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1. 发明申请

US20080188928A1 Medical device delivery sheath 审中-公开
标题翻译：医疗器械输送护套
公开(公告)号：US20080188928A1
公开(公告)日：2008-08-07
申请号：US11314183
申请日：2005-12-20
申请人： Amr Salahieh , Emma Leung , Daniel Hildebrand , Jonah Lepak , Ulrich R. Haug , Dwight Morejohn , Tom Saul
发明人： Amr Salahieh , Emma Leung , Daniel Hildebrand , Jonah Lepak , Ulrich R. Haug , Dwight Morejohn , Tom Saul
IPC分类号： A61F2/24
CPC分类号： A61M25/0662 , A61F2/2436 , A61F2002/9528 , A61F2002/9534 , A61M25/0045 , A61M25/0051 , A61M25/0053 , A61M25/0054 , A61M25/0074 , A61M25/008 , A61M25/0138
摘要： A support member for a catheter sheath is disclosed. The support member has a series of ribs with a distal member having integrated fingers for providing radial compliance. The support member provides sufficient axial stiffness to provide a desired pushability of a minimally invasive device for replacing a heart valve. Various alternative embodiments are also described.
摘要翻译：公开了用于导管护套的支撑构件。支撑构件具有一系列肋，其具有具有用于提供径向顺应性的集成指状物的远端构件。支撑构件提供足够的轴向刚度以提供用于更换心脏瓣膜的微创装置的期望推进性。还描述了各种替代实施例。

2. 发明授权

US08287584B2 Medical implant deployment tool 有权
标题翻译：医疗植入物部署工具
公开(公告)号：US08287584B2
公开(公告)日：2012-10-16
申请号：US11274889
申请日：2005-11-14
申请人： Amr Salahieh , Ulrich R. Haug , Claudio Argento , Dwight Morejohn , Daniel Hildebrand , Tom Saul
发明人： Amr Salahieh , Ulrich R. Haug , Claudio Argento , Dwight Morejohn , Daniel Hildebrand , Tom Saul
IPC分类号： A61F2/06
CPC分类号： A61F2/2418 , A61F2/2439 , A61F2002/9517 , A61F2230/0054 , A61M25/0136 , A61M25/0144 , A61M25/0147
摘要： A medical implant deployment tool and deployment method are disclosed. One aspect of the invention provides an implant system including an implant adapted for endovascular delivery and deployment; and a deployment tool adapted to deploy the implant, with the deployment tool having an actuation controller; a plurality of actuation elements adapted to apply forces to one or more implant deployment mechanisms and each adapted to extend along an actuation element path within a patient's vasculature; and an actuation element compensation mechanism adapted to compensate for differences in length between the actuation element paths. Another aspect of the invention provides a method of deploying an implant including the steps of endovascularly delivering an implant and implant deployment mechanisms to an implant site and applying an actuation force to the implant deployment mechanisms through actuation elements extending through the patient's vasculature while compensating for differences in length between actuation element path lengths to deploy the implant.
摘要翻译：公开了一种医用植入物部署工具和部署方法。本发明的一个方面提供一种植入系统，其包括适于血管内递送和展开的植入物; 以及适于部署所述植入物的展开工具，所述展开工具具有致动控制器; 多个致动元件，其适于向一个或多个植入物展开机构施加力并且每个适于沿着病人脉管系统内的致动元件路径延伸; 以及致动元件补偿机构，其适于补偿致动元件路径之间的长度差异。本发明的另一方面提供一种部署植入物的方法，所述方法包括以下步骤：血管内递送植入物和植入部署机构到植入部位，并且通过延伸穿过患者脉管系统的致动元件向植入物展开机构施加致动力，同时补偿差异在部署植入物的致动元件路径长度之间的长度。

3. 发明申请

US20130013057A1 MEDICAL IMPLANT DEPLOYMENT TOOL 审中-公开
标题翻译：医用植物部署工具
公开(公告)号：US20130013057A1
公开(公告)日：2013-01-10
申请号：US13612119
申请日：2012-09-12
申请人： Amr Salahieh , Ulrich R. Haug , Claudio Argento , Dwight Morejohn , Daniel Hildebrand , Tom Saul
发明人： Amr Salahieh , Ulrich R. Haug , Claudio Argento , Dwight Morejohn , Daniel Hildebrand , Tom Saul
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/2439 , A61F2002/9517 , A61F2230/0054 , A61M25/0136 , A61M25/0144 , A61M25/0147
摘要： A medical implant deployment tool and deployment method are disclosed. One aspect of the invention provides an implant system including an implant adapted for endovascular delivery and deployment; and a deployment tool adapted to deploy the implant, with the deployment tool having an actuation controller; a plurality of actuation elements adapted to apply forces to one or more implant deployment mechanisms and each adapted to extend along an actuation element path within a patient's vasculature; and an actuation element compensation mechanism adapted to compensate for differences in length between the actuation element paths.
摘要翻译：公开了一种医用植入物部署工具和部署方法。本发明的一个方面提供一种植入系统，其包括适于血管内递送和展开的植入物; 以及适于部署所述植入物的部署工具，所述展开工具具有致动控制器; 多个致动元件，其适于向一个或多个植入物展开机构施加力并且每个适于沿着病人脉管系统内的致动元件路径延伸; 以及致动元件补偿机构，其适于补偿致动元件路径之间的长度差异。

4. 发明授权

US07824443B2 Medical implant delivery and deployment tool 有权
标题翻译：医疗植入物交付和部署工具
公开(公告)号：US07824443B2
公开(公告)日：2010-11-02
申请号：US11275912
申请日：2006-02-02
申请人： Amr Salahieh , Dwight Morejohn , Ulrich R. Haug , Brian Brandt , Hans Valencia , Tom Saul
发明人： Amr Salahieh , Dwight Morejohn , Ulrich R. Haug , Brian Brandt , Hans Valencia , Tom Saul
IPC分类号： A61F2/24
CPC分类号： A61F2/2439 , A61B17/068 , A61B2017/00243 , A61F2/2418 , A61F2/90 , A61F2002/9517
摘要： An apparatus for endovascularly replacing a patient's heart valve. In some embodiments, the apparatus includes a replacement heart valve implant comprising a valve and an expandable anchor; and a deployment tool adapted to endovascularly deliver the replacement heart valve implant to an implant site within the patient, the deployment tool comprising an actuator adapted to exert an axially directed force on the anchor. The invention also provides a method for endovascularly replacing a heart valve of a patient. In some embodiments, the method includes the steps of endovascularly delivering a replacement heart valve implant having a valve and an anchor to an implant site within the patient; and applying an axially directed force from an actuator outside of the patient to the anchor. In invention also provides deployment tools for performing the method.
摘要翻译：用于血管内置换患者心脏瓣膜的装置。在一些实施例中，该装置包括置换心脏瓣膜植入体，其包括阀和可扩张锚; 以及适于将替代心脏瓣膜植入物血管内输送到患者体内的植入部位的部署工具，所述展开工具包括适于在锚固件上施加轴向力的致动器。本发明还提供一种用于血管内替换患者心脏瓣膜的方法。在一些实施例中，该方法包括以下步骤：血管内递送具有瓣膜和锚的置换心脏瓣膜植入物到患者体内的植入部位; 以及将来自所述患者外部的致动器的轴向力施加到所述锚固件。本发明还提供了用于执行该方法的部署工具。

5. 发明授权

US07959666B2 Methods and apparatus for endovascularly replacing a heart valve 有权
标题翻译：血管内置换心脏瓣膜的方法和装置
公开(公告)号：US07959666B2
公开(公告)日：2011-06-14
申请号：US10982388
申请日：2004-11-05
申请人： Amr Salahieh , Jean-Pierre Dueri , Hans F. Valencia , Daniel Hildebrand , Brian D Brandt , Dwight P. Morejohn , Claudio Argento , Tom Saul , Ulrich R. Haug
发明人： Amr Salahieh , Jean-Pierre Dueri , Hans F. Valencia , Daniel Hildebrand , Brian D Brandt , Dwight P. Morejohn , Claudio Argento , Tom Saul , Ulrich R. Haug
IPC分类号： A61F2/06 , A61F2/24
CPC分类号： A61F2/2439 , A61F2/24 , A61F2/2409 , A61F2/2412 , A61F2/2418 , A61F2/243 , A61F2/2433 , A61F2/2436 , A61F2/90 , A61F2002/9528 , A61F2220/0016 , A61F2220/005 , A61F2220/0058 , A61F2230/005 , A61F2230/0054 , A61F2230/0078 , A61F2230/008 , A61F2250/006
摘要： The invention includes methods of and apparatus for endovascularly replacing a heart valve of a patient. One aspect of the invention provides a method including the steps of endovascularly delivering a replacement valve and an expandable anchor to a vicinity of the heart valve in an unexpanded configuration; and applying an external non-hydraulically expanding or non-pneumatically expanding actuation force on the anchor to change the shape of the anchor, such as by applying proximally and/or distally directed force on the anchor using a releasable deployment tool to expand and contract the anchor or parts of the anchor. Another aspect of the invention provides an apparatus including a replacement valve; an anchor; and a deployment tool comprising a plurality of anchor actuation elements adapted to apply a non-hydraulically expanding or non-pneumatically expanding actuation force on the anchor to reshape the anchor.
摘要翻译：本发明包括用于血管内置换患者心脏瓣膜的方法和装置。本发明的一个方面提供了一种方法，包括以未膨胀的构造将置换瓣膜和可扩张锚固体血管内输送到心脏瓣膜附近的步骤; 以及在所述锚上施加外部非液压膨胀或非气动扩张的致动力以改变所述锚的形状，例如通过使用可释放的展开工具向所述锚上施加近端和/或远端定向的力，锚或锚的部分。本发明的另一方面提供了一种包括置换阀的装置; 锚点以及展开工具，其包括适于在锚上施加非液压膨胀或非气动膨胀的致动力的多个锚致动元件，以重构锚固件。

6. 发明申请

US20120016469A1 Methods and Apparatus for Endovascularly Replacing a Heart Valve 有权
标题翻译：血管内置换心脏瓣膜的方法和装置
公开(公告)号：US20120016469A1
公开(公告)日：2012-01-19
申请号：US13157733
申请日：2011-06-10
申请人： Amr Salahieh , Jean-Pierre Dueri , Hans F. Valencia , Daniel Hildebrand , Brian D. Brandt , Dwight P. Morejohn , Claudio Argento , Tom Saul , Ulrich R. Haug
发明人： Amr Salahieh , Jean-Pierre Dueri , Hans F. Valencia , Daniel Hildebrand , Brian D. Brandt , Dwight P. Morejohn , Claudio Argento , Tom Saul , Ulrich R. Haug
IPC分类号： A61F2/24
CPC分类号： A61F2/2439 , A61F2/24 , A61F2/2409 , A61F2/2412 , A61F2/2418 , A61F2/243 , A61F2/2433 , A61F2/2436 , A61F2/90 , A61F2002/9528 , A61F2220/0016 , A61F2220/005 , A61F2220/0058 , A61F2230/005 , A61F2230/0054 , A61F2230/0078 , A61F2230/008 , A61F2250/006
摘要： The invention includes methods of and apparatus for endovascularly replacing a heart valve of a patient. One aspect of the invention provides a method including the steps of endovascularly delivering a replacement valve and an expandable anchor to a vicinity of the heart valve in an unexpanded configuration; and applying an external non-hydraulically expanding or non-pneumatically expanding actuation force on the anchor to change the shape of the anchor, such as by applying proximally and/or distally directed force on the anchor using a releasable deployment tool to expand and contract the anchor or parts of the anchor. Another aspect of the invention provides an apparatus including a replacement valve; an anchor; and a deployment tool comprising a plurality of anchor actuation elements adapted to apply a non-hydraulically expanding or non-pneumatically expanding actuation force on the anchor to reshape the anchor.
摘要翻译：本发明包括用于血管内置换患者心脏瓣膜的方法和装置。本发明的一个方面提供了一种方法，包括以未膨胀的构造将置换瓣膜和可扩张锚固件血管内输送到心脏瓣膜附近的步骤; 以及在所述锚上施加外部非液压膨胀或非气动扩张的致动力以改变所述锚的形状，例如通过使用可释放的展开工具向所述锚上施加近端和/或远端定向的力，锚或锚的部分。本发明的另一方面提供了一种包括置换阀的装置; 锚点以及展开工具，其包括适于在锚上施加非液压膨胀或非气动膨胀的致动力的多个锚致动元件，以重构锚固件。

7. 发明授权

US07988724B2 Systems and methods for delivering a medical implant 有权
标题翻译：用于输送医疗植入物的系统和方法
公开(公告)号：US07988724B2
公开(公告)日：2011-08-02
申请号：US11706549
申请日：2007-02-14
申请人： Amr Salahieh , Hans F. Valencia , Brian D. Brandt , Claudio Argento , Ulrich R. Haug , Jean-Pierre Dueri , Daniel Hildebrand , Dwight P. Morejohn , Tom Saul
发明人： Amr Salahieh , Hans F. Valencia , Brian D. Brandt , Claudio Argento , Ulrich R. Haug , Jean-Pierre Dueri , Daniel Hildebrand , Dwight P. Morejohn , Tom Saul
IPC分类号： A61F2/24 , A61F2/06
CPC分类号： A61F2/2427 , A61B17/0644 , A61B17/068 , A61B17/221 , A61B2017/22035 , A61B2017/2215 , A61F2/2409 , A61F2/2418 , A61F2/2433 , A61F2/2436 , A61F2/2439 , A61F2/90 , A61F2002/9534 , A61F2220/0008 , A61F2220/0016 , A61F2220/0025 , A61F2220/005 , A61F2220/0058 , A61F2230/005 , A61F2230/0078 , A61F2230/008 , A61F2250/001
摘要： The present invention relates to apparatus and methods for endovascularly delivering and releasing a prosthesis, e.g., an aortic prosthesis, within and/or across a patient's native heart valve, referred to hereinafter as replacing the patient's heart valve. In some embodiments the delivery system comprises a plurality of first actuatable element adapted to engage a plurality of second elements in a first configuration to capture the implant within the delivery system, and wherein the plurality of first actuatable element are adapted to engage the plurality of second elements in a second configuration and to release the implant from the delivery system.
摘要翻译：本发明涉及用于在患者的天然心脏瓣膜内和/或穿过患者的天然心脏瓣膜内血管内递送和释放假体（例如主动脉假体）的装置和方法，以下称为替换患者的心脏瓣膜。在一些实施例中，递送系统包括多个第一致动元件，其适于以第一构造接合多个第二元件以在输送系统内捕获植入物，并且其中多个第一可致动元件适于接合多个第二可动元件元件处于第二配置并且从输送系统释放植入物。

8. 发明授权

US08858620B2 Methods and apparatus for endovascularly replacing a heart valve 有权
标题翻译：血管内置换心脏瓣膜的方法和装置
公开(公告)号：US08858620B2
公开(公告)日：2014-10-14
申请号：US13157733
申请日：2011-06-10
申请人： Amr Salahieh , Jean-Pierre Dueri , Hans F. Valencia , Daniel Hildebrand , Brian D. Brandt , Dwight P. Morejohn , Claudio Argento , Tom Saul , Ulrich R. Haug
发明人： Amr Salahieh , Jean-Pierre Dueri , Hans F. Valencia , Daniel Hildebrand , Brian D. Brandt , Dwight P. Morejohn , Claudio Argento , Tom Saul , Ulrich R. Haug
IPC分类号： A61F2/24 , A61F2/06 , A61F2/90 , A61F2/95
CPC分类号： A61F2/2439 , A61F2/24 , A61F2/2409 , A61F2/2412 , A61F2/2418 , A61F2/243 , A61F2/2433 , A61F2/2436 , A61F2/90 , A61F2002/9528 , A61F2220/0016 , A61F2220/005 , A61F2220/0058 , A61F2230/005 , A61F2230/0054 , A61F2230/0078 , A61F2230/008 , A61F2250/006
摘要： The invention includes methods of and apparatus for endovascularly replacing a heart valve of a patient. One aspect of the invention provides a method including the steps of endovascularly delivering a replacement valve and an expandable anchor to a vicinity of the heart valve in an unexpanded configuration; and applying an external non-hydraulically expanding or non-pneumatically expanding actuation force on the anchor to change the shape of the anchor, such as by applying proximally and/or distally directed force on the anchor using a releasable deployment tool to expand and contract the anchor or parts of the anchor. Another aspect of the invention provides an apparatus including a replacement valve; an anchor; and a deployment tool comprising a plurality of anchor actuation elements adapted to apply a non-hydraulically expanding or non-pneumatically expanding actuation force on the anchor to reshape the anchor.
摘要翻译：本发明包括用于血管内置换患者心脏瓣膜的方法和装置。本发明的一个方面提供了一种方法，包括以未膨胀的构造将置换瓣膜和可扩张锚固件血管内输送到心脏瓣膜附近的步骤; 以及在所述锚上施加外部非液压膨胀或非气动扩张的致动力以改变所述锚的形状，例如通过使用可释放的展开工具向所述锚上施加近端和/或远端定向的力，锚或锚的部分。本发明的另一方面提供了一种包括置换阀的装置; 锚点以及展开工具，其包括适于在锚上施加非液压膨胀或非气动膨胀的致动力的多个锚致动元件，以重构锚固件。

9. 发明申请

US20110257735A1 SYSTEMS AND METHODS FOR DELIVERING A MEDICAL IMPLANT 有权
标题翻译：用于输送医疗植入物的系统和方法
公开(公告)号：US20110257735A1
公开(公告)日：2011-10-20
申请号：US13166184
申请日：2011-06-22
申请人： Amr Salahieh , Hans F. Valencia , Brian D. Brandt , Claudio Argento , Ulrich R. Haug , Jean-Pierre Dueri , Daniel Hildebrand , Dwight P. Morejohn , Tom Saul
发明人： Amr Salahieh , Hans F. Valencia , Brian D. Brandt , Claudio Argento , Ulrich R. Haug , Jean-Pierre Dueri , Daniel Hildebrand , Dwight P. Morejohn , Tom Saul
IPC分类号： A61F2/24
CPC分类号： A61F2/2427 , A61B17/0644 , A61B17/068 , A61B17/221 , A61B2017/22035 , A61B2017/2215 , A61F2/2409 , A61F2/2418 , A61F2/2433 , A61F2/2436 , A61F2/2439 , A61F2/90 , A61F2002/9534 , A61F2220/0008 , A61F2220/0016 , A61F2220/0025 , A61F2220/005 , A61F2220/0058 , A61F2230/005 , A61F2230/0078 , A61F2230/008 , A61F2250/001
摘要： The present invention relates to apparatus and methods for endovascularly delivering and releasing a prosthesis, e.g., an aortic prosthesis, within and/or across a patient's native heart valve, referred to hereinafter as replacing the patient's heart valve. In some embodiments the delivery system comprises a plurality of first actuatable element adapted to engage a plurality of second elements in a first configuration to capture the implant within the delivery system, and wherein the plurality of first actuatable element are adapted to engage the plurality of second elements in a second configuration and to release the implant from the delivery system.
摘要翻译：本发明涉及用于在患者的天然心脏瓣膜内和/或穿过患者的天然心脏瓣膜内血管内递送和释放假体（例如主动脉假体）的装置和方法，以下称为替换患者的心脏瓣膜。在一些实施例中，递送系统包括多个第一致动元件，其适于以第一构造接合多个第二元件以在输送系统内捕获植入物，并且其中多个第一可致动元件适于接合多个第二可动元件元件处于第二配置并且从输送系统释放植入物。

10. 发明授权

US07824442B2 Methods and apparatus for endovascularly replacing a heart valve 有权
标题翻译：血管内置换心脏瓣膜的方法和装置
公开(公告)号：US07824442B2
公开(公告)日：2010-11-02
申请号：US10982692
申请日：2004-11-05
申请人： Amr Salahieh , Hans F. Valencia , Brian D. Brandt , Claudio Argento , Ulrich R. Haug , Jean-Pierre Dueri , Daniel Hildebrand , Dwight P. Morejohn , Tom Saul
发明人： Amr Salahieh , Hans F. Valencia , Brian D. Brandt , Claudio Argento , Ulrich R. Haug , Jean-Pierre Dueri , Daniel Hildebrand , Dwight P. Morejohn , Tom Saul
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/2433 , A61F2/2436 , A61F2/2439 , A61F2002/9528 , A61F2220/005 , A61F2220/0058 , A61F2250/006
摘要： The invention includes methods of and apparatus for endovascularly replacing a heart valve of a patient. One aspect of the invention provides a method including the steps of endovascularly delivering a replacement valve and an expandable anchor in an unexpanded configuration within a sheath to a vicinity of the heart valve; deploying the anchor from the sheath; expanding the anchor with a deployment tool comprising a plurality of actuation elements to contact tissue at an anchor site; and retrieving the anchor into the sheath. Another aspect of the invention provides apparatus including a sheath; a deployment tool comprising a plurality of anchor actuation elements; a replacement valve configured to be disposed within the sheath for delivery to a vicinity of the heart valve; and an expandable anchor configured to be disposed within the sheath for delivery to the vicinity of the heart valve, to be deployed from the sheath, to be expanded by the deployment tool to contact tissue at an anchor site and to be retrieved back into the sheath after having been expanded.
摘要翻译：本发明包括用于血管内置换患者心脏瓣膜的方法和装置。本发明的一个方面提供了一种方法，包括以下步骤：血管内递送替代瓣膜和可膨胀锚固件，所述替换瓣膜和可扩张锚固件处于护套内的未膨胀构型至心脏瓣膜附近; 从护套部署锚; 使用包括多个致动元件的展开工具来扩展锚，以在锚定位置处接触组织; 并将锚固件收回到护套中。本发明的另一方面提供了一种包括护套的装置; 包括多个锚致动元件的展开工具; 配置成设置在所述护套内用于输送到所述心脏瓣膜附近的置换瓣膜; 以及被构造成设置在所述护套内以用于输送到所述心脏瓣膜附近的可扩张锚，以从所述鞘部署，以由所述展开工具扩张以在锚定位置处接触组织并被回收到所述鞘中在扩大后。

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