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1. 发明申请

WO2010042649A2 PHTHALAZINE COMPOUNDS AS p38 MAP KINASE MODULATORS AND METHODS OF USE THEREOF 审中-公开
标题翻译：哒嗪化合物作为p38 MAP激酶调节剂及其使用方法
公开(公告)号：WO2010042649A2
公开(公告)日：2010-04-15
申请号：PCT/US2009/059888
申请日：2009-10-07
申请人： AMGEN INC. , TASKER, Andrew , FALSEY, James Richard , RZASA, Robert M. , HERBERICH, Bradley J. , ZHANG, Dawei
发明人： TASKER, Andrew , FALSEY, James Richard , RZASA, Robert M. , HERBERICH, Bradley J. , ZHANG, Dawei
IPC分类号： C07D237/30 , C07D237/32 , C07D237/34 , A61K31/498 , A61P9/00
CPC分类号： C07D401/12 , C07D237/30 , C07D237/32 , C07D237/34 , C07D401/04 , C07D403/04 , C07D413/04
摘要： The present invention comprises a new class of compounds useful for the prophylaxis and treatment of protein kinase mediated diseases, including inflammation and related conditions. The compounds have a general Formula I wherein A 4 , L, R 1 , R 2 , R 3 , R 5 and m are as defined herein. The invention also comprises pharmaceutical compositions including one or more compounds of Formula I, uses of such compounds and compositions for treatment of p38 map kinase mediated diseases including rheumatoid arthritis, psoriasis, chronic obstructive pulmonary disease, ankylosing spondylitis, pain and other inflammatory disorders, as well as intermediates and processes useful for the preparation of compounds of Formula I.
摘要翻译：本发明包括可用于预防和治疗蛋白激酶介导的疾病，包括炎症和相关病症的一类新化合物。该化合物具有通式I，其中A 4，L，R 1，R 2，R 3，R 4，R 4，R 5， R 5和m如本文所定义。本发明还包括包含一种或多种式I化合物的药物组合物，所述化合物和组合物用于治疗p38图谱激酶介导的疾病，包括类风湿性关节炎，牛皮癣，慢性阻塞性肺病，强直性脊柱炎，疼痛和其它炎性病症以及用于制备式I化合物的中间体和方法。

2. 发明申请

WO2008118455A1 δ3- SUBSTITUTED QUINOLINE OR QUINOXALINE DERIVATIVES AND THEIR USE AS PHOSPHATIDYLINOSITOL 3-KINASE ( PI3K) INHIBITORS 审中-公开
标题翻译： d3-取代的喹啉或喹喔啉衍生物及其作为磷酸胆碱3-激酶（PI3K）抑制剂的用途
公开(公告)号：WO2008118455A1
公开(公告)日：2008-10-02
申请号：PCT/US2008/003936
申请日：2008-03-24
申请人： AMGEN INC.
发明人： CHEN, Yi , CUSHING, Timothy D. , HAO, Xiaolin , HE, Xiao , REICHELT, Andreas , RZASA, Robert M. , SEGANISH, Jennifer , SHIN, Youngsook , ZHANG, Dawei
IPC分类号： C07D401/12 , C07D401/14 , A61K31/4709 , A61K31/506
CPC分类号： C07D401/12 , C07D401/14
摘要： Substituted bicyclic heteroaryls having the structure: (I) or any pharmaceutically-acceptable salt thereof, wherein: X 1 is C(R 9 ) or N; X 2 is C(R 10 ) or N; Y is N(R 11 ), O or S; which are useful to inhibit the biological activity of human PI3Kδ and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, Sjoegren's syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity, The present invention also enables methods for treating cancers that are mediated, dependent on or associated with p110δ activity, including but not restricted to leukemias, such as Acute Myeloid leukaemia (AML) Myelo- dysplastic syndrome (MDS) myeloproliferative diseases (MPD) Chronic Myeloid Leukemia (CML) T-cell Acute Lymphoblastic leukaemia ( T-ALL) B-cell Acute Lymphoblastic leukaemia (B-ALL) Non Hodgkins Lymphoma (NHL) B-cell lymphoma and solid tumors, such as breast cancer.
摘要翻译：具有以下结构的取代的双环杂芳基：（I）或其任何药学上可接受的盐，其中：X 1是C（R 9）或N; X 2是C（R 10）或N; Y是N（R 11），O或S; 其用于抑制人PI3Kd和含有它们的组合物的生物活性，用于治疗一般炎症，关节炎，风湿性疾病，骨关节炎，炎性肠病，炎症性眼病，炎性或不稳定性膀胱病，牛皮癣，皮肤炎症反应包括但不限于自身免疫性疾病如系统性红斑狼疮（SLE），重症肌无力，类风湿性关节炎，急性播散性脑脊髓炎，特发性血小板减少性紫癜，多发性硬化症，Sjoegren综合征和自身免疫性溶血性贫血，过敏性疾病包括全部本发明还使得能够治疗依赖于p110d活性或与p110d活性相关的癌症的方法，包括但不限于白血病，例如急性骨髓性白血病（AML）骨髓增生异常综合征（MDS）骨髓增生性疾病（MPD）慢性骨髓性白血病（CML）T细胞急性淋巴细胞白血病（T-ALL）B细胞急性淋巴细胞性白血病（B-ALL）非霍奇金淋巴瘤（NHL）B细胞淋巴瘤和实体瘤如乳腺癌。

3. 发明申请

WO2006094187A3 PHTHALAZINE, AZA- AND DIAZA-PHTHALAZINE COMPOUNDS AND METHODS OF USE 审中-公开
公开(公告)号：WO2006094187A3
公开(公告)日：2006-09-08
申请号：PCT/US2006/007583
申请日：2006-03-03
申请人： AMGEN INC
发明人： TASKER, Andrew , ZHANG, Dawei , CAO, Guo-Qiang , CHAKRABARTI, Partha, Pratim , FALSEY, James, Richard , HERBERICH, Bradley, J. , HUNGATE, Randall, W. , PETTUS, Liping, H. , REED, Anthony , RZASA, Robert, M. , SHAM, Kelvin, K.C. , THAMAN, Maya, C. , XU, Shimin
IPC分类号： C07D237/32 , C07D237/34 , C07D237/30 , C07D413/12 , C07D417/12 , C07D498/04 , C07D487/04 , C07D417/04 , C07D491/10 , C07D409/04 , C07D401/04 , C07D403/04 , A61K31/502 , A61P29/00
摘要： The present invention comprises a new class of compounds useful for the prophylaxis and treatment of protein kinase mediated diseases, including inflammation and related conditions. The compounds have a general Formula (I), wherein A 1 , A 2 , B, R 1 , R 2 , R 3 and R 4 are defined herein. The invention also comprises pharmaceutical compositions including one or more compounds of Formula I, uses of such compounds and compositions for treatment of kinase mediated diseases including rheumatoid arthritis, psoriasis and other inflammation disorders, as well as intermediates and processes useful for the preparation of compounds of Formula I. The compounds have effect on the levels of TNF-X and various Interleukins.

4. 发明申请

WO2008030466A1 PHTHALAZINE, AZA- AND DIAZA-PHTHALAZINE COMPOUNDS AND METHODS OF USE 审中-公开
标题翻译：苯丙氨酸，亚氨基和二氮杂苯并咪唑化合物及其使用方法
公开(公告)号：WO2008030466A1
公开(公告)日：2008-03-13
申请号：PCT/US2007/019350
申请日：2007-09-04
申请人： AMGEN INC. , TASKER, Andrew , ZHANG, Dawei , PETTUS, Liping, H. , RZASA, Robert, M. , SHAM, Kelvin, K.C. , XU, Shimin , CHAKRABARTI, Partha, Pratim
发明人： TASKER, Andrew , ZHANG, Dawei , PETTUS, Liping, H. , RZASA, Robert, M. , SHAM, Kelvin, K.C. , XU, Shimin , CHAKRABARTI, Partha, Pratim
IPC分类号： C07D237/30 , C07D237/34 , C07D403/10 , C07D403/12 , C07D413/12 , C07D417/10 , C07D471/04 , A61K31/501 , A61P29/00
CPC分类号： C07D403/12 , C07D237/30 , C07D237/34 , C07D403/10 , C07D413/12 , C07D417/10 , C07D471/04
摘要： The present invention comprises a new class of compounds useful for the prophylaxis and treatment of protein kinase mediated diseases, including inflammation and related conditions. The compounds have a general Formula I wherein A 1 , A 2 , B, R 1 , R 2 , R 3 and R 4 are defined herein. The invention also comprises pharmaceutical compositions including one or more compounds of Formula I, uses of such compounds and compositions for treatment of kinase mediated diseases including rheumatoid arthritis, psoriasis and other inflammation disorders, as well as intermediates and processes useful for the preparation of compounds of Formula I.
摘要翻译：本发明包括一类新的可用于预防和治疗蛋白激酶介导的疾病，包括炎症和相关病症的化合物。化合物具有通式I，其中A 1，A 2，B，R 1，R 2， R 3和R 4在本文中定义。本发明还包括药物组合物，其包含一种或多种式I化合物，这些化合物和组合物用于治疗激酶介导的疾病包括类风湿性关节炎，牛皮癣和其它炎症疾病的用途，以及可用于制备一级方程式

5. 发明申请

WO2003099808A8 SUBSTITUTED HETEROCYCLIC COMPOUNDS AND METHODS OF USE 审中-公开
公开(公告)号：WO2003099808A8
公开(公告)日：2003-12-04
申请号：PCT/US2003/015473
申请日：2003-05-13
申请人： AMGEN INC. , DOMINGUEZ, Celia , ZHANG, Dawei , CAO, Guo-Qiang , GOLDBERG, Martin, H. , HONG, Fang-Tsao , SHAM, Kelvin, K., C. , TADESSE, Seifu , TAMAYO, Nuria, A. , WEILER, Kurt, E. , LIAO, Hongyu
发明人： DOMINGUEZ, Celia , ZHANG, Dawei , CAO, Guo-Qiang , GOLDBERG, Martin, H. , HONG, Fang-Tsao , SHAM, Kelvin, K., C. , TADESSE, Seifu , TAMAYO, Nuria, A. , WEILER, Kurt, E. , LIAO, Hongyu
IPC分类号： C07D401/04
摘要： The present invention relates to compounds having the general formula (I) or a pharmaceutically acceptable salt thereof, wherein R l is a saturated or unsaturated 5-, 6- or 7-membered, ring containing 0, 1, 2 or 3 atoms selected from N, O and S, wherein the ring may be fused with a benzo group, and is substituted by 0, 1 or 2 oxo groups, and wherein R 1 is additionally substituted; and R 2 is a substituted C 1 -6 balkyl. Also included is a method of prophylaxis or treatment of inflammation, rheumatoid arthritis, Pagets disease, osteoporosis, multiple myeloma, uveititis, acute or chronic myelogenous leukemia, pancreatic β cell destruction, osteoarthritis, rheumatoid spondylitis, gouty arthritis, inflammatory bowel disease, adult respiratory distress syndrome (ARDS), psoriasis, Crohn's disease, allergic rhinitis, ulcerative colitis, anaphylaxis, contact dermatitis, asthma, muscle degeneration, cachexia, Reiter's syndrome, type I diabetes, type II diabetes, bone resorption diseases, graft vs. host reaction, Alzheimer's disease, stroke, myocardial infarction, ischemia reperfusion injury, atherosclerosis, brain trauma, multiple sclerosis, cerebral malaria, sepsis, septic shock, toxic shock syndrome, fever, myalgias due to HIV-1, HIV-2, HIV-3, cytomegalovirus (CMV), influenza, adenovirus, the herpes viruses or herpes zoster infection in a mammal comprising administering an effective amount a compound as described above.

6. 发明申请

WO2003099808A1 SUBSTITUTED HETEROCYCLIC COMPOUNDS AND METHODS OF USE 审中-公开
标题翻译：取代的杂环化合物及其使用方法
公开(公告)号：WO2003099808A1
公开(公告)日：2003-12-04
申请号：PCT/US2003/015473
申请日：2003-05-15
申请人： AMGEN INC. , DOMINGUEZ, Celia , ZHANG, Dawei , CAO, Guo-Qiang , GOLDBERG, Martin, H. , HONG, Fang-Tsao , SHAM, Kelvin, K., C. , TADESSE, Seifu , TAMAYO, Nuria, A. , WEILER, Kurt, E. , LIAO, Hongyu
发明人： DOMINGUEZ, Celia , ZHANG, Dawei , CAO, Guo-Qiang , GOLDBERG, Martin, H. , HONG, Fang-Tsao , SHAM, Kelvin, K., C. , TADESSE, Seifu , TAMAYO, Nuria, A. , WEILER, Kurt, E. , LIAO, Hongyu
IPC分类号： C07D401/04
CPC分类号： C07D401/04
摘要： The present invention relates to compounds having the general formula (I) or a pharmaceutically acceptable salt thereof, wherein R l is a saturated or unsaturated 5-, 6- or 7-membered, ring containing 0, 1, 2 or 3 atoms selected from N, O and S, wherein the ring may be fused with a benzo group, and is substituted by 0, 1 or 2 oxo groups, and wherein R 1 is additionally substituted; and R 2 is a substituted C 1 -6 balkyl. Also included is a method of prophylaxis or treatment of inflammation, rheumatoid arthritis, Pagets disease, osteoporosis, multiple myeloma, uveititis, acute or chronic myelogenous leukemia, pancreatic β cell destruction, osteoarthritis, rheumatoid spondylitis, gouty arthritis, inflammatory bowel disease, adult respiratory distress syndrome (ARDS), psoriasis, Crohn's disease, allergic rhinitis, ulcerative colitis, anaphylaxis, contact dermatitis, asthma, muscle degeneration, cachexia, Reiter's syndrome, type I diabetes, type II diabetes, bone resorption diseases, graft vs. host reaction, Alzheimer's disease, stroke, myocardial infarction, ischemia reperfusion injury, atherosclerosis, brain trauma, multiple sclerosis, cerebral malaria, sepsis, septic shock, toxic shock syndrome, fever, myalgias due to HIV1, HIV-2, HIV-3, cytomegalovirus (CMV), influenza, adenovirus, the herpes viruses or herpes zoster infection in a mammal comprising administering an effective amount a compound as described above.
摘要翻译：本发明涉及具有通式（I）的化合物或其药学上可接受的盐，其中R 1是含有0,1,2或3个原子的饱和或不饱和的5-，6-或7-元环选自N，O和S，其中所述环可以与苯并稠合，并且被0,1或2个氧代基取代，并且其中R 1另外被取代; R 2是取代的C 1-6烷基。还包括预防或治疗炎症，类风湿性关节炎，斑节病，骨质疏松症，多发性骨髓瘤，葡萄膜炎，急性或慢性骨髓性白血病，胰腺β细胞破坏，骨关节炎，类风湿性脊椎炎，痛风性关节炎，炎性肠病，成人呼吸窘迫综合征（ARDS），牛皮癣，克罗恩病，过敏性鼻炎，溃疡性结肠炎，过敏反应，接触性皮炎，哮喘，肌肉退化，恶病质，赖特综合征，I型糖尿病，II型糖尿病，骨吸收疾病，移植物抗宿主反应，阿尔茨海默病，中风，心肌梗死，缺血再灌注损伤，动脉粥样硬化，脑外伤，多发性硬化，脑疟疾，败血症，败血性休克，中毒性休克综合征，发热，HIV1，HIV-2，HIV-3，巨细胞病毒），流感，腺病毒，哺乳动物中的疱疹病毒或带状疱疹感染，包括给予有效量的化合物如上所述。

7. 发明申请

WO2009011880A3 HETEROCYCLIC MODULATORS OF PKB 审中-公开
公开(公告)号：WO2009011880A3
公开(公告)日：2009-01-22
申请号：PCT/US2008/008723
申请日：2008-07-16
申请人： AMGEN INC. , ZENG, Qingping , ZHANG, Dawei , YAO, Guomin , WOHLHIETER, George E. , WANG, Xianghong , RIDER, James , REICHELT, Andreas , MONENSCHEIN, Holger , HONG, Fang-tsao , FALSEY, James R. , DOMINGUEZ, Celia , BOURBEAU, Matthew P. , ALLEN, John G.
发明人： ZENG, Qingping , ZHANG, Dawei , YAO, Guomin , WOHLHIETER, George E. , WANG, Xianghong , RIDER, James , REICHELT, Andreas , MONENSCHEIN, Holger , HONG, Fang-tsao , FALSEY, James R. , DOMINGUEZ, Celia , BOURBEAU, Matthew P. , ALLEN, John G.
IPC分类号： C07D263/48 , C07D401/04 , C07D403/04 , C07D413/04 , C07D413/14 , C07D417/04 , A61P35/00 , A61K31/5377 , A61K31/41
摘要： The invention relates to heterocyclic compounds of Formula I and compositions thereof useful for treating diseases mediated by protein kinase B (PKB) where the variables have the definitions provided herein Formula (I). The invention also relates to the therapeutic use of such compounds and compositions thereof in treating disease states associated with abnormal cell growth, cancer, inflammation, and metabolic disorders.

8. 发明申请

WO2008118454A2 HETEROCYCLIC COMPOUNDS AND THEIR USES 审中-公开
标题翻译：杂环化合物及其用途
公开(公告)号：WO2008118454A2
公开(公告)日：2008-10-02
申请号：PCT/US2008/003935
申请日：2008-03-24
申请人： AMGEN INC.
发明人： CHEN, Yi , CUSHING, Timothy D. , HAO, Xiaolin , HE, Xiao , REICHELT, Andreas , RZASA, Robert M. , SEGANISH, Jennifer , SHIN, Youngsook , ZHANG, Dawei
IPC分类号： C07D471/04 , C07D487/04 , A61K31/4985 , A61P9/00 , A61P19/02 , A61P37/00 , A61P35/00
CPC分类号： C07D487/04 , C07D471/04 , C07D519/00
摘要： Substituted bicyclic heteroaryls and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, Sjoegren's syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity, The present invention also enables methods for treating cancers that are mediated, dependent on or associated with p110 activity, including but not restricted to leukemias, such as Acute Myeloid leukaemia (AML) Myelo-dysplastic syndrome (MDS) myelo-proliferative diseases (MPD) Chronic Myeloid Leukemia (CML) T-cell Acute Lymphoblastic leukaemia ( T-ALL) B-cell Acute Lymphoblastic leukaemia (B-ALL) Non Hodgkins Lymphoma (NHL) B-cell lymphoma and solid tumors, such as breast cancer.
摘要翻译：取代的双环杂芳基和含有它们的组合物，用于治疗一般炎症，关节炎，风湿性疾病，骨关节炎，炎性肠病，炎症性眼病，炎症性或不稳定性膀胱病，牛皮癣，皮肤炎症成分的投诉，慢性炎性病症不限于自身免疫疾病如系统性红斑狼疮（SLE），重症肌无力，类风湿性关节炎，急性播散性脑脊髓炎，特发性血小板减少性紫癜，多发性硬化症，Sjoegren综合征和自身免疫性溶血性贫血，包括所有形式的超敏反应的过敏症状包括但不限于白血病，如急性骨髓性白血病（AML）骨髓增生异常综合征（MDS）骨髓增殖性疾病（MPD）慢性骨髓性白血病（MPD），慢性骨髓性白血病 C ML）T细胞急性淋巴细胞白血病（T-ALL）B细胞急性淋巴细胞白血病（B-ALL）非霍奇金淋巴瘤（NHL）B细胞淋巴瘤和实体瘤如乳腺癌。

9. 发明申请

WO2006039718A3 ARYL NITROGEN-CONTAINING BICYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS 审中-公开
公开(公告)号：WO2006039718A3
公开(公告)日：2006-04-13
申请号：PCT/US2005/035873
申请日：2005-10-03
申请人： AMGEN INC
发明人： PATEL, Vinod F. , KIM, Joseph L. , GEUNS-MEYER, Stephanie D. , CHAFFEE, Stuart C. , CEE, Victor J. , HODOUS, Brian L. , BELLON, Steven , HARMANGE, Jean-christophe , OLIVIERI, Philip R. , THAMAN, Maya C. , DIMAURO, Erin F. , BUCHANAN, John L. , MCGOWAN, David C. , ALBRECHT, Brian K. , DEAK, Holly L. , BEMIS, Jean E. , WHITE, Ryan , MARTIN, Matthew W. , HABGOOD, Gregory J. , TEMPEST, Paul A. , MASSE, Craig E. , BUCKNER, William H. , HERBERICH, Bradley J. , GRACEFFA, Russell , ZHANG, Dawei , XU, Shimin , SHAM, Kelvin , RZASA, Robert M. , FALSEY, James Richard , CHAKRABARTI, Partha P. , CAO, Guo-qiang , TOMLINSON, Susan Ann , PETTUS, Liping H. , SMITH, Adrian Leonard , PARAS, Nick A. , LIU, Gang , DEMORIN, Frenel F. , TASKER, Andrew , REED, Anthony
IPC分类号： C07D239/84 , C07D239/95 , C07D401/12 , C07D409/04 , C07D405/12 , C07D409/14 , C07D405/04 , C07D403/10 , C07D401/04 , C07D471/04 , C07D403/12 , C07D413/12 , C07D417/12 , C07D409/12 , C07D215/12
摘要： The present invention comprises a new class of compounds useful for the prophylaxis and treatment of protein kinase mediated diseases, including inflammation, cancer and related conditions. The compounds have a general Formula I, wherein A1, A2, A3, B, R1, R2, R3 and R4 are defined herein. Accordingly, the invention also comprises pharmaceutical compositions comprising the compounds of the invention, methods for the prophylaxis and treatment of kinase mediated diseases using the compounds and compositions of the invention, and intermediates and processes useful for the preparation of compounds of the invention.

10. 发明申请

WO2008118468A1 HETEROCYCLIC COMPOUNDS AND THEIR USES 审中-公开
标题翻译：杂环化合物及其用途
公开(公告)号：WO2008118468A1
公开(公告)日：2008-10-02
申请号：PCT/US2008/003962
申请日：2008-03-24
申请人： AMGEN INC.
发明人： CHEN, Yi , CUSHING, Timothy D. , DUQUETTE, Jason A. , GONZALEZ LOPEZ DE TURISO, Felix , HAO, Xiaolin , HE, Xiao , LUCAS, Brian , MCGEE, Lawrence R. , REICHELT, Andreas , RZASA, Robert M. , SEGANISH, Jennifer , SHIN, Youngsook , ZHANG, Dawei
IPC分类号： C07D473/30 , C07D473/34 , C07D487/04 , A61K31/519 , A61K31/52 , A61P29/00 , A61P35/00
CPC分类号： C07D487/04 , C07D471/04 , C07D473/30 , C07D473/34
摘要： Substituted bicyclic heteroaryls and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, Sjoegren's syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity. The present invention also enables methods for treating cancers that are mediated, dependent on, or associated with p110 activity, including but not restricted to leukemias, such as acute myeloid leukaemia (AML), myelo-dysplastic syndrome (MDS), myelo-proliferative diseases (MPD), chronic myeloid leukemia (CML), T-cell acute lymphoblastic leukaemia (T-ALL), B-cell acute lymphoblastic leukaemia (B-ALL), non Hodgkins lymphoma (NHL), B-cell lymphoma and solid tumors, such as breast cancer.
摘要翻译：取代的双环杂芳基和含有它们的组合物，用于治疗一般炎症，关节炎，风湿性疾病，骨关节炎，炎性肠病，炎症性眼病，炎症性或不稳定性膀胱病，牛皮癣，皮肤炎症成分的投诉，慢性炎性病症不限于自身免疫性疾病如系统性红斑狼疮（SLE），重症肌无力，类风湿关节炎，急性播散性脑脊髓炎，特发性血小板减少性紫癜，多发性硬化症，Sjoegren综合征和自身免疫性溶血性贫血，包括所有形式的超敏反应的过敏症状。本发明还能够治疗与p110活性介导，依赖或相关的癌症的方法，包括但不限于白血病，例如急性骨髓性白血病（AML），骨髓增生异常综合征（myelo-dysplastic syndrome，MDS），骨髓增殖性疾病（MPD），慢性骨髓性白血病（CML），T细胞急性淋巴细胞白血病（T-ALL），B细胞急性淋巴细胞白血病（B-ALL），非霍奇金淋巴瘤（NHL），B细胞淋巴瘤和实体瘤，如乳腺癌。

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