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    • 4. 发明申请
    • ANTI-ACTIVIN A ANTIBODIES AND USES THEREOF
    • 抗激活素A抗体及其用途
    • WO2008031061A2
    • 2008-03-13
    • PCT/US2007077923
    • 2007-09-07
    • AMGEN INCHAN HQCHEN QINGKWAK KEITH SOO-NYUNGZHOU XIAOLAN
    • HAN HQCHEN QINGKWAK KEITH SOO-NYUNGZHOU XIAOLAN
    • C07K16/00
    • C07K16/22A61K2039/505C07K2317/14C07K2317/21C07K2317/56C07K2317/565C07K2317/567C07K2317/76C07K2317/92
    • The disclosure provides compositions and methods relating to or derived from anti-activin A binding proteins, including antibodies. In particular embodiments, the disclosure provides fully human, humanized, and chimeric anti-activin A antibodies that bind human activin A, activin A-binding fragments and derivatives of such antibodies, and activin A-binding polypeptides comprising such fragments. Other embodiments provide nucleic acids encoding such antibodies, antibody fragments and derivatives and polypeptides, cells comprising such polynucleotides, methods of making such antibodies, antibody fragments and derivatives and polypeptides, and methods of using such antibodies, antibody fragments and derivatives and polypeptides, including methods of treating or diagnosing subjects having activin A-related disorders or conditions including cachexia related to gonadal cancer, other cancers, rheumatoid arthritis, and other diseases.
    • 本公开提供了涉及或衍生自抗激活素A结合蛋白(包括抗体)的组合物和方法。 在具体的实施方案中,本公开提供了结合人激活素A,激活素A结合片段和此类抗体的衍生物以及包含此类片段的激活素A结合多肽的完全人源化,人源化和嵌合抗激活素A抗体。 其他实施方案提供了编码此类抗体的核酸,抗体片段和衍生物和多肽,包含此类多核苷酸的细胞,制备此类抗体的方法,抗体片段和衍生物和多肽,以及使用此类抗体,抗体片段和衍生物和多肽的方法,包括方法 治疗或诊断具有与激素A相关的病症或病症(包括与性腺癌相关的恶病质,其他癌症,类风湿性关节炎和其他疾病)的受试者。