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1. 发明申请

US20060287522A1 Pyrrolobenzodiazepine pyridine carboxamides and derivatives as follicle-stimulating hormone receptor antagonists 失效
标题翻译：吡咯并苯并二氮杂吡啶甲酰胺及其衍生物作为促卵泡激素受体拮抗剂
公开(公告)号：US20060287522A1
公开(公告)日：2006-12-21
申请号：US11449376
申请日：2006-06-08
申请人： Amedeo Failli , Gavin Heffernan , Arthur Santilli , Dominick Quagliato , Richard Coghlan , Patrick Andrae , Susan Croce , Emily Shen , Eugene Trybulski
发明人： Amedeo Failli , Gavin Heffernan , Arthur Santilli , Dominick Quagliato , Richard Coghlan , Patrick Andrae , Susan Croce , Emily Shen , Eugene Trybulski
IPC分类号： C07D487/12
CPC分类号： C07D487/04
摘要： This invention provides pyrrolobenzodiazepine pyridine carboxamides selected from those of Formula (1), which act as follicle stimulating hormone receptor antagonists. The invention also provides pharmaceutical compositions and methods of treatment utilizing the compounds of Formulae (1) and (2).
摘要翻译：本发明提供了选自式（1）的吡咯并苯并二氮杂吡啶甲酰胺，其作为促卵泡激素受体拮抗剂。本发明还提供使用式（1）和（2）的化合物的药物组合物和治疗方法。

2. 发明申请

US20060199806A1 Pyrrolobenzodiazepine arylcarboxamides and derivatives thereof as follicle-stimulating hormone receptor antagonists 失效
标题翻译：吡咯并苯并二氮杂芳基甲酰胺及其衍生物作为促卵泡激素受体拮抗剂
公开(公告)号：US20060199806A1
公开(公告)日：2006-09-07
申请号：US11365035
申请日：2006-03-01
申请人： Amedeo Failli , Dominick Quagliato , Patrick Andrae , Gavin Heffernan , Richard Coghlan , Emily Shen
发明人： Amedeo Failli , Dominick Quagliato , Patrick Andrae , Gavin Heffernan , Richard Coghlan , Emily Shen
IPC分类号： C07D487/12 , A61K31/551
CPC分类号： C07D487/04
摘要： This invention provides pyrrolobenzodiazepine arylcarboxamides selected from those of Formula (1), which act as follicle stimulating hormone receptor antagonists, as well as pharmaceutical compositions and methods of treatment
摘要翻译：本发明提供了选自式（1）的吡咯并苯并二氮杂芳基羧酰胺，其作为促卵泡激素受体拮抗剂，以及药物组合物和治疗方法

3. 发明申请

US20060258645A1 Pyrrolobenzodiazepines and heterocyclic carboxamide derivatives as follicle stimulating hormone receptor (FSH-R) antagonists 失效
标题翻译：吡咯并苯并二氮杂类和杂环羧酰胺衍生物作为促卵泡激素受体（FSH-R）拮抗剂
公开(公告)号：US20060258645A1
公开(公告)日：2006-11-16
申请号：US11432200
申请日：2006-05-11
申请人： Amedeo Failli , Dominick Quagliato , Gavin Heffernan , Richard Coghlan , Emily Shen
发明人： Amedeo Failli , Dominick Quagliato , Gavin Heffernan , Richard Coghlan , Emily Shen
IPC分类号： A61K31/551 , C07D487/04
CPC分类号： C07D487/04
摘要： The invention provides compounds of formula or a pharmaceutically acceptable salt thereof, wherein R, R1, R2, R3, and B are as defined in the accompanying specification. Methods of making such compounds are also provided.
摘要翻译：本发明提供了式或其药学上可接受的盐的化合物，其中R 1，R 2，R 2，R 3和B分别为在所附说明书中定义。还提供了制备这些化合物的方法。

4. 发明申请

US20060258644A1 Pyrrolobenzodiazepines and heteroaryl, aryl and cycloalkylamino ketone derivatives as follicle stimulating hormone receptor (FSH-R) antagonists 审中-公开
标题翻译：吡咯并苯并二氮杂和杂芳基，芳基和环烷基氨基酮衍生物作为促卵泡激素受体（FSH-R）拮抗剂
公开(公告)号：US20060258644A1
公开(公告)日：2006-11-16
申请号：US11432177
申请日：2006-05-11
申请人： Amedeo Failli , Arthur Santilli , Dominick Quagliato , Emily Shen
发明人： Amedeo Failli , Arthur Santilli , Dominick Quagliato , Emily Shen
IPC分类号： A61K31/551 , C07D487/04
CPC分类号： C07D487/04
摘要： The invention provides compounds of formula or a pharmaceutically acceptable salt thereof, wherein R, R1, R2, R3, A, and B are as defined in the accompanying specification. Methods of making such compounds are also provided.
摘要翻译：本发明提供式或其药学上可接受的盐的化合物，其中R 1，R 2，R 2，R 3，A和B 如所附说明书中所定义。还提供了制备这些化合物的方法。

5. 发明申请

US20070237778A1 GDF-9/BMP-15 MODULATORS FOR THE TREATMENT OF BONE DISORDERS 失效
标题翻译：用于治疗骨质疏松症的GDF-9 / BMP-15调节剂
公开(公告)号：US20070237778A1
公开(公告)日：2007-10-11
申请号：US11691824
申请日：2007-03-27
申请人： Emily Shen , Frederick Bex , Yogendra Kharode , Vargheese Chennathukuzhi , Murty Chengalvala , Ashok Bapat , Panayiotis Stevis , Gregory Kopf
发明人： Emily Shen , Frederick Bex , Yogendra Kharode , Vargheese Chennathukuzhi , Murty Chengalvala , Ashok Bapat , Panayiotis Stevis , Gregory Kopf
IPC分类号： A61K48/00 , A61K39/395 , A61K38/17
CPC分类号： A61K31/663 , A01K67/0276 , A01K2217/075 , A01K2227/105 , A61K31/675 , A61K38/00 , A61K38/179 , A61K45/06 , C07K14/4753 , C07K14/51 , C07K16/22 , C12Q1/6883 , C12Q2600/158 , G01N33/74 , G01N2333/475 , G01N2333/51 , G01N2800/10 , G01N2800/108 , A61K2300/00
摘要： The invention provides methods for treating or preventing bone degenerative disorders. The disorders treated or prevented include, for example, osteopenia, osteomalacia, osteoporosis, osteomyeloma, osteodystrophy, Paget's disease, osteogenesis imperfecta, and bone degenerative disorders associated with chronic renal disease, hyperparathyroidism, and long-term use of corticosteroids. The disclosed therapeutic methods include administering to a mammal an inhibitor of GDF-9 or BMP-15 in an amount effective to: (1) treat or prevent a bone degenerative disorder; (2) slow bone deterioration; (3) restore lost bone; (4) stimulate new bone formation; and/or (5) maintain bone mass and/or bone quality. The invention also provides methods for administering a GDF-9 agonist or a BMP-15 agonist to treat a bone disorder characterized by increased bone density or mass.
摘要翻译：本发明提供治疗或预防骨退行性疾病的方法。所治疗或预防的疾病包括例如骨质减少症，骨软化症，骨质疏松症，骨髓瘤，骨营养不良，佩吉特氏病，成骨不全症以及与慢性肾脏病，甲状旁腺功能亢进和长期使用皮质类固醇相关的骨退行性疾病。所公开的治疗方法包括给予哺乳动物GDF-9或BMP-15的抑制剂，其量有效：（1）治疗或预防骨退行性疾病; （2）慢骨退化; （3）恢复失骨; （4）刺激新骨形成; 和/或（5）维持骨量和/或骨质量。本发明还提供了用于施用GDF-9激动剂或BMP-15激动剂以治疗以增加的骨密度或质量为特征的骨病症的方法。

6. 发明授权

US09525551B1 Randomly skewing secret values as a countermeasure to compromise 有权
标题翻译：随机倾斜秘密价值作为妥协的对策
公开(公告)号：US09525551B1
公开(公告)日：2016-12-20
申请号：US13248127
申请日：2011-09-29
申请人： Karl Ackerman , Marten Erik van Dijk , Ari Juels , Emily Shen
发明人： Karl Ackerman , Marten Erik van Dijk , Ari Juels , Emily Shen
IPC分类号： H04L9/32 , G06F21/31 , G06F21/34
CPC分类号： H04L9/3228 , G06F21/31 , G06F21/34 , H04L9/088
摘要： A first cryptographic device is authenticated by a second cryptographic device. The second cryptographic device stores an alternative version of a secret value associated with the first cryptographic device as a countermeasure to compromise of the secret value. In conjunction with a protocol carried out between the first cryptographic device and the second cryptographic device, the second cryptographic device determines the secret value based at least in part on the alternative version of the secret value, and utilizes the determined secret value to authenticate the first cryptographic device. The alternative version of the secret value may comprise a randomly-skewed version of the secret value. For example, the secret value may comprise a key or other parameter of the first cryptographic device and the alternative version of the secret value may comprise a randomly-skewed version of the key or other parameter.
摘要翻译：第一加密设备由第二加密设备认证。第二加密设备存储与第一密码设备相关联的秘密值的备选版本作为妥协秘密值的对策。结合在第一加密装置和第二密码装置之间执行的协议，第二加密装置至少部分地基于秘密值的备选版本来确定秘密值，并利用所确定的秘密值来认证第一加密装置加密设备秘密值的替代版本可以包括秘密值的随机倾斜版本。例如，秘密值可以包括第一密码设备的密钥或其他参数，秘密值的备选版本可以包括密钥或其他参数的随机倾斜版本。

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