配合物
公开(公告)号：US08877799B2
公开(公告)日：2014-11-04
申请号：US13500356
申请日：2010-10-07
申请人： Andras Mravik , Imre Koehegyi , Laszlo Pongo , Balazs Volk , Gabor Nemeth , Jozsef Barkoczy , Kalman Nagy , Gyoergy Ruzsics , Judit Broda , Andras Dancso , Adrienn Keszthelyi , Jozsef Debreczeni
发明人： Andras Mravik , Imre Koehegyi , Laszlo Pongo , Balazs Volk , Gabor Nemeth , Jozsef Barkoczy , Kalman Nagy , Gyoergy Ruzsics , Judit Broda , Andras Dancso , Adrienn Keszthelyi , Jozsef Debreczeni
IPC分类号： C07D207/16
CPC分类号： C07D207/16
摘要： The present invention relates to the use of novel vildagliptin complexes for the manufacture of high purity vildagliptin of Formula I and/or pharmaceutical acceptable salts thereof. Further objects of the present invention are pharmaceutically acceptable complexes of vildagliptin and/or amorphous and crystalline forms, anhydrous forms, amorphous and crystalline hydrates, amorphous and crystalline solvates of the complexes and a process for the preparation thereof. Another object of the present invention is the high purity vildagliptin and pharmaceutically acceptable salts thereof prepared form the vildagliptin complexes of the present invention, a process for the preparation thereof and pharmaceutical compositions containing vildagliptin base, pharmaceutically acceptable salts and/or complexes and use thereof for the treatment of type 2 diabetes (NIDDM). The present invention provides pharmaceutically advantageous high purity vildagliptin complexes.
摘要翻译：本发明涉及新型维格列汀复合物用于制备式I的高纯度维格列汀和/或其药学上可接受的盐。本发明的另外的目的是维格列汀和/或无定形和结晶形式，无水形式，无定形和结晶水合物，络合物的无定形和结晶溶剂合物的药学上可接受的复合物及其制备方法。本发明的另一个目的是从本发明的维格列汀复合物制备的高纯度维格列汀及其药学上可接受的盐，其制备方法和含有维格列汀碱，药学上可接受的盐和/或配合物的药物组合物及其用途治疗2型糖尿病（NIDDM）。本发明提供药学上有利的高纯度维格列汀复合物。

3. 发明申请

US20090137563A1 PROCESS FOR THE PREPARTION OF OLANZAPINE 失效
标题翻译：制备奥兰波星的方法
公开(公告)号：US20090137563A1
公开(公告)日：2009-05-28
申请号：US12093344
申请日：2006-11-10
申请人： Gyorgyi Kovanyine Lax , Gabor Nemeth , Gyorgy Krasznay , Norbert Mesterhazy , Kalman Nagy , Gyorgyi Vereczkeyne Donath , Zsuzsanna Szent-Kirallyi
发明人： Gyorgyi Kovanyine Lax , Gabor Nemeth , Gyorgy Krasznay , Norbert Mesterhazy , Kalman Nagy , Gyorgyi Vereczkeyne Donath , Zsuzsanna Szent-Kirallyi
IPC分类号： A61K31/551 , C07D495/04 , A61P25/18
CPC分类号： C07D495/04
摘要： The invention relates to a process for the preparation of 2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno-[2,3-b][1,5]benzodiazepine (olanzapine) of the formula (I) by reacting 4-amino-2-methyl-10H-thieno [2,3-b][1/5]benzodiazepine hydrochloride of the formula (II) with N-methylpiperazine in an organic solvent, which comprises carrying out the reaction in the mixture of toluene and 1,3-dimethyl-2-imidazolidinone. The invention also encompasses new 2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno [2,3-b][1,5]benzodiazepine dihydrochloride trihydrate of the formula (IB), the preparation thereof and pharmaceutical compositions comprising said new compound.
摘要翻译：本发明涉及制备式（2-甲基-4-（4-甲基哌嗪-1-基）-10H-噻吩并[2,3-b] [1,5]苯并二氮杂（奥氮平） I）通过在有机溶剂中将式（II）的4-氨基-2-甲基-10H-噻吩并[2,3-b] [1/5]苯并二氮杂盐酸盐与N-甲基哌嗪反应，其包括进行反应在甲苯和1,3-二甲基-2-咪唑烷酮的混合物中。本发明还包括式（IB）的新的2-甲基-4-（4-甲基哌嗪-1-基）-10H-噻吩并[2,3-b] [1,5]苯并二氮杂三水合物，其制备方法和包含所述新化合物的药物组合物。

4. 发明授权

US6130215A Piperazinylalkylthiopyrimidine derivatives, pharmaceutical compositions containing the same and a process for the preparation of the novel compounds 失效
标题翻译：哌嗪基烷基硫代嘧啶衍生物，含有它们的药物组合物和制备新化合物的方法
公开(公告)号：US6130215A
公开(公告)日：2000-10-10
申请号：US66465
申请日：1998-06-23
申请人： Ivan Jakoczi , Daniel Bozsing , Ildiko Ratz nee Simonek , Istvan Gacsalyi , Gabor Szenasi , Eva Schmidt , Aniko Miklos nee Kovacs , Andras Bilkei-Gorzo , Gabor Blasko , Istvan Gyertyan , Gabor Nemeth , Gyula Simig , Karoly Tihanyi , Andras Egyed
发明人： Ivan Jakoczi , Daniel Bozsing , Ildiko Ratz nee Simonek , Istvan Gacsalyi , Gabor Szenasi , Eva Schmidt , Aniko Miklos nee Kovacs , Andras Bilkei-Gorzo , Gabor Blasko , Istvan Gyertyan , Gabor Nemeth , Gyula Simig , Karoly Tihanyi , Andras Egyed
IPC分类号： A61K31/00 , A61K31/505 , A61K31/506 , A61K31/55 , A61K31/551 , A61P25/18 , A61P25/28 , C07D239/22 , C07D239/38 , C07D239/46 , C07D239/48 , C07D403/12 , A01N43/58
CPC分类号： C07D239/22 , C07D239/38 , C07D239/47 , C07D239/48
摘要： The invention refers to novel piperazinylalkylthiopyrimidine derivatives of formula (I) being suitable for the treatment of diseases due to pathological alterations of the central nervous system, pharmaceutical compositions containing the above derivatives, and a process for the preparation of the novel compounds. ##STR1##
摘要翻译： PCT No.PCT / HU96 / 00061 Sec。 371日期1998年6月23日第 102（e）日期1998年6月23日PCT 1996年10月25日PCT公布。公开号WO97 / 16429 日期1997年5月9日本发明涉及适用于治疗由于中枢神经系统的病理改变引起的疾病的式（I）的新型哌嗪基烷基硫代嘧啶衍生物，含有上述衍生物的药物组合物及其制备方法。

5. 发明申请

US20110149730A1 TECHNIQUE FOR IMPROVING CONGESTION CONTROL 有权
标题翻译：改进控制的技术
公开(公告)号：US20110149730A1
公开(公告)日：2011-06-23
申请号：US12996475
申请日：2008-06-06
申请人： Gabor Nemeth , Ferenc Kubinszky , Andras Veres , Gergely Biczok , Peter Tarjan
发明人： Gabor Nemeth , Ferenc Kubinszky , Andras Veres , Gergely Biczok , Peter Tarjan
IPC分类号： H04L12/56
CPC分类号： H04L47/10 , H04L43/045 , H04L43/0864 , H04L47/11 , H04L47/12 , H04L47/14 , H04L47/193 , H04L47/25 , H04L47/263 , H04L47/283
摘要： A technique for controlling data transmission over a connection employing congestion control is provided. The technique comprises two basic aspects: Detecting a decrease of Round Trip Time in respect of the connection, wherein the detection is facilitated by comparing a short-term Round Trip Time average with a long-term Round Trip Time average (302); and, in response to a result of the detection, adjusting the congestion control so as to increase the data transmission rate (304). Particularly, adjusting the congestion control includes enabling a data transmission rate that is (even) higher than what would have been allowed by any conventional, congestion control. In effect, the present technique may ‘push’ the conventional congestion control when it is not increasing the data transmission rate fast enough.
摘要翻译：提供一种通过使用拥塞控制的连接来控制数据传输的技术。该技术包括两个基本方面：检测相对于连接的往返时间的减少，其中通过比较短期往返时间平均值与长期往返时间平均值（302）来促进检测; 并且响应于检测结果，调整拥塞控制以增加数据传输速率（304）。特别地，调整拥塞控制包括实现比任何常规的拥塞控制允许的数据传输速率（甚至）更高的数据传输速率。实际上，当技术不能足够快地提高数据传输速率时，本技术可以“推动”传统的拥塞控制。

6. 发明申请

US20150085656A1 Technique for Projecting Network Load in a Communication Network 有权
标题翻译：在通信网络中投射网络负载的技术
公开(公告)号：US20150085656A1
公开(公告)日：2015-03-26
申请号：US14376584
申请日：2012-02-09
申请人： Péter Kersch , Gabor Nemeth , Laszlo Toka
发明人： Péter Kersch , Gabor Nemeth , Laszlo Toka
IPC分类号： H04L12/803 , H04L12/26
CPC分类号： H04L47/125 , H04L43/0876 , H04L47/822 , H04L47/823
摘要： A technique for predicting network load in a communication network is described. For multiple subscriptions, a network load snapshot is provided. The network load snapshot comprises multiple network load records. Each network load record reflects network load caused by an associated subscription in the network at a particular point of time. Each network load record comprises at least one network load value reflecting a network load caused by the corresponding subscription and at least one network load influencing factor reflecting a parameter associated with the subscription which has the potential of influencing the network load value. The network load snapshot is transformed into a predicted network load snapshot comprising at least one predicted network load record, each predicted network load record reflecting estimated network load caused by the corresponding subscription at a particular point of time in the future. The transformation of a network load snapshot into a corresponding predicted network load snapshot is done based on both the network load values and the associated network load influencing factors.
摘要翻译：描述了一种用于预测通信网络中的网络负载的技术。对于多个订阅，提供了网络加载快照。网络负载快照包含多个网络负载记录。每个网络负载记录反映在特定时间点由网络中的相关订阅引起的网络负载。每个网络负载记录包括反映由相应订阅引起的网络负载的至少一个网络负载值和反映与订阅相关联的参数的至少一个网络负载影响因素，其具有影响网络负载值的潜力。网络负载快照被转换成包括至少一个预测的网络负载记录的预测的网络负载快照，每个预测的网络负载记录反映在将来在特定时间点由对应的订阅引起的估计的网络负载。基于网络负载值和相关网络负载影响因素，将网络负载快照转换为相应的预测网络负载快照。

7. 发明授权

US08837279B2 Technique for improving congestion control 有权
标题翻译：改善拥塞控制的技术
公开(公告)号：US08837279B2
公开(公告)日：2014-09-16
申请号：US12996475
申请日：2008-06-06
申请人： Gabor Nemeth , Ferenc Kubinszky , Andras Veres , Gergely Biczok , Peter Tarjan
发明人： Gabor Nemeth , Ferenc Kubinszky , Andras Veres , Gergely Biczok , Peter Tarjan
IPC分类号： G06F11/00 , H04L1/00 , H04L12/26 , H04L12/801 , H04L12/841 , H04L12/825
CPC分类号： H04L47/10 , H04L43/045 , H04L43/0864 , H04L47/11 , H04L47/12 , H04L47/14 , H04L47/193 , H04L47/25 , H04L47/263 , H04L47/283
摘要： A technique for controlling data transmission over a connection employing congestion control is provided. The technique comprises two basic aspects: Detecting a decrease of Round Trip Time in respect of the connection, wherein the detection is facilitated by comparing a short-term Round Trip Time average with a long-term Round Trip Time average (302); and, in response to a result of the detection, adjusting the congestion control so as to increase the data transmission rate (304). Particularly, adjusting the congestion control includes enabling a data transmission rate that is (even) higher than what would have been allowed by any conventional, congestion control. In effect, the present technique may ‘push’ the conventional congestion control when it is not increasing the data transmission rate fast enough.
摘要翻译：提供一种通过使用拥塞控制的连接来控制数据传输的技术。该技术包括两个基本方面：检测相对于连接的往返时间的减少，其中通过比较短期往返时间平均值与长期往返时间平均值（302）来促进检测; 并且响应于检测结果，调整拥塞控制以增加数据传输速率（304）。特别地，调整拥塞控制包括实现比任何常规的拥塞控制允许的数据传输速率（甚至）更高的数据传输速率。实际上，当技术不能足够快地提高数据传输速率时，本技术可以“推动”传统的拥塞控制。

8. 发明授权

US08205600B2 Apparatus and system for the production of ozone for an internal combustion engine 有权
标题翻译：用于生产内燃机臭氧的装置和系统
公开(公告)号：US08205600B2
公开(公告)日：2012-06-26
申请号：US12909987
申请日：2010-10-22
申请人： Leslie G. Hammer , Gabor Nemeth , George Mismas
发明人： Leslie G. Hammer , Gabor Nemeth , George Mismas
IPC分类号： F02M26/00
CPC分类号： F02M27/04 , F02M25/12 , Y02T10/121
摘要： An apparatus for the production of ozone for an internal combustion engine comprising a non-conductive shell having a first and second opening which allows air to flow therethrough and first and second electrodes disposed inside the shell. The first electrode is spaced a distance from the second electrode, the first electrode having a smaller diameter than, and being aligned axially within the second electrode. The first electrode permits air to flow therethrough. A high voltage source is connected to the first and second electrode, the high voltage source capable of producing a voltage differential on the first and second electrodes sufficient to cause the production of ozone. A change from oxygen to ozone occurs in the air flowing through the apparatus. The shell is preferably cylindrical.
摘要翻译：一种用于生产用于内燃机的臭氧的装置，包括具有允许空气流过第一和第二开口的非导电壳体，以及设置在壳体内的第一和第二电极。第一电极与第二电极隔开一定距离，第一电极具有比第二电极小的直径并且在轴向上对准的第二电极。第一电极允许空气流过其中。高电压源连接到第一和第二电极，高电压源能够在第一和第二电极上产生足以导致臭氧产生的电压差。在通过设备的空气中发生氧气变为臭氧。壳体优选为圆柱形。

9. 发明申请

US20110182176A1 METHOD AND APPARATUS TO PROVIDE MINIMUM RESOURCE SHARING WITHOUT BUFFERING REQUESTS 有权
标题翻译：提供最低资源共享的方法和设备，无需缓冲请求
公开(公告)号：US20110182176A1
公开(公告)日：2011-07-28
申请号：US12695734
申请日：2010-01-28
申请人： Zsolt Kenesi , Gabor Nemeth , Benedek Kovacs
发明人： Zsolt Kenesi , Gabor Nemeth , Benedek Kovacs
IPC分类号： H04L12/56
CPC分类号： H04L47/10 , H04L47/11 , H04L47/215 , H04L47/24
摘要： A throttle device is coupled with a central processing unit in a node for reducing traffic overload in a Next Generation Network (NGN). The device is coupled with a basic throttle with different levels of traffic priority and both are situated between a source node and a target node for processing traffic. When a traffic offer is received by the throttle, the throttle device by provisionally updating the basic throttle priority levels, determines whether to send the traffic offer on to the source node. If the provisional, traffic priority level is greater than a new traffic priority level the traffic is admitted and rejected if the updated priority level is less than the new traffic priority level.
摘要翻译：节气门装置与节点中的中央处理单元耦合，以减少下一代网络（NGN）中的交通负荷。该设备与具有不同级别的业务优先级的基本节流器相耦合，并且两者都位于源节点和用于处理业务的目标节点之间。当通过节气门接收到交通报价时，节气门装置通过临时更新基本油门优先级来确定是否将交通报价发送到源节点。如果临时流量优先级大于新的流量优先级，则如果更新的优先级小于新的流量优先级，流量被允许并被拒绝。

10. 发明申请

US20100056151A1 Reducing Buffer Overflow 有权
标题翻译：减少缓冲区溢出
公开(公告)号：US20100056151A1
公开(公告)日：2010-03-04
申请号：US12525716
申请日：2007-02-08
申请人： Andras Veres , Gabor Nemeth , Ferenc Kubinszky , Gergely Biczok , Peter Tarjan
发明人： Andras Veres , Gabor Nemeth , Ferenc Kubinszky , Gergely Biczok , Peter Tarjan
IPC分类号： H04W36/00 , H04W28/14
CPC分类号： H04W28/14 , H04W36/08 , H04W84/042
摘要： A method of reducing buffer overflow in a cellular radio network caused by a transfer of data from a buffer in a first cell to a buffer in a second cell when a handover of mobile equipment from said first cell to said second cell occurs. The method comprises temporarily increasing an amount of temporary buffer space required to handle data transferred from the buffer of the first cell to the buffer of the second cell. In one embodiment of the method, prior to increasing the amount of temporary buffer space, the amount of temporary buffer space required is calculated.
摘要翻译：发生当移动设备从所述第一小区切换到所述第二小区时，由数据从第一小区中的缓冲器传送到第二小区中的缓冲器而导致在蜂窝无线电网络中减少缓冲区溢出的方法。该方法包括临时增加处理从第一小区的缓冲器传送到第二小区的缓冲器的数据所需的临时缓冲区空间量。在该方法的一个实施例中，在增加临时缓冲区空间的量之前，计算所需的临时缓冲区空间量。

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