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    • 9. 发明申请
    • FURANOPYRIDINE DERIVATIVES AND METHODS OF USE
    • 呋喃并吡啶衍生物及其使用方法
    • WO2006130160A2
    • 2006-12-07
    • PCT/US2005/025725
    • 2005-07-19
    • AMGEN INC.NUNES, Joseph, J.MARTIN, Matthew, W.WHITE, RyanMCGOWAN, DavidBEMIS, Jean, E.KAYSER, FrankFU, JiashengLIU, JinqianJIAO, XianYun
    • NUNES, Joseph, J.MARTIN, Matthew, W.WHITE, RyanMCGOWAN, DavidBEMIS, Jean, E.KAYSER, FrankFU, JiashengLIU, JinqianJIAO, XianYun
    • C07D491/04C07D491/14
    • The present invention relates to furanopyridine compounds having the general Formula I (I) and stereoisomers, tautomers, solvates, pharmaceutically acceptable salts and derivatives, and prodrugs thereof. The invention also includes pharmaceutical compositions comprising a compound of Formula I, methods of modulating Lck and ACK-1 enzymes and of treating various related diseases and conditions, including inflammation, inhibition of T cell activation, proliferation, arthritis, organ transplant, ischemic or reperfusion injury, myocardial infarction, stroke, multiple sclerosis, inflammatory bowel disease, Crohn's disease, lupus, hypersensitivity, type 1 diabetes, psoriasis, dermatitis, Hashimoto's thyroiditis, Sjogren's syndrome, autoimmune hyperthyroidism, Addison's disease, autoimmune diseases, glomerulonephritis, allergic diseases, asthma, hayfever, eczema, cancer, colon carcinoma, thymoma, just to name a few, in a mammal, comprising administering to the mammal a therapeutically effective amount a compound of Formula I, as described above, and methods of manufacturing medicaments comprising the compound of Formula I.
    • 本发明涉及具有通式I(I)的呋喃并吡啶化合物及其立体异构体,互变异构体,溶剂合物,药学上可接受的盐和衍生物及其前药。 本发明还包括药物组合物,其包含式I化合物,调节Lck和ACK-1酶的方法以及治疗各种相关疾病和病症,包括炎症,T细胞活化抑制,增殖,关节炎,器官移植,缺血或再灌注 损伤,心肌梗塞,中风,多发性硬化,炎性肠病,克罗恩病,狼疮,超敏反应,1型糖尿病,牛皮癣,皮炎,桥本氏甲状腺炎,干燥综合征,自身免疫性甲状腺功能亢进,艾迪生病,自身免疫性疾病,肾小球肾炎,过敏性疾病,哮喘 ,干草组织,湿疹,癌症,结肠癌,胸腺瘤,仅举几个例子,在哺乳动物中,包括向哺乳动物施用治疗有效量的如上所述的式I化合物和制备包含以下化合物的药物的方法: 一级方程式